JPS57138398A - Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt - Google Patents

Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Info

Publication number
JPS57138398A
JPS57138398A JP2458681A JP2458681A JPS57138398A JP S57138398 A JPS57138398 A JP S57138398A JP 2458681 A JP2458681 A JP 2458681A JP 2458681 A JP2458681 A JP 2458681A JP S57138398 A JPS57138398 A JP S57138398A
Authority
JP
Japan
Prior art keywords
salt
keto
dihydroxy
cultured
cholanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2458681A
Other languages
Japanese (ja)
Inventor
Masao Tsuji
Yoshihiro Ichihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kuraray Co Ltd
Original Assignee
Kuraray Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kuraray Co Ltd filed Critical Kuraray Co Ltd
Priority to JP2458681A priority Critical patent/JPS57138398A/en
Publication of JPS57138398A publication Critical patent/JPS57138398A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: A bacterium in Arthrobacter or Brevibacterium, capable of producing the titled substance, is cultured in an enriched medium containing cholic acid salt of less than specified concentration and the titled substance formed in the cultured mixture is collected.
CONSTITUTION: A bacterium capable of producing 3α,7α-dihydroxy-12-keto-5β- cholanic acid and/or its salt, such as Arthrobacter CA-35 or Brevibacterium CA- 6, is cultured aerobically in a liquid medium containing less than 20g/l of cholic acid salt and other nutrients which can be assimilated by the baterium 3α,7α- dihydroxy-12- keto-5β-cholanic and/or its salt accumulated in the culture mixture is separated by removing the insoluble substances, making the filtrate or supernatant acidic to effect the preicitation of the objective substance. Or the product is obtained from the remaining solution after removal of precipitate by use of ethyl acetate.
COPYRIGHT: (C)1982,JPO&Japio
JP2458681A 1981-02-20 1981-02-20 Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt Pending JPS57138398A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2458681A JPS57138398A (en) 1981-02-20 1981-02-20 Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2458681A JPS57138398A (en) 1981-02-20 1981-02-20 Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Publications (1)

Publication Number Publication Date
JPS57138398A true JPS57138398A (en) 1982-08-26

Family

ID=12142256

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2458681A Pending JPS57138398A (en) 1981-02-20 1981-02-20 Production of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Country Status (1)

Country Link
JP (1) JPS57138398A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS578796A (en) * 1980-06-17 1982-01-18 Kuraray Co Ltd Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS578796A (en) * 1980-06-17 1982-01-18 Kuraray Co Ltd Preparation of 3alpha,7alpha-dihydroxy-12-keto-5beta-cholanic acid and/or its salt

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