WO1988000968A3 - Procede et moyens pour induire la production de metabolites secondaires dans des cultures vegetales - Google Patents

Procede et moyens pour induire la production de metabolites secondaires dans des cultures vegetales Download PDF

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Publication number
WO1988000968A3
WO1988000968A3 PCT/JP1987/000583 JP8700583W WO8800968A3 WO 1988000968 A3 WO1988000968 A3 WO 1988000968A3 JP 8700583 W JP8700583 W JP 8700583W WO 8800968 A3 WO8800968 A3 WO 8800968A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkaloids
secondary metabolite
metabolite production
stressors
synthesis
Prior art date
Application number
PCT/JP1987/000583
Other languages
English (en)
Other versions
WO1988000968A2 (fr
Inventor
Jane Isobel Smith
Nigel John Smart
Masanaru Misawa
Original Assignee
Mitsui Petrochemical Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Petrochemical Ind filed Critical Mitsui Petrochemical Ind
Priority to KR1019880700360A priority Critical patent/KR900004437B1/ko
Publication of WO1988000968A2 publication Critical patent/WO1988000968A2/fr
Publication of WO1988000968A3 publication Critical patent/WO1988000968A3/fr
Priority to FI881491A priority patent/FI881491A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

On améliore la synthèse d'alkaloïdes par des cellules de Catharanthus roseus cultivées en suspension en sollicitant par voie osmotique les cellules cultivées, en y ajoutant des inducteurs tels que des agents aggressifs osmotiques ioniques du type sels haloïdes, par exemple NaCl, KCl et FeCl3, ou des agents aggressifs osmotiques organiques tels que des alcools de sucre ou des acides de sucre. On améliore également la synthèse des alcaloïdes en y ajoutant des composés anti-gibbérellines et d'autres composés tels que de l'acide abscissique qui est un régulateur de la croissance végétale. On augmente ainsi les rendements d'alcaloïdes.
PCT/JP1987/000583 1986-08-04 1987-08-03 Procede et moyens pour induire la production de metabolites secondaires dans des cultures vegetales WO1988000968A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019880700360A KR900004437B1 (ko) 1986-08-04 1987-08-03 식물배양에 있어서의 2차 대사산물 생산의 유도방법 및 그 수단
FI881491A FI881491A (fi) 1986-08-04 1988-03-30 Foerfarande foer inducering av sekundaer metabolitproduktion i vaextkulturer.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89293886A 1986-08-04 1986-08-04
US892,938 1986-08-04

Publications (2)

Publication Number Publication Date
WO1988000968A2 WO1988000968A2 (fr) 1988-02-11
WO1988000968A3 true WO1988000968A3 (fr) 1988-03-24

Family

ID=25400744

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1987/000583 WO1988000968A2 (fr) 1986-08-04 1987-08-03 Procede et moyens pour induire la production de metabolites secondaires dans des cultures vegetales

Country Status (6)

Country Link
EP (1) EP0277250A1 (fr)
JP (1) JP2845443B2 (fr)
KR (1) KR900004437B1 (fr)
CA (1) CA1283874C (fr)
FI (1) FI881491A (fr)
WO (1) WO1988000968A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0378921A3 (fr) * 1988-12-21 1990-09-19 Idaho Research Foundation, Inc. Augmentation de production de métabolites végétaux par provocation temporelle
JP2005530708A (ja) 2002-03-20 2005-10-13 エナマニィ，ラスィド フィトアレキシンの製造方法
WO2012074502A1 (fr) * 2010-11-29 2012-06-07 Chayil Technologies, Llc Stimulation des métabolites secondaires dans des cultures photoautotrophiques
ES2638888T3 (es) * 2011-03-27 2017-10-24 Arch Chemicals, Inc. Modulación de la metilación epigenética del AND para provocar que las células adopten patrones de metilación del ADN asociados con células jóvenes
WO2016120713A2 (fr) 2015-01-30 2016-08-04 Naolys Sarl Composition topique et son procédé de préparation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300131A1 (fr) * 1975-02-04 1976-09-03 Synthelabo Production d'alcaloides par culture " in vitro " de cellules de vinca minor. l.
FR2470603A1 (fr) * 1979-12-07 1981-06-12 Synthelabo Extraits a activite antimitotique obtenus a partir de nouvelles souches de tissus de catharanthus roseus g. don

