DK172456B1 - Lægemidler indeholdende insulinderivater til behandling af diabetes mellitus - Google Patents

Lægemidler indeholdende insulinderivater til behandling af diabetes mellitus Download PDF

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Publication number
DK172456B1
DK172456B1 DK198403583A DK358384A DK172456B1 DK 172456 B1 DK172456 B1 DK 172456B1 DK 198403583 A DK198403583 A DK 198403583A DK 358384 A DK358384 A DK 358384A DK 172456 B1 DK172456 B1 DK 172456B1
Authority
DK
Denmark
Prior art keywords
insulin
alkylamino
alkoxy
proinsulin
formula
Prior art date
Application number
DK198403583A
Other languages
Danish (da)
English (en)
Other versions
DK358384A (da
DK358384D0 (da
Inventor
Ulrich Grau
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK358384D0 publication Critical patent/DK358384D0/da
Publication of DK358384A publication Critical patent/DK358384A/da
Application granted granted Critical
Publication of DK172456B1 publication Critical patent/DK172456B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK198403583A 1983-07-22 1984-07-20 Lægemidler indeholdende insulinderivater til behandling af diabetes mellitus DK172456B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3326473 1983-07-22
DE19833326473 DE3326473A1 (de) 1983-07-22 1983-07-22 Pharmazeutisches mittel zur behandlung des diabetes mellitus

Publications (3)

Publication Number Publication Date
DK358384D0 DK358384D0 (da) 1984-07-20
DK358384A DK358384A (da) 1985-01-23
DK172456B1 true DK172456B1 (da) 1998-08-24

Family

ID=6204661

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198403583A DK172456B1 (da) 1983-07-22 1984-07-20 Lægemidler indeholdende insulinderivater til behandling af diabetes mellitus

Country Status (19)

Country Link
US (1) US4608364A (hu)
EP (1) EP0132769B1 (hu)
JP (1) JPS6042334A (hu)
AT (1) ATE31625T1 (hu)
AU (1) AU564648B2 (hu)
CA (1) CA1236012A (hu)
DE (2) DE3326473A1 (hu)
DK (1) DK172456B1 (hu)
ES (1) ES534488A0 (hu)
FI (1) FI79786C (hu)
GR (1) GR81550B (hu)
HU (1) HUT34889A (hu)
IE (1) IE57690B1 (hu)
IL (1) IL72468A (hu)
NO (1) NO167187C (hu)
NZ (1) NZ208960A (hu)
PH (1) PH21328A (hu)
PT (1) PT78941A (hu)
ZA (1) ZA845621B (hu)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
US4946828A (en) * 1985-03-12 1990-08-07 Novo Nordisk A/S Novel insulin peptides
CA1339416C (en) * 1987-02-25 1997-09-02 Liselotte Langkjaer Insulin derivatives
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
DE3717370A1 (de) * 1987-05-22 1988-12-01 Hoechst Ag Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
US4789660A (en) * 1987-09-10 1988-12-06 American Home Products Corporation Insulin administration using methyl and propyl paraben
ES2061797T3 (es) * 1988-06-23 1994-12-16 Hoechst Ag Mini-proinsulina, su preparacion y empleo.
US6875589B1 (en) 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
WO1992010284A2 (en) 1990-12-07 1992-06-25 Cnc Development, Inc. Catalytic chemical reactor
YU66892A (sh) * 1991-08-20 1995-10-24 Hoechst Ag. Fosfoinositolglikan - peptid sa delovanjem kao insulin
TW224471B (hu) * 1991-11-26 1994-06-01 Lilly Co Eli
ES2137937T3 (es) * 1991-11-29 2000-01-01 Hoechst Ag Peptidos con efecto del tipo de insulina.
CA2087087C (en) * 1992-01-22 2000-07-18 Burton H. Sage, Jr. Molecules for iontophoretic delivery
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
US6451970B1 (en) * 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
SE520392C2 (sv) 1996-09-27 2003-07-01 Creative Peptides Sweden Ab C Specifika peptider för behandling av diabetes mellitus
DE19649350A1 (de) * 1996-11-28 1998-06-04 Hoechst Ag Inositolglykane mit insulinartiger Wirkung
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
TR200001050T2 (tr) 1997-10-24 2000-08-21 Eli Lilly And Company Çözünmez insülin bileşimleri
CO4970787A1 (es) 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
ES2208305T3 (es) * 1999-04-08 2004-06-16 Genentech, Inc. Composicion basada en polipeptidos de carga opuesta..
US6852694B2 (en) 2001-02-21 2005-02-08 Medtronic Minimed, Inc. Stabilized insulin formulations
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
GB0323979D0 (en) 2003-10-13 2003-11-19 Creative Peptides Sweden Ab Therapeutic applications for c-peptide
GB0601950D0 (en) * 2006-01-31 2006-03-15 Creative Peptides Sweden Ab Compositions and methods of treating diabetes
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
EP2898900B1 (en) 2008-09-19 2017-11-15 Nektar Therapeutics Polymer conjugates of ziconotide
PL2349324T3 (pl) 2008-10-17 2018-02-28 Sanofi-Aventis Deutschland Gmbh Kombinacja insuliny i agonisty GLP-1
US8410049B2 (en) 2009-10-28 2013-04-02 Cebix Methods and kits for preventing hypoglycemia
RU2573995C2 (ru) 2009-11-13 2016-01-27 Санофи-Авентис Дойчланд Гмбх Фармацевтическая композиция, содержащая агонист гпп-1 и метионин
ES2534191T3 (es) 2009-11-13 2015-04-20 Sanofi-Aventis Deutschland Gmbh Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina
SG187904A1 (en) 2010-08-30 2013-04-30 Sanofi Aventis Deutschland Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PL2750699T3 (pl) 2011-08-29 2015-12-31 Sanofi Aventis Deutschland Kombinacja farmaceutyczna do stosowania w kontroli glikemii u pacjentów z cukrzycą typu 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
EP3463413A4 (en) * 2016-05-25 2020-03-04 Merck Sharp & Dohme Corp. PARTIAL INSULIN RECEPTOR AGONISTS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP1982004086A (es) * 1981-08-27 1988-03-22 Lilly Co Eli Formula farmaceutica que comprende insulina humana y proinsulina humana
ZW17682A1 (en) * 1981-08-27 1982-11-24 Lilly Co Eli Pharmaceutical formulations comprising human insulin human c-peptide and human proinsulin
CH650677A5 (de) * 1981-08-27 1985-08-15 Lilly Co Eli Gegen diabetes mellitus wirksames pharmazeutisches mittel.
CA1176158A (en) * 1981-08-27 1984-10-16 Ronald E. Chance Pharmaceutical formulations comprising human insulin and human c-peptide
NL8201650A (nl) * 1982-04-21 1983-11-16 Akzo Nv Semisynthetische bereiding van humane insuline.

Also Published As

Publication number Publication date
NZ208960A (en) 1989-02-24
GR81550B (hu) 1984-12-11
IE57690B1 (en) 1993-03-10
PT78941A (de) 1984-08-01
IL72468A0 (en) 1984-11-30
HUT34889A (en) 1985-05-28
JPH0469128B2 (hu) 1992-11-05
ES8504456A1 (es) 1985-05-01
AU3091784A (en) 1985-01-24
AU564648B2 (en) 1987-08-20
PH21328A (en) 1987-10-13
FI842915A (fi) 1985-01-23
FI79786C (fi) 1990-03-12
US4608364A (en) 1986-08-26
CA1236012A (en) 1988-05-03
JPS6042334A (ja) 1985-03-06
EP0132769B1 (de) 1988-01-07
DK358384A (da) 1985-01-23
DE3468323D1 (en) 1988-02-11
ATE31625T1 (de) 1988-01-15
EP0132769A1 (de) 1985-02-13
DE3326473A1 (de) 1985-01-31
NO167187C (no) 1991-10-16
ES534488A0 (es) 1985-05-01
NO842978L (no) 1985-01-23
IE841890L (en) 1985-01-22
FI842915A0 (fi) 1984-07-19
DK358384D0 (da) 1984-07-20
IL72468A (en) 1989-08-15
FI79786B (fi) 1989-11-30
NO167187B (no) 1991-07-08
ZA845621B (en) 1985-02-27

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PBP Patent lapsed

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