DE69033342D1 - Etoposidanaloge - Google Patents

Etoposidanaloge

Info

Publication number
DE69033342D1
DE69033342D1 DE69033342T DE69033342T DE69033342D1 DE 69033342 D1 DE69033342 D1 DE 69033342D1 DE 69033342 T DE69033342 T DE 69033342T DE 69033342 T DE69033342 T DE 69033342T DE 69033342 D1 DE69033342 D1 DE 69033342D1
Authority
DE
Germany
Prior art keywords
beta
nhch2ch
alpha
etoposide
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69033342T
Other languages
English (en)
Other versions
DE69033342T2 (de
Inventor
Kuo-Hsiung Lee
Zhe Wang
Yung-Chi Cheng
Su-Ying Liu
Yasuhiro Imakura
Mitsumasa - Haruna
Scott Beers
Lee Thurston
Hua-Juan Room Dai
Chung-Hsiung Chen
Phillip Bowen
Dora Schnur
Yao Kuo
Masami - Mori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
University of North Carolina System
Original Assignee
University of North Carolina at Chapel Hill
University of North Carolina System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/406,330 external-priority patent/US5132322A/en
Application filed by University of North Carolina at Chapel Hill, University of North Carolina System filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of DE69033342D1 publication Critical patent/DE69033342D1/de
Publication of DE69033342T2 publication Critical patent/DE69033342T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
DE69033342T 1989-02-23 1990-02-23 Etoposidanaloge Expired - Fee Related DE69033342T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31382689A 1989-02-23 1989-02-23
US07/406,330 US5132322A (en) 1989-02-23 1989-09-12 Etoposide analogues
PCT/US1990/000842 WO1990009788A1 (en) 1989-02-23 1990-02-23 Etoposide analogues

Publications (2)

Publication Number Publication Date
DE69033342D1 true DE69033342D1 (de) 1999-12-09
DE69033342T2 DE69033342T2 (de) 2000-05-11

Family

ID=26979072

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69033342T Expired - Fee Related DE69033342T2 (de) 1989-02-23 1990-02-23 Etoposidanaloge

Country Status (6)

Country Link
EP (1) EP0461141B1 (de)
JP (1) JP3043802B2 (de)
AT (1) ATE186302T1 (de)
AU (1) AU632796B2 (de)
DE (1) DE69033342T2 (de)
WO (1) WO1990009788A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300500A (en) * 1989-02-23 1994-04-05 The University Of North Carolina At Chapel Hill 4 beta-amino podophyllotoxin analog compounds and methods
TW221441B (de) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
AU4113693A (en) * 1992-04-24 1993-11-29 University Of North Carolina At Chapel Hill, The 4-beta-amino podophyllotoxin derivatives antitumor agents
US5338867A (en) * 1992-04-24 1994-08-16 Genelabs Technologies, Inc. Preparation of 4β- amino podophyllotoxin compounds
FR2742439B1 (fr) * 1995-12-14 1998-03-06 Pf Medicament Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
JPH1135454A (ja) * 1997-07-22 1999-02-09 Meiji Milk Prod Co Ltd 抗腫瘍剤
FR2859208B1 (fr) * 2003-09-02 2006-01-21 Servier Lab Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN103613600B (zh) * 2013-11-15 2017-01-04 湖北工业大学 具抗肿瘤活性的苯胺基鬼臼类衍生物及其制备方法和用途
CN103601732A (zh) * 2013-11-15 2014-02-26 湖北工业大学 具抗肿瘤活性的氮取代鬼臼类衍生物及其制备方法和用途
CN105732651B (zh) * 2016-03-17 2018-07-20 重庆药友制药有限责任公司 一种小分子肺靶向药物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH361293A (de) * 1957-06-03 1962-04-15 Sandoz Ag Verfahren zur Herstellung von Podophyllsäure- und Pikropodophyllsäure-Derivaten
US2984674A (en) * 1958-06-02 1961-05-16 Sandoz Ag Amides of podophyllic acid and picropodophyllic acid
NL6613143A (de) * 1965-09-21 1967-03-22
CH472403A (de) * 1965-09-21 1969-05-15 Sandoz Ag Verfahren zur Herstellung eines 4'-Demethyl-epipodophyllotoxins
FR2316939A1 (fr) * 1975-07-08 1977-02-04 Troponwerke Dinklage & Co Derives de 2-benzopyranone et leur application comme medicaments
US4122092A (en) * 1977-08-25 1978-10-24 University Of Rochester Total synthesis of (±)-picropodophyllone and (±)-4'-demethylpicropodophyllone
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
HU201672B (en) * 1984-12-28 1990-12-28 Conpharm Ab Process for producing pharmaceutical compositions comprising podophyllotoxin
JPS6310789A (ja) * 1986-07-01 1988-01-18 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
JPS6323884A (ja) * 1986-07-17 1988-02-01 Nippon Kayaku Co Ltd 新規ポドフイロトキシン誘導体
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH07116197B2 (ja) * 1987-05-14 1995-12-13 財団法人微生物化学研究会 ４′−０−デメチル−１−エピポドフィロトキシン誘導体
JPH01117885A (ja) * 1987-10-30 1989-05-10 Dai Ichi Seiyaku Co Ltd 新規ボドフィロトキシン誘導体及びその製造法

Also Published As

Publication number Publication date
ATE186302T1 (de) 1999-11-15
EP0461141B1 (de) 1999-11-03
JP3043802B2 (ja) 2000-05-22
EP0461141A4 (en) 1992-07-01
AU632796B2 (en) 1993-01-14
WO1990009788A1 (en) 1990-09-07
DE69033342T2 (de) 2000-05-11
AU5157190A (en) 1990-09-26
EP0461141A1 (de) 1991-12-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee