NO974812L - Nytt protein og fremgangsmåte for fremstilling av dette - Google Patents

Nytt protein og fremgangsmåte for fremstilling av dette

Info

Publication number
NO974812L
NO974812L NO974812A NO974812A NO974812L NO 974812 L NO974812 L NO 974812L NO 974812 A NO974812 A NO 974812A NO 974812 A NO974812 A NO 974812A NO 974812 L NO974812 L NO 974812L
Authority
NO
Norway
Prior art keywords
protein
seq
purifying
amino acid
acid sequence
Prior art date
Application number
NO974812A
Other languages
English (en)
Other versions
NO321153B1 (no
NO974812D0 (no
Inventor
Fusao Makishima
Hiroyuki Takamatsu
Hideo Miki
Shinji Kawai
Michio Kimura
Tomoaki Matsumoto
Mieko Katsuura
Koichi Enomoto
Yusuke Satoh
Original Assignee
Hoechst Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Japan filed Critical Hoechst Japan
Publication of NO974812D0 publication Critical patent/NO974812D0/no
Publication of NO974812L publication Critical patent/NO974812L/no
Publication of NO321153B1 publication Critical patent/NO321153B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19974812A 1995-04-19 1997-10-17 Preparat av MP-52-protein pa 119 aminosyrer, farmasoytisk preparat som inneholder dette, fremgangsmate for fremstilling av preparatet av MP-52-protein, fremgangsmate for fremstilling av dimert protein som er omfattet av et preparat av MP-52-protein som er homodimert, og anvendelse av det homodimere proteinet for fremstilling av medikament. NO321153B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9366495 1995-04-19
JP32240395 1995-11-17
PCT/JP1996/001062 WO1996033215A1 (fr) 1995-04-19 1996-04-19 Proteine nouvelle et son procede de fabrication

Publications (3)

Publication Number Publication Date
NO974812D0 NO974812D0 (no) 1997-10-17
NO974812L true NO974812L (no) 1997-12-19
NO321153B1 NO321153B1 (no) 2006-03-27

Family

ID=26434967

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19974812A NO321153B1 (no) 1995-04-19 1997-10-17 Preparat av MP-52-protein pa 119 aminosyrer, farmasoytisk preparat som inneholder dette, fremgangsmate for fremstilling av preparatet av MP-52-protein, fremgangsmate for fremstilling av dimert protein som er omfattet av et preparat av MP-52-protein som er homodimert, og anvendelse av det homodimere proteinet for fremstilling av medikament.

Country Status (18)

Country Link
US (3) US7235527B2 (no)
EP (1) EP0955313B1 (no)
AT (1) ATE325131T1 (no)
AU (1) AU704515C (no)
BR (1) BR9608019A (no)
CA (1) CA2216741C (no)
DE (2) DE69636728T4 (no)
DK (1) DK0955313T3 (no)
EA (1) EA000582B1 (no)
ES (1) ES2258774T3 (no)
HU (1) HU225424B1 (no)
NO (1) NO321153B1 (no)
NZ (1) NZ305472A (no)
OA (1) OA10528A (no)
PL (1) PL186518B1 (no)
PT (1) PT955313E (no)
UA (1) UA46767C2 (no)
WO (1) WO1996033215A1 (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
NZ336509A (en) * 1997-01-30 2001-03-30 Hoechst Marion Roussel Ltd Freeze-dried composition of bone morphogenetic protein human MP52
JP4388602B2 (ja) † 1997-02-07 2009-12-24 ストライカー コーポレイション マトリクスを含まない骨形成デバイス、移植片、およびその使用方法
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US20070105762A1 (en) * 2005-03-30 2007-05-10 Jung Kim Non-activated polypeptides having a function of tissue regeneration and method for preparing the same
KR100775958B1 (ko) 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
US20060286144A1 (en) * 2005-06-17 2006-12-21 Chunlin Yang Reinforced collagen scaffold
JP5654730B2 (ja) 2005-11-18 2015-01-14 バイオファーム・ゲゼルシャフト・ツア・バイオテクノロジシェン・エントヴィックルング・フォン・ファーマカ・ミット・ベシュレンクテル・ハフツング 高活性の増殖因子変異体
EP1880731A1 (en) * 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Human growth and differentiation factor GDF-5
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
ES2402672T3 (es) * 2007-01-25 2013-05-07 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Uso del GDF-5 para el mejoramiento o el mantenimiento del aspecto dérmico
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2019117A1 (en) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimized purification process of recombinant growth factor protein
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
JP2009106163A (ja) * 2007-10-26 2009-05-21 Kyushu Univ 核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー
AU2009236459B2 (en) * 2008-04-14 2013-07-25 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered GDF-5 formulations
US11260110B2 (en) 2009-11-18 2022-03-01 Ptlnv, Llc, Series Four (4) Nanoparticles for the therapeutic treatment of radiation-induced skin ulcers
US9226898B1 (en) * 2009-11-18 2016-01-05 Richard C. K. Yen Submicron particles for the treatment of radiation damage in patients
US20130122066A1 (en) 2010-07-30 2013-05-16 Biopham Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
EP2537538A1 (en) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbable Wound Dressing
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (en) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5 mutant for inducing cartilage formation
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
AU2020403846A1 (en) 2019-12-18 2022-08-11 Merck Patent Gmbh Use of the GDF-5 mutant for the treatment of pain and cartilage destruction
KR20240064367A (ko) * 2022-11-04 2024-05-13 주식회사 대웅제약 TGF-β3 단백질의 정제방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725234A (en) * 1985-08-15 1988-02-16 Ethridge Edwin C Alveolar bone grafting process with controlled surface active ceramics
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
DE69233022T2 (de) 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
JP3193050B2 (ja) 1992-02-12 2001-07-30 ビオファルム ゲゼルシャフト ツア ビオテヒノロ ギッシェン エントヴィックルング フォン ファル マカ ミット ベシュレンクテル ハフツング 新規の増殖／分化因子をコード化するｄｎａ配列
WO1994015949A1 (en) * 1993-01-12 1994-07-21 Johns Hopkins University School Of Medicine Growth differentiation factor-5
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6248554B1 (en) 1993-11-24 2001-06-19 The Procter & Gamble Company DNA sequence coding for a BMP receptor
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
ATE319823T1 (de) * 1993-12-07 2006-03-15 Inst Genetics Llc Bmp-12, bmp-13 und diese enthaltende sehne- induzierende zusammensetzungen
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof

Also Published As

Publication number Publication date
HUP9801697A2 (hu) 1998-10-28
UA46767C2 (uk) 2002-06-17
WO1996033215A1 (fr) 1996-10-24
PL186518B1 (pl) 2004-01-30
MX9708011A (es) 1998-03-31
AU704515B2 (en) 1999-04-22
ES2258774T3 (es) 2006-09-01
US7235527B2 (en) 2007-06-26
ATE325131T1 (de) 2006-06-15
DK0955313T3 (da) 2006-08-21
NO321153B1 (no) 2006-03-27
NZ305472A (en) 1999-09-29
HUP9801697A3 (en) 2000-06-28
DE69636728D1 (de) 2007-01-04
PT955313E (pt) 2006-07-31
US20030181378A1 (en) 2003-09-25
US7816103B2 (en) 2010-10-19
OA10528A (en) 2002-04-26
AU704515C (en) 2002-03-28
CA2216741A1 (en) 1996-10-24
PL322945A1 (en) 1998-03-02
DE69636728T2 (de) 2007-02-22
NO974812D0 (no) 1997-10-17
US20090325864A1 (en) 2009-12-31
CA2216741C (en) 2008-01-15
HU225424B1 (en) 2006-11-28
DE69636728T4 (de) 2007-06-28
AU5347096A (en) 1996-11-07
EA199700329A1 (ru) 1998-04-30
EP0955313A1 (en) 1999-11-10
EA000582B1 (ru) 1999-12-29
EP0955313B1 (en) 2006-05-03
EP0955313A4 (en) 2001-11-07
BR9608019A (pt) 1999-11-30
US7268114B2 (en) 2007-09-11
US20020102633A1 (en) 2002-08-01

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Legal Events

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MM1K Lapsed by not paying the annual fees