DE69020335D1 - B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung. - Google Patents
B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.Info
- Publication number
- DE69020335D1 DE69020335D1 DE69020335T DE69020335T DE69020335D1 DE 69020335 D1 DE69020335 D1 DE 69020335D1 DE 69020335 T DE69020335 T DE 69020335T DE 69020335 T DE69020335 T DE 69020335T DE 69020335 D1 DE69020335 D1 DE 69020335D1
- Authority
- DE
- Germany
- Prior art keywords
- analogs
- pdgf
- present
- growth factor
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/454,794 US5149792A (en) | 1989-12-19 | 1989-12-19 | Platelet-derived growth factor B chain analogs |
US07/624,451 US5272064A (en) | 1989-12-19 | 1990-12-13 | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
PCT/US1990/007451 WO1991008761A1 (en) | 1989-12-19 | 1990-12-17 | Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69020335D1 true DE69020335D1 (de) | 1995-07-27 |
DE69020335T2 DE69020335T2 (de) | 1995-11-02 |
Family
ID=27037609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69020335T Expired - Fee Related DE69020335T2 (de) | 1989-12-19 | 1990-12-17 | B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5272064A (de) |
EP (1) | EP0458959B1 (de) |
JP (1) | JPH04504064A (de) |
AT (1) | ATE123949T1 (de) |
AU (1) | AU646014B2 (de) |
CA (1) | CA2032675A1 (de) |
DE (1) | DE69020335T2 (de) |
DK (1) | DK0458959T3 (de) |
ES (1) | ES2073735T3 (de) |
FI (1) | FI913892A0 (de) |
GR (1) | GR3017317T3 (de) |
IE (1) | IE904608A1 (de) |
IL (1) | IL96723A0 (de) |
NO (1) | NO913232D0 (de) |
NZ (1) | NZ236549A (de) |
PT (1) | PT96272A (de) |
WO (1) | WO1991008761A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07507055A (ja) * | 1992-02-26 | 1995-08-03 | アラーガン、インコーポレイテッド | 眼の創傷の治癒における血小板誘導化成長因子の使用 |
WO1993020204A1 (en) * | 1992-03-30 | 1993-10-14 | Schering Corporation | Monomeric platelet-derived growth factor and prevention of stenosis or restenosis |
MXPA04009381A (es) | 2002-03-27 | 2005-01-25 | Immunex Corp | Metodos para incrementar la produccion de polipeptidos. |
EP1594527A2 (de) * | 2003-02-04 | 2005-11-16 | Ludwig Institute For Cancer Research | Vegf-b und pdgf modulierung von stammzellen |
BR112012000865A2 (pt) | 2009-07-17 | 2019-09-24 | T Tabor Aaron | "composição e método para a modificação genética cosmética de células substancialmente intactas" |
CN103080300B (zh) | 2010-08-05 | 2015-11-25 | 安姆根有限公司 | 增加细胞培养物的产率和活力的二肽 |
AU2012245231B2 (en) | 2011-04-20 | 2016-10-13 | Amgen Inc. | Autoinjector apparatus |
US9133493B2 (en) | 2011-04-21 | 2015-09-15 | Amgen Inc. | Method for culturing mammalian cells to improve recombinant protein production |
AU2012279230B2 (en) | 2011-07-01 | 2016-08-18 | Amgen Inc. | Mammalian cell culture |
BR112014004591A2 (pt) | 2011-09-02 | 2017-03-28 | Amgen Inc | produto farmacêutico de análise da exposição à luz de um produto farmacêutico |
AR089231A1 (es) | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
US20140199728A1 (en) | 2013-01-14 | 2014-07-17 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
TWI625390B (zh) | 2013-03-14 | 2018-06-01 | 安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
HUE038565T2 (hu) | 2013-03-14 | 2018-10-29 | Amgen Inc | Kiszivárgott affinitás tisztító ligandumok eltávolítása |
TWI639453B (zh) | 2013-03-15 | 2018-11-01 | 美商安美基公司 | 用於注射器之匣盒 |
TWI580451B (zh) | 2013-03-15 | 2017-05-01 | 安美基公司 | 用於注射器之匣盒及使用具有自動注射器及匣盒之自動注射器設備之方法 |
US9481901B2 (en) | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
CA2929077A1 (en) | 2013-10-31 | 2015-05-07 | Amgen Inc. | Use of monensin to regulate glycosylation of recombinant proteins |
US10513723B2 (en) | 2014-01-13 | 2019-12-24 | Amgen Inc. | Decreasing ornithine production to decrease high mannose glycoform content of recombinant proteins |
US10106829B2 (en) | 2014-01-29 | 2018-10-23 | Amgen Inc. | Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins |
EA202190244A3 (ru) | 2014-01-29 | 2021-08-31 | Эмджен Инк. | Сверхэкспрессия регуляторов пути n-гликозилирования для модуляции гликозилирования рекомбинантных белков |
ES2709994T3 (es) | 2014-06-04 | 2019-04-22 | Amgen Inc | Métodos de recolección en cultivos de células de mamífero |
MX2017006463A (es) | 2014-11-19 | 2018-04-20 | Amgen Inc | Cuantificacion de porcion de glicano en glicoproteinas recombinantes. |
PT3227454T (pt) | 2014-12-01 | 2020-04-06 | Amgen Inc | Processo para a manipulação do nível do teor de glicano de uma glicoproteína |
CA3084486A1 (en) | 2017-11-16 | 2019-05-23 | Amgen Inc. | Autoinjector with stall and end point detection |
WO2023079058A1 (en) | 2021-11-05 | 2023-05-11 | Yokogawa Insilico Biotechnology Gmbh | Cell culture with reduced production of lactate |
WO2023129974A1 (en) | 2021-12-29 | 2023-07-06 | Bristol-Myers Squibb Company | Generation of landing pad cell lines |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4479896A (en) * | 1981-12-11 | 1984-10-30 | Antoniades Harry N | Method for extraction localization and direct recovery of platelet derived growth factor |
US4766073A (en) * | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US4801542A (en) * | 1984-10-12 | 1989-01-31 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US4769328A (en) * | 1984-10-12 | 1988-09-06 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in yeast |
EP0487116B1 (de) * | 1984-10-12 | 1999-12-29 | ZymoGenetics, Inc. | Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen |
EP0259632B1 (de) * | 1986-08-13 | 1995-12-13 | Zymogenetics, Inc. | Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen |
DE3834079A1 (de) * | 1988-10-06 | 1990-04-12 | Biotechnolog Forschung Gmbh | Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren |
IL96682A0 (en) * | 1989-12-15 | 1991-09-16 | Amgen Inc | Production of biologically active platelet-derived growth factor from high expression host cell systems |
-
1990
- 1990-12-13 US US07/624,451 patent/US5272064A/en not_active Expired - Lifetime
- 1990-12-17 WO PCT/US1990/007451 patent/WO1991008761A1/en active IP Right Grant
- 1990-12-17 JP JP3502837A patent/JPH04504064A/ja active Pending
- 1990-12-17 EP EP91902366A patent/EP0458959B1/de not_active Expired - Lifetime
- 1990-12-17 ES ES91902366T patent/ES2073735T3/es not_active Expired - Lifetime
- 1990-12-17 DK DK91902366.3T patent/DK0458959T3/da active
- 1990-12-17 DE DE69020335T patent/DE69020335T2/de not_active Expired - Fee Related
- 1990-12-17 AU AU71534/91A patent/AU646014B2/en not_active Ceased
- 1990-12-17 AT AT91902366T patent/ATE123949T1/de not_active IP Right Cessation
- 1990-12-19 CA CA002032675A patent/CA2032675A1/en not_active Abandoned
- 1990-12-19 PT PT96272A patent/PT96272A/pt not_active Application Discontinuation
- 1990-12-19 NZ NZ236549A patent/NZ236549A/xx unknown
- 1990-12-19 IE IE460890A patent/IE904608A1/en unknown
- 1990-12-19 IL IL96723A patent/IL96723A0/xx unknown
-
1991
- 1991-08-16 FI FI913892A patent/FI913892A0/fi not_active Application Discontinuation
- 1991-08-19 NO NO913232A patent/NO913232D0/no unknown
-
1995
- 1995-09-06 GR GR950402446T patent/GR3017317T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT96272A (pt) | 1991-09-30 |
ATE123949T1 (de) | 1995-07-15 |
EP0458959B1 (de) | 1995-06-21 |
CA2032675A1 (en) | 1991-06-20 |
WO1991008761A1 (en) | 1991-06-27 |
JPH04504064A (ja) | 1992-07-23 |
ES2073735T3 (es) | 1995-08-16 |
US5272064A (en) | 1993-12-21 |
AU7153491A (en) | 1991-07-18 |
DE69020335T2 (de) | 1995-11-02 |
IL96723A0 (en) | 1991-09-16 |
FI913892A0 (fi) | 1991-08-16 |
EP0458959A4 (en) | 1993-06-16 |
DK0458959T3 (da) | 1995-08-14 |
IE904608A1 (en) | 1991-06-19 |
AU646014B2 (en) | 1994-02-03 |
NO913232L (no) | 1991-08-19 |
GR3017317T3 (en) | 1995-12-31 |
NO913232D0 (no) | 1991-08-19 |
NZ236549A (en) | 1993-03-26 |
EP0458959A1 (de) | 1991-12-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |