DK174203B1 - Stabiliserede human-vævsplasminogenaktivator-præparater - Google Patents

Stabiliserede human-vævsplasminogenaktivator-præparater Download PDF

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Publication number
DK174203B1
DK174203B1 DK198606057A DK605786A DK174203B1 DK 174203 B1 DK174203 B1 DK 174203B1 DK 198606057 A DK198606057 A DK 198606057A DK 605786 A DK605786 A DK 605786A DK 174203 B1 DK174203 B1 DK 174203B1
Authority
DK
Denmark
Prior art keywords
composition according
concentration
human tissue
composition
arginine
Prior art date
Application number
DK198606057A
Other languages
Danish (da)
English (en)
Other versions
DK605786A (da
DK605786D0 (da
Inventor
William Franklin Bennett
Stuart Elliot Builder
Larry Alan Gatlin
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25205495&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK174203(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK605786D0 publication Critical patent/DK605786D0/da
Publication of DK605786A publication Critical patent/DK605786A/da
Application granted granted Critical
Publication of DK174203B1 publication Critical patent/DK174203B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
DK198606057A 1985-12-17 1986-12-16 Stabiliserede human-vævsplasminogenaktivator-præparater DK174203B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/811,081 US4777043A (en) 1985-12-17 1985-12-17 Stabilized human tissue plasminogen activator compositions
US81108185 1985-12-17

Publications (3)

Publication Number Publication Date
DK605786D0 DK605786D0 (da) 1986-12-16
DK605786A DK605786A (da) 1987-06-18
DK174203B1 true DK174203B1 (da) 2002-09-16

Family

ID=25205495

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198606057A DK174203B1 (da) 1985-12-17 1986-12-16 Stabiliserede human-vævsplasminogenaktivator-præparater

Country Status (23)

Country Link
US (2) US4777043A (de)
EP (1) EP0228862B1 (de)
JP (2) JPH0714886B2 (de)
KR (1) KR950010322B1 (de)
AT (1) ATE79273T1 (de)
AU (1) AU600246B2 (de)
DD (1) DD255477A5 (de)
DE (2) DE3686410T2 (de)
DK (1) DK174203B1 (de)
ES (1) ES2044840T3 (de)
FI (1) FI88873C (de)
FR (1) FR2591485B1 (de)
GB (1) GB2184354B (de)
GR (1) GR3006078T3 (de)
HU (1) HU200101B (de)
IE (1) IE59060B1 (de)
IL (1) IL80904A (de)
MY (1) MY102185A (de)
NO (1) NO168988C (de)
NZ (1) NZ218612A (de)
PH (1) PH24716A (de)
PT (1) PT83933B (de)
ZA (1) ZA869457B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3687255T2 (de) * 1985-09-10 1993-05-06 Eisai Co Ltd Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
DE3877529T2 (de) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
US4898826A (en) * 1987-12-10 1990-02-06 Invitron Corporation Method to solubilize tissue plasminogen activator
HU206367B (en) * 1988-04-30 1992-10-28 Sandoz Ag Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
JP2520975B2 (ja) * 1989-09-21 1996-07-31 三井東圧化学株式会社 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤
US6207151B1 (en) * 1989-09-21 2001-03-27 Mitsui Chemicals Inc. Aqueous solution of t-PA
DE3942143A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh T-pa pro stabilisierung
DE3942144A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von k1k2p pro
DE3942145A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh T-pa-solubilisierung
DE3942141A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh K2p pro-stabilisierung
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
US5358708A (en) * 1993-01-29 1994-10-25 Schering Corporation Stabilization of protein formulations
US5656730A (en) * 1995-04-07 1997-08-12 Enzon, Inc. Stabilized monomeric protein compositions
DE19606551C2 (de) * 1996-02-22 2000-06-08 Basotherm Gmbh rt-PA zur Prävention des Nachstars nach Kataraktoperation
US5972912A (en) * 1998-12-17 1999-10-26 S.P. Pharmaceuticals Method for lyophilizing ifosfamide
AU6558400A (en) * 1999-08-17 2001-03-13 Novo Nordisk A/S Stabilisation of freeze-dried cake
US6586574B1 (en) 1999-08-17 2003-07-01 Nn A/S Stabilization of freeze-dried cake
MXPA02004401A (es) * 1999-11-04 2002-09-02 Genentech Inc Ensayo de cromatografia liquida de alta resolucion de fase inversa para activadores de plasminogeno.
MXPA02009485A (es) 2000-03-31 2003-03-10 Kirin Brewery Preparacion en polvo para administracion a traves de la mucosa, que comprende un farmaco de alto peso molecular y que muestra una estabilidad mejorada en almacenamiento.
CA2459120A1 (en) * 2001-09-07 2003-03-20 Kenneth S. S. Chang Human tissue urokinase type plasminogen activator formulation
US20110179558A1 (en) * 2009-07-29 2011-07-28 International Enviroguard Systems, Inc. Breathable Protective Fabric and Garment
KR20150128857A (ko) * 2013-03-14 2015-11-18 알러간, 인코포레이티드 지속된-방출 전달의 조성물 및 제조 공정 동안 단백질을 안정화시키는 방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK98833C (da) * 1961-04-25 1964-05-25 Novo Terapeutisk Labor As Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger.
EP0112940B1 (de) * 1982-12-30 1986-10-15 Kowa Company, Ltd. Verfahren zur Herstellung eines gewebeplasminogen Aktivators und eine denselben enthaltende Zubereitung
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
DE3584902D1 (de) * 1984-02-29 1992-01-30 Asahi Chemical Ind Waessrige loesung eines darin in erhoehter konzentration aufgeloesten gewebe-plasminogen-aktivators und herstellungsverfahren.
HU206520B (en) * 1985-04-22 1992-11-30 Genentech Inc Process for producing new human tissue plasminogen activator /tpa/ mutants and pharmaceutical compositions containing them
US4929444A (en) * 1985-05-28 1990-05-29 Burroughs Wellcome Co. Low pH pharmaceutical formulation containing t-PA
IT1191925B (it) * 1985-05-28 1988-03-31 Wellcome Found Soluzione acquosa parenterale di attivatore di plasminogeno dei tessuti e procedimento di preparazione
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
DE3687255T2 (de) * 1985-09-10 1993-05-06 Eisai Co Ltd Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
DE3537708A1 (de) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh Verfahren zur aktivierung von t-pa nach expression in prokaryonten
JPS62120321A (ja) * 1985-11-20 1987-06-01 Eisai Co Ltd ｔＰＡ含有医薬組成物
JPS62283932A (ja) * 1986-05-29 1987-12-09 Green Cross Corp:The 組織プラスミノ−ゲンアクチベ−タの乾燥製剤

Also Published As

Publication number Publication date
FI88873C (fi) 1993-07-26
KR950010322B1 (ko) 1995-09-14
AU6661086A (en) 1987-06-18
GB2184354A (en) 1987-06-24
HUT42955A (en) 1987-09-28
IE863279L (en) 1987-06-17
ES2044840T3 (es) 1994-01-16
PT83933B (pt) 1989-01-17
ZA869457B (en) 1988-08-31
PT83933A (en) 1987-01-01
NO168988B (no) 1992-01-20
DD255477A5 (de) 1988-04-06
GR3006078T3 (de) 1993-06-21
DK605786A (da) 1987-06-18
DE3686410D1 (de) 1992-09-17
EP0228862A2 (de) 1987-07-15
DK605786D0 (da) 1986-12-16
NO168988C (no) 1992-04-29
DE3642960A1 (de) 1987-06-19
JPS62164632A (ja) 1987-07-21
FR2591485B1 (fr) 1989-07-28
FI865159A0 (fi) 1986-12-17
FI865159A (fi) 1987-06-18
EP0228862B1 (de) 1992-08-12
AU600246B2 (en) 1990-08-09
KR870005647A (ko) 1987-07-06
NO865079D0 (no) 1986-12-16
GB2184354B (en) 1990-04-11
GB8629981D0 (en) 1987-01-28
FI88873B (fi) 1993-04-15
PH24716A (en) 1990-10-01
FR2591485A1 (fr) 1987-06-19
HU200101B (en) 1990-04-28
IE59060B1 (en) 1993-12-15
DE3686410T2 (de) 1993-02-18
US4777043A (en) 1988-10-11
ATE79273T1 (de) 1992-08-15
MY102185A (en) 1992-04-30
NZ218612A (en) 1989-07-27
EP0228862A3 (en) 1988-09-28
NO865079L (no) 1987-06-18
IL80904A (en) 1992-01-15
JPH0714886B2 (ja) 1995-02-22
JPH07173076A (ja) 1995-07-11
IL80904A0 (en) 1987-03-31
US4908205A (en) 1990-03-13

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired