DK1506179T3 - Benzoxazinderivater som 5-HT6-modulatorer og anvendelser deraf - Google Patents

Benzoxazinderivater som 5-HT6-modulatorer og anvendelser deraf

Info

Publication number
DK1506179T3
DK1506179T3 DK03727430T DK03727430T DK1506179T3 DK 1506179 T3 DK1506179 T3 DK 1506179T3 DK 03727430 T DK03727430 T DK 03727430T DK 03727430 T DK03727430 T DK 03727430T DK 1506179 T3 DK1506179 T3 DK 1506179T3
Authority
DK
Denmark
Prior art keywords
modulators
applications
benzoxazine derivatives
benzoxazine
derivatives
Prior art date
Application number
DK03727430T
Other languages
Danish (da)
English (en)
Inventor
Jacob Berger
Shu-Hai Zhao
Robin Douglas Clark
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1506179T3 publication Critical patent/DK1506179T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK03727430T 2002-05-13 2003-05-05 Benzoxazinderivater som 5-HT6-modulatorer og anvendelser deraf DK1506179T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37800302P 2002-05-13 2002-05-13

Publications (1)

Publication Number Publication Date
DK1506179T3 true DK1506179T3 (da) 2006-06-06

Family

ID=29420358

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03727430T DK1506179T3 (da) 2002-05-13 2003-05-05 Benzoxazinderivater som 5-HT6-modulatorer og anvendelser deraf

Country Status (37)

