ATE186302T1 - Etoposidanaloge - Google Patents

Etoposidanaloge

Info

Publication number
ATE186302T1
ATE186302T1 AT90903699T AT90903699T ATE186302T1 AT E186302 T1 ATE186302 T1 AT E186302T1 AT 90903699 T AT90903699 T AT 90903699T AT 90903699 T AT90903699 T AT 90903699T AT E186302 T1 ATE186302 T1 AT E186302T1
Authority
AT
Austria
Prior art keywords
beta
nhch2ch
alpha
etoposide analogues
etoposide
Prior art date
Application number
AT90903699T
Other languages
English (en)
Inventor
Kuo-Hsiung Lee
Zhe Qing Wang
Yung-Chi Cheng
Su-Ying Liu
Yasuhiro Imakura
Mitsumasa - Shirotauchi Haruna
Scott A Beers
Lee S Thurston
Hua-Juan Room A- Dai
Chung-Hsiung Chen
Phillip J Bowen
Dora M Schnur
Yao Haur Chinese Culture U Kuo
Masami - Inui Higaghiazai Mori
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/406,330 external-priority patent/US5132322A/en
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE186302T1 publication Critical patent/ATE186302T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT90903699T 1989-02-23 1990-02-23 Etoposidanaloge ATE186302T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31382689A 1989-02-23 1989-02-23
US07/406,330 US5132322A (en) 1989-02-23 1989-09-12 Etoposide analogues

Publications (1)

Publication Number Publication Date
ATE186302T1 true ATE186302T1 (de) 1999-11-15

Family

ID=26979072

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90903699T ATE186302T1 (de) 1989-02-23 1990-02-23 Etoposidanaloge

Country Status (6)

Country Link
EP (1) EP0461141B1 (de)
JP (1) JP3043802B2 (de)
AT (1) ATE186302T1 (de)
AU (1) AU632796B2 (de)
DE (1) DE69033342T2 (de)
WO (1) WO1990009788A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300500A (en) * 1989-02-23 1994-04-05 The University Of North Carolina At Chapel Hill 4 beta-amino podophyllotoxin analog compounds and methods
TW221441B (de) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
US5338867A (en) * 1992-04-24 1994-08-16 Genelabs Technologies, Inc. Preparation of 4β- amino podophyllotoxin compounds
WO1993022319A1 (en) * 1992-04-24 1993-11-11 University Of North Carolina At Chapel Hill 4-beta-amino podophyllotoxin derivatives antitumor agents
FR2742439B1 (fr) * 1995-12-14 1998-03-06 Pf Medicament Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
JPH1135454A (ja) * 1997-07-22 1999-02-09 Meiji Milk Prod Co Ltd 抗腫瘍剤
FR2859208B1 (fr) 2003-09-02 2006-01-21 Servier Lab Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN103613600B (zh) * 2013-11-15 2017-01-04 湖北工业大学 具抗肿瘤活性的苯胺基鬼臼类衍生物及其制备方法和用途
CN103601732A (zh) * 2013-11-15 2014-02-26 湖北工业大学 具抗肿瘤活性的氮取代鬼臼类衍生物及其制备方法和用途
CN105732651B (zh) * 2016-03-17 2018-07-20 重庆药友制药有限责任公司 一种小分子肺靶向药物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH361293A (de) * 1957-06-03 1962-04-15 Sandoz Ag Verfahren zur Herstellung von Podophyllsäure- und Pikropodophyllsäure-Derivaten
US2984674A (en) * 1958-06-02 1961-05-16 Sandoz Ag Amides of podophyllic acid and picropodophyllic acid
NL6613143A (de) * 1965-09-21 1967-03-22
CH472403A (de) * 1965-09-21 1969-05-15 Sandoz Ag Verfahren zur Herstellung eines 4'-Demethyl-epipodophyllotoxins
IL49971A0 (en) * 1975-07-08 1976-09-30 Troponwerke Dinklage & Co New 2-benzoypranone derivatives,their preparation and pharmaceutical compositions containing them
US4122092A (en) * 1977-08-25 1978-10-24 University Of Rochester Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
AU585936B2 (en) * 1984-12-28 1989-06-29 Conpharm A.B. Pharmaceutically active podophyllotoxins
JPS6310789A (ja) * 1986-07-01 1988-01-18 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
JPS6323884A (ja) * 1986-07-17 1988-02-01 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH07116197B2 (ja) * 1987-05-14 1995-12-13 財団法人微生物化学研究会 ４′−０−デメチル−１−エピポドフィロトキシン誘導体
JPH01117885A (ja) * 1987-10-30 1989-05-10 Dai Ichi Seiyaku Co Ltd 新規ボドフィロトキシン誘導体及びその製造法

Also Published As

Publication number Publication date
AU5157190A (en) 1990-09-26
AU632796B2 (en) 1993-01-14
DE69033342T2 (de) 2000-05-11
EP0461141A4 (en) 1992-07-01
JP3043802B2 (ja) 2000-05-22
WO1990009788A1 (en) 1990-09-07
DE69033342D1 (de) 1999-12-09
EP0461141A1 (de) 1991-12-18
EP0461141B1 (de) 1999-11-03

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties