JPS5668395A - Production of d(-)-beta-hydroxyisobutyric acid - Google Patents

Production of d(-)-beta-hydroxyisobutyric acid

Info

Publication number
JPS5668395A
JPS5668395A JP14425379A JP14425379A JPS5668395A JP S5668395 A JPS5668395 A JP S5668395A JP 14425379 A JP14425379 A JP 14425379A JP 14425379 A JP14425379 A JP 14425379A JP S5668395 A JPS5668395 A JP S5668395A
Authority
JP
Japan
Prior art keywords
acid
candida
microorganism
culture mixture
isobutyric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14425379A
Other languages
Japanese (ja)
Other versions
JPS5921600B2 (en
Inventor
Junzo Hasegawa
Masahiro Ogura
Masami Shimazaki
Hajime Kawarada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP14425379A priority Critical patent/JPS5921600B2/en
Priority to GB8033532A priority patent/GB2063873B/en
Priority to US06/201,337 priority patent/US4310635A/en
Priority to DE19803041224 priority patent/DE3041224A1/en
Priority to IT50073/80A priority patent/IT1188962B/en
Priority to NL8006026A priority patent/NL192833C/en
Priority to IE2291/80A priority patent/IE50473B1/en
Priority to CH8221/80A priority patent/CH647806A5/en
Priority to FR8023612A priority patent/FR2468646B1/en
Priority to ES496563A priority patent/ES8200400A1/en
Publication of JPS5668395A publication Critical patent/JPS5668395A/en
Publication of JPS5921600B2 publication Critical patent/JPS5921600B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: A specific microorganism or culture mixture resulting from the cultivation of the microorgansim in a medium that can grow it is made to act on isobutyric acid to produce D(-)-β-hydroxyisobutyric acid in high yield.
CONSTITUTION: A microorganism in Candida such as Candida rugosa, Candida parapsilosis or Candida utilis is cultured in a culture medium in which the microorganism can use isobutyric acid as a nutrient, that is, containing carbohydrates alcohol, hydrocarbons and organic acids at a low level of isobutyrlic acid at a pH of 4W9.5 aerobically at 20W40°C for 1W5 days. Then, the culture mixture or cell bodies separated therefrom are suspended in a M/15 phosphoric acid buffer solution (pH 8.5) and a large amount of isobutyric acid and a small amount of glucose are added, then, they are cultured at a pH of 6W9.5 aerobically for about 72hr. The objective compound is extracted from the culture mixture free from solid parts such as cell bodis and purified.
COPYRIGHT: (C)1981,JPO&Japio
JP14425379A 1979-11-06 1979-11-06 Method for producing D(-)-β-hydroxyisobutyric acid Expired JPS5921600B2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP14425379A JPS5921600B2 (en) 1979-11-06 1979-11-06 Method for producing D(-)-β-hydroxyisobutyric acid
GB8033532A GB2063873B (en) 1979-11-06 1980-10-17 Fermentative production of d(-)-hydroxyisobutyric acid
US06/201,337 US4310635A (en) 1979-11-06 1980-10-27 Fermentative production of D(-)-β-hydroxyisobutyric acid
DE19803041224 DE3041224A1 (en) 1979-11-06 1980-11-03 METHOD FOR THE FERMENTATIVE PRODUCTION OF D (-) - (BETA) -HYDROXYISOBUTTERIC ACID
IT50073/80A IT1188962B (en) 1979-11-06 1980-11-04 PROCEDURE FOR PRODUCING ACID D (-) - B-HYDROXY-ISOBUTYRIC
NL8006026A NL192833C (en) 1979-11-06 1980-11-04 Process for preparing a beta-hydroxyisobutyric acid.
IE2291/80A IE50473B1 (en) 1979-11-06 1980-11-05 Fermentative production of d(-)-b-hydroxyisobutyric acid
CH8221/80A CH647806A5 (en) 1979-11-06 1980-11-05 METHOD FOR PRODUCING D (-) - BETA HYDROXYISOBUTTERIC ACID.
FR8023612A FR2468646B1 (en) 1979-11-06 1980-11-05 PRODUCTION OF D (-) - B-HYDROXYISOBUTYRIC ACID BY FERMENTATION OF ISOBUTYRIC AND / OR METHACRYLIC ACID
ES496563A ES8200400A1 (en) 1979-11-06 1980-11-05 Fermentative production of D(-)- beta -hydroxyisobutyric acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14425379A JPS5921600B2 (en) 1979-11-06 1979-11-06 Method for producing D(-)-β-hydroxyisobutyric acid

Publications (2)

Publication Number Publication Date
JPS5668395A true JPS5668395A (en) 1981-06-09
JPS5921600B2 JPS5921600B2 (en) 1984-05-21

Family

ID=15357791

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14425379A Expired JPS5921600B2 (en) 1979-11-06 1979-11-06 Method for producing D(-)-β-hydroxyisobutyric acid

Country Status (1)

Country Link
JP (1) JPS5921600B2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59118092A (en) * 1982-12-23 1984-07-07 Mitsubishi Rayon Co Ltd Preparation of beta-hydroxyisobutyric acid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59118092A (en) * 1982-12-23 1984-07-07 Mitsubishi Rayon Co Ltd Preparation of beta-hydroxyisobutyric acid
JPH0357753B2 (en) * 1982-12-23 1991-09-03 Mitsubishi Rayon Co

Also Published As

Publication number Publication date
JPS5921600B2 (en) 1984-05-21

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