DK1390370T3 - Fremgangsmåder til fremstilling af cytotoksiske konjugater af maytansinoider og cellebindende midler - Google Patents

Fremgangsmåder til fremstilling af cytotoksiske konjugater af maytansinoider og cellebindende midler Download PDF

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Publication number
DK1390370T3
DK1390370T3 DK02720913.9T DK02720913T DK1390370T3 DK 1390370 T3 DK1390370 T3 DK 1390370T3 DK 02720913 T DK02720913 T DK 02720913T DK 1390370 T3 DK1390370 T3 DK 1390370T3
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Denmark
Prior art keywords
maytansinoid
reactive
ester
carboxy
deacetyl
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Application number
DK02720913.9T
Other languages
English (en)
Inventor
Ravi V J Chari
Wayne C Widdison
Original Assignee
Immunogen Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25350107&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1390370(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Immunogen Inc filed Critical Immunogen Inc
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Publication of DK1390370T3 publication Critical patent/DK1390370T3/da

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK02720913.9T 2001-05-31 2002-02-14 Fremgangsmåder til fremstilling af cytotoksiske konjugater af maytansinoider og cellebindende midler DK1390370T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/867,598 US6441163B1 (en) 2001-05-31 2001-05-31 Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
PCT/US2002/003378 WO2002098883A1 (en) 2001-05-31 2002-02-14 Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents

Publications (1)

Publication Number Publication Date
DK1390370T3 true DK1390370T3 (da) 2016-08-01

Family

ID=25350107

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11003908.8T DK2348024T3 (da) 2001-05-31 2002-02-14 Fremgangsmåder til fremstilling af cytotoksiske konjugater af maytansinoider og cellebindingsmidler
DK02720913.9T DK1390370T3 (da) 2001-05-31 2002-02-14 Fremgangsmåder til fremstilling af cytotoksiske konjugater af maytansinoider og cellebindende midler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK11003908.8T DK2348024T3 (da) 2001-05-31 2002-02-14 Fremgangsmåder til fremstilling af cytotoksiske konjugater af maytansinoider og cellebindingsmidler

Country Status (12)

Country Link
US (2) US6441163B1 (da)
EP (2) EP2348024B1 (da)
JP (2) JP5190170B2 (da)
AU (1) AU2002251880B2 (da)
CA (1) CA2417858C (da)
CY (2) CY1116855T1 (da)
DK (2) DK2348024T3 (da)
ES (2) ES2574640T3 (da)
HK (2) HK1149765A1 (da)
NZ (1) NZ523655A (da)
PT (2) PT2348024E (da)
WO (1) WO2002098883A1 (da)

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