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2300131A1 (fr) * 1975-02-04 1976-09-03 Synthelabo Production d'alcaloides par culture " in vitro " de cellules de vinca minor. l.
FR2470603A1 (fr) * 1979-12-07 1981-06-12 Synthelabo Extraits a activite antimitotique obtenus a partir de nouvelles souches de tissus de catharanthus roseus g. don

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
Biological Abstracts, Volume 75, No. 10, 1983, (Philadelphia, PA,. US), M. HAGIMORI et al.: "Studies on the Production of Digitalis Cardenolides by Plant Tissue Culture: 3. Effects of Nutrients on Digitoxin Formation by Shoot-Forming Cultures of Digitalis Purpurea Grown in Liquid Media", see page 7843, Abstract 75396, & Plant Cell Physiol 23(7): 1205-1212, 1982 *
Biological Abstracts, Volume 81, No. 3, 1986, (Philadelphia, PA., US), J.P. KUTNEY et al.: "Alkaloid Production in Catharanthus Roseus Cell Cultures: XIII. Effects of Bioregulators in Indole Alkaloid Biosynthesis," see page AB-773, Abstract 26364, & Plant Cell Rep 4(5): 259-262, 1985 *
Biological Abstracts, Volume 85, J.I. SMITH et al.: "Stimulation of Indole Alkaloid Production in Cell Suspension Cultures of Catharanthusroseus by Abscisic Acid", see Abstract 019176, & Planta Medica (West Germany) 1987. Vol. 53, No. 5, p. 470-474 *
CHEMICAL ABSTRACTS, Volume 107, No. 15, 12 October 1987, (Columbus, Ohio, US) J.I. SMITH et al.: "The Development of a Single-Stage Growth and Indole Alkaloid Production Medium for Catharanthus Roseus (L.) G. Don Suspension Cultures", see page 579, Abstract 132573b, & Enzyme Microb. Technol. 1987, 9(8), 466-9 *
CHEMICAL ABSTRACTS, Volume 93, No. 13, 29 September 1980, (Columbus, Ohio, US) K.H. KNOBLOCH et al.: "Influence of Medium Composition on the Formation of Secondary Compounds in Cell Suspension Cultures of Catharanthus Roseus (L.) G. Don.", see page 351, Abstract 128839t, & Z. Naturforsch., C: Biosci. 1980, 35C(7-8), 551-6 *
CHEMICAL ABSTRACTS, Volume 95, No. 19, 9 November 1981, (Columbus, Ohio, US) H. YAMAMOTO et al.: "Studies of the Fundamental Condition on Growth and Alkaloid Formation of the Callus Cultures of Coptis Japonica Var. Japonica. II. Influence of the Callus age at Inoculation and Growth Inhibitors", see page 164, Abstract 162962D, & Shoyakugaku Zasshi 1981, 35(1), 9-14 *
Phytochemistry, Volume 24, No. 10, 1985, Pergamon Press Ltd, (GB), P.M. FRISCHKNECHT et al.: "Stress Induced Formation of Purine Alkaloids in Plant Tissue Culture of Coffea Arabica", pages 2255-2257 see the whole document *
Tetrahedron, Volume 39, No. 22, 1983, Pergamon Press Ltd, (GB), J.P. KUTNEY et al.: "Studies in Plant Tissue Culture. The Synthesis and Biosynthesis of Indole Alkaloids", pages 3781-3795 *
Trends in Biotechnology, December 1986, Elsevier Science Publishers B.V., (Amsterdam, NL), M. COLLINGE: "Ways and Means to Plant Secondary Metabolites", pages 299-301 see page 300, column 2, lines 16-41 *

Also Published As

Publication number Publication date
WO1988000968A2 (fr) 1988-02-11
JP2845443B2 (ja) 1999-01-13
FI881491A0 (fi) 1988-03-30
FI881491A (fi) 1988-03-30
JPH01500401A (ja) 1989-02-16
CA1283874C (fr) 1991-05-07
EP0277250A1 (fr) 1988-08-10
KR880701774A (ko) 1988-11-05
KR900004437B1 (ko) 1990-06-25

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