SK2232001A3 - Process for purifying human papillomavirus virus-like particles - Google Patents
Process for purifying human papillomavirus virus-like particles Download PDFInfo
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- SK2232001A3 SK2232001A3 SK223-2001A SK2232001A SK2232001A3 SK 2232001 A3 SK2232001 A3 SK 2232001A3 SK 2232001 A SK2232001 A SK 2232001A SK 2232001 A3 SK2232001 A3 SK 2232001A3
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- vlps
- hpv
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- 239000000725 suspension Substances 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229940124856 vaccine component Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/02—Recovery or purification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9656898P | 1998-08-14 | 1998-08-14 | |
| PCT/US1999/017930 WO2000009671A1 (fr) | 1998-08-14 | 1999-08-10 | Procede permettant de purifier des particules humaines de type papillomavirus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK2232001A3 true SK2232001A3 (en) | 2001-08-06 |
Family
ID=22257989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK223-2001A SK2232001A3 (en) | 1998-08-14 | 1999-08-10 | Process for purifying human papillomavirus virus-like particles |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6602697B1 (fr) |
| EP (1) | EP1105466B1 (fr) |
| JP (1) | JP4440471B2 (fr) |
| KR (1) | KR20010072470A (fr) |
| CN (1) | CN1354787A (fr) |
| AT (1) | ATE324436T1 (fr) |
| AU (1) | AU760633B2 (fr) |
| BR (1) | BR9913026A (fr) |
| CA (1) | CA2339034C (fr) |
| CY (1) | CY1105084T1 (fr) |
| CZ (1) | CZ2001570A3 (fr) |
| DE (1) | DE69931053T2 (fr) |
| DK (1) | DK1105466T3 (fr) |
| EA (1) | EA200100236A1 (fr) |
| ES (1) | ES2262333T3 (fr) |
| HR (1) | HRP20010113A2 (fr) |
| HU (1) | HUP0103091A3 (fr) |
| IL (1) | IL141130A0 (fr) |
| NZ (1) | NZ509610A (fr) |
| PL (1) | PL347472A1 (fr) |
| PT (1) | PT1105466E (fr) |
| SI (1) | SI1105466T1 (fr) |
| SK (1) | SK2232001A3 (fr) |
| WO (1) | WO2000009671A1 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2347099C (fr) * | 1998-10-16 | 2014-08-05 | Smithkline Beecham Biologicals S.A. | Systemes d'adjuvants comprenant un immunostimulant absorbe sur une particule de sel metallique et vaccins derives |
| JP2000262280A (ja) * | 1999-03-18 | 2000-09-26 | Asahi Optical Co Ltd | ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法 |
| US6436402B1 (en) * | 1999-10-15 | 2002-08-20 | Merck & Co., Inc. | Process for making human papillomavirus virus-like particles with improved properties |
| GB0206360D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
| SG150501A1 (en) * | 2004-02-05 | 2009-03-30 | Millipore Corp | Porous adsorptive or chromatographic media |
| CA2560487C (fr) * | 2004-03-24 | 2013-01-29 | Merck & Co., Inc. | Expression optimisee de hpv 52 l1 dans une levure |
| CA2579882C (fr) | 2004-09-10 | 2012-07-17 | Asahi Glass Company, Limited | Vaccin comestible |
| EP1736538A1 (fr) * | 2005-06-21 | 2006-12-27 | Cytos Biotechnology AG | Procédé pour la purification préparative de particules pseudo-virales (VLPs) |
| US20100288029A1 (en) * | 2006-08-30 | 2010-11-18 | Ge Healthcar Bio-Sciences Corp. | System and method for characterizing membranes and membrane filtration devices |
| AU2008302276B2 (en) | 2006-09-29 | 2013-10-10 | Takeda Vaccines, Inc. | Method of conferring a protective immune response to norovirus |
| KR101515489B1 (ko) | 2006-09-29 | 2015-04-30 | 다케다 백신즈 인코포레이티드 | 노로바이러스 백신 제제 |
| AU2008217189B2 (en) * | 2007-02-22 | 2013-06-13 | Baxalta GmbH | Method of purification of hydrophobic proteins |
| JP5284290B2 (ja) | 2007-03-14 | 2013-09-11 | リゴサイト ファーマスーティカルズ，インコーポレイテッド | ウイルス様粒子の精製 |
| WO2008134935A1 (fr) | 2007-04-29 | 2008-11-13 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. | Protéines 18 l1 de type papillomavirus humain tronqué |
| CN101293918B (zh) | 2007-04-29 | 2013-03-27 | 北京万泰生物药业股份有限公司 | 截短的人乳头瘤病毒16型l1蛋白 |
| WO2008145021A1 (fr) * | 2007-05-29 | 2008-12-04 | Xiamen University | Protéine l1 tronquée du papillomavirus humain de type 6 |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US20100266636A1 (en) * | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| DE602007007927D1 (de) * | 2007-11-05 | 2010-09-02 | Agilent Technologies Inc | Einfrierung eines mikrofluidischen Chips |
