JPS57138398A - Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt - Google Patents
Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its saltInfo
- Publication number
- JPS57138398A JPS57138398A JP2458681A JP2458681A JPS57138398A JP S57138398 A JPS57138398 A JP S57138398A JP 2458681 A JP2458681 A JP 2458681A JP 2458681 A JP2458681 A JP 2458681A JP S57138398 A JPS57138398 A JP S57138398A
- Authority
- JP
- Japan
- Prior art keywords
- salt
- keto
- dihydroxy
- cultured
- cholanic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: A bacterium in Arthrobacter or Brevibacterium, capable of producing the titled substance, is cultured in an enriched medium containing cholic acid salt of less than specified concentration and the titled substance formed in the cultured mixture is collected.
CONSTITUTION: A bacterium capable of producing 3α,7α-dihydroxy-12-keto-5β- cholanic acid and/or its salt, such as Arthrobacter CA-35 or Brevibacterium CA- 6, is cultured aerobically in a liquid medium containing less than 20g/l of cholic acid salt and other nutrients which can be assimilated by the baterium 3α,7α- dihydroxy-12- keto-5β-cholanic and/or its salt accumulated in the culture mixture is separated by removing the insoluble substances, making the filtrate or supernatant acidic to effect the preicitation of the objective substance. Or the product is obtained from the remaining solution after removal of precipitate by use of ethyl acetate.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2458681A JPS57138398A (en) | 1981-02-20 | 1981-02-20 | Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2458681A JPS57138398A (en) | 1981-02-20 | 1981-02-20 | Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57138398A true JPS57138398A (en) | 1982-08-26 |
Family
ID=12142256
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2458681A Pending JPS57138398A (en) | 1981-02-20 | 1981-02-20 | Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57138398A (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS578796A (en) * | 1980-06-17 | 1982-01-18 | Kuraray Co Ltd | Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt |
-
1981
- 1981-02-20 JP JP2458681A patent/JPS57138398A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS578796A (en) * | 1980-06-17 | 1982-01-18 | Kuraray Co Ltd | Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt |
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