DK171197B1 - Analogifremgangsmåde til fremstilling af acetohydroxamsyrer - Google Patents

Analogifremgangsmåde til fremstilling af acetohydroxamsyrer Download PDF

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Publication number
DK171197B1
DK171197B1 DK126677A DK126677A DK171197B1 DK 171197 B1 DK171197 B1 DK 171197B1 DK 126677 A DK126677 A DK 126677A DK 126677 A DK126677 A DK 126677A DK 171197 B1 DK171197 B1 DK 171197B1
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crl
mice
effect
dose
solution
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DK126677A
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Danish (da)
English (en)
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DK126677A (da
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Louis Lafon
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Lafon Labor
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/72—Acyl halides containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/56—Radicals substituted by sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
DK126677A 1976-03-23 1977-03-22 Analogifremgangsmåde til fremstilling af acetohydroxamsyrer DK171197B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB1171076 1976-03-23
GB11710/76A GB1574822A (en) 1976-03-23 1976-03-23 Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
GB629877 1977-02-15
GB629877 1977-02-15

Publications (2)

Publication Number Publication Date
DK126677A DK126677A (da) 1977-09-24
DK171197B1 true DK171197B1 (da) 1996-07-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK126677A DK171197B1 (da) 1976-03-23 1977-03-22 Analogifremgangsmåde til fremstilling af acetohydroxamsyrer

Country Status (25)

Country Link
US (7) US4122186A (xx)
JP (1) JPS52144601A (xx)
AT (5) AT356078B (xx)
AU (1) AU516473B2 (xx)
BE (1) BE852738A (xx)
CA (2) CA1120928A (xx)
CH (1) CH620894A5 (xx)
CS (1) CS200511B2 (xx)
DD (1) DD129645A5 (xx)
DE (1) DE2711451A1 (xx)
DK (1) DK171197B1 (xx)
ES (1) ES457105A1 (xx)
FI (1) FI62821C (xx)
FR (4) FR2345430A1 (xx)
GB (1) GB1574822A (xx)
IE (1) IE44721B1 (xx)
IL (1) IL51705A (xx)
LU (1) LU76989A1 (xx)
NL (1) NL188801C (xx)
NO (4) NO144420C (xx)
NZ (1) NZ183616A (xx)
PH (1) PH16271A (xx)
PT (1) PT66300B (xx)
SE (4) SE432420B (xx)
SU (1) SU689617A3 (xx)

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US7842835B2 (en) * 2003-07-07 2010-11-30 Georgetown University Histone deacetylase inhibitors and methods of use thereof
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Also Published As

Publication number Publication date
NO144420C (no) 1981-08-26
NL7703168A (nl) 1977-09-27
SE7703263L (sv) 1977-09-24
NO803337L (no) 1977-09-26
SE452155B (sv) 1987-11-16
FI770859A (xx) 1977-09-24
AT362793B (de) 1981-06-10
FR2453148B1 (xx) 1983-12-02
IL51705A0 (en) 1977-05-31
BE852738A (fr) 1977-09-22
AU2334477A (en) 1978-09-21
ES457105A1 (es) 1978-10-16
FR2453133B1 (xx) 1984-04-06
NO146431B (no) 1982-06-21
SE8302171L (sv) 1983-04-19
LU76989A1 (xx) 1977-07-18
PT66300B (pt) 1978-08-10
DD129645A5 (de) 1978-02-01
JPS628424B2 (xx) 1987-02-23
SE8302171D0 (sv) 1983-04-19
FI62821B (fi) 1982-11-30
AT356078B (de) 1980-04-10
NO803338L (no) 1977-09-26
SE8302173D0 (sv) 1983-04-19
NL188801C (nl) 1992-10-01
DE2711451A1 (de) 1977-10-06
US4209523A (en) 1980-06-24
SE432420B (sv) 1984-04-02
ATA839978A (de) 1980-02-15
CH620894A5 (xx) 1980-12-31
NO152972C (no) 1985-12-27
CA1130301A (en) 1982-08-24
NO144420B (no) 1981-05-18
AT374191B (de) 1984-03-26
FR2345430B1 (xx) 1982-07-23
AT358556B (de) 1980-09-25
NZ183616A (en) 1979-03-28
FI62821C (fi) 1983-03-10
PT66300A (fr) 1977-04-01
SE458605B (sv) 1989-04-17
SE8302173L (sv) 1983-04-19
NO803336L (no) 1977-09-26
JPS52144601A (en) 1977-12-02
NO152972B (no) 1985-09-16
AT361932B (de) 1981-04-10
SE456992B (sv) 1988-11-21
US4209524A (en) 1980-06-24
ATA193077A (de) 1979-09-15
US4122186A (en) 1978-10-24
US4151300A (en) 1979-04-24
IE44721B1 (en) 1982-03-10
PH16271A (en) 1983-08-25
IE44721L (en) 1977-09-23
AU516473B2 (en) 1981-06-04
ATA501480A (de) 1983-08-15
NO146431C (no) 1982-09-29
NO145881B (no) 1982-03-08
FR2453148A1 (fr) 1980-10-31
FR2453158B1 (xx) 1982-08-06
CA1120928A (en) 1982-03-30
SE8302172D0 (sv) 1983-04-19
NO145881C (no) 1982-06-16
ATA840078A (de) 1980-11-15
SU689617A3 (ru) 1979-09-30
NO771006L (no) 1977-09-26
SE8302172L (sv) 1983-04-19
GB1574822A (en) 1980-09-10
US4183951A (en) 1980-01-15
FR2345430A1 (fr) 1977-10-21
DE2711451C2 (xx) 1990-05-10
IL51705A (en) 1982-09-30
US4152458A (en) 1979-05-01
ATA839878A (de) 1980-09-15
FR2453133A1 (fr) 1980-10-31
US4225617A (en) 1980-09-30
DK126677A (da) 1977-09-24
FR2453158A1 (fr) 1980-10-31
CS200511B2 (en) 1980-09-15

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