JPS5668395A - Production of d(-)-beta-hydroxyisobutyric acid - Google Patents
Production of d(-)-beta-hydroxyisobutyric acidInfo
- Publication number
- JPS5668395A JPS5668395A JP14425379A JP14425379A JPS5668395A JP S5668395 A JPS5668395 A JP S5668395A JP 14425379 A JP14425379 A JP 14425379A JP 14425379 A JP14425379 A JP 14425379A JP S5668395 A JPS5668395 A JP S5668395A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- candida
- microorganism
- culture mixture
- isobutyric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: A specific microorganism or culture mixture resulting from the cultivation of the microorgansim in a medium that can grow it is made to act on isobutyric acid to produce D(-)-β-hydroxyisobutyric acid in high yield.
CONSTITUTION: A microorganism in Candida such as Candida rugosa, Candida parapsilosis or Candida utilis is cultured in a culture medium in which the microorganism can use isobutyric acid as a nutrient, that is, containing carbohydrates alcohol, hydrocarbons and organic acids at a low level of isobutyrlic acid at a pH of 4W9.5 aerobically at 20W40°C for 1W5 days. Then, the culture mixture or cell bodies separated therefrom are suspended in a M/15 phosphoric acid buffer solution (pH 8.5) and a large amount of isobutyric acid and a small amount of glucose are added, then, they are cultured at a pH of 6W9.5 aerobically for about 72hr. The objective compound is extracted from the culture mixture free from solid parts such as cell bodis and purified.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14425379A JPS5921600B2 (en) | 1979-11-06 | 1979-11-06 | Method for producing D(-)-β-hydroxyisobutyric acid |
GB8033532A GB2063873B (en) | 1979-11-06 | 1980-10-17 | Fermentative production of d(-)-hydroxyisobutyric acid |
US06/201,337 US4310635A (en) | 1979-11-06 | 1980-10-27 | Fermentative production of D(-)-β-hydroxyisobutyric acid |
DE19803041224 DE3041224A1 (en) | 1979-11-06 | 1980-11-03 | METHOD FOR THE FERMENTATIVE PRODUCTION OF D (-) - (BETA) -HYDROXYISOBUTTERIC ACID |
IT50073/80A IT1188962B (en) | 1979-11-06 | 1980-11-04 | PROCEDURE FOR PRODUCING ACID D (-) - B-HYDROXY-ISOBUTYRIC |
NL8006026A NL192833C (en) | 1979-11-06 | 1980-11-04 | Process for preparing a beta-hydroxyisobutyric acid. |
IE2291/80A IE50473B1 (en) | 1979-11-06 | 1980-11-05 | Fermentative production of d(-)-b-hydroxyisobutyric acid |
CH8221/80A CH647806A5 (en) | 1979-11-06 | 1980-11-05 | METHOD FOR PRODUCING D (-) - BETA HYDROXYISOBUTTERIC ACID. |
FR8023612A FR2468646B1 (en) | 1979-11-06 | 1980-11-05 | PRODUCTION OF D (-) - B-HYDROXYISOBUTYRIC ACID BY FERMENTATION OF ISOBUTYRIC AND / OR METHACRYLIC ACID |
ES496563A ES8200400A1 (en) | 1979-11-06 | 1980-11-05 | Fermentative production of D(-)- beta -hydroxyisobutyric acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14425379A JPS5921600B2 (en) | 1979-11-06 | 1979-11-06 | Method for producing D(-)-β-hydroxyisobutyric acid |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5668395A true JPS5668395A (en) | 1981-06-09 |
JPS5921600B2 JPS5921600B2 (en) | 1984-05-21 |
Family
ID=15357791
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14425379A Expired JPS5921600B2 (en) | 1979-11-06 | 1979-11-06 | Method for producing D(-)-β-hydroxyisobutyric acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5921600B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59118092A (en) * | 1982-12-23 | 1984-07-07 | Mitsubishi Rayon Co Ltd | Preparation of beta-hydroxyisobutyric acid |
-
1979
- 1979-11-06 JP JP14425379A patent/JPS5921600B2/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS59118092A (en) * | 1982-12-23 | 1984-07-07 | Mitsubishi Rayon Co Ltd | Preparation of beta-hydroxyisobutyric acid |
JPH0357753B2 (en) * | 1982-12-23 | 1991-09-03 | Mitsubishi Rayon Co |
Also Published As
Publication number | Publication date |
---|---|
JPS5921600B2 (en) | 1984-05-21 |
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