DK76286D0 - Derivater af humant alfa1-antitrypsin og fremgangsmaade til fremstilling deraf - Google Patents
Derivater af humant alfa1-antitrypsin og fremgangsmaade til fremstilling derafInfo
- Publication number
- DK76286D0 DK76286D0 DK76286A DK76286A DK76286D0 DK 76286 D0 DK76286 D0 DK 76286D0 DK 76286 A DK76286 A DK 76286A DK 76286 A DK76286 A DK 76286A DK 76286 D0 DK76286 D0 DK 76286D0
- Authority
- DK
- Denmark
- Prior art keywords
- alfa1
- humant
- antitrypsin
- procedures
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8409592 | 1984-06-19 | ||
FR8409592A FR2565983B1 (fr) | 1984-06-19 | 1984-06-19 | Derives de l'a1-antitrypsine humaine et procede pour leur preparation |
FR8507393 | 1985-05-15 | ||
FR8507393A FR2582001B2 (fr) | 1985-05-15 | 1985-05-15 | Nouveaux derives de l'a1-antitrypsine humaine, composition et reactif biologique les contenant |
PCT/FR1985/000158 WO1986000337A1 (fr) | 1984-06-19 | 1985-06-18 | DERIVES DE L'alpha1-ANTITRYPSINE HUMAINE ET PROCEDE POUR LEUR PREPARATION |
FR8500158 | 1985-06-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK76286D0 true DK76286D0 (da) | 1986-02-18 |
DK76286A DK76286A (da) | 1986-02-18 |
DK171064B1 DK171064B1 (da) | 1996-05-13 |
Family
ID=26224015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK076286A DK171064B1 (da) | 1984-06-19 | 1986-02-18 | Analoger af humant alfa1-antitrypsin, fremgangsmåde til fremstilling deraf, lægemiddel indeholdende analogerne, biologisk reagens indeholdende analogerne, samt anvendelse af analogerne |
Country Status (7)
Country | Link |
---|---|
US (1) | US6072029A (da) |
EP (1) | EP0169114B1 (da) |
JP (1) | JP2599585B2 (da) |
CA (1) | CA1341216C (da) |
DE (1) | DE3581328D1 (da) |
DK (1) | DK171064B1 (da) |
WO (1) | WO1986000337A1 (da) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4711848A (en) * | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
DE3585969D1 (de) * | 1984-06-14 | 1992-06-11 | Chiron Corp | Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung. |
DE3581328D1 (de) * | 1984-06-19 | 1991-02-21 | Transgene Sa | Derivate des menschlichen alpha-1-antitrypins und verfahren zu deren herstellung. |
US4752585A (en) * | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
IL80477A0 (en) * | 1985-11-08 | 1987-02-27 | Smithkline Beckman Corp | Mutant coding sequence |
GB2188322A (en) * | 1986-03-26 | 1987-09-30 | Bayer Ag | Aprotinin and analogues thereof produced by a recombinant host |
FR2599752B1 (fr) * | 1986-06-10 | 1989-11-03 | Transgene Sa | Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine |
FR2601033B1 (fr) * | 1986-07-02 | 1990-01-19 | Transgene Sa | Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation |
FR2618159B2 (fr) * | 1987-07-15 | 1990-02-02 | Transgene Sa | Procede de stabilisation d'un plasmide contenu dans une souche bacterienne et souche obtenue |
EP0258118B1 (fr) * | 1986-08-05 | 1995-10-18 | Transgene S.A. | Procédé de stabilisation d'un plasmide contenu dans une souche bactérienne et souche obtenue |
EP0260350B1 (en) * | 1986-09-05 | 1992-02-12 | Cetus Oncology Corporation | Oxidation-resistant interferon-beta muteins and their production; formulations containing such muteins |
FR2637613B1 (fr) * | 1987-06-19 | 1991-09-27 | Transgene Sa | Procede de preparation de lignees cellulaires stables pour la production de proteines determinees, a partir d'animaux transgeniques; lignees cellulaires tumorales et proteines obtenues |
JPH01191687A (ja) * | 1988-01-28 | 1989-08-01 | Hoechst Japan Kk | ヒトα↓2−プラスミンインヒビターまたはそれと類似の蛋白質から誘導される新規蛋白質 |
WO1996010638A1 (en) * | 1994-09-30 | 1996-04-11 | Ppl Therapeutics (Scotland) Ltd. | Alpha-1-antitrypsin and antithrombine-iii variants |
GB2318732A (en) | 1996-11-01 | 1998-05-06 | Johnson & Johnson Medical | Wound healing compositions containing alpha-1-antitrypsin |
GB9825374D0 (en) * | 1998-11-19 | 1999-01-13 | Ppl Therapeutics Scotland Ltd | Method |
EP3192872A1 (en) | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
WO2011056793A2 (en) | 2009-11-03 | 2011-05-12 | Talecris Biotherapeutics, Inc. | Composition, method, and kit for alpha-1 proteinase inhibitor |
NZ600271A (en) | 2009-11-24 | 2013-09-27 | Grifols Therapeutics Inc | Lyophilization methods, compositions, and kits |
KR20200044138A (ko) | 2011-06-24 | 2020-04-28 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
BR112014007127A2 (pt) | 2011-12-30 | 2017-04-04 | Grifols Sa | métodos para retardar o início ou diminuir a progressão de um ou mais sintomas, para retardar o início ou a progressão de um ou mais sintomas, para identificar um indivíduo em necessidade de terapia de manutenção de a1pi, e para identificar indivíduos com risco elevado para exacerbações pulmonares, uso de a1pi, aparelho e meio para a administração aerossolizada de a1pi para a inalação, e, kit |
WO2013106589A1 (en) | 2012-01-10 | 2013-07-18 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses for alpha-1 antitrypsin fusion molecules |
RU2573933C1 (ru) * | 2014-08-21 | 2016-01-27 | Дафот Энтерпрайсис Лимитед | Пептид для лечения сахарного диабета 2-го типа и его осложнений |
CA3048613A1 (en) | 2015-12-31 | 2017-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Methods and uses for alpha-1 antitrypsin or recombinant forms thereof, on steroid-refractory graft versus host disease involving gastrointestinal complications |
US12031144B2 (en) * | 2017-03-29 | 2024-07-09 | Cornell University | Oxidation-resistant AAT gene therapy |
PL3723790T3 (pl) | 2017-12-12 | 2024-05-13 | Kamada Ltd | Sposoby indukowania tolerancji immunologicznej i redukcji odpowiedzi przeciwciała antylekowego |
WO2023083859A1 (en) | 2021-11-09 | 2023-05-19 | Danmarks Tekniske Universitet | Variants of alpha-1-antitrypsin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
BE895961A (fr) * | 1983-02-21 | 1983-06-16 | Wallone Region | Procede de preparation d'un clone bacterien produisant de 1'alpha 1-antitrypsine humaine |
US4711848A (en) * | 1984-03-14 | 1987-12-08 | Zymogenetics, Inc. | Site specific mutagenesis in alpha-1-antitrypsin |
US4732973A (en) * | 1984-06-14 | 1988-03-22 | Chiron Corporation | Active site modified protease α-1-antitrypsin inhibitors |
DE3585969D1 (de) * | 1984-06-14 | 1992-06-11 | Chiron Corp | Protease-inhibitoren des alpha-1-antitrypsin typs mit modifizierter aktiever stelle und deren herstellung. |
DE3581328D1 (de) * | 1984-06-19 | 1991-02-21 | Transgene Sa | Derivate des menschlichen alpha-1-antitrypins und verfahren zu deren herstellung. |
US4752585A (en) * | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
-
1985
- 1985-06-18 DE DE8585401207T patent/DE3581328D1/de not_active Expired - Lifetime
- 1985-06-18 WO PCT/FR1985/000158 patent/WO1986000337A1/fr unknown
- 1985-06-18 EP EP85401207A patent/EP0169114B1/fr not_active Expired - Lifetime
- 1985-06-18 JP JP60502680A patent/JP2599585B2/ja not_active Expired - Lifetime
- 1985-06-19 CA CA000484504A patent/CA1341216C/fr not_active Expired - Fee Related
-
1986
- 1986-02-18 DK DK076286A patent/DK171064B1/da not_active IP Right Cessation
-
1992
- 1992-10-27 US US07/967,576 patent/US6072029A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0169114A3 (en) | 1986-11-20 |
DK76286A (da) | 1986-02-18 |
JP2599585B2 (ja) | 1997-04-09 |
JPS62500420A (ja) | 1987-02-26 |
CA1341216C (fr) | 2001-04-24 |
US6072029A (en) | 2000-06-06 |
DE3581328D1 (de) | 1991-02-21 |
DK171064B1 (da) | 1996-05-13 |
WO1986000337A1 (fr) | 1986-01-16 |
EP0169114B1 (fr) | 1991-01-16 |
EP0169114A2 (fr) | 1986-01-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PBP | Patent lapsed |
Country of ref document: DK |