ATE72582T1 - Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. - Google Patents

Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.

Info

Publication number
ATE72582T1
ATE72582T1 AT86306895T AT86306895T ATE72582T1 AT E72582 T1 ATE72582 T1 AT E72582T1 AT 86306895 T AT86306895 T AT 86306895T AT 86306895 T AT86306895 T AT 86306895T AT E72582 T1 ATE72582 T1 AT E72582T1
Authority
AT
Austria
Prior art keywords
muteins
beta
interferon
production
preparations containing
Prior art date
Application number
AT86306895T
Other languages
English (en)
Inventor
Alice M Wang
Ze Ev Shaked
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Application granted granted Critical
Publication of ATE72582T1 publication Critical patent/ATE72582T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT86306895T 1986-09-05 1986-09-05 Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. ATE72582T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP86306895A EP0260350B1 (de) 1986-09-05 1986-09-05 Oxidationsresistente Muteine von beta-Interferon, deren Herstellung und diese Muteine enthaltende Präparate

Publications (1)

Publication Number Publication Date
ATE72582T1 true ATE72582T1 (de) 1992-02-15

Family

ID=8196130

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86306895T ATE72582T1 (de) 1986-09-05 1986-09-05 Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.

Country Status (3)

Country Link
EP (1) EP0260350B1 (de)
AT (1) ATE72582T1 (de)
DE (1) DE3683910D1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992011286A1 (en) * 1990-12-21 1992-07-09 Allelix Biopharmaceuticals Inc. Oxidation resistant variants of parathyroid hormone
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) * 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
US5545723A (en) * 1994-03-15 1996-08-13 Biogen Inc. Muteins of IFN-β
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US6531122B1 (en) 1999-08-27 2003-03-11 Maxygen Aps Interferon-β variants and conjugates
BR0207576A (pt) 2001-02-27 2004-04-27 Maxygen Aps Variante glicosilada de um polipeptìdeo de interferon beta precursor (ifnb), processos de aumentar a glicosilação in vivo de uma molécula de ifnb precursora, de produzir uma molécula de ifnb glicosilada, para preparar uma variante conjugada e de tratar um mamìfero com esclerose múltiplam composição farmacêutica, molécula de ifnb variante, sequência de nucleotìdeo, vetor de expressão, célula hospedeira de glicosilação conjugado, e, uso de um conjugado
EP1539960B1 (de) 2002-09-09 2010-04-28 Hanall Pharmaceutical Co., Ltd. Protease-resistente modifizierte interferon alpha polypeptide
JP2007519422A (ja) 2004-02-02 2007-07-19 アンブレツクス・インコーポレイテツド 修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用
WO2007130453A2 (en) * 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides
CA2685596A1 (en) 2007-05-02 2008-11-13 Ambrx, Inc. Modified interferon beta polypeptides and their uses
CN113683675A (zh) * 2020-05-19 2021-11-23 北京志道生物科技有限公司 干扰素-κ突变体及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI82266C (fi) * 1982-10-19 1991-02-11 Cetus Corp Foerfarande foer framstaellning av il-2 -mutein.
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
GB8317880D0 (en) * 1983-07-01 1983-08-03 Searle & Co Structure and synthesis of interferons
EP0164719B1 (de) * 1984-06-14 1992-05-06 Chiron Corporation Protease-Inhibitoren des Alpha-1-Antitrypsin Typs mit modifizierter aktiever Stelle und deren Herstellung
JP2599585B2 (ja) * 1984-06-19 1997-04-09 トランスジ−ン ソシエテ アノニム ヒトα▲下１▼−アンチトリプシン誘導体及びその製造法

Also Published As

Publication number Publication date
EP0260350B1 (de) 1992-02-12
DE3683910D1 (de) 1992-03-26
EP0260350A1 (de) 1988-03-23

Similar Documents

Publication Publication Date Title
AU585084B2 (en) Oxidation resistant muteins
ATE72582T1 (de) Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.
DK163930C (da) Biologisk aktivt peptid og peptidfragment deraf med natriuretisk, diuretisk og vasodilataterende aktivitet og terapeutisk middel indeholdende et saadant peptid eller peptidfragment
ATE33503T1 (de) Pharmazeutische und tiermedizinische praeparate von interleukin-2, in dem cystein-125 ausgetauscht worden ist (muteine), sowie deren herstellung.
FI870169A (fi) Stabiliserat tokoferol i fri-flytande partikelform
DK0591914T4 (da) Retrovirus fra HIV-gruppen og dets anvendelse
NL930040I2 (nl) Humaan immuun interferon.
FI860153A0 (fi) Oligopeptider, deras mellanprodukter och foerfarande foer deras framstaellning.
DE69020335D1 (de) B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
FI91160B (fi) Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi
IL80562A0 (en) Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
DE69126049D1 (de) Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C
LV12000A (lv) Olbaltumviela ar uratoksidazes aktivitati un tas iegusana
FR2585572B3 (fr) Nouvelles compositions pharmaceutiques a base d'un sel de l'acide p. chlorophenoxyacetique destinees au traitement des neuropathies et assurant la regeneration nerveuse
BR9007115A (pt) Novo trombolitico
DE68917061D1 (de) O-glycosylierter IGF-1.
FR2635527B1 (fr) Il2 humaine recombinante non glycosylee sous forme reduite, son procede d'obtention et son application comme medicament
DK0457035T3 (da) Fremgangsmåde til inaktivering af den biologiske aktivitet af DNA
RO95059A (ro) Procedeu pentru prepararea unor cicloalcancarboxanilide
ATE102997T1 (de) Thymosin und tnf-kodierende dna.
FR2621488B1 (fr) Produit comprenant a titre de principes actifs a) un peptide ayant une activite du type de celle de l'interferon gamma humain, b) l'hyfroxyuree

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time