Country Link
US (4) US6867204B2 (pt)
EP (1) EP1506179B1 (pt)
JP (1) JP4307377B2 (pt)
KR (1) KR100636475B1 (pt)
CN (1) CN100429206C (pt)
AR (1) AR039988A1 (pt)
AT (1) ATE316523T1 (pt)
AU (1) AU2003233231B2 (pt)
BR (1) BRPI0310032B8 (pt)
CA (1) CA2485136C (pt)
DE (1) DE60303376T2 (pt)
DK (1) DK1506179T3 (pt)
EA (1) EA009982B1 (pt)
EC (1) ECSP045420A (pt)
EG (1) EG25683A (pt)
ES (1) ES2256744T3 (pt)
GT (1) GT200300108A (pt)
HK (1) HK1080846A1 (pt)
HR (1) HRP20041030B1 (pt)
IL (1) IL164928A0 (pt)
JO (1) JO2413B1 (pt)
MA (1) MA27118A1 (pt)
MX (1) MXPA04011254A (pt)
MY (1) MY139612A (pt)
NO (1) NO329380B1 (pt)
NZ (1) NZ536230A (pt)
PA (1) PA8573501A1 (pt)
PE (1) PE20040757A1 (pt)
PL (1) PL211057B1 (pt)
PT (1) PT1506179E (pt)
RS (1) RS51042B (pt)
TN (1) TNSN04225A1 (pt)
TW (1) TWI258479B (pt)
UA (1) UA76877C2 (pt)
UY (1) UY27803A1 (pt)
WO (1) WO2003095434A1 (pt)
ZA (1) ZA200408783B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2453837C (en) * 2001-07-20 2011-10-04 Psychogenics, Inc. Treatment for attention-deficit hyperactivity disorder using eltoprazine and related compounds
PL209872B1 (pl) 2002-03-27 2011-10-31 Glaxo Group Ltd Pochodna chinolinowa, sposób jej wytwarzania i jej zastosowanie oraz zawierająca ją farmaceutyczna kompozycja
PL211057B1 (pl) * 2002-05-13 2012-04-30 Hoffmann La Roche Pochodne benzoksazyny, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie pochodnych benzoksazyny
CN100390157C (zh) 2002-11-08 2008-05-28 弗·哈夫曼-拉罗切有限公司 取代的苯并嗪酮及其用途
RS20060035A (en) 2003-07-22 2008-08-07 Arena Pharmaceuticals Inc., Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
ES2291984T3 (es) * 2003-12-09 2008-03-01 F. Hoffmann-La Roche Ag Derivados de benzoxazina y su empleo.
RU2006129464A (ru) * 2004-01-16 2008-02-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные 1-бензил-5-пиперазин-1-ил-3, 4-дигидро-1н-хиназолин-2-она и соответствующие производные 1н-бензо (1, 2, 6) тиадиазин-2, 2-диоксида и 1, 4-дигидробензо (1, 3)оксазин-2-она в качестве модуляторов рецептора 5-гидрокситриптамина (5нт) для лечения заболевания центральной нервной системы
NZ550441A (en) * 2004-05-05 2009-07-31 Hoffmann La Roche Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
WO2006037481A1 (en) * 2004-09-30 2006-04-13 F.Hoffmann-La Roche Ag Benzoxazine and quinoxaline derivatives and uses
US7378415B2 (en) * 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
ES2359725T3 (es) * 2004-09-30 2011-05-26 F. Hoffmann-La Roche Ag Composiciones y métodos para el tratamiento de trastornos cognitivos.
WO2009074607A1 (en) 2007-12-12 2009-06-18 Glaxo Group Limited Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
AR078770A1 (es) * 2009-10-27 2011-11-30 Elara Pharmaceuticals Gmbh Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) * 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) * 2012-01-24 2016-08-02 Chemregen, Inc. Compounds for inhibition of cancer cell proliferation
CA2935944A1 (en) 2014-01-09 2015-07-16 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Substituted benzoxazine and related compounds
CN109562085A (zh) 2015-06-12 2019-04-02 阿速万科学有限责任公司 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物
AU2016291673A1 (en) 2015-07-15 2018-01-25 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1029479C (zh) * 1989-11-08 1995-08-09 山之内制药株式会社 新型苯并噁嗪衍生物的制备方法
US5492914A (en) * 1994-07-28 1996-02-20 Syntex (U.S.A.) Inc. 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof
GB9507203D0 (en) 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
DZ2376A1 (fr) * 1996-12-19 2002-12-28 Smithkline Beecham Plc Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant.
BR9809092A (pt) 1997-04-18 2002-01-22 Smithkline Beecham Plc Derivados de indol tendo atividade combinada de antagonista de receptor de 5ht1a, 5ht1b e 5ht1d
PL338016A1 (en) 1997-07-11 2000-09-25 Smithkline Beecham Plc Novel chemical compounds
AU736596B2 (en) * 1997-07-25 2001-08-02 H. Lundbeck A/S Indole and 2,3-dihydroindole derivatives, their preparation and use
GB9801392D0 (en) 1998-01-22 1998-03-18 Smithkline Beecham Plc Novel compounds
CA2335711A1 (en) * 1998-06-19 1999-12-29 Ivan Mikkelsen 4,5,6 and 7-indole and indoline derivatives, their preparation and use
GB9818916D0 (en) * 1998-08-28 1998-10-21 Smithkline Beecham Plc Use
US6380235B1 (en) 1999-05-04 2002-04-30 American Home Products Corporation Benzimidazolones and analogues
PL201178B1 (pl) * 1999-08-23 2009-03-31 Solvay Pharm Bv Nowe pochodne fenylopiperazyny, sposób ich wytwarzania, kompozycja farmaceutyczna oraz zastosowanie
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
EP1255743A1 (en) 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
PL211057B1 (pl) * 2002-05-13 2012-04-30 Hoffmann La Roche Pochodne benzoksazyny, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie pochodnych benzoksazyny

Also Published As

Publication number Publication date
US6867204B2 (en) 2005-03-15
MA27118A1 (fr) 2004-12-20
JP2005530774A (ja) 2005-10-13
PA8573501A1 (es) 2003-12-10
EP1506179B1 (en) 2006-01-25
US20050130962A1 (en) 2005-06-16
CA2485136A1 (en) 2003-11-20
JO2413B1 (en) 2007-11-11
DE60303376T2 (de) 2006-11-16
DE60303376D1 (de) 2006-04-13
HK1080846A1 (en) 2006-05-04
US20090325950A1 (en) 2009-12-31
EG25683A (en) 2012-05-16
ECSP045420A (es) 2005-01-03
HRP20041030B1 (hr) 2013-03-31
US8377931B2 (en) 2013-02-19
ATE316523T1 (de) 2006-02-15
BRPI0310032B1 (pt) 2019-01-08
AU2003233231A1 (en) 2003-11-11
UY27803A1 (es) 2003-11-28
TWI258479B (en) 2006-07-21
EP1506179A1 (en) 2005-02-16
BR0310032A (pt) 2005-02-15
HRP20041030A2 (en) 2005-06-30
IL164928A0 (en) 2005-12-18
GT200300108A (es) 2004-03-15
PT1506179E (pt) 2006-06-30
RS97004A (en) 2006-10-27
PE20040757A1 (es) 2004-11-06
US20130123251A1 (en) 2013-05-16
PL211057B1 (pl) 2012-04-30
NO329380B1 (no) 2010-10-04
EA009982B1 (ru) 2008-04-28
ES2256744T3 (es) 2006-07-16
WO2003095434A1 (en) 2003-11-20
MY139612A (en) 2009-10-30
NO20044665L (no) 2004-12-03
KR20040106538A (ko) 2004-12-17
PL374019A1 (en) 2005-09-19
JP4307377B2 (ja) 2009-08-05
MXPA04011254A (es) 2005-01-25
AR039988A1 (es) 2005-03-09
CN1653054A (zh) 2005-08-10
KR100636475B1 (ko) 2006-10-18
US20030232825A1 (en) 2003-12-18
ZA200408783B (en) 2005-12-28
CN100429206C (zh) 2008-10-29
TW200400188A (en) 2004-01-01
RS51042B (sr) 2010-10-31
UA76877C2 (uk) 2006-09-15
AU2003233231B2 (en) 2009-02-26
TNSN04225A1 (fr) 2007-03-12
BRPI0310032B8 (pt) 2021-05-25
NZ536230A (en) 2007-05-31
CA2485136C (en) 2011-12-20
EA200401455A1 (ru) 2005-06-30

Similar Documents

Publication Publication Date Title
DK1506179T3 (da) Benzoxazinderivater som 5-HT6-modulatorer og anvendelser deraf
DK1956004T3 (da) Quinolinderivater og deres anvendelse som 5-HT6-ligander
NO20051451D0 (no) Pyrimidinderivater og deres anvendelse som CB2 modulatorer
DK1478629T3 (da) N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler
NO20053356D0 (no) Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
IS7948A (is) Fosfónóoxýkínasólínafleiður og lyfjafræileg notkun þeirra
DK1480955T3 (da) O-cyclopropyl-carboxanilider og deres anvendelse som fungicider
DK1492785T3 (da) 2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
DK1660491T3 (da) Benzimidazol-, benzthiazol- og benzoxazolderivater og deres anvendelse som LTA4Hmodulatorer
DK1534277T3 (da) Acylerede, heteroaryl-kondenserede cycloalkenylaminer og anvendelse af disse som lægemidler
ATE478870T1 (de) Spiroindolinpiperidinderivate
ATE460418T1 (de) Heterocyclocarboxamidderivate
ATE450506T1 (de) Indol-3-schwefelderivate
ATE467631T1 (de) Chinuclidinamidderivate
DK1500654T3 (da) Benzoxazinonderivater, fremstilling deraf og anvendelse deraf som lægemidler
NO20054135D0 (no) Kipolinon/benzoksazin derivater og anvendelser derav
DK1427711T3 (da) Oxazolidinon og/eller isoxazolinderivater som antibakterielle midler
DK1902050T3 (da) Oxazolidinonderivater og anvendelse deraf som antibiotika
DK1709018T3 (da) Acylaminothiazolderivater og anvendelse deraf som beta-amyloid-hæmmere
DK1587788T3 (da) 2,7-substituerede indoler og anvendelsen deraf som 5-HT6-modulatorer
ATE335729T1 (de) 3h-chinazoline -4-on derivaten
DK1387838T3 (da) Cyanoanthranylamid-derivater og deres anvendelse som lægemidler
DK1309585T3 (da) Nye indolderivater og anvendelse af disse som lægemidler
DK1727805T3 (da) 1-phenyl- og 1-pyridylpyrazolderivater og anvendelse deraf som pesticider
ATE423771T1 (de) Tetrahydrochinolinderivate