ES2064336T3 - Procedimiento para la preparacion de proteinas. - Google Patents
Procedimiento para la preparacion de proteinas.Info
- Publication number
- ES2064336T3 ES2064336T3 ES88116739T ES88116739T ES2064336T3 ES 2064336 T3 ES2064336 T3 ES 2064336T3 ES 88116739 T ES88116739 T ES 88116739T ES 88116739 T ES88116739 T ES 88116739T ES 2064336 T3 ES2064336 T3 ES 2064336T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- protein
- anhydromevalonolactone
- hydroxy
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
METODO PARA LA ELEVACION DE LA PRODUCCION DE PROTEINA, ESPECIALMENTE DE T-PA EN CULTIVOS DE CELULAS PRODUCTORAS DE ESTA PROTEINA, EN EL QUE SE AÑADE AL CULTIVO DE CALULAS UNA SUSTANCIA INDUCTORA DE LA PRODUCCION DE PROTEINAS, CARACTERIZADO POR EL USO COMO INDUCTOR DE PROTEINAS DE ACIDO DE TIOGLICOL, ACIDO DE TIODIGLICOL, L-CISTEINA, GLUTATION, BROMURO DE BUTIRILCOLINA, CLORURO DE BUTIRILCOLINA, ACIDO NONACTINICO, ACIDO FURANOGRASO, ACIDO ASCORBICO, AFIDICOLINA, 6-HIDROXI-4,6-DIMETIL-3-HEPTEN-2-ONA, ACIDO FUSARINICO, ACIDO MEVALONICO, ACIDO DE TRANS-ANHIDROMEVALONA, LACTONA DEL ACIDO ANHIDROMEVALONICO, LACTONA DEL ACIDO CISANHIDROMEVALONICO, ACIDO MONO- O DICARBOXILICO D-(ALFA)-HIDROXISUSTITUIDO (C3 O C4) ALIFATICO O SUS SALES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873734632 DE3734632A1 (de) | 1987-10-13 | 1987-10-13 | Verfahren zur herstellung von t-pa |
DE19873738649 DE3738649A1 (de) | 1987-11-13 | 1987-11-13 | Verfahren zur herstellung von proteinen |
DE19883801562 DE3801562A1 (de) | 1988-01-20 | 1988-01-20 | Verfahren zur herstellung von proteinen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2064336T3 true ES2064336T3 (es) | 1995-02-01 |
Family
ID=27196629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88116739T Expired - Lifetime ES2064336T3 (es) | 1987-10-13 | 1988-10-10 | Procedimiento para la preparacion de proteinas. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0315782B1 (es) |
JP (1) | JP2688222B2 (es) |
KR (1) | KR890006671A (es) |
AT (1) | ATE112308T1 (es) |
AU (1) | AU614999B2 (es) |
CA (1) | CA1341400C (es) |
DE (1) | DE3851685D1 (es) |
DK (1) | DK175411B1 (es) |
ES (1) | ES2064336T3 (es) |
FI (1) | FI94963C (es) |
HU (1) | HU205381B (es) |
IE (1) | IE65986B1 (es) |
IL (1) | IL88001A (es) |
NO (1) | NO174778C (es) |
NZ (1) | NZ226521A (es) |
PT (1) | PT88751B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE210150T1 (de) * | 1991-04-18 | 2001-12-15 | Toray Industries | Verfahren zur herstellung von interleukin-6 zusammensetzungen |
DE4113750A1 (de) | 1991-04-26 | 1992-10-29 | Boehringer Mannheim Gmbh | Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen |
CA2286395C (en) * | 1997-04-03 | 2009-06-23 | Yoshitomi Pharmaceutical Industries Ltd. | Production method of heterologous protein |
AU2002354363A1 (en) * | 2001-12-04 | 2003-06-17 | Mitsubishi Pharma Corporation | Method of activating protein |
JPWO2004056872A1 (ja) * | 2002-12-20 | 2006-04-20 | 三菱ウェルファーマ株式会社 | タンパク質のチオール基を保護する方法 |
WO2008136398A1 (ja) | 2007-04-26 | 2008-11-13 | Chugai Seiyaku Kabushiki Kaisha | 高濃度アミノ酸含有培地を用いた細胞の培養方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3479814D1 (en) * | 1984-06-05 | 1989-10-26 | Asahi Chemical Ind | Process for the preparation of a plasminogen activator |
GB8606386D0 (en) * | 1986-03-14 | 1986-04-23 | Celltech Ltd | Production of protein |
-
1988
- 1988-10-10 EP EP88116739A patent/EP0315782B1/de not_active Expired - Lifetime
- 1988-10-10 ES ES88116739T patent/ES2064336T3/es not_active Expired - Lifetime
- 1988-10-10 DE DE3851685T patent/DE3851685D1/de not_active Expired - Lifetime
- 1988-10-10 AT AT88116739T patent/ATE112308T1/de not_active IP Right Cessation
- 1988-10-11 FI FI884652A patent/FI94963C/fi not_active IP Right Cessation
- 1988-10-11 IL IL8800188A patent/IL88001A/xx active Protection Beyond IP Right Term
- 1988-10-11 NZ NZ226521A patent/NZ226521A/en unknown
- 1988-10-12 HU HU885275A patent/HU205381B/hu unknown
- 1988-10-12 IE IE307988A patent/IE65986B1/en not_active IP Right Cessation
- 1988-10-12 NO NO884549A patent/NO174778C/no not_active IP Right Cessation
- 1988-10-12 DK DK198805678A patent/DK175411B1/da active
- 1988-10-12 JP JP63256882A patent/JP2688222B2/ja not_active Expired - Lifetime
- 1988-10-12 AU AU23733/88A patent/AU614999B2/en not_active Expired
- 1988-10-13 PT PT88751A patent/PT88751B/pt not_active IP Right Cessation
- 1988-10-13 CA CA000579969A patent/CA1341400C/en not_active Expired - Lifetime
- 1988-10-13 KR KR1019880013334A patent/KR890006671A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO884549D0 (no) | 1988-10-12 |
FI884652A (fi) | 1989-04-14 |
HU205381B (en) | 1992-04-28 |
DE3851685D1 (de) | 1994-11-03 |
HUT48306A (en) | 1989-05-29 |
DK567888A (da) | 1989-04-14 |
IE883079L (en) | 1989-04-13 |
DK567888D0 (da) | 1988-10-12 |
EP0315782B1 (de) | 1994-09-28 |
IL88001A0 (en) | 1989-06-30 |
IL88001A (en) | 1996-01-19 |
AU2373388A (en) | 1989-05-11 |
PT88751B (pt) | 1995-03-01 |
NZ226521A (en) | 1991-04-26 |
EP0315782A3 (en) | 1989-09-20 |
PT88751A (pt) | 1989-07-31 |
EP0315782A2 (de) | 1989-05-17 |
AU614999B2 (en) | 1991-09-19 |
ATE112308T1 (de) | 1994-10-15 |
DK175411B1 (da) | 2004-09-27 |
FI884652A0 (fi) | 1988-10-11 |
CA1341400C (en) | 2002-11-19 |
FI94963C (fi) | 1995-11-27 |
NO174778B (no) | 1994-03-28 |
JPH01231887A (ja) | 1989-09-18 |
JP2688222B2 (ja) | 1997-12-08 |
NO174778C (no) | 1994-07-06 |
IE65986B1 (en) | 1995-11-29 |
FI94963B (fi) | 1995-08-15 |
NO884549L (no) | 1989-04-14 |
KR890006671A (ko) | 1989-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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