ES2044840T3 - Composiciones estabilizadas del activador del plasminogeno de tejido humano. - Google Patents
Composiciones estabilizadas del activador del plasminogeno de tejido humano.Info
- Publication number
- ES2044840T3 ES2044840T3 ES86309811T ES86309811T ES2044840T3 ES 2044840 T3 ES2044840 T3 ES 2044840T3 ES 86309811 T ES86309811 T ES 86309811T ES 86309811 T ES86309811 T ES 86309811T ES 2044840 T3 ES2044840 T3 ES 2044840T3
- Authority
- ES
- Spain
- Prior art keywords
- plasminogen activator
- human tissue
- tissue plasminogen
- stabilized compositions
- stabilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
COMPOSICIONES ACEPTABLES FARMACEUTICAMENTE ESTABLES QUE CONTIENEN CARACTERISTICAS DE TEJIDO ACTIVADOR PLASMINOGENO HUMANO, POR EJEMPLO, UN ION ARGININIUM CONTENIENDO UN NIVEL DE UN COMPONENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/811,081 US4777043A (en) | 1985-12-17 | 1985-12-17 | Stabilized human tissue plasminogen activator compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2044840T3 true ES2044840T3 (es) | 1994-01-16 |
Family
ID=25205495
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES86309811T Expired - Lifetime ES2044840T3 (es) | 1985-12-17 | 1986-12-16 | Composiciones estabilizadas del activador del plasminogeno de tejido humano. |
Country Status (23)
Country | Link |
---|---|
US (2) | US4777043A (es) |
EP (1) | EP0228862B1 (es) |
JP (2) | JPH0714886B2 (es) |
KR (1) | KR950010322B1 (es) |
AT (1) | ATE79273T1 (es) |
AU (1) | AU600246B2 (es) |
DD (1) | DD255477A5 (es) |
DE (2) | DE3642960A1 (es) |
DK (1) | DK174203B1 (es) |
ES (1) | ES2044840T3 (es) |
FI (1) | FI88873C (es) |
FR (1) | FR2591485B1 (es) |
GB (1) | GB2184354B (es) |
GR (1) | GR3006078T3 (es) |
HU (1) | HU200101B (es) |
IE (1) | IE59060B1 (es) |
IL (1) | IL80904A (es) |
MY (1) | MY102185A (es) |
NO (1) | NO168988C (es) |
NZ (1) | NZ218612A (es) |
PH (1) | PH24716A (es) |
PT (1) | PT83933B (es) |
ZA (1) | ZA869457B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE83153T1 (de) * | 1985-09-10 | 1992-12-15 | Eisai Co Ltd | Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. |
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
US5453363A (en) * | 1985-10-23 | 1995-09-26 | Boehringer Mannheim Gmbh | Process for the activation of t-PA or Ing after genetic expression in prokaryotes |
US5034225A (en) * | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
JP2708749B2 (ja) * | 1987-08-10 | 1998-02-04 | エーザイ株式会社 | 修飾型tPA含有注射用組成物 |
ES2045167T5 (es) * | 1987-10-23 | 1996-07-01 | Centre Regional De Transfusion | Preparacion de concentrado de factor ix humano de elevada pureza y de otras proteinas plasmaticas. |
US4898826A (en) * | 1987-12-10 | 1990-02-06 | Invitron Corporation | Method to solubilize tissue plasminogen activator |
HU206367B (en) * | 1988-04-30 | 1992-10-28 | Sandoz Ag | Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts |
US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
DE3903581A1 (de) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | Gewebs-plasminogenaktivator-derivat |
JP2520975B2 (ja) * | 1989-09-21 | 1996-07-31 | 三井東圧化学株式会社 | 組織プラスミノ―ゲンアクチベ―タ―若しくはその誘導体を含有する血栓溶解剤 |
US6207151B1 (en) * | 1989-09-21 | 2001-03-27 | Mitsui Chemicals Inc. | Aqueous solution of t-PA |
DE3942143A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | T-pa pro stabilisierung |
DE3942141A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | K2p pro-stabilisierung |
DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
DE3942144A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von k1k2p pro |
DE3942145A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | T-pa-solubilisierung |
US5358708A (en) * | 1993-01-29 | 1994-10-25 | Schering Corporation | Stabilization of protein formulations |
US5656730A (en) * | 1995-04-07 | 1997-08-12 | Enzon, Inc. | Stabilized monomeric protein compositions |
DE19606551C2 (de) * | 1996-02-22 | 2000-06-08 | Basotherm Gmbh | rt-PA zur Prävention des Nachstars nach Kataraktoperation |
US5972912A (en) * | 1998-12-17 | 1999-10-26 | S.P. Pharmaceuticals | Method for lyophilizing ifosfamide |
ATE264340T1 (de) * | 1999-08-17 | 2004-04-15 | Novo Nordisk Healthcare Ag | Stabilisierung von gefriergetrocknetem kuchen |
