JPS578796A - Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt - Google Patents

Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Info

Publication number
JPS578796A
JPS578796A JP8225680A JP8225680A JPS578796A JP S578796 A JPS578796 A JP S578796A JP 8225680 A JP8225680 A JP 8225680A JP 8225680 A JP8225680 A JP 8225680A JP S578796 A JPS578796 A JP S578796A
Authority
JP
Japan
Prior art keywords
arthrobacter
strain
salt
cholic acid
5beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8225680A
Other languages
Japanese (ja)
Other versions
JPH0120873B2 (en
Inventor
Masao Tsuji
Yoshihiro Ichihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP8225680A priority Critical patent/JPS578796A/en
Priority to GB8024436A priority patent/GB2057447B/en
Priority to HU205180A priority patent/HU183201B/en
Priority to CH628980A priority patent/CH646442A5/en
Priority to IT68301/80A priority patent/IT1166482B/en
Priority to DE3031334A priority patent/DE3031334C2/en
Priority to NLAANVRAGE8004741,A priority patent/NL185731C/en
Priority to FR8018288A priority patent/FR2463809A1/en
Priority to CA000368547A priority patent/CA1169795A/en
Publication of JPS578796A publication Critical patent/JPS578796A/en
Publication of JPH0120873B2 publication Critical patent/JPH0120873B2/ja
Granted legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PURPOSE: To prepare the titled substance useful as a raw material of pharmaceuticals, in high yield, in a short time, by culturing a microbial strain obtained by the mutagenic treatment of microorganisms belonging to Arthrobacter genus, in a medium containing a cholic acid salt.
CONSTITUTION: Arthrobacter CA-35 strain is subjected to the mutagenic treatment such as treatment with N-methyl-N'-nitro-N-nitrosoguanidine, ultraviolet irradiation, etc. to obtain strains such as Arthrobacter CA-35-A589-29-32 (FERM-P No.5522), Arthrobacter CA-35-A589-47 (FERM-P No.5523), etc. The strain is cultured in a medium containing a carbon source, a nitrogen source, inorganic salts, etc. assimilable with the strain, and containing a cholic acid salt such as cholic acid alkali metal salt as a substrate. The titled substance can be separated from the cultured product by the removal of the cells, addition of hydrochloric acid, addition of ethyl acetate, etc.
COPYRIGHT: (C)1982,JPO&Japio
JP8225680A 1979-08-21 1980-06-17 Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt Granted JPS578796A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP8225680A JPS578796A (en) 1980-06-17 1980-06-17 Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt
GB8024436A GB2057447B (en) 1979-08-21 1980-07-25 Microbal process for producing cholanic acid derivatives and microbes used therein
HU205180A HU183201B (en) 1979-08-21 1980-08-18 Microbiological process for preparing derivatives of cholanic acid
CH628980A CH646442A5 (en) 1979-08-21 1980-08-20 MICROBIAL METHOD FOR PRODUCING CHOLANIC ACID DERIVATIVES AND MICROORGANISMS USED IN SUCH A METHOD.
IT68301/80A IT1166482B (en) 1979-08-21 1980-08-20 MICROBIOLOGICAL PROCEDURE FOR THE PRODUCTION OF COLANIC ACID DERIVATIVES AND MICROORGANISMS USED IN THE PROCEDURE
DE3031334A DE3031334C2 (en) 1979-08-21 1980-08-20 Microbiological process for the production of cholanic acid derivatives
NLAANVRAGE8004741,A NL185731C (en) 1979-08-21 1980-08-21 PROCESS FOR PREPARING 3-ALFA, 7-ALFA-DIHYDROXY 12-KETO 5-BETA-CHOLIC ACID OR AN ALKALI OR EARTHALAL METAL SALT, AND MICRO-ORGANISMS FOR USE IN THE PROCESS.
FR8018288A FR2463809A1 (en) 1979-08-21 1980-08-21 MICROBIAL PROCESS FOR PRODUCING CHOLANIC ACID DERIVATIVES AND THE MICROBES USED THEREIN
CA000368547A CA1169795A (en) 1980-06-17 1981-01-15 Microbial process for producing cholanic acid derivatives and microbes used therein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8225680A JPS578796A (en) 1980-06-17 1980-06-17 Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP18878080A Division JPS578781A (en) 1980-12-29 1980-12-29 Microorganism producing 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid

Publications (2)

Publication Number Publication Date
JPS578796A true JPS578796A (en) 1982-01-18
JPH0120873B2 JPH0120873B2 (en) 1989-04-18

Family

ID=13769359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8225680A Granted JPS578796A (en) 1979-08-21 1980-06-17 Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Country Status (1)

Country Link
JP (1) JPS578796A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57138398A (en) * 1981-02-20 1982-08-26 Kuraray Co Ltd Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt
JPH0329286A (en) * 1989-06-26 1991-02-07 Osamu Miyake Far infrared ray radiator

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3082973B2 (en) * 1991-10-24 2000-09-04 三菱東京製薬株式会社 Method for producing 3α, 7α-dihydroxy-12-keto-5β-cholanic acid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57138398A (en) * 1981-02-20 1982-08-26 Kuraray Co Ltd Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt
JPH0329286A (en) * 1989-06-26 1991-02-07 Osamu Miyake Far infrared ray radiator

Also Published As

Publication number Publication date
JPH0120873B2 (en) 1989-04-18

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