ES8605813A1 - Procedimiento de tecnologia genetica para preparar interleu-quina-2 de humano - Google Patents
Procedimiento de tecnologia genetica para preparar interleu-quina-2 de humanoInfo
- Publication number
- ES8605813A1 ES8605813A1 ES543508A ES543508A ES8605813A1 ES 8605813 A1 ES8605813 A1 ES 8605813A1 ES 543508 A ES543508 A ES 543508A ES 543508 A ES543508 A ES 543508A ES 8605813 A1 ES8605813 A1 ES 8605813A1
- Authority
- ES
- Spain
- Prior art keywords
- gene
- human interleukin
- preparation
- carrying
- sequences
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
METODO PARA LA PRODUCCION DE PROTEINAS CON ACTIVIDAD BIOLOGICA DE INTERLEUQUINA-2 DE HUMANO. CONSISTE EN LA INCORPORACION DE UN GEN SINTETICO QUE CONTIENE TOTAL O PARCIALMENTE LA SECUENCIA I DE ADN, NUCLEOTIDOS 9 A 407 CORRESPONDIENTE A LOS AMINOACIDOS 1 A 133, EN UN PLASMIDO HIBRIDO; TRANSFORMACION DE ESTE PLASMIDO EN UN ORGANISMO HOSPEDANTE, EN EL QUE SE LLEVA A EXPRESION EL GEN SINTETICO Y SE AISLA EL POLIPEPTIDO DESEADO. EL GEN SINTETICO, DELANTE DEL TRIPLETE PARA EL PRIMER AMINOACIDO, TIENE EL CODON ATG, SIGUIENDO DESPUES DEL TRIPLETE PARA EL ULTIMO AMINOACIDO UNO O DOS CODONES DE DETENCION; EL ADN ESTA ACORTADO EN EL EXTREMO C-TERMINAL O EN EL N-TERMINAL, Y EL ORGANISMO HOSPEDANTE ES E. COLI.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19843419995 DE3419995A1 (de) | 1984-05-29 | 1984-05-29 | Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8605813A1 true ES8605813A1 (es) | 1986-01-16 |
ES543508A0 ES543508A0 (es) | 1986-01-16 |
Family
ID=6237111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES543508A Expired ES8605813A1 (es) | 1984-05-29 | 1985-05-27 | Procedimiento de tecnologia genetica para preparar interleu-quina-2 de humano |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0163249B1 (es) |
JP (1) | JPS6199A (es) |
AT (1) | ATE65797T1 (es) |
AU (1) | AU589896B2 (es) |
DE (2) | DE3419995A1 (es) |
DK (1) | DK166681B1 (es) |
ES (1) | ES8605813A1 (es) |
GR (1) | GR851291B (es) |
IE (1) | IE57996B1 (es) |
PT (1) | PT80542B (es) |
ZA (1) | ZA854031B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340853C (en) * | 1983-12-23 | 1999-12-21 | Hsiang-Fu Kung | Purification of recombinant interleukin-2 |
CA1340265C (en) * | 1985-01-18 | 1998-12-15 | Kirston E. Koths | Oxidation resistant muteins |
DE3537461A1 (de) * | 1985-10-22 | 1987-04-23 | Hoechst Ag | Derivat des interleukin-2, seine herstellung und verwendung |
US5496924A (en) * | 1985-11-27 | 1996-03-05 | Hoechst Aktiengesellschaft | Fusion protein comprising an interleukin-2 fragment ballast portion |
DE3712985A1 (de) * | 1987-04-16 | 1988-11-03 | Hoechst Ag | Bifunktionelle proteine |
JPS62185098A (ja) * | 1986-02-10 | 1987-08-13 | Otsuka Pharmaceut Co Ltd | インタ−ロイキン−2活性を有するポリペプチド |
US5831022A (en) * | 1986-02-18 | 1998-11-03 | Hoffmann-La Roche Inc. | Purification of recombinant human IL-1α |
US4992367A (en) * | 1986-05-12 | 1991-02-12 | Hoffmann-La Roche Inc. | Enhanced expression of human interleukin-2 in mammalian cells |
