DK173604B1 - Vektor for udtrykkelse i gær, bestående af et fremmed DNA-kodningssegment og en fremgangsmåde til udtrykkelse af DNA-kodningssegmentet i gær ved hjælp af en sådan vektor - Google Patents
Vektor for udtrykkelse i gær, bestående af et fremmed DNA-kodningssegment og en fremgangsmåde til udtrykkelse af DNA-kodningssegmentet i gær ved hjælp af en sådan vektor Download PDFInfo
- Publication number
- DK173604B1 DK173604B1 DK198305777A DK577783A DK173604B1 DK 173604 B1 DK173604 B1 DK 173604B1 DK 198305777 A DK198305777 A DK 198305777A DK 577783 A DK577783 A DK 577783A DK 173604 B1 DK173604 B1 DK 173604B1
- Authority
- DK
- Denmark
- Prior art keywords
- yeast
- coding segment
- expression vector
- segment
- dna
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Toys (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK199301074A DK173763B1 (da) | 1983-02-22 | 1993-09-23 | Vektor for udtrykkelse i gær med en PyK promotor og en fremgangsmåde til syntese af hepatitis B virus overfladeantigen ved hjælp af en sådan vektor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46858983A | 1983-02-22 | 1983-02-22 | |
US46858983 | 1983-02-22 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK577783D0 DK577783D0 (da) | 1983-12-15 |
DK577783A DK577783A (da) | 1984-08-23 |
DK173604B1 true DK173604B1 (da) | 2001-04-23 |
Family
ID=23860419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198305777A DK173604B1 (da) | 1983-02-22 | 1983-12-15 | Vektor for udtrykkelse i gær, bestående af et fremmed DNA-kodningssegment og en fremgangsmåde til udtrykkelse af DNA-kodningssegmentet i gær ved hjælp af en sådan vektor |
Country Status (7)
Country | Link |
---|---|
EP (4) | EP0120551B1 (fr) |
JP (2) | JPS59210888A (fr) |
AT (3) | ATE138975T1 (fr) |
CA (2) | CA1341302C (fr) |
DE (3) | DE3482844D1 (fr) |
DK (1) | DK173604B1 (fr) |
SG (1) | SG48422A1 (fr) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
JPS5936699A (ja) * | 1982-08-20 | 1984-02-28 | Chemo Sero Therapeut Res Inst | シヤトルベクタ− |
JPS5931799A (ja) * | 1982-08-16 | 1984-02-20 | Science & Tech Agency | B型肝炎ウイルス遺伝子を組込んだ組換えプラスミド |
US5422267A (en) * | 1984-05-22 | 1995-06-06 | Robert R. Yocum | Industrial yeast comprising an integrated glucoamylase gene |
EP0173997A1 (fr) * | 1984-09-06 | 1986-03-12 | Chiron Corporation | Vaccins protéiniques de virus de leucémie du chat et leur préparation |
DE3587307T2 (de) * | 1984-12-06 | 1993-09-02 | Fina Research | Transformierte hefen die lysozym produzieren, fuer diese transformation zu verwendende plasmide und deren verwendung. |
DE3677851D1 (de) * | 1985-08-05 | 1991-04-11 | Merck & Co Inc | Verfahren zur steigerung der produktion von rekombinantem protein in hefearten der gattung saccharomyces. |
ES2028779T3 (es) * | 1985-10-03 | 1992-07-16 | Green Cross Corporation | Promotor de levadura y procedimiento para preparar proteina heterologa. |
JPH0655155B2 (ja) * | 1985-10-03 | 1994-07-27 | 株式会社ミドリ十字 | 蛋白質の製造方法 |
DK162900C (da) * | 1985-10-24 | 1992-05-11 | Danisco | Fremgangsmaade til ekspression af gener i gaer samt dna-fragment, rekombineret dna-segment og plasmider, hvor disse indgaar til brug ved udoevelse af fremgangsmaaden |
US4895800A (en) * | 1985-11-26 | 1990-01-23 | Phillips Petroleum Company | Yeast production of hepatitis B surface antigen |
JPS62236496A (ja) * | 1986-04-07 | 1987-10-16 | Green Cross Corp:The | HBsAgの製造方法 |
US4839283A (en) * | 1986-12-30 | 1989-06-13 | Zymogenetics, Inc. | Method of expressing alpha-1-antitrypsin in yeast |
EP0300213A1 (fr) * | 1987-06-22 | 1989-01-25 | Hexal-Pharma Gentechnik GmbH & Co. KG | Particules immunogènes peptidiques virales d'hépatite A |
CA1340772C (fr) | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression et secretion de proteines heterologues dans une levure au moyen de sequences leader tronquees du facteur alpha |
AU644619B2 (en) | 1989-12-21 | 1993-12-16 | Advanced Technologies (Cambridge) Limited | Modification of plant metabolism |
NZ236434A (en) * | 1990-01-29 | 1992-08-26 | Ciba Geigy Ag | Dna molecules comprising the a niger pyruvate kinase transcription promoter, vectors containing it and their use in transforming host cells |
US6194140B1 (en) * | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
EP0785273A1 (fr) | 1990-11-26 | 1997-07-23 | Genetics Institute, Inc. | Enzyme de conversion d'acides aminés basiques couplés et séquence d'ADN codant pour cette enzyme |
EP0491077A1 (fr) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | Composition utilisée comme agent thérapeutique contre des maladies hépatiques chroniques |
ATE249838T1 (de) | 1993-05-12 | 2003-10-15 | Chiron Corp | Konserviertes motiv der hepatitis c virus e2/ns1 region |
US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
JPH08173170A (ja) * | 1994-05-25 | 1996-07-09 | Kirin Brewery Co Ltd | キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現 |
US5712249A (en) * | 1994-09-08 | 1998-01-27 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
DE69633343T2 (de) | 1995-12-22 | 2005-09-22 | Dsm Ip Assets B.V. | Verbesserte verfahren zur transformation von phaffiastämmen,transformierte phaffiastämme auf diese weise erhaltend, und rekominante dns in besagtem verfahren verwendbar |
EP1900818A3 (fr) | 1997-11-06 | 2008-06-11 | Novartis Vaccines and Diagnostics S.r.l. | Antigènes de Neisserial |
PT1047784E (pt) | 1998-01-14 | 2009-12-21 | Novartis Vaccines & Diagnostic | Antigénios de neisseria meningitidis |
US6087128A (en) | 1998-02-12 | 2000-07-11 | Ndsu Research Foundation | DNA encoding an avian E. coli iss |
GB9808932D0 (en) | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
BR9910089A (pt) | 1998-05-01 | 2004-06-08 | Chiron Corp | Composições e antìgenos de neisseria meningitidis |
ES2397918T3 (es) | 1999-04-30 | 2013-03-12 | Novartis Vaccines And Diagnostics S.R.L. | Antígenos Neisseriales conservados |
GB9911683D0 (en) | 1999-05-19 | 1999-07-21 | Chiron Spa | Antigenic peptides |
GB9916529D0 (en) | 1999-07-14 | 1999-09-15 | Chiron Spa | Antigenic peptides |
CA2864069A1 (fr) | 1999-10-29 | 2001-05-03 | Novartis Vaccines And Diagnostics S.R.L. | Peptides antigeniques de neisseria |
US6709863B2 (en) | 1999-12-08 | 2004-03-23 | Iowa State University Research Foundation | Nucleic acid molecules encoding multiple start codons and histidine tags |
CA2871789C (fr) | 2000-01-17 | 2017-04-04 | Novartis Vaccines And Diagnostics S.R.L. | Vaccin a base de vesicule de membrane externe (omv) comprenant des proteines de membrane externe du serogroupe b de n. meningitis |
NZ524888A (en) | 2000-10-27 | 2006-09-29 | Chiron S | Nucleic acids and proteins from streptococcus groups A & B |
US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
WO2002059297A2 (fr) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | Échantillothèque pour collection de cellules |
