DK149095C - Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k - Google Patents

Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k

Info

Publication number
DK149095C
DK149095C DK73080A DK73080A DK149095C DK 149095 C DK149095 C DK 149095C DK 73080 A DK73080 A DK 73080A DK 73080 A DK73080 A DK 73080A DK 149095 C DK149095 C DK 149095C
Authority
DK
Denmark
Prior art keywords
preparing
procedure
cholesterol synthesis
compound called
inhibitive compound
Prior art date
Application number
DK73080A
Other languages
Danish (da)
English (en)
Other versions
DK149095B (da
DK73080A (da
Inventor
Akira Endo
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK73080A publication Critical patent/DK73080A/da
Priority to DK47085A priority Critical patent/DK165990C/da
Publication of DK149095B publication Critical patent/DK149095B/da
Application granted granted Critical
Publication of DK149095C publication Critical patent/DK149095C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DK73080A 1979-02-20 1980-02-20 Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k DK149095C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK47085A DK165990C (da) 1979-02-20 1985-02-01 Fremgangsmaade til fremstilling af carboxylsyren af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k eller salte deraf

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1785679 1979-02-20
JP54017856A JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法

Publications (3)

Publication Number Publication Date
DK73080A DK73080A (da) 1980-08-21
DK149095B DK149095B (da) 1986-01-20
DK149095C true DK149095C (da) 1986-06-16

Family

ID=11955290

Family Applications (2)

Application Number Title Priority Date Filing Date
DK73080A DK149095C (da) 1979-02-20 1980-02-20 Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k
DK021889A DK21889D0 (da) 1979-02-20 1989-01-18 Anvendelse af monacolin k, den tilsvarende carboxylsyreforbindelse eller salte af carboxylsyren til fremstilling af et laegemiddel til behandling af hypercholesterolaemi

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK021889A DK21889D0 (da) 1979-02-20 1989-01-18 Anvendelse af monacolin k, den tilsvarende carboxylsyreforbindelse eller salte af carboxylsyren til fremstilling af et laegemiddel til behandling af hypercholesterolaemi

Country Status (27)

Country Link
JP (1) JPS5925599B2 (ko)
KR (1) KR830002801B1 (ko)
AT (1) AT373915B (ko)
AU (1) AU532626B2 (ko)
BE (1) BE881825A (ko)
CA (1) CA1129794A (ko)
CH (1) CH645890A5 (ko)
DD (1) DD154494A5 (ko)
DE (2) DE3006216C2 (ko)
DK (2) DK149095C (ko)
ES (1) ES8103171A1 (ko)
FI (1) FI66427C (ko)
FR (1) FR2449685B1 (ko)
GB (1) GB2046737B (ko)
HU (1) HU182069B (ko)
IE (1) IE49743B1 (ko)
IT (1) IT1175260B (ko)
MX (1) MX6314E (ko)
NL (1) NL191540C (ko)
NO (1) NO153974C (ko)
NZ (1) NZ192919A (ko)
PH (1) PH15145A (ko)
PL (1) PL124304B1 (ko)
SE (1) SE453301B (ko)
SG (1) SG6784G (ko)
SU (2) SU1158048A3 (ko)
ZA (1) ZA80962B (ko)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
EP0629184A1 (en) * 1992-03-04 1994-12-21 Fujisawa Pharmaceutical Co., Ltd. TETRALIN DERIVATIVES AS HMG-CoA REDUCTASE INHIBITORS
NZ247617A (en) 1992-05-15 1995-07-26 Sankyo Co Octahydronaphthalene oxime derivatives and pharmaceutical compositions
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
IL132822A0 (en) 1998-03-20 2001-03-19 Biogal Gyogyszergyar Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
YU63602A (sh) 2000-02-24 2006-01-16 Biogal Gyogyszergyar Rt. Postupak za prečišćavanje fermentacionog bujona
US6521762B2 (en) 2000-03-03 2003-02-18 BIOGAL Gyógyszergyar RT. Process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities
KR20010095780A (ko) * 2000-04-12 2001-11-07 나가오카 마사시 배아 홍국
IN192861B (ko) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
EP1357807B1 (en) 2001-02-09 2007-03-14 Unilever N.V. Food product comprising soy protein and statins
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (ko) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 성인병 예방 및 치료 보조제
KR100710500B1 (ko) 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 ｋ 생산방법
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (ro) 2012-10-12 2013-09-30 Ion Gigel Fulga Compoziţie pentru tratamentul sau prevenirea dislipidemiilor
CN110331151A (zh) * 2019-04-11 2019-10-15 北京工商大学 紫色红曲菌mokH基因过表达菌株的构建方法
CN111297938A (zh) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 一种辅助降血脂组合物中洛伐他汀的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (ko) * 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus

Also Published As

Publication number Publication date
JPS5925599B2 (ja) 1984-06-19
IE49743B1 (en) 1985-12-11
FI66427C (fi) 1984-10-10
FR2449685A1 (fr) 1980-09-19
AT373915B (de) 1984-03-12
SE8001339L (sv) 1980-08-21
GB2046737B (en) 1983-01-12
NZ192919A (en) 1984-07-06
FR2449685B1 (fr) 1985-06-28
CH645890A5 (de) 1984-10-31
IT8067262A0 (it) 1980-02-20
NL191540C (nl) 1995-09-04
ES488796A0 (es) 1981-02-16
PL222120A1 (ko) 1980-10-20
NL191540B (nl) 1995-05-01
IT1175260B (it) 1987-07-01
DE3051175C2 (ko) 1989-12-21
SU1158048A3 (ru) 1985-05-23
NO800451L (no) 1980-08-21
JPS55111790A (en) 1980-08-28
GB2046737A (en) 1980-11-19
AU5567380A (en) 1980-08-28
ES8103171A1 (es) 1981-02-16
DK149095B (da) 1986-01-20
ATA92980A (de) 1983-07-15
DK21889A (da) 1989-01-18
DK21889D0 (da) 1989-01-18
PL124304B1 (en) 1983-01-31
DD154494A5 (de) 1982-03-24
HU182069B (en) 1983-12-28
KR830002030A (ko) 1983-05-21
IE800321L (en) 1980-08-20
DE3006216A1 (de) 1980-09-04
SE453301B (sv) 1988-01-25
ZA80962B (en) 1981-03-25
SG6784G (en) 1985-02-08
KR830002801B1 (ko) 1983-12-16
NO153974C (no) 1986-06-25
DK73080A (da) 1980-08-21
NL8001041A (nl) 1980-08-22
NO153974B (no) 1986-03-17
DE3006216C2 (de) 1985-10-31
PH15145A (en) 1982-08-24
FI66427B (fi) 1984-06-29
BE881825A (fr) 1980-08-20
CA1129794A (en) 1982-08-17
AU532626B2 (en) 1983-10-06
FI800506A (fi) 1980-08-21
MX6314E (es) 1985-04-01
SU969702A1 (ru) 1982-10-30

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PUP Patent expired