US6586574B1 (en) | 1999-08-17 | 2003-07-01 | Nn A/S | Stabilization of freeze-dried cake |
NZ518187A (en) * | 1999-11-04 | 2002-12-20 | Genentech Inc | Reversed-phase HPLC assay for plasminogen activators |
US7282219B2 (en) | 2000-03-31 | 2007-10-16 | Kirin Beer Kabushiki Kaisha | Powdery preparation for transmucosal administration containing a polymeric form of drug and exhibiting improved storage stability |
EP1432437A2 (en) * | 2001-09-07 | 2004-06-30 | Global Biotech Inc. | Human tissue urokinase type plasminogen activator formulation |
US20110179558A1 (en) * | 2009-07-29 | 2011-07-28 | International Enviroguard Systems, Inc. | Breathable Protective Fabric and Garment |
WO2014151725A1 (en) * | 2013-03-14 | 2014-09-25 | Allergan, Inc. | Composition of a sustained-release delivery and method of stabilizing proteins during fabrication process |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK98833C (da) * | 1961-04-25 | 1964-05-25 | Novo Terapeutisk Labor As | Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger. |
EP0112940B1 (en) * | 1982-12-30 | 1986-10-15 | Kowa Company, Ltd. | Method of producing a tissue plasminogen activator and composition comprising same |
JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
EP0156169B1 (en) * | 1984-02-29 | 1991-12-18 | Asahi Kasei Kogyo Kabushiki Kaisha | An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method |
DE3682104D1 (de) * | 1985-04-22 | 1991-11-28 | Genentech Inc | Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen. |
NZ216306A (en) * | 1985-05-28 | 1989-10-27 | Wellcome Found | Pharmaceutical compositions containing tissue plasminogen activator |
US4929444A (en) * | 1985-05-28 | 1990-05-29 | Burroughs Wellcome Co. | Low pH pharmaceutical formulation containing t-PA |
ZW14486A1 (en) * | 1985-07-29 | 1986-10-22 | Smithkline Beckman Corp | Pharmaceutical dosage unit |
ATE83153T1 (de) * | 1985-09-10 | 1992-12-15 | Eisai Co Ltd | Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung. |
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
JPS62120321A (ja) * | 1985-11-20 | 1987-06-01 | Eisai Co Ltd | tPA含有医薬組成物 |
JPS62283932A (ja) * | 1986-05-29 | 1987-12-09 | Green Cross Corp:The | 組織プラスミノ−ゲンアクチベ−タの乾燥製剤 |
-
1985
- 1985-12-17 US US06/811,081 patent/US4777043A/en not_active Expired - Lifetime
-
1986
- 1986-12-08 IL IL80904A patent/IL80904A/xx not_active IP Right Cessation
- 1986-12-12 NZ NZ218612A patent/NZ218612A/xx unknown
- 1986-12-15 PT PT83933A patent/PT83933B/pt unknown
- 1986-12-16 ES ES86309811T patent/ES2044840T3/es not_active Expired - Lifetime
- 1986-12-16 PH PH34602A patent/PH24716A/en unknown
- 1986-12-16 AU AU66610/86A patent/AU600246B2/en not_active Expired
- 1986-12-16 KR KR1019860010747A patent/KR950010322B1/ko not_active IP Right Cessation
- 1986-12-16 DE DE19863642960 patent/DE3642960A1/de not_active Ceased
- 1986-12-16 GB GB8629981A patent/GB2184354B/en not_active Revoked
- 1986-12-16 IE IE327986A patent/IE59060B1/en not_active IP Right Cessation
- 1986-12-16 AT AT86309811T patent/ATE79273T1/de not_active IP Right Cessation
- 1986-12-16 DD DD86297695A patent/DD255477A5/de unknown
- 1986-12-16 HU HU865225A patent/HU200101B/hu unknown
- 1986-12-16 NO NO865079A patent/NO168988C/no not_active IP Right Cessation
- 1986-12-16 DE DE8686309811T patent/DE3686410T2/de not_active Expired - Lifetime
- 1986-12-16 DK DK198606057A patent/DK174203B1/da not_active IP Right Cessation
- 1986-12-16 FR FR8617593A patent/FR2591485B1/fr not_active Expired
- 1986-12-16 EP EP86309811A patent/EP0228862B1/en not_active Expired - Lifetime
- 1986-12-17 FI FI865159A patent/FI88873C/fi not_active IP Right Cessation
- 1986-12-17 ZA ZA869457A patent/ZA869457B/xx unknown
- 1986-12-17 JP JP61302767A patent/JPH0714886B2/ja not_active Expired - Lifetime
-
1987
- 1987-10-01 MY MYPI87002760A patent/MY102185A/en unknown
-
1988
- 1988-03-28 US US07/173,854 patent/US4908205A/en not_active Expired - Lifetime
-
1992
- 1992-10-26 GR GR920402407T patent/GR3006078T3/el unknown
-
1994
- 1994-08-04 JP JP6183274A patent/JPH07173076A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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