GB0107658D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
EP1463520B1 (fr) | 2001-12-12 | 2008-09-03 | Novartis Vaccines and Diagnostics S.r.l. | Immunisation contre chlamydia trachomatis |
EP1572720A4 (fr) | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | Procede de production enzymatique de peptides glp-2 (1-34) et glp-2 (1-33) |
DK2279746T3 (da) | 2002-11-15 | 2013-11-25 | Novartis Vaccines & Diagnostic | Overfladeproteiner i neisseria meningitidis |
GB0308198D0 (en) | 2003-04-09 | 2003-05-14 | Chiron Srl | ADP-ribosylating bacterial toxin |
EP1704234B1 (fr) | 2003-11-21 | 2012-01-18 | NPS Pharmaceuticals, Inc. | Production de peptides 2 de type glucagon et de leurs analogues |
DE10356218A1 (de) * | 2003-12-03 | 2005-06-30 | Bayer Cropscience Ag | Verfahren zum Identifizieren von fungizid wirksamen Verbindungen basierend auf Pyruvatkinasen aus Pilzen |
BRPI0507159A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos em feixe de quatro hélices humanos modificados e seus usos |
BRPI0512235A (pt) | 2004-06-18 | 2008-02-19 | Ambrx Inc | polipeptìdeos ligadores de antìgenos e seus usos |
WO2006068802A2 (fr) | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Compositions de synthetase d'aminoacyl-arnt et utilisations correspondantes |
JP2008525473A (ja) | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 修飾されたヒト成長ホルモン |
AU2005319125A1 (en) | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
BRPI0610297A2 (pt) | 2005-04-18 | 2010-06-08 | Novartis Vaccines & Diagnostic | expressão de antìgeno de superfìcie de vìrus da hepatite b para a preparação de vacina |
NZ565294A (en) | 2005-08-18 | 2010-06-25 | Ambrx Inc | Compositions of tRNA and uses thereof |
WO2007026249A2 (fr) | 2005-09-01 | 2007-03-08 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Vaccination multiple comprenant des meningocoques du serogroupe c |
AU2006315347A1 (en) | 2005-11-16 | 2007-05-24 | Ambrx, Inc. | Methods and compositions comprising non-natural amino acids |
US20080317670A1 (en) | 2005-12-14 | 2008-12-25 | Ambrx, Inc. | Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides |
WO2008020335A2 (fr) | 2006-06-09 | 2008-02-21 | Novartis Ag | Compositions immunogènes pour streptococcus agalactiae |
JP5840345B2 (ja) | 2006-09-08 | 2016-01-06 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 修飾ヒト血漿ポリペプチドまたは修飾ヒトFc足場タンパク質ならびにこれらの利用 |
AU2007292892B9 (en) | 2006-09-08 | 2013-02-28 | Ambrx, Inc. | Hybrid suppressor tRNA for vertebrate cells |
KR20160121601A (ko) | 2007-03-30 | 2016-10-19 | 암브룩스, 인코포레이티드 | 변형된 fgf-21 폴리펩티드 및 그 용도 |
WO2008139591A1 (fr) * | 2007-05-11 | 2008-11-20 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Procédé de fabrication d'aprotinine recombinante |
WO2009067636A2 (fr) | 2007-11-20 | 2009-05-28 | Ambrx, Inc. | Polypeptides d'insuline modifiés et leurs utilisations |
NZ602170A (en) | 2008-02-08 | 2014-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
EA019968B1 (ru) | 2008-07-23 | 2014-07-30 | Амбркс, Инк. | Модифицированные бычьи полипептиды g-csf и их применение |
CA2738033C (fr) | 2008-09-26 | 2019-11-26 | Ambrx, Inc. | Vaccins et micro-organismes dependant de la replication d'acide amine non naturels |
CN102232085A (zh) | 2008-09-26 | 2011-11-02 | Ambrx公司 | 修饰的动物促红细胞生成素多肽和其用途 |
EA201290541A1 (ru) | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
EA201290542A1 (ru) | 2009-12-21 | 2013-07-30 | Амбркс, Инк. | Модифицированные свиные соматотропиновые полипептиды и их применение |
WO2011146833A1 (fr) | 2010-05-20 | 2011-11-24 | Evolva Inc. | Procédé de fabrication de composés isoprénoïdes dans une levure |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
MX346786B (es) | 2010-08-17 | 2017-03-31 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos. |
TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
PL3412302T3 (pl) | 2014-10-24 | 2021-11-02 | Bristol-Myers Squibb Company | Zmodyfikowane polipeptydy fgf-21 i ich zastosowania |
US10266578B2 (en) | 2017-02-08 | 2019-04-23 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ199722A (en) * | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
GR76274B (fr) * | 1981-08-04 | 1984-08-04 | Univ California | |
NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
JPS58146281A (ja) * | 1981-10-19 | 1983-08-31 | Suntory Ltd | 酵母細胞の形質転換法 |
US4446235A (en) * | 1982-03-22 | 1984-05-01 | Genentech, Inc. | Method for cloning human growth hormone varient genes |
ATE49421T1 (de) * | 1982-05-19 | 1990-01-15 | Gist Brocades Nv | Klonierungssystem fuer kluyveromyce spezies. |
AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
JPH0716432B2 (ja) * | 1982-10-20 | 1995-03-01 | サントリー株式会社 | 酵母の高発現ベクタープラスミドを用いたペプチドの生産方法 |
-
1983
- 1983-10-25 CA CA000439701A patent/CA1341302C/fr not_active Expired - Lifetime
- 1983-10-25 CA CA000524802A patent/CA1341116C/fr not_active Expired - Lifetime
- 1983-12-15 DK DK198305777A patent/DK173604B1/da not_active IP Right Cessation
-
1984
- 1984-01-06 AT AT91114001T patent/ATE138975T1/de not_active IP Right Cessation
- 1984-01-06 SG SG1996009565A patent/SG48422A1/en unknown
- 1984-01-06 AT AT84300091T patent/ATE55151T1/de not_active IP Right Cessation
- 1984-01-06 DE DE8484300091T patent/DE3482844D1/de not_active Expired - Lifetime
- 1984-01-06 EP EP84300091A patent/EP0120551B1/fr not_active Expired - Lifetime
- 1984-01-06 EP EP91114001A patent/EP0460716B2/fr not_active Expired - Lifetime
- 1984-01-06 EP EP89106868A patent/EP0329203B1/fr not_active Expired - Lifetime
- 1984-01-06 DE DE89106868T patent/DE3486206T2/de not_active Expired - Lifetime
- 1984-01-06 EP EP96200286A patent/EP0732403A1/fr not_active Withdrawn
- 1984-01-06 AT AT89106868T patent/ATE93894T1/de not_active IP Right Cessation
- 1984-01-06 DE DE3486431T patent/DE3486431T3/de not_active Expired - Lifetime
- 1984-02-16 JP JP59026172A patent/JPS59210888A/ja active Granted
-
1992
- 1992-06-17 JP JP4200091A patent/JPH0724594B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH05268984A (ja) | 1993-10-19 |
DE3486206D1 (de) | 1993-10-07 |
EP0329203A1 (fr) | 1989-08-23 |
DK577783D0 (da) | 1983-12-15 |
EP0329203B1 (fr) | 1993-09-01 |
JPS59210888A (ja) | 1984-11-29 |
JPH0724594B2 (ja) | 1995-03-22 |
EP0732403A1 (fr) | 1996-09-18 |
CA1341116C (fr) | 2000-10-17 |
DE3486206T2 (de) | 1994-02-03 |
EP0120551A3 (en) | 1986-05-14 |
DE3486431T3 (de) | 2000-05-04 |
DE3486431D1 (de) | 1996-07-11 |
JPH0515431B2 (fr) | 1993-03-01 |
ATE93894T1 (de) | 1993-09-15 |
DE3486431T2 (de) | 1996-10-10 |
EP0120551A2 (fr) | 1984-10-03 |
ATE55151T1 (de) | 1990-08-15 |
DE3482844D1 (de) | 1990-09-06 |
EP0460716B1 (fr) | 1996-06-05 |
CA1341302C (fr) | 2001-10-09 |
EP0460716A1 (fr) | 1991-12-11 |
EP0120551B1 (fr) | 1990-08-01 |
ATE138975T1 (de) | 1996-06-15 |
SG48422A1 (en) | 1998-04-17 |
DK577783A (da) | 1984-08-23 |
EP0460716B2 (fr) | 1999-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |