WO1988000968A3 - Process for inducing secondary metabolite production in plant cultures and means thereof - Google Patents

Process for inducing secondary metabolite production in plant cultures and means thereof Download PDF

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Publication number
WO1988000968A3
WO1988000968A3 PCT/JP1987/000583 JP8700583W WO8800968A3 WO 1988000968 A3 WO1988000968 A3 WO 1988000968A3 JP 8700583 W JP8700583 W JP 8700583W WO 8800968 A3 WO8800968 A3 WO 8800968A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkaloids
secondary metabolite
metabolite production
stressors
synthesis
Prior art date
Application number
PCT/JP1987/000583
Other languages
French (fr)
Other versions
WO1988000968A2 (en
Inventor
Jane Isobel Smith
Nigel John Smart
Masanaru Misawa
Original Assignee
Mitsui Petrochemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Petrochemical Ind filed Critical Mitsui Petrochemical Ind
Priority to KR1019880700360A priority Critical patent/KR900004437B1/en
Publication of WO1988000968A2 publication Critical patent/WO1988000968A2/en
Publication of WO1988000968A3 publication Critical patent/WO1988000968A3/en
Priority to FI881491A priority patent/FI881491A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Synthesis of alkaloids by suspension cultured Catharanthus roseus cells is enhanced by stressing the cultured cells osmotically by addition to the culture of such inducers as ionic osmotic stressors such as halide salts e.g. NaCl, KCl and FeCl3 or organic osmotic stressors such as sugar alcohols and sugar acids. Synthesis of alkaloids is also enhanced by addition of anti-gibberellin compounds and other compounds such as abscissic acid which is a plant growth regulator. Yields of alkaloids are consequently increased.
PCT/JP1987/000583 1986-08-04 1987-08-03 Process for inducing secondary metabolite production in plant cultures and means thereof WO1988000968A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019880700360A KR900004437B1 (en) 1986-08-04 1987-08-03 Process for inducing secondary metabolite production in plant cultures and means thereof
FI881491A FI881491A0 (en) 1986-08-04 1988-03-30 FOERFARANDE FOER INDUCERING AV SEKUNDAER METABOLITPRODUKTION I VAEXTKULTURER.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89293886A 1986-08-04 1986-08-04
US892,938 1986-08-04

Publications (2)

Publication Number Publication Date
WO1988000968A2 WO1988000968A2 (en) 1988-02-11
WO1988000968A3 true WO1988000968A3 (en) 1988-03-24

Family

ID=25400744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1987/000583 WO1988000968A2 (en) 1986-08-04 1987-08-03 Process for inducing secondary metabolite production in plant cultures and means thereof

Country Status (6)

Country Link
EP (1) EP0277250A1 (en)
JP (1) JP2845443B2 (en)
KR (1) KR900004437B1 (en)
CA (1) CA1283874C (en)
FI (1) FI881491A0 (en)
WO (1) WO1988000968A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378921A3 (en) * 1988-12-21 1990-09-19 Idaho Research Foundation, Inc. Enhancement of plant metabolite production by timed elicitation
AU2003215781A1 (en) 2002-03-20 2003-09-29 Rachid Ennamany Method for production of phytoalexins
WO2012074502A1 (en) * 2010-11-29 2012-06-07 Chayil Technologies, Llc Secondary metabolite stimulation in photoautotrophic cultures
CN103841956B (en) * 2011-03-27 2016-11-09 奥麒化工有限公司 Regulation epigenetic DNA methylation is to cause cell to take the DNA methylation pattern relevant to young cell
EP3250295B1 (en) 2015-01-30 2020-07-15 Naolys Sarl Method of manufacturing a topical composition comprising dedifferentiated plant cells elicited in in vitro culture

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300131A1 (en) * 1975-02-04 1976-09-03 Synthelabo Alkaloid prodn by culturing Vinca minor cells - in undifferentiated state in liq medium (BE030876)
FR2470603A1 (en) * 1979-12-07 1981-06-12 Synthelabo Anti-mitotic extracts of Catharanthus roseus G-Don - two new strains cr-1 and cr-2 produce extracts of high activity and low toxicity, whose activity is compared with that of vinblastine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300131A1 (en) * 1975-02-04 1976-09-03 Synthelabo Alkaloid prodn by culturing Vinca minor cells - in undifferentiated state in liq medium (BE030876)
FR2470603A1 (en) * 1979-12-07 1981-06-12 Synthelabo Anti-mitotic extracts of Catharanthus roseus G-Don - two new strains cr-1 and cr-2 produce extracts of high activity and low toxicity, whose activity is compared with that of vinblastine

