DK1343480T3 - Induceret faseovergangsmetode til fremstilling af mikropartikler indeholdende hydrofobe aktive midler - Google Patents
Induceret faseovergangsmetode til fremstilling af mikropartikler indeholdende hydrofobe aktive midlerInfo
- Publication number
- DK1343480T3 DK1343480T3 DK01992358T DK01992358T DK1343480T3 DK 1343480 T3 DK1343480 T3 DK 1343480T3 DK 01992358 T DK01992358 T DK 01992358T DK 01992358 T DK01992358 T DK 01992358T DK 1343480 T3 DK1343480 T3 DK 1343480T3
- Authority
- DK
- Denmark
- Prior art keywords
- active agents
- phase transition
- microparticles containing
- induced phase
- hydrophobic active
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 title abstract 2
- 230000002209 hydrophobic effect Effects 0.000 title 1
- 230000007704 transition Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000003094 microcapsule Substances 0.000 abstract 1
- 239000004005 microsphere Substances 0.000 abstract 1
- 238000005580 one pot reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Colloid Chemistry (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25752700P | 2000-12-21 | 2000-12-21 | |
US30002101P | 2001-06-21 | 2001-06-21 | |
PCT/US2001/050259 WO2002049620A2 (en) | 2000-12-21 | 2001-12-19 | Induced phase transition method for the production of microparticles containing hydrophobic active agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1343480T3 true DK1343480T3 (da) | 2007-08-06 |
DK1343480T4 DK1343480T4 (da) | 2016-04-18 |
Family
ID=26946029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01992358.0T DK1343480T4 (da) | 2000-12-21 | 2001-12-19 | Induceret faseovergangsmetode til fremstilling af mikropartikler indeholdende hydrofobe aktive midler. |
Country Status (10)
Country | Link |
---|---|
US (2) | US7252842B2 (da) |
EP (2) | EP1343478B1 (da) |
JP (2) | JP2004516262A (da) |
AT (2) | ATE375145T1 (da) |
AU (3) | AU2002232824A1 (da) |
CA (2) | CA2432900C (da) |
DE (2) | DE60130917T2 (da) |
DK (1) | DK1343480T4 (da) |
ES (2) | ES2292634T3 (da) |
WO (2) | WO2002049620A2 (da) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4241041B2 (ja) * | 2000-12-07 | 2009-03-18 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 酸分解性活性成分を含有するペースト形の医薬品製造物 |
ATE375145T1 (de) * | 2000-12-21 | 2007-10-15 | Alrise Biosystems Gmbh | Induziertes phasenübergangs verfahren zur herstellung von hydrophile wirkstoffe enthaltende mikropartikeln |
DE60222734T2 (de) * | 2002-03-15 | 2008-07-17 | Alrise Biosystems Gmbh | Mikropartikel und Verfahren zur deren Herstellung |
US8506617B1 (en) * | 2002-06-21 | 2013-08-13 | Advanced Cardiovascular Systems, Inc. | Micronized peptide coated stent |
US20040097419A1 (en) * | 2002-11-19 | 2004-05-20 | Holger Petersen | Organic compounds |
US8685428B2 (en) * | 2002-12-10 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Therapeutic composition and a method of coating implantable medical devices |
US6887207B2 (en) * | 2003-02-26 | 2005-05-03 | Medtronic, Inc. | Methods and apparatus for estimation of ventricular afterload based on ventricular pressure measurements |
CA2520475C (en) * | 2003-04-03 | 2012-10-09 | Jessie L.-S. Au | Tumor-targeting drug-loaded particles |
GB0324086D0 (en) * | 2003-10-14 | 2003-11-19 | Glaxo Group Ltd | Process for preparing a co-precipitate of a non-crystalline solid drug substance |
DE10358461B4 (de) * | 2003-12-13 | 2008-09-11 | Man Roland Druckmaschinen Ag | Gummierungsmedium |
AU2005240078A1 (en) * | 2004-04-30 | 2005-11-17 | Allergan, Inc. | Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing |
WO2005112569A2 (en) * | 2004-05-13 | 2005-12-01 | Medtronic Vascular, Inc. | Methods for compounding and delivering a therapeutic agent to the adventitia of a vessel |
US20060057215A1 (en) * | 2004-09-15 | 2006-03-16 | Raiche Adrian T | Method for the production of nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility |
US20090092650A1 (en) * | 2004-12-15 | 2009-04-09 | Warren Stephen L | Sustained Delivery Formulations of Octreotide Compounds |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
ES2272156B1 (es) * | 2005-04-18 | 2008-04-01 | Italfarmaco, S.A. | Sistemas microparticulares. |
JP5067976B2 (ja) | 2006-07-01 | 2012-11-07 | オーパス ケイエスディー インコーポレイテッド | 組織固定具ならびに関連する挿入デバイス、機構、および方法 |
EP3047860A1 (en) | 2006-07-20 | 2016-07-27 | OrbusNeich Medical, Inc. | Bioabsorbable polymeric composition for a medical device |
DK2049081T3 (da) | 2006-08-09 | 2013-02-25 | Intarcia Therapeutics Inc | Osmotiske leveringssystemer og stempelarrangementer |
JP5302888B2 (ja) * | 2006-08-31 | 2013-10-02 | エスケー ケミカルズ カンパニー リミテッド | 薬物含有高分子微小球の製造方法及びその方法により製造された薬物含有高分子微小球 |
US8691321B2 (en) | 2006-10-20 | 2014-04-08 | Orbusneich Medical, Inc. | Bioabsorbable polymeric composition and medical device background |
US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
US7887984B2 (en) * | 2007-01-18 | 2011-02-15 | Eastman Kodak Company | Toner porous particles containing hydrocolloids |
CA2683698C (en) | 2007-04-19 | 2013-09-10 | Hyun Hee Kwak | A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof |
ES2402172T3 (es) | 2007-04-23 | 2013-04-29 | Intarcia Therapeutics, Inc | Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos |
US8124601B2 (en) * | 2007-11-21 | 2012-02-28 | Bristol-Myers Squibb Company | Compounds for the treatment of Hepatitis C |
WO2009085952A1 (en) | 2007-12-20 | 2009-07-09 | Brookwood Pharmaceuticals, Inc. | Process for preparing microparticles having a low residual solvent volume |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
ES2569556T3 (es) * | 2008-06-03 | 2016-05-11 | Indivior Uk Limited | Complejo de inclusión de hidrogel deshidratado de un agente bioactivo con sistema fluido de administración de medicamento |
WO2010005726A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences Inc. | Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same |
PT2774608T (pt) | 2008-06-16 | 2020-01-17 | Pfizer | Nanopartículas poliméricas carregadas com fármaco e métodos de produção e utilização das mesmas |
EA020753B1 (ru) | 2008-06-16 | 2015-01-30 | Бинд Терапьютикс, Инк. | Терапевтические полимерные наночастицы, содержащие алкалоиды vinca, и их применение |
EP3685837A1 (en) * | 2008-09-04 | 2020-07-29 | Amylin Pharmaceuticals, LLC | Sustained release formulations using non-aqueous carriers |
JP2012512175A (ja) | 2008-12-15 | 2012-05-31 | バインド バイオサイエンシズ インコーポレイテッド | 治療薬を徐放するための長時間循環性ナノ粒子 |
US20100291027A1 (en) * | 2009-05-14 | 2010-11-18 | Jason Campbell | Hyaluronic acid (ha) injection vehicle |
US9637408B2 (en) * | 2009-05-29 | 2017-05-02 | Corsam Technologies Llc | Fusion formable sodium containing glass |
CN107638562B (zh) | 2009-09-28 | 2022-12-02 | 精达制药公司 | 基本稳态药物递送的快速建立和/或终止 |
US20110081420A1 (en) * | 2009-10-07 | 2011-04-07 | Zyga Technology, Inc. | Method of forming prolonged-release injectable steroids |
US8357401B2 (en) | 2009-12-11 | 2013-01-22 | Bind Biosciences, Inc. | Stable formulations for lyophilizing therapeutic particles |
US9295649B2 (en) * | 2009-12-15 | 2016-03-29 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers |
WO2011163469A1 (en) | 2010-06-23 | 2011-12-29 | Teva Pharmaceutical Industries Ltd. | Hydrated form of anti-inflammatory roflumilast-n-oxide |
UA111162C2 (uk) | 2010-08-04 | 2016-04-11 | Флекшен Терап'Ютікс, Інк. | Ін'єкційна композиція ацетоніду триамцинолону для лікування болю |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
ES2642312T3 (es) * | 2011-08-04 | 2017-11-16 | Flexion Therapeutics, Inc. | Corticosteroides para el tratamiento del dolor de articulaciones |
US8927619B2 (en) | 2011-12-21 | 2015-01-06 | Jorg Thomas Wilken | Color-stabilized iodopropynyl butylcarbamate |
MX356097B (es) | 2012-09-17 | 2018-05-14 | Pfizer Inc Star | Proceso para la preparacion de nanoparticulas terapeuticas. |
US9232943B2 (en) | 2013-01-31 | 2016-01-12 | Opus Ksd Inc. | Delivering bioabsorbable fasteners |
KR20160093611A (ko) * | 2013-12-05 | 2016-08-08 | 알라이즈 바이오시스템즈 게엠베하 | 경구 투여를 위한 약물 제제의 제조 방법 |
PL3116547T3 (pl) | 2014-03-14 | 2019-11-29 | Pfizer | Terapeutyczne nanocząstki zawierające środek terapeutyczny i sposoby ich wytwarzania i zastosowania |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
US9321899B1 (en) * | 2014-10-29 | 2016-04-26 | Xerox Corporation | Preparing latex using a biosolvent |
US10925639B2 (en) | 2015-06-03 | 2021-02-23 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
CA2987081C (en) * | 2015-06-11 | 2022-08-30 | Alrise Biosystems Gmbh | Process for the preparation of drug loaded microparticles |
BR112018073511A2 (pt) | 2016-05-16 | 2019-03-26 | Intarcia Therapeutics, Inc. | polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
IT201600123644A1 (it) * | 2016-12-06 | 2018-06-06 | I E T S P A | Apparato di ripartizione selettiva della potenza di un veicolo plurimotorizzato |
MX2019008006A (es) | 2017-01-03 | 2019-08-29 | Intarcia Therapeutics Inc | Metodos que comprenden la administracion continua de un agonista del receptor de glp-1 y la co-administracion de un farmaco. |
CN106719638A (zh) * | 2017-01-04 | 2017-05-31 | 安徽国星生物化学有限公司 | 一种百草枯微胶囊悬浮剂及其制备方法 |
EP3372224A1 (en) * | 2017-03-07 | 2018-09-12 | Alrise Biosystems GmbH | New controlled drug delivery system using water miscible solvents for production of drug loaded micro- and nanoparticles |
KR102047983B1 (ko) | 2017-11-30 | 2019-11-22 | 주식회사 지투지바이오 | 안전성 및 저장 안정성이 향상된 생분해성 미립구의 제조방법 |
CN109260173B (zh) * | 2018-11-15 | 2019-08-20 | 朗天药业(湖北)有限公司 | 一种胸腺法新药物组合物及其制备方法 |
CN114349986B (zh) * | 2021-12-28 | 2024-02-27 | 华熙生物科技股份有限公司 | 一种增加甘油粘度的方法和用途 |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL280825A (da) | 1962-07-11 | |||
BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
BE792550A (nl) | 1971-12-23 | 1973-06-12 | Agfa Gevaert Nv | Procede voor het vervaardigen van microcapsules |
JPS528795B2 (da) | 1971-12-30 | 1977-03-11 | ||
JPS523342B2 (da) | 1972-01-26 | 1977-01-27 | ||
GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
US4166800A (en) | 1977-08-25 | 1979-09-04 | Sandoz, Inc. | Processes for preparation of microspheres |
US4732763A (en) | 1978-10-17 | 1988-03-22 | Stolle Research And Development Corporation | Active/passive immunization of the internal female reproductive organs |
US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US4389330A (en) † | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4675189A (en) | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
US5366734A (en) | 1981-02-16 | 1994-11-22 | Zeneca Limited | Continuous release pharmaceutical compositions |
CH661206A5 (fr) | 1983-09-23 | 1987-07-15 | Debiopharm Sa | Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes. |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4568559A (en) | 1984-02-06 | 1986-02-04 | Biotek, Inc. | Composite core coated microparticles and process of preparing same |
US6410056B1 (en) * | 1984-03-16 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
DE3678308D1 (de) | 1985-02-07 | 1991-05-02 | Takeda Chemical Industries Ltd | Verfahren zur herstellung von mikrokapseln. |
JP2551756B2 (ja) | 1985-05-07 | 1996-11-06 | 武田薬品工業株式会社 | ポリオキシカルボン酸エステルおよびその製造法 |
US4962091A (en) | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
AU612591B2 (en) | 1986-08-11 | 1991-07-18 | Innovata Biomed Limited | Pharmaceutical formulations comprising microcapsules |
JPS63122620A (ja) | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
FR2608942B1 (fr) † | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
US5690954A (en) | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
DE3738228A1 (de) | 1987-11-11 | 1989-05-24 | Hoechst Ag | Verfahren zur herstellung von bioabbaubaren mikrokapseln wasserloeslicher peptide und proteine sowie nach diesem verfahren erhaltene mikrokapseln |
JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
US4902515A (en) | 1988-04-28 | 1990-02-20 | E. I. Dupont De Nemours And Company | Polylactide compositions |
DK0383047T3 (da) | 1989-02-16 | 1994-06-27 | Sig Schweiz Industrieges | Indretning til passagertogvogne med UIC-træk- og stødindretninger, samt en sådan togvogn |
US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
HU221294B1 (en) | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
US5478564A (en) | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
US6120805A (en) | 1990-04-06 | 2000-09-19 | Rhone-Poulenc Rorer Sa | Microspheres, process for their preparation and their use |
JP3116311B2 (ja) | 1990-06-13 | 2000-12-11 | エーザイ株式会社 | マイクロスフィアの製法 |
NZ240214A (en) | 1990-10-16 | 1993-02-25 | Takeda Chemical Industries Ltd | Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs |
IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
CH683149A5 (fr) | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
GB9116610D0 (en) | 1991-08-01 | 1991-09-18 | Danbiosyst Uk | Preparation of microparticles |
ATE154241T1 (de) | 1991-10-01 | 1997-06-15 | Takeda Chemical Industries Ltd | Mikropartikeln-zusammenfassung zur verlängerten freigabe und herstellung derselbe |
US5676968A (en) | 1991-10-31 | 1997-10-14 | Schering Aktiengesellschaft | Transdermal therapeutic systems with crystallization inhibitors |
DE4223169C1 (de) | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
JP2651320B2 (ja) | 1992-07-16 | 1997-09-10 | 田辺製薬株式会社 | 徐放性マイクロスフェア製剤の製造方法 |
AU4198793A (en) | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
FR2693905B1 (fr) | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
US5661125A (en) | 1992-08-06 | 1997-08-26 | Amgen, Inc. | Stable and preserved erythropoietin compositions |
EP0582459B1 (en) | 1992-08-07 | 1998-01-07 | Takeda Chemical Industries, Ltd. | Production of microcapsules of water-soluble drugs |
WO1994008599A1 (en) | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
ES2127835T3 (es) | 1992-10-26 | 1999-05-01 | Sanol Arznei Schwarz Gmbh | Procedimiento para la preparacion de microcapsulas. |
US5603960A (en) | 1993-05-25 | 1997-02-18 | O'hagan; Derek T. | Preparation of microparticles and method of immunization |
US5635216A (en) | 1993-12-16 | 1997-06-03 | Eli Lilly And Company | Microparticle compositions containing peptides, and methods for the preparation thereof |
US5500161A (en) | 1993-09-21 | 1996-03-19 | Massachusetts Institute Of Technology And Virus Research Institute | Method for making hydrophobic polymeric microparticles |
US5643605A (en) | 1993-10-25 | 1997-07-01 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
US6080429A (en) | 1993-10-25 | 2000-06-27 | Genentech, Inc. | Method for drying microspheres |
US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5902565A (en) | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
CA2143044C (en) | 1994-02-21 | 2005-04-12 | Yasutaka Igari | Matrix for sustained-release preparation |
DE4406172C2 (de) | 1994-02-25 | 2003-10-02 | Sanol Arznei Schwarz Gmbh | Polyester |
GB9406094D0 (en) | 1994-03-28 | 1994-05-18 | Univ Nottingham And University | Polymer microspheres and a method of production thereof |
FR2718642B1 (fr) | 1994-04-15 | 1996-07-12 | Pf Medicament | Microsphères biodégradables à libération contrôlée et leur procédé de préparation. |
JP3608625B2 (ja) | 1994-05-15 | 2005-01-12 | アメルシャム・バイオサイエンシーズ・アクチボラグ | 粒子の製造方法、及び該方法によって製造され得る粒子 |
US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
AU705968B2 (en) † | 1995-06-07 | 1999-06-03 | Alkermes Controlled Therapeutics, Inc. | Device for releasing aggregation-stabilized, biologically active agent |
US6143211A (en) * | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
JP2909418B2 (ja) | 1995-09-18 | 1999-06-23 | 株式会社資生堂 | 薬物の遅延放出型マイクロスフイア |
DE19545257A1 (de) * | 1995-11-24 | 1997-06-19 | Schering Ag | Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln |
CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
AU1354497A (en) | 1995-12-21 | 1997-07-14 | Drexel University | Hollow polymer microcapsules and method of producing |
US5985312A (en) | 1996-01-26 | 1999-11-16 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers |
US5611344A (en) | 1996-03-05 | 1997-03-18 | Acusphere, Inc. | Microencapsulated fluorinated gases for use as imaging agents |
US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
GB2316316A (en) | 1996-08-23 | 1998-02-25 | Int Centre Genetic Eng & Bio | Sustained release of erythropoietin from microspheres |
US5766637A (en) | 1996-10-08 | 1998-06-16 | University Of Delaware | Microencapsulation process using supercritical fluids |
ATE272394T1 (de) | 1996-10-31 | 2004-08-15 | Takeda Chemical Industries Ltd | Zubereitung mit verzögerter freisetzung |
AUPO379596A0 (en) * | 1996-11-22 | 1996-12-19 | Soltec Research Pty Ltd | Percutaneous delivery system |
EP0959873B1 (en) | 1996-12-20 | 2006-03-01 | ALZA Corporation | Gel composition and methods |
US5976574A (en) * | 1996-12-31 | 1999-11-02 | Inhale Therapeutic Systems | Processes for spray drying hydrophobic drugs in organic solvent suspensions |
US5783567A (en) | 1997-01-22 | 1998-07-21 | Pangaea Pharmaceuticals, Inc. | Microparticles for delivery of nucleic acid |
US6048551A (en) | 1997-03-27 | 2000-04-11 | Hilfinger; John M. | Microsphere encapsulation of gene transfer vectors |
US6020004A (en) | 1997-04-17 | 2000-02-01 | Amgen Inc. | Biodegradable microparticles for the sustained delivery of therapeutic drugs |
SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
EP1028746B1 (en) † | 1997-11-07 | 2003-02-26 | Chiron Corporation | Method for producing igf-i sustained-release formulations |
US6197229B1 (en) | 1997-12-12 | 2001-03-06 | Massachusetts Institute Of Technology | Method for high supercoiled DNA content microspheres |
GB9810236D0 (en) | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
KR19990085365A (ko) | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
WO2000004916A1 (en) | 1998-07-23 | 2000-02-03 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Encapsulation of water soluble peptides |
DE69929904T2 (de) * | 1998-11-18 | 2006-08-31 | University Of Florida, Gainesville | Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen |
US6194006B1 (en) † | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
DE19916384A1 (de) * | 1999-03-31 | 2000-10-05 | Schering Ag | Cyproteronacetat, Chlormadinonacetat oder 17alpha-Propylmesterolon enthaltende, bioerosive Mikropartikeln, Verfahren zu deren Herstellung, therapeutische Verwendung dieser in topischen Arzneiformen |
US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
FR2797784B1 (fr) * | 1999-08-27 | 2001-11-30 | Mainelab | Procede d'encapsulation de matieres actives par coacervation de polymeres en solvant organique non-chlore |
ATE375145T1 (de) * | 2000-12-21 | 2007-10-15 | Alrise Biosystems Gmbh | Induziertes phasenübergangs verfahren zur herstellung von hydrophile wirkstoffe enthaltende mikropartikeln |
-
2001
- 2001-12-19 AT AT01985618T patent/ATE375145T1/de not_active IP Right Cessation
- 2001-12-19 DE DE60130917T patent/DE60130917T2/de not_active Expired - Lifetime
- 2001-12-19 EP EP01985618A patent/EP1343478B1/en not_active Expired - Lifetime
- 2001-12-19 WO PCT/US2001/050259 patent/WO2002049620A2/en active IP Right Grant
- 2001-12-19 JP JP2002550961A patent/JP2004516262A/ja active Pending
- 2001-12-19 DE DE60128261.2T patent/DE60128261T3/de not_active Expired - Lifetime
- 2001-12-19 DK DK01992358.0T patent/DK1343480T4/da active
- 2001-12-19 US US10/028,258 patent/US7252842B2/en not_active Expired - Lifetime
- 2001-12-19 ES ES01985618T patent/ES2292634T3/es not_active Expired - Lifetime
- 2001-12-19 AU AU2002232824A patent/AU2002232824A1/en not_active Abandoned
- 2001-12-19 EP EP01992358.0A patent/EP1343480B2/en not_active Expired - Lifetime
- 2001-12-19 AT AT01992358T patent/ATE361057T1/de not_active IP Right Cessation
- 2001-12-19 AU AU2002235253A patent/AU2002235253A8/xx not_active Abandoned
- 2001-12-19 CA CA002432900A patent/CA2432900C/en not_active Expired - Lifetime
- 2001-12-19 WO PCT/US2001/050105 patent/WO2002049619A2/en active IP Right Grant
- 2001-12-19 AU AU2002235253A patent/AU2002235253A1/en not_active Abandoned
- 2001-12-19 US US10/027,401 patent/US6899898B2/en not_active Expired - Lifetime
- 2001-12-19 CA CA002432904A patent/CA2432904C/en not_active Expired - Lifetime
- 2001-12-19 JP JP2002550962A patent/JP2004516263A/ja active Pending
- 2001-12-19 ES ES01992358.0T patent/ES2286157T5/es not_active Expired - Lifetime
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