DK1408050T3 - Fremgangsmåde til fremstilling af glucagon-lignende peptid 1 (GLP-1) 7-36 og en GLP-1-analog - Google Patents

Fremgangsmåde til fremstilling af glucagon-lignende peptid 1 (GLP-1) 7-36 og en GLP-1-analog

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Publication number
DK1408050T3
DK1408050T3 DK02752955.1T DK02752955T DK1408050T3 DK 1408050 T3 DK1408050 T3 DK 1408050T3 DK 02752955 T DK02752955 T DK 02752955T DK 1408050 T3 DK1408050 T3 DK 1408050T3
Authority
DK
Denmark
Prior art keywords
glp
colibracillus
peptide
genes
promoting
Prior art date
Application number
DK02752955.1T
Other languages
English (en)
Inventor
Dengxi Wu
Aizhen Wu
Zhiyong Zhu
Gang Yu
Shaoling Zhao
Yukun Sun
Jiaxiang Zhou
Original Assignee
Shanghai Hua Yi Bio Tech Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hua Yi Bio Tech Lab filed Critical Shanghai Hua Yi Bio Tech Lab
Application granted granted Critical
Publication of DK1408050T3 publication Critical patent/DK1408050T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK02752955.1T 2001-07-19 2002-07-17 Fremgangsmåde til fremstilling af glucagon-lignende peptid 1 (GLP-1) 7-36 og en GLP-1-analog DK1408050T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN01126278A CN1363654A (zh) 2001-07-19 2001-07-19 生产促胰岛素分泌肽glp－1(7－36)的基因工程菌以及生产glp－1(7－36)的方法
PCT/CN2002/000502 WO2003016349A1 (fr) 2001-07-19 2002-07-17 Methode de production d'un peptide 1 de type glucagon (glp-1) 7-36 et d'un analogue de glp-1

Publications (1)

Publication Number Publication Date
DK1408050T3 true DK1408050T3 (da) 2010-01-18

Family

ID=4666300

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02752955.1T DK1408050T3 (da) 2001-07-19 2002-07-17 Fremgangsmåde til fremstilling af glucagon-lignende peptid 1 (GLP-1) 7-36 og en GLP-1-analog

Country Status (13)

Country Link
US (1) US7544512B2 (da)
EP (1) EP1408050B1 (da)
JP (1) JP4504014B2 (da)
KR (1) KR100959549B1 (da)
CN (2) CN1363654A (da)
AT (1) ATE443081T1 (da)
AU (1) AU2002313869B2 (da)
BR (1) BR0211435B1 (da)
CA (1) CA2454264C (da)
DE (1) DE60233734D1 (da)
DK (1) DK1408050T3 (da)
ES (1) ES2333413T3 (da)
WO (1) WO2003016349A1 (da)

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CN1162446C (zh) 2001-05-10 2004-08-18 上海华谊生物技术有限公司 促胰岛素分泌肽衍生物
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US8129504B2 (en) 2001-08-30 2012-03-06 Biorexis Technology, Inc. Oral delivery of modified transferrin fusion proteins
EP1626981A4 (en) * 2003-03-04 2006-11-22 Biorexis Pharmaceutical Corp PROTEINS PROTECTED AGAINST DIPEPTIDYLPEPTIDASE
CN100392070C (zh) * 2004-09-08 2008-06-04 华东师范大学 表达人胰高血糖素样肽-1的基因工程菌及其构建方法和应用
JPWO2006030492A1 (ja) * 2004-09-14 2008-07-31 日本製紙株式会社 Ｇｌｐ−１誘導体が集積された植物及び植物貯蔵器官とその生産方法
US7893017B2 (en) * 2004-10-07 2011-02-22 Novo Nordisk A/S Protracted GLP-1 compounds
EP2330126B1 (en) 2004-10-07 2015-12-23 Novo Nordisk A/S Protracted exendin-4 compounds
ES2336575T3 (es) 2005-09-22 2010-04-14 Biocompatibles Uk Limited Polipeptidos de fusion glp-1 (peptido-1 similar al glucagon) con resistencia aumentada a la peptidasa.
US8202837B2 (en) * 2005-11-04 2012-06-19 Glaxosmithkline Llc Methods for administering hypoglycemic agents
ATE444741T1 (de) * 2006-05-10 2009-10-15 Biocompatibles Uk Ltd Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung
PL2038423T3 (pl) * 2006-06-21 2013-05-31 Biocon Ltd Metoda wytwarzania biologicznie aktywnego polipeptydu insulinotropowego
EP2049567A2 (en) 2006-07-18 2009-04-22 Centocor, Inc. Human glp-1 mimetibodies, compositions, methods and uses
ATE524493T1 (de) 2006-07-24 2011-09-15 Biorexis Pharmaceutical Corp Exendin-fusionsproteine
EP1972349A1 (en) * 2007-03-21 2008-09-24 Biocompatibles UK Limited GLP-1 fusion peptides conjugated to polymer(s), their production and use
EP1975176A1 (en) * 2007-03-27 2008-10-01 Biocompatibles UK Limited Novel glp-1 fusion peptides, their production and use
CN101220088B (zh) * 2007-09-24 2012-01-25 中国人民解放军第四军医大学 人胰高血糖素样肽-1类似物的融合蛋白及其应用
EP2163243A1 (en) * 2008-09-12 2010-03-17 Biocompatibles UK Limited Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof
CN102093475B (zh) * 2009-12-11 2014-02-26 吴晓琰 胰高血糖素样肽-1的类似物
CN102242127B (zh) * 2011-05-20 2012-12-12 严杰 串联抗菌肽Alloferon-1的制备方法及rAlloferon-1-K的应用
SG11201405721VA (en) * 2012-03-19 2014-10-30 Madeleine Pharmaceuticals Ρτy Ltd Method of producing a recombinant peptide
CN107586330B (zh) * 2016-07-08 2021-04-16 上海多米瑞生物技术有限公司 替度鲁肽串联多肽及替度鲁肽制备方法
US20220127324A1 (en) * 2019-02-24 2022-04-28 Oncosimis Biotech Private Limited Method for continuous production of recombinant glp-1 peptide by bacteria
TW202307010A (zh) * 2021-06-30 2023-02-16 美商雅利斯塔製藥公司 單體融合肽及其使用方法

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US5459049A (en) 1989-01-06 1995-10-17 Sanwa Kagaku Kenkyushko Co., Ltd. Motilin-like polypeptide and use thereof
JPH0722517B2 (ja) * 1989-08-24 1995-03-15 株式会社三和化学研究所 モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド
EP0378078A1 (en) 1989-01-06 1990-07-18 Sanwa Kagaku Kenkyusho Co., Ltd. Motilin-like polypeptide and use thereof
US5545618A (en) 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
US5595887A (en) * 1990-07-16 1997-01-21 Bionebraska, Inc. Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment
NZ245015A (en) * 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
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DK144093D0 (da) * 1993-12-23 1993-12-23 Novo Nordisk As
JP2001503963A (ja) * 1996-02-06 2001-03-27 イーライ・リリー・アンド・カンパニー 糖尿病治療
US6006753A (en) * 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
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US5846774A (en) * 1997-03-21 1998-12-08 Bionebraska, Inc. Chlorella virus promoters
US6395965B1 (en) * 1997-03-21 2002-05-28 Restoragen, Inc. Plant containing a gene construct comprising a chlorella virus promoter and a lac operator
JPH11178574A (ja) * 1997-12-22 1999-07-06 Toyota Central Res & Dev Lab Inc 新規コラーゲン様タンパク質
EP1056774A1 (en) * 1998-02-27 2000-12-06 Novo Nordisk A/S N-terminally truncated glp-1 derivatives
WO1999043341A1 (en) 1998-02-27 1999-09-02 Novo Nordisk A/S Glp-1 derivatives with helix-content exceeding 25 %, forming partially structured micellar-like aggregates
ATE424413T1 (de) 2000-06-16 2009-03-15 Lilly Co Eli Analoge des glucagon-ähnlichen peptids-1

Also Published As

Publication number Publication date
KR20040097114A (ko) 2004-11-17
CA2454264C (en) 2010-06-22
WO2003016349A1 (fr) 2003-02-27
ATE443081T1 (de) 2009-10-15
JP4504014B2 (ja) 2010-07-14
EP1408050A1 (en) 2004-04-14
CA2454264A1 (en) 2003-02-27
EP1408050A4 (en) 2005-08-10
ES2333413T3 (es) 2010-02-22
CN1363654A (zh) 2002-08-14
US7544512B2 (en) 2009-06-09
US20040146985A1 (en) 2004-07-29
AU2002313869B2 (en) 2008-04-03
CN100579986C (zh) 2010-01-13
EP1408050B1 (en) 2009-09-16
JP2005515167A (ja) 2005-05-26
CN1531551A (zh) 2004-09-22
BR0211435A (pt) 2004-07-13
KR100959549B1 (ko) 2010-05-27
BR0211435B1 (pt) 2014-12-23
DE60233734D1 (de) 2009-10-29

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