US5017692A (en) * | 1986-09-04 | 1991-05-21 | Schering Corporation | Truncated human interleukin-a alpha |
US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
CA1339757C (en) | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
US5162507A (en) * | 1987-05-11 | 1992-11-10 | Cetus Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
FR2643646B1 (fr) * | 1989-02-27 | 1993-09-17 | Pasteur Institut | Expression de sequences de nucleotides codant pour des vesicules a gaz |
US6008319A (en) * | 1996-12-23 | 1999-12-28 | University Of Southern California | Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof |
US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2483592A1 (fr) * | 1980-06-02 | 1981-12-04 | Stein Industrie | Dispositif de reduction des contraintes thermiques sur un echangeur de chaleur |
CA1341562C (en) * | 1982-03-31 | 2007-11-27 | Tadatsugu Taniguchi | Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell |
DE3377363D1 (en) * | 1982-03-31 | 1988-08-18 | Ajinomoto Kk | Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells |
AU579089B2 (en) * | 1983-02-08 | 1988-11-17 | Biogen, Inc. | Human interleukin-2-like polypeptides |
IL71275A0 (en) * | 1983-03-21 | 1984-06-29 | Sparamedica Ag | Human interleukin-2-and its preparation |
WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
FR2559782B1 (fr) * | 1984-02-16 | 1986-07-18 | Transgene Sa | Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2 |
DE3574731D1 (de) * | 1984-05-08 | 1990-01-18 | Genetics Inst | Ein menschlicher t-zellwachstumsfaktor. |
-
1984
- 1984-05-29 DE DE19843419995 patent/DE3419995A1/de not_active Withdrawn
-
1985
- 1985-05-22 AT AT85106279T patent/ATE65797T1/de not_active IP Right Cessation
- 1985-05-22 DE DE8585106279T patent/DE3583634D1/de not_active Expired - Fee Related
- 1985-05-22 EP EP85106279A patent/EP0163249B1/de not_active Expired - Lifetime
- 1985-05-27 ES ES543508A patent/ES8605813A1/es not_active Expired
- 1985-05-27 GR GR851291A patent/GR851291B/el unknown
- 1985-05-28 JP JP60113324A patent/JPS6199A/ja active Pending
- 1985-05-28 AU AU43070/85A patent/AU589896B2/en not_active Ceased
- 1985-05-28 ZA ZA854031A patent/ZA854031B/xx unknown
- 1985-05-28 DK DK237985A patent/DK166681B1/da not_active IP Right Cessation
- 1985-05-28 IE IE1319/85A patent/IE57996B1/en not_active IP Right Cessation
- 1985-05-29 PT PT80542A patent/PT80542B/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK237985D0 (da) | 1985-05-28 |
DE3419995A1 (de) | 1985-12-05 |
PT80542A (de) | 1985-06-01 |
EP0163249A2 (de) | 1985-12-04 |
EP0163249B1 (de) | 1991-07-31 |
EP0163249A3 (en) | 1988-05-11 |
DE3583634D1 (de) | 1991-09-05 |
ZA854031B (en) | 1986-01-29 |
ES543508A0 (es) | 1986-01-16 |
AU589896B2 (en) | 1989-10-26 |
ATE65797T1 (de) | 1991-08-15 |
DK237985A (da) | 1985-11-30 |
IE851319L (en) | 1985-11-29 |
DK166681B1 (da) | 1993-06-28 |
JPS6199A (ja) | 1986-01-06 |
AU4307085A (en) | 1985-12-05 |
GR851291B (es) | 1985-11-25 |
IE57996B1 (en) | 1993-06-02 |
PT80542B (pt) | 1987-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20001102 |