DK1155015T3 - Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat - Google Patents

Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat

Info

Publication number
DK1155015T3
DK1155015T3 DK00903810T DK00903810T DK1155015T3 DK 1155015 T3 DK1155015 T3 DK 1155015T3 DK 00903810 T DK00903810 T DK 00903810T DK 00903810 T DK00903810 T DK 00903810T DK 1155015 T3 DK1155015 T3 DK 1155015T3
Authority
DK
Denmark
Prior art keywords
dioxan
methylsulfonyl
pyrimidin
fluorophenyl
tert
Prior art date
Application number
DK00903810T
Other languages
Danish (da)
English (en)
Inventor
Haruo Koike
Mikio Kabaki
Nigel Philip Taylor
Louis Joseph Diorazio
Original Assignee
Astrazeneca Ab
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10847843&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1155015(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab, Shionogi & Co filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1155015T3 publication Critical patent/DK1155015T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00903810T 1999-02-17 2000-02-15 Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat DK1155015T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9903472.0A GB9903472D0 (en) 1999-02-17 1999-02-17 Chemical process
PCT/GB2000/000481 WO2000049014A1 (en) 1999-02-17 2000-02-15 Process for the production of tert-butyl (e)-(6-[2- [4-(4-fluorophenyl) -6-isopropyl-2-[ methyl (methylsulfonyl) amino] pyrimidin-5-yl] vinyl](4r, 6s)-2,2-dimethyl [1,3]dioxan-4-yl) acetate

Publications (1)

Publication Number Publication Date
DK1155015T3 true DK1155015T3 (da) 2009-03-02

Family

ID=10847843

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00903810T DK1155015T3 (da) 1999-02-17 2000-02-15 Fremgangsmåde til fremstilling af tert-butyl-(E)-(6{2-[4-4(4-flourphenyl)-6-isopropyl-2-[methyld(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)acetat

Country Status (34)

Country Link
US (2) US6844437B1 (pt)
EP (1) EP1155015B1 (pt)
JP (3) JP2003518474A (pt)
KR (1) KR100648160B1 (pt)
CN (1) CN1145625C (pt)
AR (1) AR022600A1 (pt)
AT (1) ATE415398T1 (pt)
AU (1) AU760145B2 (pt)
BR (1) BRPI0008301B8 (pt)
CA (1) CA2362594C (pt)
CL (1) CL2003002336A1 (pt)
CY (1) CY1108733T1 (pt)
CZ (1) CZ299844B6 (pt)
DE (1) DE60040905D1 (pt)
DK (1) DK1155015T3 (pt)
EE (2) EE05531B1 (pt)
ES (1) ES2316349T3 (pt)
GB (1) GB9903472D0 (pt)
HK (1) HK1041265B (pt)
HU (1) HU229835B1 (pt)
IL (2) IL144793A0 (pt)
IS (1) IS2711B (pt)
MX (1) MXPA01008235A (pt)
NO (1) NO320739B1 (pt)
NZ (1) NZ513261A (pt)
PL (1) PL218518B1 (pt)
PT (1) PT1155015E (pt)
RU (1) RU2243969C2 (pt)
SI (1) SI1155015T1 (pt)
SK (1) SK286988B6 (pt)
TR (2) TR200401874T2 (pt)
TW (1) TWI285202B (pt)
WO (1) WO2000049014A1 (pt)
ZA (1) ZA200106370B (pt)

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CN104788387A (zh) * 2015-04-17 2015-07-22 浙江海森药业有限公司 高纯度瑞舒伐他汀钙的制备方法
KR20160126700A (ko) 2015-04-24 2016-11-02 미래파인켐 주식회사 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법
CN105461636A (zh) * 2015-12-30 2016-04-06 安徽美诺华药物化学有限公司 一种瑞舒伐他汀甲酯的合成方法
CN106478518A (zh) * 2016-09-27 2017-03-08 南通常佑药业科技有限公司 一种庚烯酸环戊酯衍生物的制备方法
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Publication number Publication date
BR0008301B1 (pt) 2013-01-22
DE60040905D1 (de) 2009-01-08
HU229835B1 (en) 2014-09-29
US6844437B1 (en) 2005-01-18
WO2000049014A1 (en) 2000-08-24
HUP0200301A3 (en) 2004-03-29
CY1108733T1 (el) 2014-04-09
CN1340052A (zh) 2002-03-13
JP4130844B2 (ja) 2008-08-06
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