DK164546C - Analogifremgangsmaade til fremstilling af 1-substituerede piperid-4-yl-urinstof- og -thiourinstof-derivater - Google Patents
Analogifremgangsmaade til fremstilling af 1-substituerede piperid-4-yl-urinstof- og -thiourinstof-derivaterInfo
- Publication number
- DK164546C DK164546C DK087881A DK87881A DK164546C DK 164546 C DK164546 C DK 164546C DK 087881 A DK087881 A DK 087881A DK 87881 A DK87881 A DK 87881A DK 164546 C DK164546 C DK 164546C
- Authority
- DK
- Denmark
- Prior art keywords
- thiour
- piperid
- urine
- analogue
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8007048 | 1980-03-01 | ||
| GB8007048 | 1980-03-01 | ||
| GB8027435 | 1980-08-22 | ||
| GB8027435 | 1980-08-22 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK87881A DK87881A (da) | 1981-09-02 |
| DK164546B DK164546B (da) | 1992-07-13 |
| DK164546C true DK164546C (da) | 1992-11-30 |
Family
ID=26274662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK087881A DK164546C (da) | 1980-03-01 | 1981-02-26 | Analogifremgangsmaade til fremstilling af 1-substituerede piperid-4-yl-urinstof- og -thiourinstof-derivater |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4426387A (pl) |
| EP (1) | EP0035374B1 (pl) |
| KR (4) | KR850000630B1 (pl) |
| AU (1) | AU542950B2 (pl) |
| CA (1) | CA1173037A (pl) |
| DE (1) | DE3168564D1 (pl) |
| DK (1) | DK164546C (pl) |
| EG (1) | EG16004A (pl) |
| ES (4) | ES8203840A1 (pl) |
| FI (1) | FI77231C (pl) |
| GR (1) | GR73576B (pl) |
| HU (1) | HU187768B (pl) |
| IE (1) | IE52014B1 (pl) |
| IL (1) | IL62200A (pl) |
| NO (1) | NO156864C (pl) |
| NZ (1) | NZ196324A (pl) |
| PH (1) | PH17019A (pl) |
| PL (4) | PL129174B1 (pl) |
| PT (1) | PT72562B (pl) |
| YU (4) | YU47381A (pl) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8528235D0 (en) * | 1985-11-15 | 1985-12-18 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| US4508722A (en) * | 1981-05-18 | 1985-04-02 | Eli Lilly And Company | 1-Benzoyl-3-(arylpyridyl)urea compounds |
| ATE27152T1 (de) * | 1982-04-07 | 1987-05-15 | Ici Plc | Chinolin-derivate. |
| EP0093521B1 (en) * | 1982-05-04 | 1988-08-24 | Imperial Chemical Industries Plc | Quinoline derivatives |
| FR2527205A1 (fr) * | 1982-05-18 | 1983-11-25 | Bouchara Emile | Nouvelles phenyloxoalcoyl piperidines, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant |
| EP0157762B1 (fr) * | 1983-09-19 | 1990-08-08 | Bouchara S.A. | Nouvelles piperidinoguanidines substituees, leur procede de preparation et les compositions pharmaceutiques en renfermant |
| US4569933A (en) * | 1984-04-13 | 1986-02-11 | Cornu Pierre Jean | Antihypertensive substituted derivatives of 2,5-diamino 1,4-diazole |
| GB8528234D0 (en) * | 1985-11-15 | 1985-12-18 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| US5478863A (en) * | 1986-07-10 | 1995-12-26 | State Of Oregon, Oregon Health Sciences University Of Oregon | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| US4709094A (en) * | 1986-07-10 | 1987-11-24 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Sigma brain receptor ligands and their use |
| US5312840A (en) * | 1986-07-10 | 1994-05-17 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| EP0343307A1 (en) * | 1988-05-26 | 1989-11-29 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. | 4-Piperidinealkanamine derivatives |
| GR1000662B (el) * | 1988-07-01 | 1992-09-25 | Janssen Pharmaceutica Nv | Μεθοδος παρασκευης cis-ν-(3-μεθοξυ-4-πιπεριδινυλο)βενζαμιδιων. |
| US5262568A (en) * | 1990-03-02 | 1993-11-16 | State Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
| AU655176B2 (en) | 1990-03-02 | 1994-12-08 | State of Oregon, acting by and through The Oregon Board of Higher Education acting for and on behalf of The Oregon Health Sciences University, Portland, Oregon, and The University of Oregon, Eugene, Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
| FR2662162B1 (fr) * | 1990-05-18 | 1995-01-20 | Adir | Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| AU653729B2 (en) * | 1990-05-25 | 1994-10-13 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| JPH06506455A (ja) * | 1991-02-08 | 1994-07-21 | ケンブリッジ・ニューロサイエンス・インコーポレイテッド | 神経伝達物質放出調節剤としてのグアニジン置換体及びその誘導体ならびに神経伝達物質放出遮断物質を同定するための新規な方法 |
| US5741661A (en) * | 1991-02-08 | 1998-04-21 | Cambridge Neuroscience, Inc. | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
| US5847006A (en) * | 1991-02-08 | 1998-12-08 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
| FR2690158B1 (fr) * | 1992-04-17 | 1994-07-22 | Sanofi Elf | Nouveau derive arylpiperidinique, procede pour sa preparation et compositions pharmaceutiques le contenant. |
| JP3610368B2 (ja) * | 1993-05-27 | 2005-01-12 | セネス リミティド | 治療用置換グアニジン |
| US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| WO1995014461A1 (en) * | 1993-11-23 | 1995-06-01 | Cambridge Neuroscience, Inc. | Therapeutic substituted guanidines |
| US6787569B1 (en) | 1994-02-03 | 2004-09-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
| US6143791A (en) * | 1994-02-03 | 2000-11-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
| AU1912595A (en) | 1994-02-03 | 1995-08-21 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
| US7351743B1 (en) | 1994-02-03 | 2008-04-01 | Wyeth | Therapeutic guanidines |
| US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| US6242198B1 (en) | 1996-07-25 | 2001-06-05 | Cambridge Neuroscience, Inc. | Methods of treatment of eye trauma and disorders |
| US6756389B2 (en) | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| DE19824470A1 (de) * | 1998-05-30 | 1999-12-02 | Boehringer Ingelheim Pharma | Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3072663A (en) * | 1961-09-25 | 1963-01-08 | Warner Lambert Pharmaceutical | Polyalkyl substituted-4-guanidopiperidines |
| US3161637A (en) * | 1961-10-10 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds |
| US3171838A (en) * | 1961-10-10 | 1965-03-02 | Res Lab Dr C Janssen N V | Aroylalkyl and hydroxyaralkyl derivatives of 4-(n-arylalkanamido)-piperidines and related compounds |
| GB1411783A (en) * | 1972-02-24 | 1975-10-29 | Wyeth John & Brother Ltd | Piperidine derivatives |
| GB1411782A (en) * | 1972-02-24 | 1975-10-29 | Wyeth John & Brother Ltd | Piperidine derivatives |
| US3910930A (en) * | 1973-01-04 | 1975-10-07 | Janssen Pharmaceutica Nv | 1-{55 1-{8 2-(1,4-Benzodioxan-2-yl)-2-hydroxyethyl{9 -4-piperidyl{56 -2-benzimidazolinones |
| US4177279A (en) * | 1973-10-10 | 1979-12-04 | John Wyeth & Brother Ltd. | 1-[(3-Indolyl)-alkyl]-piperidyl ureas and hypotensive compositions |
| GB1459506A (en) * | 1974-02-18 | 1976-12-22 | Wyeth John & Brother Ltd | Piperidine derivatives |
| JPS5152176A (pl) | 1974-10-12 | 1976-05-08 | Yoshitomi Pharmaceutical | |
| AU500990B2 (en) * | 1975-07-25 | 1979-06-07 | John Wyeth & Brother Limited | Piperidine derivatives |
| JPS6039680B2 (ja) * | 1975-12-22 | 1985-09-06 | 日本化薬株式会社 | ３‐（メチルメルカプト）プロピルアミノブレオマイシンの製造法 |
| JPS5285174A (en) * | 1976-01-05 | 1977-07-15 | Yoshitomi Pharmaceut Ind Ltd | Novel urea or thiourea derivatives |
| GB1582239A (en) * | 1976-12-11 | 1981-01-07 | Wyeth John & Brother Ltd | Piperidin-4-yl ureas and thioureas |
| GB1561023A (en) * | 1977-04-22 | 1980-02-13 | Beecham Group Ltd | 2-methoxy - 5 - chloro aniline derivatives |
| IN148482B (pl) * | 1977-06-03 | 1981-03-07 | Pfizer | |
| EP0000485A1 (de) * | 1977-07-08 | 1979-02-07 | Ciba-Geigy Ag | Piperidino-propanole, ihre Herstellung und pharmazeutische Präparate die diese enthalten |
| US4281132A (en) * | 1977-10-29 | 1981-07-28 | John Wyeth & Brother Limited | Piperidino ureas and thioureas |
| GB1586817A (en) * | 1977-12-01 | 1981-03-25 | Wyeth John & Brother Ltd | Indole derivatives |
| US4169202A (en) * | 1978-06-05 | 1979-09-25 | American Home Products Corporation | Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives |
| GB2034305B (en) * | 1978-10-24 | 1982-12-22 | Wyeth John & Brother Ltd | Preparation of piperidine derivatives |
-
1981
- 1981-02-23 PH PH25247A patent/PH17019A/en unknown
- 1981-02-23 NO NO810610A patent/NO156864C/no unknown
- 1981-02-23 PL PL1981229830A patent/PL129174B1/pl unknown
- 1981-02-23 PL PL1981234317A patent/PL128510B1/pl unknown
- 1981-02-23 CA CA000371466A patent/CA1173037A/en not_active Expired
- 1981-02-23 PL PL1981234316A patent/PL135545B1/pl unknown
- 1981-02-23 IL IL62200A patent/IL62200A/xx not_active IP Right Cessation
- 1981-02-23 PL PL1981234318A patent/PL128409B1/pl unknown
- 1981-02-23 NZ NZ196324A patent/NZ196324A/xx unknown
- 1981-02-23 ES ES499716A patent/ES8203840A1/es not_active Expired
- 1981-02-23 GR GR64215A patent/GR73576B/el unknown
- 1981-02-24 AU AU67614/81A patent/AU542950B2/en not_active Expired
- 1981-02-24 YU YU00473/81A patent/YU47381A/xx unknown
- 1981-02-24 PT PT72562A patent/PT72562B/pt unknown
- 1981-02-25 EG EG69/81D patent/EG16004A/xx active
- 1981-02-25 FI FI810587A patent/FI77231C/fi not_active IP Right Cessation
- 1981-02-25 IE IE392/81A patent/IE52014B1/en not_active IP Right Cessation
- 1981-02-26 DK DK087881A patent/DK164546C/da not_active IP Right Cessation
- 1981-02-26 EP EP81300801A patent/EP0035374B1/en not_active Expired
- 1981-02-26 HU HU81469A patent/HU187768B/hu unknown
- 1981-02-26 DE DE8181300801T patent/DE3168564D1/de not_active Expired
- 1981-02-26 KR KR1019810000637A patent/KR850000630B1/ko active
-
1982
- 1982-01-29 ES ES509164A patent/ES8302657A1/es not_active Expired
- 1982-01-29 ES ES509163A patent/ES509163A0/es active Granted
- 1982-01-29 ES ES509165A patent/ES509165A0/es active Granted
- 1982-04-07 US US06/366,266 patent/US4426387A/en not_active Expired - Lifetime
-
1983
- 1983-05-04 YU YU00975/83A patent/YU97583A/xx unknown
- 1983-05-04 YU YU00974/83A patent/YU97483A/xx unknown
- 1983-05-04 YU YU00973/83A patent/YU97383A/xx unknown
- 1983-10-26 US US06/545,802 patent/US4563466A/en not_active Expired - Lifetime
-
1984
- 1984-08-24 KR KR1019840005137A patent/KR850001035B1/ko not_active IP Right Cessation
- 1984-08-24 KR KR1019840005135A patent/KR850000631B1/ko not_active IP Right Cessation
- 1984-08-24 KR KR1019840005136A patent/KR850001063B1/ko not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |