HRP920498B1 - Process for the preparation of new triiodobenzene compounds with nonionic iodine and contrast products containing them - Google Patents

Process for the preparation of new triiodobenzene compounds with nonionic iodine and contrast products containing them

Info

Publication number
HRP920498B1
HRP920498B1 HRP-1042/89A HRP920498A HRP920498B1 HR P920498 B1 HRP920498 B1 HR P920498B1 HR P920498 A HRP920498 A HR P920498A HR P920498 B1 HRP920498 B1 HR P920498B1
Authority
HR
Croatia
Prior art keywords
new
preparation
products containing
compounds
contrast products
Prior art date
Application number
HRP-1042/89A
Inventor
Michel Guillemot
Original Assignee
Michel Guillemot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8807369A external-priority patent/FR2632304B1/en
Priority claimed from FR8900762A external-priority patent/FR2643077B1/en
Application filed by Michel Guillemot filed Critical Michel Guillemot
Publication of HRP920498A2 publication Critical patent/HRP920498A2/en
Publication of HRP920498B1 publication Critical patent/HRP920498B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to new nonionic compounds of formula <IMAGE> These compounds can be employed as contrast agents.
HRP-1042/89A 1988-06-02 1992-09-25 Process for the preparation of new triiodobenzene compounds with nonionic iodine and contrast products containing them HRP920498B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8807369A FR2632304B1 (en) 1988-06-02 1988-06-02 NON-IONIC TRIODOBENZENIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND CONTRAST PRODUCTS CONTAINING THEM
FR8900762A FR2643077B1 (en) 1989-01-23 1989-01-23 NOVEL IODIC NON-IONIC COMPOUNDS AND CONTRAST PRODUCTS CONTAINING THEM
YU104289A YU48318B (en) 1988-06-02 1989-05-22 PROCEDURE FOR OBTAINING NEW TRIODOBENZEN UNITS AND THE CONTRAST AGENCY CONTAINING THEM

Publications (2)

Publication Number Publication Date
HRP920498A2 HRP920498A2 (en) 1994-04-30
HRP920498B1 true HRP920498B1 (en) 1998-06-30

Family

ID=26226693

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-1042/89A HRP920498B1 (en) 1988-06-02 1992-09-25 Process for the preparation of new triiodobenzene compounds with nonionic iodine and contrast products containing them

Country Status (25)

Country Link
EP (1) EP0357467B1 (en)
JP (1) JPH07100684B2 (en)
KR (1) KR0148358B1 (en)
CN (1) CN1021440C (en)
AT (1) ATE98220T1 (en)
AU (1) AU617810B2 (en)
CA (1) CA1339665C (en)
CZ (1) CZ277984B6 (en)
DE (1) DE68911237T2 (en)
DK (1) DK175034B1 (en)
DZ (1) DZ1341A1 (en)
EG (1) EG19008A (en)
ES (1) ES2060800T3 (en)
FI (1) FI102745B (en)
GE (1) GEP19960460B (en)
HR (1) HRP920498B1 (en)
HU (1) HU201732B (en)
IL (1) IL90326A (en)
LV (1) LV10234B (en)
MA (1) MA21565A1 (en)
NO (1) NO177461C (en)
PT (1) PT90696B (en)
RU (1) RU1833365C (en)
SI (1) SI8911042A (en)
YU (1) YU48318B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2656865B1 (en) * 1990-01-05 1993-03-26 Guerbet Sa NON-IONIC IODINE COMPOUND, PROCESS FOR PREPARING THE SAME, AND CONTRAST PRODUCT CONTAINING THE SAME.
FR2673180B1 (en) * 1991-02-25 1994-03-04 Guerbet Sa NOVEL POLY-IODIC NON-IONIC COMPOUNDS, PREPARATION METHOD, CONTRAST PRODUCT CONTAINING THE SAME.
DE4109169A1 (en) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz WATER-SOLUBLE NON-IONIC X-RAY CONTRASTING AGENTS AND AGENTS AND METHOD FOR THE PRODUCTION THEREOF
FR2695125B1 (en) * 1992-08-25 1994-12-23 Guerbet Sa New polyiodinated compounds, preparation process, contrast medium containing them.
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (en) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A PROCESS FOR THE PURIFICATION AND CRYSTALLIZATION OF IOPAMIDOL
US5705692A (en) * 1996-09-27 1998-01-06 Abbott Laboratories Process for the preparation of iohexol
CN110903275A (en) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 Process for producing iobitridol, intermediate therefor, and process for producing the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media
KR960016747B1 (en) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 Preparation of 5-acylamino-2,4,6 triiodo or tribromo benzoic acid derivatives
FR2632304B1 (en) * 1988-06-02 1991-05-17 Guerbert Sa NON-IONIC TRIODOBENZENIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND CONTRAST PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
LV10234B (en) 1995-04-20
LV10234A (en) 1994-10-20
PT90696A (en) 1989-12-29
EG19008A (en) 1994-06-30
DZ1341A1 (en) 2004-09-13
DK175034B1 (en) 2004-05-03
HRP920498A2 (en) 1994-04-30
YU48318B (en) 1998-05-15
JPH07100684B2 (en) 1995-11-01
FI892681A0 (en) 1989-06-01
GEP19960460B (en) 1996-07-10
CN1038094A (en) 1989-12-20
JPH0225456A (en) 1990-01-26
EP0357467B1 (en) 1993-12-08
CN1021440C (en) 1993-06-30
DE68911237T2 (en) 1994-05-11
NO177461B (en) 1995-06-12
HUT50107A (en) 1989-12-28
KR900000329A (en) 1990-01-30
CZ277984B6 (en) 1993-07-14
CA1339665C (en) 1998-02-10
NO892189L (en) 1989-12-04
YU104289A (en) 1991-04-30
ATE98220T1 (en) 1993-12-15
SI8911042A (en) 1997-10-31
AU617810B2 (en) 1991-12-05
NO892189D0 (en) 1989-05-31
DE68911237D1 (en) 1994-01-20
PT90696B (en) 1995-03-01
FI102745B1 (en) 1999-02-15
EP0357467A1 (en) 1990-03-07
MA21565A1 (en) 1989-12-31
DK259589A (en) 1989-12-03
DK259589D0 (en) 1989-05-26
CZ329189A3 (en) 1993-04-14
ES2060800T3 (en) 1994-12-01
AU3523589A (en) 1989-12-07
IL90326A (en) 1993-05-13
FI102745B (en) 1999-02-15
HU201732B (en) 1990-12-28
IL90326A0 (en) 1989-12-15
FI892681A (en) 1989-12-03
RU1833365C (en) 1993-08-07
KR0148358B1 (en) 1998-08-17
NO177461C (en) 1995-09-20

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20080507

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20090523