JPS578795A - Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt - Google Patents

Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt

Info

Publication number
JPS578795A
JPS578795A JP8347880A JP8347880A JPS578795A JP S578795 A JPS578795 A JP S578795A JP 8347880 A JP8347880 A JP 8347880A JP 8347880 A JP8347880 A JP 8347880A JP S578795 A JPS578795 A JP S578795A
Authority
JP
Japan
Prior art keywords
salt
keto
hydroxy
substituted
cholic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8347880A
Other languages
Japanese (ja)
Other versions
JPH0120874B2 (en
Inventor
Masao Tsuji
Yoshihiro Ichihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP8347880A priority Critical patent/JPS578795A/en
Priority to GB8024436A priority patent/GB2057447B/en
Priority to US06/173,815 priority patent/US4359529A/en
Priority to HU205180A priority patent/HU183201B/en
Priority to DE3031334A priority patent/DE3031334C2/en
Priority to IT68301/80A priority patent/IT1166482B/en
Priority to CH628980A priority patent/CH646442A5/en
Priority to FR8018288A priority patent/FR2463809A1/en
Priority to NLAANVRAGE8004741,A priority patent/NL185731C/en
Priority to CA000368547A priority patent/CA1169795A/en
Publication of JPS578795A publication Critical patent/JPS578795A/en
Publication of JPH0120874B2 publication Critical patent/JPH0120874B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To prepare the titled substance useful as a raw material of pharmaceuticals, economically, by culturing microorganisms belonging to Corynebacterium genus in a medium containing a cholic acid salt.
CONSTITUTION: Microorganisms belonging to Corynebacterium genus, e.g. Corynebacterium CA-53 (FERM-P No.5532), etc. are cultured in a medium containing a cholic acid salt as a substrate. The medium contains a carbon source, a nitrogen source, inorganic salts, etc. assimilable with the microorganisms. The cholic acid salt is, e.g. an alkali metal salt. The culturing is carried out under aerobic conditions, and after the completion of the cultivation, the objective 3-substituted-7α- hydroxy-12-keto-5β-cholanic acid and/or its salt are obtained by the removal of the cells, addition of hydrochloric acid, addition of ethyl acetate, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP8347880A 1979-08-21 1980-06-19 Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt Granted JPS578795A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP8347880A JPS578795A (en) 1980-06-19 1980-06-19 Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt
GB8024436A GB2057447B (en) 1979-08-21 1980-07-25 Microbal process for producing cholanic acid derivatives and microbes used therein
US06/173,815 US4359529A (en) 1979-08-21 1980-07-30 Microbial process for producing cholanic acid derivatives
HU205180A HU183201B (en) 1979-08-21 1980-08-18 Microbiological process for preparing derivatives of cholanic acid
DE3031334A DE3031334C2 (en) 1979-08-21 1980-08-20 Microbiological process for the production of cholanic acid derivatives
IT68301/80A IT1166482B (en) 1979-08-21 1980-08-20 MICROBIOLOGICAL PROCEDURE FOR THE PRODUCTION OF COLANIC ACID DERIVATIVES AND MICROORGANISMS USED IN THE PROCEDURE
CH628980A CH646442A5 (en) 1979-08-21 1980-08-20 MICROBIAL METHOD FOR PRODUCING CHOLANIC ACID DERIVATIVES AND MICROORGANISMS USED IN SUCH A METHOD.
FR8018288A FR2463809A1 (en) 1979-08-21 1980-08-21 MICROBIAL PROCESS FOR PRODUCING CHOLANIC ACID DERIVATIVES AND THE MICROBES USED THEREIN
NLAANVRAGE8004741,A NL185731C (en) 1979-08-21 1980-08-21 PROCESS FOR PREPARING 3-ALFA, 7-ALFA-DIHYDROXY 12-KETO 5-BETA-CHOLIC ACID OR AN ALKALI OR EARTHALAL METAL SALT, AND MICRO-ORGANISMS FOR USE IN THE PROCESS.
CA000368547A CA1169795A (en) 1980-06-17 1981-01-15 Microbial process for producing cholanic acid derivatives and microbes used therein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8347880A JPS578795A (en) 1980-06-19 1980-06-19 Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt

Publications (2)

Publication Number Publication Date
JPS578795A true JPS578795A (en) 1982-01-18
JPH0120874B2 JPH0120874B2 (en) 1989-04-18

Family

ID=13803567

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8347880A Granted JPS578795A (en) 1979-08-21 1980-06-19 Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt

Country Status (1)

Country Link
JP (1) JPS578795A (en)

Also Published As

Publication number Publication date
JPH0120874B2 (en) 1989-04-18

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