DK0458959T3 - Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf - Google Patents

Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf

Info

Publication number
DK0458959T3
DK0458959T3 DK91902366.3T DK91902366T DK0458959T3 DK 0458959 T3 DK0458959 T3 DK 0458959T3 DK 91902366 T DK91902366 T DK 91902366T DK 0458959 T3 DK0458959 T3 DK 0458959T3
Authority
DK
Denmark
Prior art keywords
analogs
pdgf
present
growth factor
novel
Prior art date
Application number
DK91902366.3T
Other languages
English (en)
Inventor
Arlen Read Thomason
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/454,794 external-priority patent/US5149792A/en
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of DK0458959T3 publication Critical patent/DK0458959T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
DK91902366.3T 1989-12-19 1990-12-17 Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf DK0458959T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/454,794 US5149792A (en) 1989-12-19 1989-12-19 Platelet-derived growth factor B chain analogs
US07/624,451 US5272064A (en) 1989-12-19 1990-12-13 DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof

Publications (1)

Publication Number Publication Date
DK0458959T3 true DK0458959T3 (da) 1995-08-14

Family

ID=27037609

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91902366.3T DK0458959T3 (da) 1989-12-19 1990-12-17 Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf

Country Status (17)

Country Link
US (1) US5272064A (da)
EP (1) EP0458959B1 (da)
JP (1) JPH04504064A (da)
AT (1) ATE123949T1 (da)
AU (1) AU646014B2 (da)
CA (1) CA2032675A1 (da)
DE (1) DE69020335T2 (da)
DK (1) DK0458959T3 (da)
ES (1) ES2073735T3 (da)
FI (1) FI913892A0 (da)
GR (1) GR3017317T3 (da)
IE (1) IE904608A1 (da)
IL (1) IL96723A0 (da)
NO (1) NO913232L (da)
NZ (1) NZ236549A (da)
PT (1) PT96272A (da)
WO (1) WO1991008761A1 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2130748A1 (en) * 1992-02-26 1993-09-02 Michael E. Stern Use of platelet derived growth factor in ophthalmic wound healing
ZA932179B (en) * 1992-03-30 1994-09-26 Schering Corp Monomeric platelet-derived growth factor and prevention of stenosis or restenosis
JP2005521401A (ja) 2002-03-27 2005-07-21 イミュネックス・コーポレーション ポリペプチド産生を増加させる方法
US20040248796A1 (en) * 2003-02-04 2004-12-09 Kari Alitalo VEGF-B and PDGF modulation of stem cells
BR112012000865A2 (pt) 2009-07-17 2019-09-24 T Tabor Aaron "composição e método para a modificação genética cosmética de células substancialmente intactas"
CN103080300B (zh) 2010-08-05 2015-11-25 安姆根有限公司 增加细胞培养物的产率和活力的二肽
WO2012145685A1 (en) 2011-04-20 2012-10-26 Amgen Inc. Autoinjector apparatus
US9133493B2 (en) 2011-04-21 2015-09-15 Amgen Inc. Method for culturing mammalian cells to improve recombinant protein production
ES2625045T3 (es) 2011-07-01 2017-07-18 Amgen Inc. Cultivo de células de mamífero
WO2013033600A1 (en) 2011-09-02 2013-03-07 Amgen Inc. Pharmaceutical product and method of analysing light exposure of a pharmaceutical product
AR089231A1 (es) 2011-12-15 2014-08-06 Amgen Inc Metodo de floculacion
US20150353542A1 (en) 2013-01-14 2015-12-10 Amgen Inc. Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture
PL2969099T5 (pl) 2013-03-14 2022-06-13 Amgen Inc. Usuwanie wypłukanego ligandu do oczyszczania na zasadzie powinowactwa
TWI625390B (zh) 2013-03-14 2018-06-01 安美基公司 用於增加重組蛋白質之甘露糖含量之方法
TWI614041B (zh) 2013-03-15 2018-02-11 安美基公司 用於注射器之匣盒
TWI580451B (zh) 2013-03-15 2017-05-01 安美基公司 用於注射器之匣盒及使用具有自動注射器及匣盒之自動注射器設備之方法
US9481901B2 (en) 2013-05-30 2016-11-01 Amgen Inc. Methods for increasing mannose content of recombinant proteins
MX2016005572A (es) 2013-10-31 2016-12-09 Amgen Inc Uso de monensina para regular la glicosilacion de proteinas recombinantes.
US10513723B2 (en) 2014-01-13 2019-12-24 Amgen Inc. Decreasing ornithine production to decrease high mannose glycoform content of recombinant proteins
AU2014380174B2 (en) 2014-01-29 2018-08-30 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
US10106829B2 (en) 2014-01-29 2018-10-23 Amgen Inc. Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins
BR112016028285B1 (pt) 2014-06-04 2023-02-23 Amgen Inc Método para uma colheita periódica prolongada, sistema de filtro de unidade única e método para cultivo de células que expressam proteína recombinante
ES2727380T3 (es) 2014-11-19 2019-10-15 Amgen Inc Cuantificación de resto glucano en glucoproteínas recombinantes
EA202091598A3 (ru) 2014-12-01 2021-01-29 Эмджен Инк. Процесс контроля уровня содержания гликанов в составе
WO2019099322A1 (en) 2017-11-16 2019-05-23 Amgen Inc. Autoinjector with stall and end point detection
WO2023079058A1 (en) 2021-11-05 2023-05-11 Yokogawa Insilico Biotechnology Gmbh Cell culture with reduced production of lactate
WO2023129974A1 (en) 2021-12-29 2023-07-06 Bristol-Myers Squibb Company Generation of landing pad cell lines

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479896A (en) * 1981-12-11 1984-10-30 Antoniades Harry N Method for extraction localization and direct recovery of platelet derived growth factor
US4801542A (en) * 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
EP0487116B1 (en) * 1984-10-12 1999-12-29 ZymoGenetics, Inc. Biologically active PDGF analogs in eucaryotic cells
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4769328A (en) * 1984-10-12 1988-09-06 Zymogenetics Inc. Expression of biologically active PDGF analogs in yeast
DE3751632T2 (de) * 1986-08-13 1996-06-13 Zymogenetics Inc Expression von biologisch-aktiven PDGF-Analogen in eukaryotischen Zellen
DE3834079A1 (de) * 1988-10-06 1990-04-12 Biotechnolog Forschung Gmbh Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems

Also Published As

Publication number Publication date
FI913892A0 (fi) 1991-08-16
NO913232D0 (no) 1991-08-19
ATE123949T1 (de) 1995-07-15
DE69020335D1 (de) 1995-07-27
WO1991008761A1 (en) 1991-06-27
ES2073735T3 (es) 1995-08-16
IE904608A1 (en) 1991-06-19
EP0458959A1 (en) 1991-12-04
DE69020335T2 (de) 1995-11-02
US5272064A (en) 1993-12-21
AU646014B2 (en) 1994-02-03
CA2032675A1 (en) 1991-06-20
NO913232L (no) 1991-08-19
PT96272A (pt) 1991-09-30
IL96723A0 (en) 1991-09-16
AU7153491A (en) 1991-07-18
GR3017317T3 (en) 1995-12-31
EP0458959A4 (en) 1993-06-16
EP0458959B1 (en) 1995-06-21
JPH04504064A (ja) 1992-07-23
NZ236549A (en) 1993-03-26

Similar Documents

Publication Publication Date Title
DK0458959T3 (da) Hidtil ukendte blodpladeafledte vækstfaktor B-kædeanaloger og fremgangsmåde til homogen fremstilling deraf
Burgess et al. Two forms of murine epidermal growth factor: rapid separation by using reverse-phase HPLC.
KR880007734A (ko) 폴리펩타이드 유도체
NO974812D0 (no) Nytt protein og fremgangsmåte for fremstilling av dette
AU7681687A (en) Expression of platelet-derived growth factor and analogues
DE3852706T2 (de) Verfahren zur Herstellung eines physiologisch aktiven Peptids mit einem Cysteinrest.
TW275066B (da)
KR900702027A (ko) 사람 / 소의 염기성 섬유 아세포 성장 인자의 유도체
NZ335633A (en) Production of recombinant H. pylori polypeptides for treatment and diagnosis of H. pylori related diseases
EP0330700A4 (en) Human prourokinase-like polypeptide.
DE3782549D1 (de) Neue polypeptide, ihre herstellung und ihre verwendung.
CA2072587A1 (en) Oxidized variants of gm-csf
DK27097A (da) Minactivin og fremgangsmåde til fremstilling deraf
DK0555785T3 (da) Glat-muskel-mitogent stof og DNA, der koder herfor
DE60138885D1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
Butnev et al. Multiple forms of hypophyseal prolactin. A new glycosylated form of prolactin with increased biological activity
EP0613946A3 (en) Hst-2 mutein, dna coding for the same and preparation thereof.