DK155977C - Fremgangsmaade til fremstilling af en stabil injicerbar vandig oploesning af et tetracyclin-antibiotikum og en jordalkalimetalforbindelse - Google Patents

Fremgangsmaade til fremstilling af en stabil injicerbar vandig oploesning af et tetracyclin-antibiotikum og en jordalkalimetalforbindelse

Info

Publication number
DK155977C
DK155977C DK182578A DK182578A DK155977C DK 155977 C DK155977 C DK 155977C DK 182578 A DK182578 A DK 182578A DK 182578 A DK182578 A DK 182578A DK 155977 C DK155977 C DK 155977C
Authority
DK
Denmark
Prior art keywords
earthal
preparing
procedure
aqueous solution
metal compound
Prior art date
Application number
DK182578A
Other languages
Danish (da)
English (en)
Other versions
DK155977B (da
DK182578A (da
Inventor
William Wellesley Armstrong
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK182578A publication Critical patent/DK182578A/da
Publication of DK155977B publication Critical patent/DK155977B/da
Application granted granted Critical
Publication of DK155977C publication Critical patent/DK155977C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
DK182578A 1977-04-27 1978-04-26 Fremgangsmaade til fremstilling af en stabil injicerbar vandig oploesning af et tetracyclin-antibiotikum og en jordalkalimetalforbindelse DK155977C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/791,627 US4126680A (en) 1977-04-27 1977-04-27 Tetracycline antibiotic compositions
US79162777 1977-04-27

Publications (3)

Publication Number Publication Date
DK182578A DK182578A (da) 1978-10-28
DK155977B DK155977B (da) 1989-06-12
DK155977C true DK155977C (da) 1989-10-30

Family

ID=25154289

Family Applications (1)

Application Number Title Priority Date Filing Date
DK182578A DK155977C (da) 1977-04-27 1978-04-26 Fremgangsmaade til fremstilling af en stabil injicerbar vandig oploesning af et tetracyclin-antibiotikum og en jordalkalimetalforbindelse

Country Status (38)

Country Link
US (1) US4126680A (cs)
JP (1) JPS53136514A (cs)
AR (1) AR217844A1 (cs)
AT (1) AT360148B (cs)
AU (1) AU503139B1 (cs)
BE (1) BE866419A (cs)
BG (1) BG47943A3 (cs)
CA (1) CA1100875A (cs)
CH (1) CH630260A5 (cs)
CS (1) CS199527B2 (cs)
DD (1) DD135445A5 (cs)
DE (1) DE2817335C3 (cs)
DK (1) DK155977C (cs)
EG (1) EG14348A (cs)
ES (1) ES468749A1 (cs)
FI (3) FI781300A7 (cs)
FR (1) FR2388561A1 (cs)
GB (1) GB1563478A (cs)
GR (1) GR70062B (cs)
HU (1) HU179050B (cs)
IE (1) IE47049B1 (cs)
IL (1) IL54581A0 (cs)
IN (1) IN148197B (cs)
IT (1) IT1094557B (cs)
LU (1) LU79547A1 (cs)
MX (1) MX6087E (cs)
NL (1) NL7804455A (cs)
NO (1) NO148280C (cs)
NZ (1) NZ187046A (cs)
OA (1) OA05949A (cs)
PH (1) PH12962A (cs)
PL (1) PL110459B1 (cs)
PT (1) PT67895B (cs)
RO (2) RO75099A (cs)
SE (1) SE443507B (cs)
YU (1) YU87178A (cs)
ZA (1) ZA782400B (cs)
ZM (1) ZM3878A1 (cs)

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US4386083A (en) * 1980-04-10 1983-05-31 Walter Hacke Injectable oxytetracycline compositions
US4806529A (en) * 1982-11-18 1989-02-21 Trustees Of Tufts College, Tufts University Tetracycline activity enhancement
US5589470A (en) * 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US5064821A (en) * 1982-11-18 1991-11-12 Trustees Of Tufts College Method and compositions for overcoming tetracycline resistance within living cells
US4769232A (en) * 1984-03-22 1988-09-06 Pfizer Inc. Parenteral formulations of indolmycin
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
EP0621033A1 (en) * 1993-04-20 1994-10-26 Nostras S.A. Antibiotic composition containing oxytetracycline and glycofurol
EP2327686A3 (en) 1999-09-14 2012-08-22 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
JP2003523963A (ja) * 2000-01-24 2003-08-12 トラスティーズ・オブ・タフツ・カレッジ クリプトスポリジウム・パルヴム関連疾患の治療のためのテトラサイクリン化合物
ES2288945T3 (es) * 2000-03-31 2008-02-01 Trustees Of Tufts College Compuestos de tetraciclina 7 y 9-carbamato, urea, tiourea, tiocarbamato y heteroaril-amino sustituidos.
EP1286954B1 (en) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
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AU2001268475A1 (en) 2000-06-16 2002-01-02 Trustees Of Tufts College 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
JP4963771B2 (ja) 2000-07-07 2012-06-27 トラスティーズ・オブ・タフツ・カレッジ ７、８および９−置換テトラサイクリン化合物
KR101083571B1 (ko) 2000-07-07 2011-11-14 파라테크 파마슈티컬스, 인크. 7-치환 테트라사이클린 화합물
EP2308832B8 (en) * 2000-07-07 2019-04-24 Trustees Of Tufts College 9-substituted minocycline compounds
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
AU2001271616A1 (en) 2000-07-07 2002-01-21 Paratek Pharmaceuticals, Inc 13-substituted methacycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EA201000388A1 (ru) 2001-03-13 2010-10-29 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
CA2457234A1 (en) 2001-03-14 2002-09-19 Mark L. Nelson Substituted tetracycline compounds as antifungal agents
EP1381372A2 (en) 2001-03-14 2004-01-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
AU2002254714C1 (en) 2001-04-24 2010-01-07 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2311797A1 (en) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP2005526754A (ja) 2002-03-08 2005-09-08 パラテック ファーマシューティカルズ インコーポレイテッド アミノメチル置換されたテトラサイクリン化合物
CN1653037A (zh) 2002-03-21 2005-08-10 帕拉特克药品公司 取代的四环素化合物
EP2345637A3 (en) 2002-07-12 2012-02-15 Paratek Pharmaceuticals, Inc. 3, 10, and 12a substituted tetracycline compounds
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US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US7541347B2 (en) * 2007-04-02 2009-06-02 Medicis Pharmaceutical Coropration Minocycline oral dosage forms for the treatment of acne
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WO2007120913A2 (en) * 2006-04-17 2007-10-25 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
PL2016045T3 (pl) * 2006-04-24 2015-04-30 Teva Pharma Krystaliczna postać tygecykliny i sposoby jej otrzymywania
EP2026776A2 (en) * 2006-05-15 2009-02-25 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
ES2315123B1 (es) * 2006-09-25 2009-12-30 Divasa-Farmavic, S.A. Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
MX2009006846A (es) 2006-12-21 2009-08-20 Paratek Pharm Innc Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias.
US8513223B2 (en) 2006-12-21 2013-08-20 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
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US9434680B2 (en) * 2007-04-27 2016-09-06 Paratek Pharmaceuticals, Inc. Methods for synthesizing and purifying aminoalkyl tetracycline compounds
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US1913323A (en) * 1931-02-28 1933-06-06 Hoffmann La Roche Stable concentrated solution for therapeutic purposes
DE647766C (de) * 1931-03-01 1937-07-12 Hoffmanni La Roche & Co Akt Ge Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) * 1931-12-04 1932-09-29 Andrew Home Morton Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) * 1931-12-08 1938-07-22 Hoffmanni La Roche & Co Akt Ge Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) * 1933-01-15 1939-03-23 Hoffmann La Roche & Co Akt Ges Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) * 1963-01-30 1966-02-02 Chugai Pharmaceutical Co Ltd Hemostatic preparation for injection and process for the production thereof
DK129969B (da) * 1973-01-11 1974-12-09 Rosco Ak Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) * 1974-01-19 1978-04-26 Norbrook Labor Ltd Oxytetracycline solution
US4018889A (en) * 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions

Also Published As

Publication number Publication date
LU79547A1 (fr) 1979-11-07
IL54581A0 (en) 1978-07-31
CH630260A5 (fr) 1982-06-15
DE2817335C3 (de) 1982-04-22
FR2388561A1 (fr) 1978-11-24
PT67895A (en) 1978-05-01
SE443507B (sv) 1986-03-03
FI801197A7 (fi) 1981-01-01
FI781300A7 (fi) 1978-10-28
RO77953A (ro) 1981-12-25
PL110459B1 (en) 1980-07-31
DK155977B (da) 1989-06-12
NO781457L (no) 1978-10-30
BG47943A3 (bg) 1990-10-15
HU179050B (en) 1982-08-28
YU87178A (en) 1984-04-30
ES468749A1 (es) 1979-01-01
US4126680A (en) 1978-11-21
FI801196A7 (fi) 1981-01-01
RO75099A (ro) 1980-12-30
DE2817335B2 (de) 1981-06-11
JPS53136514A (en) 1978-11-29
NZ187046A (en) 1980-03-05
PH12962A (en) 1979-10-19
NO148280B (no) 1983-06-06
DK182578A (da) 1978-10-28
FR2388561B1 (cs) 1980-07-18
DD135445A5 (de) 1979-05-09
GR70062B (cs) 1982-07-26
IE780828L (en) 1978-10-27
ZM3878A1 (en) 1978-11-21
CS199527B2 (en) 1980-07-31
JPS5632290B2 (cs) 1981-07-27
PT67895B (en) 1979-11-14
BE866419A (fr) 1978-10-26
AU503139B1 (en) 1979-08-23
ZA782400B (en) 1979-04-25
NO148280C (no) 1983-09-21
IE47049B1 (en) 1983-12-14
AT360148B (de) 1980-12-29
MX6087E (es) 1984-11-08
NL7804455A (nl) 1978-10-31
OA05949A (fr) 1981-06-30
IT1094557B (it) 1985-08-02
IT7822720A0 (it) 1978-04-26
DE2817335A1 (de) 1978-11-16
GB1563478A (en) 1980-03-26
AR217844A1 (es) 1980-04-30
SE7801816L (sv) 1978-10-28
PL206050A1 (pl) 1979-03-26
ATA300478A (de) 1980-05-15
IN148197B (cs) 1980-11-29
EG14348A (en) 1984-09-30
CA1100875A (en) 1981-05-12

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