NO913232L - Nye blodplatederiverte vekstfaktor-b-kjedeanaloger og metode for homogen produksjon av disse. - Google Patents
Nye blodplatederiverte vekstfaktor-b-kjedeanaloger og metode for homogen produksjon av disse.Info
- Publication number
- NO913232L NO913232L NO91913232A NO913232A NO913232L NO 913232 L NO913232 L NO 913232L NO 91913232 A NO91913232 A NO 91913232A NO 913232 A NO913232 A NO 913232A NO 913232 L NO913232 L NO 913232L
- Authority
- NO
- Norway
- Prior art keywords
- analogs
- production
- pdgf
- present
- growth factor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
Nye blodplatederiverte vekst- faktoranaloger. De nye analoger har, når renaturert, i alt vesentlig samme biologiske aktivitet som naturlig fore- kommende PDGF-B109. Fremgangsmåten be- nytter bruk av et stoppkodon i c-sis- genet, eller annen kodende sekvens for et forløperprotein for PDGF-B109, eller analoger av dette, i en posisjon som tilsvarer tilnærmet aminosyre 111 til aminosyre 160. Fremgangsmåten resul- terer i produksjon av relativt store homogene mengder av rekombinant PDGF-B- analoger fra høyekspresjonsvertceller, som f.eks. E. coli. En fremgangsmåte .for produksjon av homogene mengder av disse nye analoger er også beskrevet.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/454,794 US5149792A (en) | 1989-12-19 | 1989-12-19 | Platelet-derived growth factor B chain analogs |
US07/624,451 US5272064A (en) | 1989-12-19 | 1990-12-13 | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
PCT/US1990/007451 WO1991008761A1 (en) | 1989-12-19 | 1990-12-17 | Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
NO913232D0 NO913232D0 (no) | 1991-08-19 |
NO913232L true NO913232L (no) | 1991-08-19 |
Family
ID=27037609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO91913232A NO913232L (no) | 1989-12-19 | 1991-08-19 | Nye blodplatederiverte vekstfaktor-b-kjedeanaloger og metode for homogen produksjon av disse. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5272064A (no) |
EP (1) | EP0458959B1 (no) |
JP (1) | JPH04504064A (no) |
AT (1) | ATE123949T1 (no) |
AU (1) | AU646014B2 (no) |
CA (1) | CA2032675A1 (no) |
DE (1) | DE69020335T2 (no) |
DK (1) | DK0458959T3 (no) |
ES (1) | ES2073735T3 (no) |
FI (1) | FI913892A0 (no) |
GR (1) | GR3017317T3 (no) |
IE (1) | IE904608A1 (no) |
IL (1) | IL96723A0 (no) |
NO (1) | NO913232L (no) |
NZ (1) | NZ236549A (no) |
PT (1) | PT96272A (no) |
WO (1) | WO1991008761A1 (no) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU670075B2 (en) * | 1992-02-26 | 1996-07-04 | Allergan, Inc. | Use of platelet derived growth factor in ophthalmic wound healing |
WO1993020204A1 (en) * | 1992-03-30 | 1993-10-14 | Schering Corporation | Monomeric platelet-derived growth factor and prevention of stenosis or restenosis |
MXPA04009381A (es) | 2002-03-27 | 2005-01-25 | Immunex Corp | Metodos para incrementar la produccion de polipeptidos. |
WO2004070018A2 (en) * | 2003-02-04 | 2004-08-19 | Ludwig Institute For Cancer Research | Vegf-b and pdgf modulation of stem cells |
BR112012000865A2 (pt) | 2009-07-17 | 2019-09-24 | T Tabor Aaron | "composição e método para a modificação genética cosmética de células substancialmente intactas" |
SG187198A1 (en) | 2010-08-05 | 2013-03-28 | Amgen Inc | Dipeptides to enhance yield and viability from cell cultures |
LT2699293T (lt) | 2011-04-20 | 2019-04-25 | Amgen Inc. | Automatinio purškimo prietaisas |
WO2012145682A1 (en) | 2011-04-21 | 2012-10-26 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
WO2013006479A2 (en) | 2011-07-01 | 2013-01-10 | Amgen Inc. | Mammalian cell culture |
AU2012301656A1 (en) | 2011-09-02 | 2014-01-16 | Amgen Inc. | Pharmaceutical product and method of analysing light exposure of a pharmaceutical product |
AR089231A1 (es) | 2011-12-15 | 2014-08-06 | Amgen Inc | Metodo de floculacion |
US20140199728A1 (en) | 2013-01-14 | 2014-07-17 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
EP4026596A1 (en) | 2013-03-14 | 2022-07-13 | Amgen, Inc | Removal of leaked affinity purification ligand |
TWI771890B (zh) | 2013-03-14 | 2022-07-21 | 美商安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
CA2904725C (en) | 2013-03-15 | 2022-04-12 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
TWI639449B (zh) | 2013-03-15 | 2018-11-01 | 美商安美基公司 | 用於注射器之匣盒 |
US9481901B2 (en) | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
US11130980B2 (en) | 2013-10-31 | 2021-09-28 | Amgen Inc. | Use of monensin to regulate glycosylation of recombinant proteins |
SG11201605640UA (en) | 2014-01-13 | 2016-08-30 | Amgen Inc | Regulating ornithine metabolism to manipulate the high mannose glycoform content of recombinant proteins |
US10106829B2 (en) | 2014-01-29 | 2018-10-23 | Amgen Inc. | Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins |
KR102410393B1 (ko) | 2014-01-29 | 2022-06-16 | 암젠 인크 | 재조합 단백질의 글리코실화를 조절하기 위한 n-글리코실화 경로 조절자의 과발현 |
MX2016015944A (es) | 2014-06-04 | 2017-08-15 | Amgen Inc | Metodos para cosechar cultivos de celulas de mamifero. |
CA2968372A1 (en) | 2014-11-19 | 2016-05-26 | Amgen Inc. | Quantitation of glycan moiety in recombinant glycoproteins |
EP3227454B1 (en) | 2014-12-01 | 2020-01-29 | Amgen Inc. | Process for manipulating the level of glycan content of a glycoprotein |
AU2018368338A1 (en) | 2017-11-16 | 2020-04-09 | Amgen Inc. | Autoinjector with stall and end point detection |
WO2023079058A1 (en) | 2021-11-05 | 2023-05-11 | Yokogawa Insilico Biotechnology Gmbh | Cell culture with reduced production of lactate |
AU2022424002A1 (en) | 2021-12-29 | 2024-06-13 | Bristol-Myers Squibb Company | Generation of landing pad cell lines |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4479896A (en) * | 1981-12-11 | 1984-10-30 | Antoniades Harry N | Method for extraction localization and direct recovery of platelet derived growth factor |
US4769328A (en) * | 1984-10-12 | 1988-09-06 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in yeast |
EP0487116B1 (en) * | 1984-10-12 | 1999-12-29 | ZymoGenetics, Inc. | Biologically active PDGF analogs in eucaryotic cells |
US4766073A (en) * | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US4801542A (en) * | 1984-10-12 | 1989-01-31 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
DE3751632T2 (de) * | 1986-08-13 | 1996-06-13 | Zymogenetics Inc | Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen |
DE3834079A1 (de) * | 1988-10-06 | 1990-04-12 | Biotechnolog Forschung Gmbh | Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren |
IL96682A0 (en) * | 1989-12-15 | 1991-09-16 | Amgen Inc | Production of biologically active platelet-derived growth factor from high expression host cell systems |
-
1990
- 1990-12-13 US US07/624,451 patent/US5272064A/en not_active Expired - Lifetime
- 1990-12-17 DK DK91902366.3T patent/DK0458959T3/da active
- 1990-12-17 EP EP91902366A patent/EP0458959B1/en not_active Expired - Lifetime
- 1990-12-17 WO PCT/US1990/007451 patent/WO1991008761A1/en active IP Right Grant
- 1990-12-17 ES ES91902366T patent/ES2073735T3/es not_active Expired - Lifetime
- 1990-12-17 AU AU71534/91A patent/AU646014B2/en not_active Ceased
- 1990-12-17 JP JP3502837A patent/JPH04504064A/ja active Pending
- 1990-12-17 DE DE69020335T patent/DE69020335T2/de not_active Expired - Fee Related
- 1990-12-17 AT AT91902366T patent/ATE123949T1/de not_active IP Right Cessation
- 1990-12-19 IE IE460890A patent/IE904608A1/en unknown
- 1990-12-19 CA CA002032675A patent/CA2032675A1/en not_active Abandoned
- 1990-12-19 PT PT96272A patent/PT96272A/pt not_active Application Discontinuation
- 1990-12-19 IL IL96723A patent/IL96723A0/xx unknown
- 1990-12-19 NZ NZ236549A patent/NZ236549A/xx unknown
-
1991
- 1991-08-16 FI FI913892A patent/FI913892A0/fi not_active Application Discontinuation
- 1991-08-19 NO NO91913232A patent/NO913232L/no unknown
-
1995
- 1995-09-06 GR GR950402446T patent/GR3017317T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO913232D0 (no) | 1991-08-19 |
AU7153491A (en) | 1991-07-18 |
NZ236549A (en) | 1993-03-26 |
WO1991008761A1 (en) | 1991-06-27 |
EP0458959A1 (en) | 1991-12-04 |
GR3017317T3 (en) | 1995-12-31 |
JPH04504064A (ja) | 1992-07-23 |
DE69020335T2 (de) | 1995-11-02 |
IE904608A1 (en) | 1991-06-19 |
DE69020335D1 (de) | 1995-07-27 |
FI913892A0 (fi) | 1991-08-16 |
AU646014B2 (en) | 1994-02-03 |
CA2032675A1 (en) | 1991-06-20 |
DK0458959T3 (da) | 1995-08-14 |
US5272064A (en) | 1993-12-21 |
ATE123949T1 (de) | 1995-07-15 |
PT96272A (pt) | 1991-09-30 |
EP0458959A4 (en) | 1993-06-16 |
IL96723A0 (en) | 1991-09-16 |
ES2073735T3 (es) | 1995-08-16 |
EP0458959B1 (en) | 1995-06-21 |
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