ES2137937T3 - Peptidos con efecto del tipo de insulina. - Google Patents

Peptidos con efecto del tipo de insulina.

Info

Publication number
ES2137937T3
ES2137937T3 ES92119913T ES92119913T ES2137937T3 ES 2137937 T3 ES2137937 T3 ES 2137937T3 ES 92119913 T ES92119913 T ES 92119913T ES 92119913 T ES92119913 T ES 92119913T ES 2137937 T3 ES2137937 T3 ES 2137937T3
Authority
ES
Spain
Prior art keywords
insulin
residue
acid residue
alkyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92119913T
Other languages
English (en)
Inventor
Wendelin Dr Frick
Gunter Dr Muller
Stefan Dr Mullner
Gerhard Dr Breipohl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2137937T3 publication Critical patent/ES2137937T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0819—Tripeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBEN PEPTIDOS CON ACCION SIMILAR A LA DE LA INSULINA, DE FORMULA I, DONDE C ES UN ATOMO DE HIDROGENO, UN RESTO DE AMINOACIDO, UN RESTO DE AMINOACIDO SUSTITUIDO, O UN RESTO DE AZUCAR, D ES UN RESTO DE AMINOACIDO, UN RESTO DE FOSFOAMINOACIDO, RESTO DE AZUCAR, ENLACE COVALENTE O RESTO HIDROXILO, E ES UN ATOMO DE HIDROGENO, RESTO HIDROXILO, RESTOS DE AZUCAR SUSTITUIDOS, ALQUILDIAMINA SUSTITUIDA O RESTO DE GLICERINA, R1 ES (C1 UPO PROTECTOR DE AZUFRE, SO2, SO3, (C1 O2, RESTO O3, O ES UN ATOMO DE HIDROGENO, R3 Y R4 INDEPENDIENTE UNO DE OTRO, ES HIDROGENO O METILO, Y W ES UNA CIFRA ENTERA 1 O 2, SU OBTENCION Y SU UTILIZACION PARA EL TRATAMIENTO DE LA DIABETES MELLITUS O DIABETES NO DEPENDIENTES DE LA INSULINA.
ES92119913T 1991-11-29 1992-11-23 Peptidos con efecto del tipo de insulina. Expired - Lifetime ES2137937T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4139376 1991-11-29

Publications (1)

Publication Number Publication Date
ES2137937T3 true ES2137937T3 (es) 2000-01-01

Family

ID=6445910

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92119913T Expired - Lifetime ES2137937T3 (es) 1991-11-29 1992-11-23 Peptidos con efecto del tipo de insulina.

Country Status (11)

Country Link
US (1) US5622934A (es)
EP (1) EP0545198B1 (es)
JP (1) JP3324804B2 (es)
AT (1) ATE184611T1 (es)
DE (1) DE59209745D1 (es)
DK (1) DK0545198T3 (es)
ES (1) ES2137937T3 (es)
FI (1) FI925370A (es)
GR (1) GR3031850T3 (es)
NO (1) NO309146B1 (es)
SG (1) SG46640A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
KR100481746B1 (ko) * 1996-11-28 2005-08-10 훽스트 악티엔게젤샤프트 인슐린-유사작용을갖는이노시톨글리칸및이를포함하는약제학적제제
DE19649350A1 (de) * 1996-11-28 1998-06-04 Hoechst Ag Inositolglykane mit insulinartiger Wirkung
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
EP1836161B1 (en) 2004-12-22 2016-07-20 BHI Limited Partnership Methods and compositions for treating amyloid-related diseases
PL2089417T3 (pl) 2006-10-12 2015-07-31 Bhi Lp Sposoby, związki, kompozycje i nośniki dostarczające kwas 3-amino-1-propanosulfonowy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2801175A1 (de) * 1978-01-12 1979-07-19 Hoechst Ag Verfahren zur herstellung cysteinhaltiger peptide
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
US4515920A (en) * 1984-04-30 1985-05-07 The Rockefeller University Synthesis of peptides and proteins
ES2039402T3 (es) * 1986-10-24 1993-10-01 Pfrimmer Kabi Gmbh & Co. Kg Empleo de peptidos n,n'-bis-l-aminoacido-l-cistina en preparados de aminoacidos para alimentacion oral y parenteral.
EP0288897B1 (de) * 1987-04-25 1993-08-11 Hoechst Aktiengesellschaft Enkastine: Neue Glycopeptide mit Enkephalinase-hemmender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als pharmazeutische Präparate
NZ232562A (en) * 1989-02-17 1992-10-28 Coselco Mimotopes Pty Ltd Immobilised peptide - solid support comprising a cleavable ester link between the peptide carboxy terminus and the solid support
US5214181A (en) * 1989-11-27 1993-05-25 Santen Pharmaceutical Co., Ltd. Amino acid derivatives
TW227004B (es) * 1990-12-19 1994-07-21 Hoechst Ag
YU66892A (sh) * 1991-08-20 1995-10-24 Hoechst Ag. Fosfoinositolglikan - peptid sa delovanjem kao insulin

Also Published As

Publication number Publication date
FI925370A (fi) 1993-05-30
DE59209745D1 (de) 1999-10-21
JPH05247088A (ja) 1993-09-24
EP0545198A3 (es) 1994-03-23
NO924585D0 (no) 1992-11-27
EP0545198B1 (de) 1999-09-15
NO309146B1 (no) 2000-12-18
JP3324804B2 (ja) 2002-09-17
NO924585L (no) 1993-06-01
FI925370A0 (fi) 1992-11-26
GR3031850T3 (en) 2000-02-29
SG46640A1 (en) 1998-02-20
DK0545198T3 (da) 2000-03-20
US5622934A (en) 1997-04-22
ATE184611T1 (de) 1999-10-15
EP0545198A2 (de) 1993-06-09

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