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Biological Abstracts, Volume 75, No. 10, 1983, (Philadelphia, PA,. US), M. HAGIMORI et al.: "Studies on the Production of Digitalis Cardenolides by Plant Tissue Culture: 3. Effects of Nutrients on Digitoxin Formation by Shoot-Forming Cultures of Digitalis Purpurea Grown in Liquid Media", see page 7843, Abstract 75396, & Plant Cell Physiol 23(7): 1205-1212, 1982 *
Biological Abstracts, Volume 81, No. 3, 1986, (Philadelphia, PA., US), J.P. KUTNEY et al.: "Alkaloid Production in Catharanthus Roseus Cell Cultures: XIII. Effects of Bioregulators in Indole Alkaloid Biosynthesis," see page AB-773, Abstract 26364, & Plant Cell Rep 4(5): 259-262, 1985 *
Biological Abstracts, Volume 85, J.I. SMITH et al.: "Stimulation of Indole Alkaloid Production in Cell Suspension Cultures of Catharanthusroseus by Abscisic Acid", see Abstract 019176, & Planta Medica (West Germany) 1987. Vol. 53, No. 5, p. 470-474 *
CHEMICAL ABSTRACTS, Volume 107, No. 15, 12 October 1987, (Columbus, Ohio, US) J.I. SMITH et al.: "The Development of a Single-Stage Growth and Indole Alkaloid Production Medium for Catharanthus Roseus (L.) G. Don Suspension Cultures", see page 579, Abstract 132573b, & Enzyme Microb. Technol. 1987, 9(8), 466-9 *
CHEMICAL ABSTRACTS, Volume 93, No. 13, 29 September 1980, (Columbus, Ohio, US) K.H. KNOBLOCH et al.: "Influence of Medium Composition on the Formation of Secondary Compounds in Cell Suspension Cultures of Catharanthus Roseus (L.) G. Don.", see page 351, Abstract 128839t, & Z. Naturforsch., C: Biosci. 1980, 35C(7-8), 551-6 *
CHEMICAL ABSTRACTS, Volume 95, No. 19, 9 November 1981, (Columbus, Ohio, US) H. YAMAMOTO et al.: "Studies of the Fundamental Condition on Growth and Alkaloid Formation of the Callus Cultures of Coptis Japonica Var. Japonica. II. Influence of the Callus age at Inoculation and Growth Inhibitors", see page 164, Abstract 162962D, & Shoyakugaku Zasshi 1981, 35(1), 9-14 *
Phytochemistry, Volume 24, No. 10, 1985, Pergamon Press Ltd, (GB), P.M. FRISCHKNECHT et al.: "Stress Induced Formation of Purine Alkaloids in Plant Tissue Culture of Coffea Arabica", pages 2255-2257 see the whole document *
Tetrahedron, Volume 39, No. 22, 1983, Pergamon Press Ltd, (GB), J.P. KUTNEY et al.: "Studies in Plant Tissue Culture. The Synthesis and Biosynthesis of Indole Alkaloids", pages 3781-3795 *
Trends in Biotechnology, December 1986, Elsevier Science Publishers B.V., (Amsterdam, NL), M. COLLINGE: "Ways and Means to Plant Secondary Metabolites", pages 299-301 see page 300, column 2, lines 16-41 *

Also Published As

Publication number Publication date
FI881491A (en) 1988-03-30
FI881491A0 (en) 1988-03-30
KR900004437B1 (en) 1990-06-25
JP2845443B2 (en) 1999-01-13
KR880701774A (en) 1988-11-05
EP0277250A1 (en) 1988-08-10
CA1283874C (en) 1991-05-07
WO1988000968A2 (en) 1988-02-11
JPH01500401A (en) 1989-02-16

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