CN1029966C - 结晶态的β-内酰胺水合物的制备方法 - Google Patents
结晶态的β-内酰胺水合物的制备方法 Download PDFInfo
- Publication number
- CN1029966C CN1029966C CN88109140A CN88109140A CN1029966C CN 1029966 C CN1029966 C CN 1029966C CN 88109140 A CN88109140 A CN 88109140A CN 88109140 A CN88109140 A CN 88109140A CN 1029966 C CN1029966 C CN 1029966C
- Authority
- CN
- China
- Prior art keywords
- solution
- minutes
- milliliters
- add
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10576687A | 1987-10-06 | 1987-10-06 | |
US07/105,766 | 1987-10-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1032793A CN1032793A (zh) | 1989-05-10 |
CN1029966C true CN1029966C (zh) | 1995-10-11 |
Family
ID=22307671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN88109140A Expired - Lifetime CN1029966C (zh) | 1987-10-06 | 1988-10-05 | 结晶态的β-内酰胺水合物的制备方法 |
Country Status (32)
Country | Link |
---|---|
EP (1) | EP0311366B1 (fr) |
JP (1) | JP2641745B2 (fr) |
KR (1) | KR970002637B1 (fr) |
CN (1) | CN1029966C (fr) |
AR (1) | AR248407A1 (fr) |
AT (1) | ATE103916T1 (fr) |
AU (1) | AU598155B2 (fr) |
BG (1) | BG47036A3 (fr) |
CA (1) | CA1334970C (fr) |
CS (1) | CS270594B2 (fr) |
DD (1) | DD273634A5 (fr) |
DE (1) | DE3888913T2 (fr) |
DK (1) | DK170070B1 (fr) |
EG (1) | EG18529A (fr) |
ES (1) | ES2063049T3 (fr) |
FI (1) | FI884554A (fr) |
HK (1) | HK15497A (fr) |
HU (1) | HU206348B (fr) |
IE (1) | IE62108B1 (fr) |
IL (1) | IL87905A (fr) |
MX (1) | MX13277A (fr) |
MY (1) | MY104063A (fr) |
NO (1) | NO884416L (fr) |
NZ (1) | NZ226450A (fr) |
OA (1) | OA08958A (fr) |
PH (1) | PH31002A (fr) |
PL (1) | PL152022B1 (fr) |
PT (1) | PT88662B (fr) |
SU (1) | SU1731058A3 (fr) |
UA (1) | UA19149A (fr) |
YU (1) | YU46699B (fr) |
ZA (1) | ZA887409B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD280112A5 (de) * | 1987-10-07 | 1990-06-27 | ����@����@���@��������@���������@�������@�������k�� | Verfahren zur herstellung kristalliner formen eines 1-carbacephalosporins |
CA2002597C (fr) * | 1988-11-14 | 1999-03-23 | Thomas M. Eckrich | Solvates de beta-lactam antibiotiques |
CA2002596A1 (fr) * | 1988-11-14 | 1990-05-14 | Thomas M. Eckrich | Hydrates de beta-lactam antibiotiques |
CA2034592C (fr) * | 1990-01-26 | 2001-06-05 | Ralph R. Pfeiffer | Chlorhydrate crystallin d'un nouvel antibiotique de type beta-lactame et procede pour sa fabrication |
US5374719A (en) * | 1993-06-04 | 1994-12-20 | Eli Lilly And Company | Process for converting loracarbef dihydrate to loracarbef monohydrate |
US5352782A (en) * | 1993-06-04 | 1994-10-04 | Eli Lilly And Company | Process for preparing crystalline β-lactam monohydrate |
US5399686A (en) * | 1993-06-04 | 1995-03-21 | Eli Lilly And Company | Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate |
US5550231A (en) * | 1993-06-15 | 1996-08-27 | Eli Lilly And Company | Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof |
US5412094A (en) * | 1993-06-28 | 1995-05-02 | Eli Lilly And Company | Bicyclic beta-lactam/paraben complexes |
US5580977A (en) * | 1995-03-01 | 1996-12-03 | Eli Lilly And Company | Process for preparing loracarbef monohydrate |
US6001996A (en) * | 1995-05-11 | 1999-12-14 | Eli Lilly And Company | Complexes of cephalosporins and carbacephalosporins with parabens |
US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
CN1756756A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
ES2311806T3 (es) | 2003-03-07 | 2009-02-16 | Schering Corporation | Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3655656A (en) * | 1970-06-04 | 1972-04-11 | Lilly Co Eli | Crystalline cephalexin monohydrate |
JPS5672698A (en) * | 1979-11-14 | 1981-06-16 | Kyowa Hakko Kogyo Co Ltd | Preparation of optically active cephalosporin analogue |
DD280112A5 (de) * | 1987-10-07 | 1990-06-27 | ����@����@���@��������@���������@�������@�������k�� | Verfahren zur herstellung kristalliner formen eines 1-carbacephalosporins |
-
1988
- 1988-10-03 MY MYPI88001103A patent/MY104063A/en unknown
- 1988-10-03 CA CA000579158A patent/CA1334970C/fr not_active Expired - Fee Related
- 1988-10-03 ZA ZA887409A patent/ZA887409B/xx unknown
- 1988-10-03 EG EG506/88A patent/EG18529A/xx active
- 1988-10-03 YU YU184588A patent/YU46699B/sh unknown
- 1988-10-03 DD DD88320417A patent/DD273634A5/de unknown
- 1988-10-04 FI FI884554A patent/FI884554A/fi not_active Application Discontinuation
- 1988-10-04 DK DK553788A patent/DK170070B1/da active IP Right Grant
- 1988-10-04 AU AU23372/88A patent/AU598155B2/en not_active Expired
- 1988-10-04 JP JP63251712A patent/JP2641745B2/ja not_active Expired - Fee Related
- 1988-10-04 PH PH37636A patent/PH31002A/en unknown
- 1988-10-04 NZ NZ226450A patent/NZ226450A/xx unknown
- 1988-10-04 PT PT88662A patent/PT88662B/pt not_active IP Right Cessation
- 1988-10-04 AR AR88312109A patent/AR248407A1/es active
- 1988-10-04 IL IL87905A patent/IL87905A/xx active Protection Beyond IP Right Term
- 1988-10-04 MX MX1327788A patent/MX13277A/es unknown
- 1988-10-04 BG BG085594A patent/BG47036A3/xx unknown
- 1988-10-05 EP EP88309261A patent/EP0311366B1/fr not_active Expired - Lifetime
- 1988-10-05 ES ES88309261T patent/ES2063049T3/es not_active Expired - Lifetime
- 1988-10-05 IE IE301588A patent/IE62108B1/en not_active IP Right Cessation
- 1988-10-05 SU SU884356543A patent/SU1731058A3/ru active
- 1988-10-05 OA OA59444A patent/OA08958A/xx unknown
- 1988-10-05 HU HU885171A patent/HU206348B/hu unknown
- 1988-10-05 DE DE3888913T patent/DE3888913T2/de not_active Expired - Lifetime
- 1988-10-05 NO NO88884416A patent/NO884416L/no unknown
- 1988-10-05 PL PL1988275093A patent/PL152022B1/pl unknown
- 1988-10-05 CN CN88109140A patent/CN1029966C/zh not_active Expired - Lifetime
- 1988-10-05 AT AT88309261T patent/ATE103916T1/de not_active IP Right Cessation
- 1988-10-05 KR KR1019880012961A patent/KR970002637B1/ko not_active IP Right Cessation
- 1988-10-05 UA UA4356543A patent/UA19149A/uk unknown
- 1988-10-06 CS CS886666A patent/CS270594B2/cs not_active IP Right Cessation
-
1997
- 1997-02-05 HK HK15497A patent/HK15497A/xx not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
OR01 | Other related matters | ||
C17 | Cessation of patent right | ||
CX01 | Expiry of patent term |