JPS578795A - Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt - Google Patents
Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its saltInfo
- Publication number
- JPS578795A JPS578795A JP8347880A JP8347880A JPS578795A JP S578795 A JPS578795 A JP S578795A JP 8347880 A JP8347880 A JP 8347880A JP 8347880 A JP8347880 A JP 8347880A JP S578795 A JPS578795 A JP S578795A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- keto
- hydroxy
- substituted
- cholic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To prepare the titled substance useful as a raw material of pharmaceuticals, economically, by culturing microorganisms belonging to Corynebacterium genus in a medium containing a cholic acid salt.
CONSTITUTION: Microorganisms belonging to Corynebacterium genus, e.g. Corynebacterium CA-53 (FERM-P No.5532), etc. are cultured in a medium containing a cholic acid salt as a substrate. The medium contains a carbon source, a nitrogen source, inorganic salts, etc. assimilable with the microorganisms. The cholic acid salt is, e.g. an alkali metal salt. The culturing is carried out under aerobic conditions, and after the completion of the cultivation, the objective 3-substituted-7α- hydroxy-12-keto-5β-cholanic acid and/or its salt are obtained by the removal of the cells, addition of hydrochloric acid, addition of ethyl acetate, etc.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8347880A JPS578795A (en) | 1980-06-19 | 1980-06-19 | Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt |
GB8024436A GB2057447B (en) | 1979-08-21 | 1980-07-25 | Microbal process for producing cholanic acid derivatives and microbes used therein |
US06/173,815 US4359529A (en) | 1979-08-21 | 1980-07-30 | Microbial process for producing cholanic acid derivatives |
HU205180A HU183201B (en) | 1979-08-21 | 1980-08-18 | Microbiological process for preparing derivatives of cholanic acid |
DE3031334A DE3031334C2 (en) | 1979-08-21 | 1980-08-20 | Microbiological process for the production of cholanic acid derivatives |
IT68301/80A IT1166482B (en) | 1979-08-21 | 1980-08-20 | MICROBIOLOGICAL PROCEDURE FOR THE PRODUCTION OF COLANIC ACID DERIVATIVES AND MICROORGANISMS USED IN THE PROCEDURE |
CH628980A CH646442A5 (en) | 1979-08-21 | 1980-08-20 | MICROBIAL METHOD FOR PRODUCING CHOLANIC ACID DERIVATIVES AND MICROORGANISMS USED IN SUCH A METHOD. |
FR8018288A FR2463809A1 (en) | 1979-08-21 | 1980-08-21 | MICROBIAL PROCESS FOR PRODUCING CHOLANIC ACID DERIVATIVES AND THE MICROBES USED THEREIN |
NLAANVRAGE8004741,A NL185731C (en) | 1979-08-21 | 1980-08-21 | PROCESS FOR PREPARING 3-ALFA, 7-ALFA-DIHYDROXY 12-KETO 5-BETA-CHOLIC ACID OR AN ALKALI OR EARTHALAL METAL SALT, AND MICRO-ORGANISMS FOR USE IN THE PROCESS. |
CA000368547A CA1169795A (en) | 1980-06-17 | 1981-01-15 | Microbial process for producing cholanic acid derivatives and microbes used therein |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8347880A JPS578795A (en) | 1980-06-19 | 1980-06-19 | Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS578795A true JPS578795A (en) | 1982-01-18 |
JPH0120874B2 JPH0120874B2 (en) | 1989-04-18 |
Family
ID=13803567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8347880A Granted JPS578795A (en) | 1979-08-21 | 1980-06-19 | Preparation of 3-substituted-7alpha-hydroxy-12-keto-5beta-cholanic acid and/or its salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS578795A (en) |
-
1980
- 1980-06-19 JP JP8347880A patent/JPS578795A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPH0120874B2 (en) | 1989-04-18 |
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