DK1390070T3 - Anvendelse af IL-18-hæmmere til behandling eller forebyggelse af CNS-skader - Google Patents
Anvendelse af IL-18-hæmmere til behandling eller forebyggelse af CNS-skader Download PDFInfo
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- DK1390070T3 DK1390070T3 DK02740641.2T DK02740641T DK1390070T3 DK 1390070 T3 DK1390070 T3 DK 1390070T3 DK 02740641 T DK02740641 T DK 02740641T DK 1390070 T3 DK1390070 T3 DK 1390070T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (12)
1. Anvendelse af en IL-18-hæmmer, hvor IL-18-hæmmeren er et IL-18-bin-dingsprotein (IL-18 BP) til fremstilling af et medikament til behandling af traumatisk hjerneskade (lukket hovedskade), hvor IL-18-BP indgives i en enhedsdosis 3 dage efter skaden.
2. Anvendelse ifølge krav 1, hvor IL-18-bindingsproteinet er glycosyleret på et eller flere steder.
3. Anvendelse ifølge krav 1, hvor IL-18-BP er fusioneret med den hele eller en del af et immunoglobulin (Ig).
4. Anvendelse ifølge et af de foregående krav, hvor medikamentet yderligere omfatter et interferon.
5. Anvendelse ifølge krav 4, hvor interferonet er interferon-α eller interferon- β·
6. Anvendelse ifølge et af de foregående krav, hvor medikamentet yderligere omfatter tumornekrosefaktor (TNF).
7. Anvendelse ifølge krav 6, hvor TNF er TNF-alpha.
8. Anvendelse ifølge et af de foregående krav, hvor medikamentet yderligere omfatter et antiinflammatorisk middel.
9. Anvendelse ifølge krav 8, hvor det antiinflammatoriske middel er en COX-hæmmer, især en COX-2-hæmmer.
10. Anvendelse ifølge et af de foregående krav, hvor medikamentet yderligere omfatter en antioxidant.
11. Anvendelse ifølge et af de foregående krav, hvor hæmmeren af IL-18 anvendes i en mængde på ca. 0,001 til 100 mg/kg kropsvægt, eller ca. 0,01 til 10 mg/kg kropsvægt eller ca. 0,1 til 5 mg/kg kropsvægt eller ca. 1 til 3 mg/kg kropsvægt.
12. Anvendelse ifølge et af de foregående krav, hvor IL-18-hæmmeren indgives subkutant.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01112067 | 2001-05-25 | ||
| PCT/EP2002/005666 WO2002096456A1 (en) | 2001-05-25 | 2002-05-23 | Use of il-18 inhibitors for treating or preventing cns injuries |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1390070T3 true DK1390070T3 (da) | 2017-04-24 |
Family
ID=8177454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02740641.2T DK1390070T3 (da) | 2001-05-25 | 2002-05-23 | Anvendelse af IL-18-hæmmere til behandling eller forebyggelse af CNS-skader |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7655616B2 (da) |
| EP (1) | EP1390070B1 (da) |
| JP (1) | JP4344142B2 (da) |
| KR (1) | KR20040030625A (da) |
| CN (1) | CN1305529C (da) |
| AU (1) | AU2002314103B2 (da) |
| BG (1) | BG66395B1 (da) |
| BR (1) | BR0210007A (da) |
| CA (1) | CA2445664C (da) |
| CY (1) | CY1119190T1 (da) |
| CZ (1) | CZ307321B6 (da) |
| DK (1) | DK1390070T3 (da) |
| EA (1) | EA006744B1 (da) |
| EE (1) | EE05263B1 (da) |
| ES (1) | ES2617084T3 (da) |
| HK (1) | HK1069762A1 (da) |
| HR (1) | HRP20030842B1 (da) |
| HU (1) | HU230294B1 (da) |
| IL (2) | IL159014A0 (da) |
| LT (1) | LT1390070T (da) |
| ME (1) | ME00550B (da) |
| MX (1) | MXPA03010743A (da) |
| NO (1) | NO331882B1 (da) |
| PL (1) | PL216228B1 (da) |
| PT (1) | PT1390070T (da) |
| RS (1) | RS56006B1 (da) |
| SK (1) | SK288413B6 (da) |
| UA (1) | UA80396C2 (da) |
| WO (1) | WO2002096456A1 (da) |
| ZA (1) | ZA200308172B (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5074030B2 (ja) | 2003-05-13 | 2012-11-14 | メルク セローノ ソシエテ アノニム | Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用 |
| WO2006003927A1 (ja) * | 2004-06-30 | 2006-01-12 | Atsuo Sekiyama | 非炎症性ストレス応答の指標剤およびその利用 |
| DK2267024T3 (da) | 2005-06-03 | 2012-06-25 | Ares Trading Sa | Fremstilling af rekombinant II-18 bindingsprotein |
| JP5048658B2 (ja) * | 2005-06-03 | 2012-10-17 | メルク セローノ ソシエテ アノニム | 神経性炎症性疾患の治療、及び／又は予防のためのｉｌ−１８ｂｐアイソフォームの使用 |
| PL1891088T3 (pl) | 2005-06-10 | 2012-03-30 | Ares Trading Sa | Sposób oczyszczania białka wiążącego IL-18 |
| US8685400B2 (en) | 2007-07-30 | 2014-04-01 | University Of Miami | Modulating inflammasome activity and inflammation in the central nervous system |
| MX2016002719A (es) * | 2013-09-05 | 2016-09-06 | Ab2 Bio Sa | Proteina de union a interleucina 18 (il-18bp) en enfermedades inflamatorias. |
| MY194040A (en) | 2015-03-05 | 2022-11-09 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0873453A (ja) * | 1994-09-02 | 1996-03-19 | Otsuka Pharmaceut Co Ltd | サイトカイン阻害剤 |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| WO1999046248A1 (en) * | 1998-03-09 | 1999-09-16 | Vertex Pharmaceuticals Incorporated | 1,2-diazepane derivatives as interleukin-1beta converting enzyme inhibitors |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| UA87658C2 (uk) * | 2000-05-05 | 2009-08-10 | Апплайд Резеч Системз Арс Холдинг Н.В. | Застосування il-18 як діагностичного маркера серцевої недостатності |
| AU2001266289A1 (en) * | 2000-06-23 | 2002-01-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 2-arachidonylglycerol (2-ag) - an inhibitor of tumor necrosis factor -alfa and neuroprotector of brain in closed head injury |
| AU2002224417A1 (en) * | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
| US6671553B1 (en) * | 2001-05-23 | 2003-12-30 | Pacesetter, Inc. | Implantable cardiac lead having terminating connector strain relief and method of manufacture |
-
2002
- 2002-05-23 KR KR10-2003-7015310A patent/KR20040030625A/ko active Search and Examination
- 2002-05-23 HU HU0304067A patent/HU230294B1/hu unknown
- 2002-05-23 SK SK1603-2003A patent/SK288413B6/sk not_active IP Right Cessation
- 2002-05-23 EP EP02740641.2A patent/EP1390070B1/en not_active Expired - Lifetime
- 2002-05-23 ES ES02740641.2T patent/ES2617084T3/es not_active Expired - Lifetime
- 2002-05-23 UA UA20031212328A patent/UA80396C2/uk unknown
- 2002-05-23 EA EA200301299A patent/EA006744B1/ru not_active IP Right Cessation
- 2002-05-23 ME MEP-2008-618A patent/ME00550B/me unknown
- 2002-05-23 PL PL367545A patent/PL216228B1/pl unknown
- 2002-05-23 IL IL15901402A patent/IL159014A0/xx unknown
- 2002-05-23 AU AU2002314103A patent/AU2002314103B2/en not_active Expired
- 2002-05-23 CZ CZ2003-3268A patent/CZ307321B6/cs not_active IP Right Cessation
- 2002-05-23 LT LTEP02740641.2T patent/LT1390070T/lt unknown
- 2002-05-23 BR BR0210007-0A patent/BR0210007A/pt not_active Application Discontinuation
- 2002-05-23 EE EEP200300582A patent/EE05263B1/xx unknown
- 2002-05-23 WO PCT/EP2002/005666 patent/WO2002096456A1/en active IP Right Grant
- 2002-05-23 DK DK02740641.2T patent/DK1390070T3/da active
- 2002-05-23 US US10/478,614 patent/US7655616B2/en not_active Expired - Lifetime
- 2002-05-23 CA CA2445664A patent/CA2445664C/en not_active Expired - Lifetime
- 2002-05-23 JP JP2002592965A patent/JP4344142B2/ja not_active Expired - Lifetime
- 2002-05-23 RS YU89403A patent/RS56006B1/sr unknown
- 2002-05-23 CN CNB028147510A patent/CN1305529C/zh not_active Expired - Lifetime
- 2002-05-23 MX MXPA03010743A patent/MXPA03010743A/es active IP Right Grant
- 2002-05-23 PT PT2740641T patent/PT1390070T/pt unknown
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2003
- 2003-10-17 HR HRP20030842AA patent/HRP20030842B1/hr not_active IP Right Cessation
- 2003-10-21 ZA ZA200308172A patent/ZA200308172B/xx unknown
- 2003-11-20 NO NO20035160A patent/NO331882B1/no not_active IP Right Cessation
- 2003-11-23 IL IL159014A patent/IL159014A/en active IP Right Grant
- 2003-12-15 BG BG108451A patent/BG66395B1/bg unknown
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2004
- 2004-12-31 HK HK04110391A patent/HK1069762A1/xx not_active IP Right Cessation
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- 2017-05-08 CY CY20171100494T patent/CY1119190T1/el unknown
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