DK170070B1 - Krystallinsk monohydrat af et beta-lactam-antibiotikum, fremgangsmåde til fremstilling heraf og farmaceutisk præparat indeholdende monohydratet - Google Patents
Krystallinsk monohydrat af et beta-lactam-antibiotikum, fremgangsmåde til fremstilling heraf og farmaceutisk præparat indeholdende monohydratet Download PDFInfo
- Publication number
- DK170070B1 DK170070B1 DK553788A DK553788A DK170070B1 DK 170070 B1 DK170070 B1 DK 170070B1 DK 553788 A DK553788 A DK 553788A DK 553788 A DK553788 A DK 553788A DK 170070 B1 DK170070 B1 DK 170070B1
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- DK
- Denmark
- Prior art keywords
- solution
- monohydrate
- minutes
- stirred
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- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10576687A | 1987-10-06 | 1987-10-06 | |
| US10576687 | 1987-10-06 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK553788D0 DK553788D0 (da) | 1988-10-04 |
| DK553788A DK553788A (da) | 1989-04-07 |
| DK170070B1 true DK170070B1 (da) | 1995-05-15 |
Family
ID=22307671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK553788A DK170070B1 (da) | 1987-10-06 | 1988-10-04 | Krystallinsk monohydrat af et beta-lactam-antibiotikum, fremgangsmåde til fremstilling heraf og farmaceutisk præparat indeholdende monohydratet |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0311366B1 (fr) |
| JP (1) | JP2641745B2 (fr) |
| KR (1) | KR970002637B1 (fr) |
| CN (1) | CN1029966C (fr) |
| AR (1) | AR248407A1 (fr) |
| AT (1) | ATE103916T1 (fr) |
| AU (1) | AU598155B2 (fr) |
| BG (1) | BG47036A3 (fr) |
| CA (1) | CA1334970C (fr) |
| CS (1) | CS270594B2 (fr) |
| DD (1) | DD273634A5 (fr) |
| DE (1) | DE3888913T2 (fr) |
| DK (1) | DK170070B1 (fr) |
| EG (1) | EG18529A (fr) |
| ES (1) | ES2063049T3 (fr) |
| FI (1) | FI884554A (fr) |
| HK (1) | HK15497A (fr) |
| HU (1) | HU206348B (fr) |
| IE (1) | IE62108B1 (fr) |
| IL (1) | IL87905A (fr) |
| MX (1) | MX13277A (fr) |
| MY (1) | MY104063A (fr) |
| NO (1) | NO884416L (fr) |
| NZ (1) | NZ226450A (fr) |
| OA (1) | OA08958A (fr) |
| PH (1) | PH31002A (fr) |
| PL (1) | PL152022B1 (fr) |
| PT (1) | PT88662B (fr) |
| SU (1) | SU1731058A3 (fr) |
| UA (1) | UA19149A (fr) |
| YU (1) | YU46699B (fr) |
| ZA (1) | ZA887409B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU46700B (sh) * | 1987-10-07 | 1994-04-05 | Eli Lilly And Co. | Kristalni monohidrat i kristalni mono- i bis (n-n'-dimetilformamid) solvati beta-laktamskog antibiotika |
| CA2002596A1 (fr) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates de beta-lactam antibiotiques |
| CA2002597C (fr) * | 1988-11-14 | 1999-03-23 | Thomas M. Eckrich | Solvates de beta-lactam antibiotiques |
| CA2034592C (fr) * | 1990-01-26 | 2001-06-05 | Ralph R. Pfeiffer | Chlorhydrate crystallin d'un nouvel antibiotique de type beta-lactame et procede pour sa fabrication |
| US5352782A (en) * | 1993-06-04 | 1994-10-04 | Eli Lilly And Company | Process for preparing crystalline β-lactam monohydrate |
| US5374719A (en) * | 1993-06-04 | 1994-12-20 | Eli Lilly And Company | Process for converting loracarbef dihydrate to loracarbef monohydrate |
| US5399686A (en) * | 1993-06-04 | 1995-03-21 | Eli Lilly And Company | Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate |
| US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
| US5412094A (en) * | 1993-06-28 | 1995-05-02 | Eli Lilly And Company | Bicyclic beta-lactam/paraben complexes |
| US5580977A (en) * | 1995-03-01 | 1996-12-03 | Eli Lilly And Company | Process for preparing loracarbef monohydrate |
| US6001996A (en) * | 1995-05-11 | 1999-12-14 | Eli Lilly And Company | Complexes of cephalosporins and carbacephalosporins with parabens |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| ATE406364T1 (de) | 2003-03-07 | 2008-09-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655656A (en) * | 1970-06-04 | 1972-04-11 | Lilly Co Eli | Crystalline cephalexin monohydrate |
| JPS5672698A (en) * | 1979-11-14 | 1981-06-16 | Kyowa Hakko Kogyo Co Ltd | Preparation of optically active cephalosporin analogue |
| YU46700B (sh) * | 1987-10-07 | 1994-04-05 | Eli Lilly And Co. | Kristalni monohidrat i kristalni mono- i bis (n-n'-dimetilformamid) solvati beta-laktamskog antibiotika |
-
1988
- 1988-10-03 YU YU184588A patent/YU46699B/sh unknown
- 1988-10-03 MY MYPI88001103A patent/MY104063A/en unknown
- 1988-10-03 DD DD88320417A patent/DD273634A5/de unknown
- 1988-10-03 ZA ZA887409A patent/ZA887409B/xx unknown
- 1988-10-03 CA CA000579158A patent/CA1334970C/fr not_active Expired - Fee Related
- 1988-10-03 EG EG506/88A patent/EG18529A/xx active
- 1988-10-04 PT PT88662A patent/PT88662B/pt not_active IP Right Cessation
- 1988-10-04 MX MX1327788A patent/MX13277A/es unknown
- 1988-10-04 NZ NZ226450A patent/NZ226450A/xx unknown
- 1988-10-04 JP JP63251712A patent/JP2641745B2/ja not_active Expired - Fee Related
- 1988-10-04 FI FI884554A patent/FI884554A/fi not_active Application Discontinuation
- 1988-10-04 DK DK553788A patent/DK170070B1/da active IP Right Grant
- 1988-10-04 BG BG85594A patent/BG47036A3/xx unknown
- 1988-10-04 AR AR88312109A patent/AR248407A1/es active
- 1988-10-04 AU AU23372/88A patent/AU598155B2/en not_active Expired
- 1988-10-04 IL IL87905A patent/IL87905A/xx active Protection Beyond IP Right Term
- 1988-10-04 PH PH37636A patent/PH31002A/en unknown
- 1988-10-05 KR KR1019880012961A patent/KR970002637B1/ko not_active IP Right Cessation
- 1988-10-05 IE IE301588A patent/IE62108B1/en not_active IP Right Cessation
- 1988-10-05 SU SU884356543A patent/SU1731058A3/ru active
- 1988-10-05 ES ES88309261T patent/ES2063049T3/es not_active Expired - Lifetime
- 1988-10-05 HU HU885171A patent/HU206348B/hu unknown
- 1988-10-05 OA OA59444A patent/OA08958A/xx unknown
- 1988-10-05 CN CN88109140A patent/CN1029966C/zh not_active Expired - Lifetime
- 1988-10-05 EP EP88309261A patent/EP0311366B1/fr not_active Expired - Lifetime
- 1988-10-05 PL PL1988275093A patent/PL152022B1/pl unknown
- 1988-10-05 AT AT88309261T patent/ATE103916T1/de not_active IP Right Cessation
- 1988-10-05 DE DE3888913T patent/DE3888913T2/de not_active Expired - Lifetime
- 1988-10-05 UA UA4356543A patent/UA19149A/uk unknown
- 1988-10-05 NO NO88884416A patent/NO884416L/no unknown
- 1988-10-06 CS CS886666A patent/CS270594B2/cs not_active IP Right Cessation
-
1997
- 1997-02-05 HK HK15497A patent/HK15497A/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) |