DE69126049D1 - Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C - Google Patents

Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C

Info

Publication number
DE69126049D1
DE69126049D1 DE69126049T DE69126049T DE69126049D1 DE 69126049 D1 DE69126049 D1 DE 69126049D1 DE 69126049 T DE69126049 T DE 69126049T DE 69126049 T DE69126049 T DE 69126049T DE 69126049 D1 DE69126049 D1 DE 69126049D1
Authority
DE
Germany
Prior art keywords
vectors
human protein
expression
compositions
glycosylation mutants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69126049T
Other languages
English (en)
Other versions
DE69126049T2 (de
Inventor
Bruce Edward Gerlitz
Brian William Grinnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69126049D1 publication Critical patent/DE69126049D1/de
Publication of DE69126049T2 publication Critical patent/DE69126049T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Eye Examination Apparatus (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
DE69126049T 1990-02-23 1991-02-22 Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C Expired - Fee Related DE69126049T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48408190A 1990-02-23 1990-02-23
US62806390A 1990-12-21 1990-12-21

Publications (2)

Publication Number Publication Date
DE69126049D1 true DE69126049D1 (de) 1997-06-19
DE69126049T2 DE69126049T2 (de) 1997-09-25

Family

ID=27047851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69126049T Expired - Fee Related DE69126049T2 (de) 1990-02-23 1991-02-22 Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C

Country Status (19)

Country Link
US (1) US5460953A (de)
EP (1) EP0443874B1 (de)
JP (1) JP3004375B2 (de)
KR (1) KR910021477A (de)
CN (1) CN1055560A (de)
AT (1) ATE153069T1 (de)
AU (1) AU645776B2 (de)
CA (1) CA2036894C (de)
DE (1) DE69126049T2 (de)
DK (1) DK0443874T3 (de)
ES (1) ES2101716T3 (de)
FI (1) FI910854A (de)
GR (1) GR3023756T3 (de)
IE (1) IE910611A1 (de)
IL (1) IL97311A0 (de)
NO (1) NO910719L (de)
NZ (1) NZ237199A (de)
PT (1) PT96853A (de)
YU (1) YU31891A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110664A (en) * 1992-05-21 1999-01-30 Lilly Co Eli Protein c derivatives
SE9701228D0 (sv) * 1997-04-03 1997-04-03 Bjoern Dahlbaeck Rekombinanta protein-C-och protein-S-varianter
US7081519B1 (en) 1997-04-24 2006-07-25 Zymogenetics, Inc. Antibodies to serine protease polypeptides
US6153420A (en) * 1997-04-24 2000-11-28 Zymogenetics, Inc. Serine protease polypeptides and materials and methods for making them
US6998122B1 (en) 1999-04-30 2006-02-14 Eli Lilly And Company Protein C derivatives
WO2001036462A2 (en) * 1999-11-19 2001-05-25 Eli Lilly And Company Protein c derivatives
EP1255821B1 (de) 2000-02-02 2004-12-29 Eli Lilly And Company Protein c derivate
EP1263943A1 (de) * 2000-02-11 2002-12-11 Eli Lilly & Company Protein c derivate
EP1328622A2 (de) * 2000-10-18 2003-07-23 Maxygen Aps Konjugate und varianten von protein c
US6933367B2 (en) 2000-10-18 2005-08-23 Maxygen Aps Protein C or activated protein C-like molecules
WO2006044294A2 (en) * 2004-10-14 2006-04-27 Eli Lilly And Company Human protein c analogs
WO2007117330A2 (en) * 2005-12-22 2007-10-18 Biosite Incorporated Latent protein c assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20100041600A1 (en) * 2006-06-09 2010-02-18 Russel James A Interferon gamma polymorphisms as indicators of subject outcome in critically ill subjects
WO2008048646A1 (en) * 2006-10-18 2008-04-24 Socratech L.L.C. Use of human protein c with altered glycosylation and sialic acid content as a medicament
US20110171200A1 (en) * 2008-01-15 2011-07-14 Walley Keith R Protein c rs2069915 as a response predictor to survival and administration of activated protein c or protein c-like compound
WO2012068519A2 (en) 2010-11-19 2012-05-24 Sirius Genomics Inc. Markers associated with response to activated protein c administration, and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
DE3688900T3 (de) * 1985-06-27 1998-06-10 Univ Washington Expression von Protein C.
US4968626A (en) * 1985-08-15 1990-11-06 Board Of Reagents Of The University Of Washington DNA sequence coding for protein C
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質
US5135854A (en) * 1987-10-29 1992-08-04 Zymogenetics, Inc. Methods of regulating protein glycosylation
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C
ZA889497B (en) * 1987-12-28 1990-08-29 Lilly Co Eli Vectors and compounds for expression of zymogen forms of human protein c
JP2728240B2 (ja) * 1988-07-26 1998-03-18 ヘキスト薬品工業株式会社 ヒトプロテインｃ変異体及びその製造方法
US5270178A (en) * 1990-02-23 1993-12-14 Eli Lilly And Company Vectors and compounds for expression of zymogen forms of human protein C

Also Published As

Publication number Publication date
NZ237199A (en) 1993-04-28
GR3023756T3 (en) 1997-09-30
CA2036894A1 (en) 1991-08-24
NO910719D0 (no) 1991-02-22
ES2101716T3 (es) 1997-07-16
NO910719L (no) 1991-08-26
CA2036894C (en) 2002-01-15
CN1055560A (zh) 1991-10-23
PT96853A (pt) 1991-10-31
AU645776B2 (en) 1994-01-27
IL97311A0 (en) 1992-05-25
EP0443874B1 (de) 1997-05-14
DK0443874T3 (da) 1997-11-17
FI910854A0 (fi) 1991-02-22
US5460953A (en) 1995-10-24
KR910021477A (ko) 1991-12-20
JPH04211380A (ja) 1992-08-03
FI910854A (fi) 1991-08-24
DE69126049T2 (de) 1997-09-25
IE910611A1 (en) 1991-08-28
JP3004375B2 (ja) 2000-01-31
YU31891A (sh) 1994-06-10
AU7130791A (en) 1991-08-29
EP0443874A3 (en) 1991-10-16
EP0443874A2 (de) 1991-08-28
ATE153069T1 (de) 1997-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee