DK1105466T3 - Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler - Google Patents

Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Info

Publication number
DK1105466T3
DK1105466T3 DK99940950T DK99940950T DK1105466T3 DK 1105466 T3 DK1105466 T3 DK 1105466T3 DK 99940950 T DK99940950 T DK 99940950T DK 99940950 T DK99940950 T DK 99940950T DK 1105466 T3 DK1105466 T3 DK 1105466T3
Authority
DK
Denmark
Prior art keywords
particles
human papillomavirus
papillomavirus virus
vlps
purifying human
Prior art date
Application number
DK99940950T
Other languages
Danish (da)
English (en)
Inventor
James C Cook Iii
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK1105466T3 publication Critical patent/DK1105466T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20051—Methods of production or purification of viral material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK99940950T 1998-08-14 1999-08-10 Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler DK1105466T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9656898P 1998-08-14 1998-08-14

Publications (1)

Publication Number Publication Date
DK1105466T3 true DK1105466T3 (da) 2006-08-14

Family

ID=22257989

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99940950T DK1105466T3 (da) 1998-08-14 1999-08-10 Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler

Country Status (24)

Country Link
US (1) US6602697B1 (fr)
EP (1) EP1105466B1 (fr)
JP (1) JP4440471B2 (fr)
KR (1) KR20010072470A (fr)
CN (1) CN1354787A (fr)
AT (1) ATE324436T1 (fr)
AU (1) AU760633B2 (fr)
BR (1) BR9913026A (fr)
CA (1) CA2339034C (fr)
CY (1) CY1105084T1 (fr)
CZ (1) CZ2001570A3 (fr)
DE (1) DE69931053T2 (fr)
DK (1) DK1105466T3 (fr)
EA (1) EA200100236A1 (fr)
ES (1) ES2262333T3 (fr)
HR (1) HRP20010113A2 (fr)
HU (1) HUP0103091A3 (fr)
IL (1) IL141130A0 (fr)
NZ (1) NZ509610A (fr)
PL (1) PL347472A1 (fr)
PT (1) PT1105466E (fr)
SI (1) SI1105466T1 (fr)
SK (1) SK2232001A3 (fr)
WO (1) WO2000009671A1 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2284287T3 (es) * 1998-10-16 2007-11-01 Glaxosmithkline Biologicals S.A. Sistemas adyuvantes y vacunas.
JP2000262280A (ja) * 1999-03-18 2000-09-26 Asahi Optical Co Ltd ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
GB0206360D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
EP1729882A1 (fr) * 2004-02-05 2006-12-13 Millipore Corporation Substrats poreux adsorbants ou chromatographiques
TWI349036B (en) * 2004-03-24 2011-09-21 Merck Sharp & Dohme Optimized expression of hpv 52 l1 in yeast
EP1790332B1 (fr) 2004-09-10 2010-07-21 Asahi Glass Company, Limited Vaccin pour administration orale contre le pappilomavirus humain
EP1736538A1 (fr) * 2005-06-21 2006-12-27 Cytos Biotechnology AG Procédé pour la purification préparative de particules pseudo-virales (VLPs)
JP2010502425A (ja) * 2006-08-30 2010-01-28 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 膜を評価するシステム及び方法並びに膜濾過装置
PL2601970T3 (pl) 2006-09-29 2017-07-31 Takeda Vaccines, Inc. Preparaty szczepionki przeciw norowirusowi
US8293876B2 (en) * 2007-02-22 2012-10-23 Baxter International Inc. Method of purification of hydrophobic proteins
US8481693B2 (en) * 2007-03-14 2013-07-09 Takeda Vaccines (Montana), Inc. Virus like particle purification
CN101570571B (zh) 2007-04-29 2012-07-11 北京万泰生物药业股份有限公司 截短的人乳头瘤病毒18型l1蛋白
BRPI0811016B1 (pt) 2007-04-29 2021-09-21 Xiamen Innovax Biotech Co., Ltd. Proteína li truncada do papiloma vírus humano tipo 16
CN101343315B (zh) * 2007-05-29 2012-06-13 厦门大学 截短的人乳头瘤病毒6型l1蛋白
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20100266636A1 (en) * 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
EP2190471A4 (fr) 2007-09-18 2012-05-09 Ligocyte Pharmaceuticals Inc Procédé pour conférer une réponse immune protectrice à un norovirus
DE602007007927D1 (de) * 2007-11-05 2010-09-02 Agilent Technologies Inc Einfrierung eines mikrofluidischen Chips
US20090130738A1 (en) * 2007-11-19 2009-05-21 Mikhail Kozlov Media for membrane ion exchange chromatography
NO2324113T3 (fr) * 2008-08-08 2018-07-28
US8951807B2 (en) * 2010-01-15 2015-02-10 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
CN102985536B (zh) 2010-04-14 2017-12-05 Emd密理博公司 生产高效价、高纯度的病毒母液的方法及使用其的方法
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
JP5881744B2 (ja) 2011-02-02 2016-03-09 バイオ−ラッド ラボラトリーズ インコーポレーティッド アルカリ溶液でのアパタイトの表面中和方法
ES2656527T3 (es) 2011-07-11 2018-02-27 Takeda Vaccines, Inc. Formulaciones parenterales de vacunas de norovirus
KR102013801B1 (ko) * 2011-12-01 2019-08-23 유니버시티 오브 케이프 타운 Ｈｐｖ 키메라 입자
CN104507952B (zh) 2012-05-30 2018-08-10 生物辐射实验室股份有限公司 基于磷灰石的色谱树脂的原位恢复
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
KR101559622B1 (ko) 2012-07-30 2015-10-13 중앙대학교 산학협력단 인유두종바이러스 바이러스 유사입자의 고효율 정제방법
JP6479305B2 (ja) * 2013-07-12 2019-03-06 株式会社Ｕｍｎファーマ ウイルス様粒子の精製方法
US10099157B2 (en) 2014-06-23 2018-10-16 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
WO2015200282A1 (fr) 2014-06-23 2015-12-30 Bio-Rad Laboratories, Inc. Pré-traitement d'apatite
CN105907729B (zh) * 2015-05-05 2019-08-16 广东东阳光药业有限公司 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法
CN108524929B (zh) * 2017-03-06 2019-05-07 广州瑞贝斯药业有限公司 一种狂犬病疫苗的生产方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6078999A (ja) * 1983-10-05 1985-05-04 Chemo Sero Therapeut Res Inst ＨＢｓ抗原の精製方法
SE9000650L (sv) 1989-02-28 1990-08-29 Asahi Optical Co Ltd Separation av celler eller virus
MXPA96005662A (es) 1994-05-16 2004-08-19 Merck & Co Inc Vacunas de papilomavirus.
CZ87597A3 (cs) * 1994-09-22 1998-01-14 Merck And Co., Inc. Molekula DNK kódující lidský papilomavirus typu 6A a použití této molekuly
AR004464A1 (es) * 1994-11-14 1998-12-16 Merck Sharp & Dohme Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) * 1995-03-22 2005-11-20 Merck & Co Inc Dna encoding human papillomavirus type 18
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
US6143548A (en) * 1995-08-30 2000-11-07 Genzyme Corporation Chromatographic purification of adeno-associated virus (AAV)

Also Published As

Publication number Publication date
ATE324436T1 (de) 2006-05-15
EP1105466A4 (fr) 2002-05-15
AU760633B2 (en) 2003-05-22
EA200100236A1 (ru) 2001-08-27
CA2339034A1 (fr) 2000-02-24
BR9913026A (pt) 2001-09-25
PT1105466E (pt) 2006-07-31
HUP0103091A2 (hu) 2001-12-28
PL347472A1 (en) 2002-04-08
HUP0103091A3 (en) 2002-03-28
CA2339034C (fr) 2010-10-12
SK2232001A3 (en) 2001-08-06
CZ2001570A3 (cs) 2001-09-12
EP1105466A1 (fr) 2001-06-13
CN1354787A (zh) 2002-06-19
DE69931053D1 (de) 2006-06-01
AU5469899A (en) 2000-03-06
SI1105466T1 (sl) 2006-08-31
JP4440471B2 (ja) 2010-03-24
JP2003520188A (ja) 2003-07-02
DE69931053T2 (de) 2006-11-23
WO2000009671A1 (fr) 2000-02-24
KR20010072470A (ko) 2001-07-31
CY1105084T1 (el) 2009-11-04
ES2262333T3 (es) 2006-11-16
US6602697B1 (en) 2003-08-05
IL141130A0 (en) 2002-02-10
EP1105466B1 (fr) 2006-04-26
HRP20010113A2 (en) 2002-02-28
NZ509610A (en) 2002-10-25

Similar Documents

Publication Publication Date Title
DK1105466T3 (da) Fremgangsmåde til oprensning af humant papillomvirus-viruslignende partikler
ATE332364T1 (de) Verfahren zur gewinnung von purifizierter virenzuammensetzung
FR07C0012I1 (fr)
NO972136L (no) FremgangsmÕte for fremstilling av uronsyreblokker fra alginat
DK1133283T3 (da) Fremgangsmåde til fremstilling af lægemiddelpartikler
ES2091069T3 (es) Procedimiento de purificacion de pentafluoroetano.
AU2449500A (en) Preparation of iodixanol
AR063314A2 (es) Metodos para purificar preparados de virus
IE890181L (en) Removal of steroids
FI102962B1 (fi) Menetelmä ksylitolin valmistamiseksi
HK1047754A1 (en) Separation of fibrinogen from plasma proteases
DK0833684T3 (da) Fremgangsmåde til fjernelse af organiske bestanddele fra en vandig strøm
EP0816374A3 (fr) Procédé de préparation d'un composition à haute teneur en ganglioside
WO2002030983A3 (fr) Fraction de plasma renfermant de la bikunine, son procede de fabrication et son utilisation
IT1287138B1 (it) Procedimento per la separazione e purificazione di fsh e lh
MXPA03007992A (es) Composicion farmaceutica de fragmentos f(ab)2 de anticuerpos y un proceso para su preparacion
ATE246250T1 (de) Immunogenes konstrukt, verfahren zu dessen herstellung und verwendung als vakzine
WO2001046686A3 (fr) Materiau chromatographique et procedes d'utilisation d'un tel materiau
WO2004029279A3 (fr) Procede servant a recuperer des isotopes filles d'un materiau de source
FI953493A0 (fi) Menetelmä molybdeenin talteen ottamiseksi lähtien epäpuhtaasta kalsiummolybdaatista, joka on saatu käsittelemällä uraanipitoisia malmeja
CY1107210T1 (el) Μεθοδος δια τον καθαρισμο πρωτεϊνων epi-hne
EP0955367A3 (fr) Nucleoproteines recombinantes du virus Toscana
AU2003222305A1 (en) Separation process of 1,1,1,2-tetrafluoro-2-chloroethane (hcfc-124) from 1,1,2,2-tetrafluoro-1-chloroethane (hcfc-124a)
UA42928A (uk) Спосіб лікування гепатоцелюлярної недостатності