| US20090130738A1 (en) * | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| SG2013057732A (en) * | 2008-08-08 | 2015-02-27 | Ligocyte Pharmaceuticals Inc | Virus-like particles comprising composite capsid amino acid sequences for enhanced cross reactivity |
| US8951807B2 (en) * | 2010-01-15 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
| CN102985536B (zh) | 2010-04-14 | 2017-12-05 | Emd密理博公司 | 生产高效价、高纯度的病毒母液的方法及使用其的方法 |
| US8895707B2 (en) | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
| JP5881744B2 (ja) | 2011-02-02 | 2016-03-09 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | アルカリ溶液でのアパタイトの表面中和方法 |
| EA029470B1 (ru) | 2011-07-11 | 2018-03-30 | Такеда Вэксинс, Инк. | Способ стимулирования формирования защитного иммунитета против норовируса |
| CA2850293C (fr) * | 2011-12-01 | 2019-10-08 | University Of Cape Town | Particule de hpv chimere |
| WO2013180933A1 (fr) | 2012-05-30 | 2013-12-05 | Bio-Rad Laboratories, Inc. | Restauration in-situ de résines à base d'apatite par chromatographie |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| KR101559622B1 (ko) * | 2012-07-30 | 2015-10-13 | 중앙대학교 산학협력단 | 인유두종바이러스 바이러스 유사입자의 고효율 정제방법 |
| JP6479305B2 (ja) * | 2013-07-12 | 2019-03-06 | 株式会社Ｕｍｎファーマ | ウイルス様粒子の精製方法 |
| US10099157B2 (en) | 2014-06-23 | 2018-10-16 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
| WO2015200282A1 (fr) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Pré-traitement d'apatite |
| CN105907729B (zh) * | 2015-05-05 | 2019-08-16 | 广东东阳光药业有限公司 | 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法 |
| CN108524929B (zh) * | 2017-03-06 | 2019-05-07 | 广州瑞贝斯药业有限公司 | 一种狂犬病疫苗的生产方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6078999A (ja) | 1983-10-05 | 1985-05-04 | Chemo Sero Therapeut Res Inst | ＨＢｓ抗原の精製方法 |
| SE9000650L (sv) | 1989-02-28 | 1990-08-29 | Asahi Optical Co Ltd | Separation av celler eller virus |
| SK147696A3 (en) | 1994-05-16 | 1997-08-06 | Merck & Co Inc | Isolated and purified protein of papillomavirus, a capside, a viral particle, pharmaceutical composition comprising its, a method of making them and their use |
| EP0782615A4 (fr) * | 1994-09-22 | 2001-08-22 | Merck & Co Inc | Adn codant pour le papillomavirus humain du type 6a |
| AR004464A1 (es) * | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
| IL117459A (en) * | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| IL117591A0 (en) * | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| CA2625279A1 (fr) * | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Purification d'adenovirus et de virus adeno-associe (aav) par voie chromatographique |
-
1999
- 1999-08-10 CN CN99811968A patent/CN1354787A/zh active Pending
- 1999-08-10 SI SI9930901T patent/SI1105466T1/sl unknown
- 1999-08-10 WO PCT/US1999/017930 patent/WO2000009671A1/fr active IP Right Grant
- 1999-08-10 EP EP99940950A patent/EP1105466B1/fr not_active Expired - Lifetime
- 1999-08-10 CA CA 2339034 patent/CA2339034C/fr not_active Expired - Lifetime
- 1999-08-10 AT AT99940950T patent/ATE324436T1/de active
- 1999-08-10 AU AU54698/99A patent/AU760633B2/en not_active Expired
- 1999-08-10 PL PL34747299A patent/PL347472A1/xx unknown
- 1999-08-10 HU HU0103091A patent/HUP0103091A3/hu unknown
- 1999-08-10 NZ NZ50961099A patent/NZ509610A/xx not_active IP Right Cessation
- 1999-08-10 CZ CZ2001570A patent/CZ2001570A3/cs unknown
- 1999-08-10 KR KR1020017001885A patent/KR20010072470A/ko not_active Application Discontinuation
- 1999-08-10 ES ES99940950T patent/ES2262333T3/es not_active Expired - Lifetime
- 1999-08-10 PT PT99940950T patent/PT1105466E/pt unknown
- 1999-08-10 SK SK223-2001A patent/SK2232001A3/sk unknown
- 1999-08-10 JP JP2000565108A patent/JP4440471B2/ja not_active Expired - Lifetime
- 1999-08-10 EA EA200100236A patent/EA200100236A1/ru unknown
- 1999-08-10 DK DK99940950T patent/DK1105466T3/da active
- 1999-08-10 IL IL14113099A patent/IL141130A0/xx unknown
- 1999-08-10 DE DE1999631053 patent/DE69931053T2/de not_active Expired - Lifetime
- 1999-08-10 BR BR9913026A patent/BR9913026A/pt not_active Application Discontinuation
- 1999-08-10 US US09/762,662 patent/US6602697B1/en not_active Expired - Lifetime
-
2001
- 2001-02-14 HR HR20010113A patent/HRP20010113A2/hr not_active Application Discontinuation
-
2006
- 2006-07-11 CY CY20061100963T patent/CY1105084T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000009671A1 (fr) | 2000-02-24 |
| CY1105084T1 (el) | 2009-11-04 |
| US6602697B1 (en) | 2003-08-05 |
| AU760633B2 (en) | 2003-05-22 |
| HUP0103091A2 (hu) | 2001-12-28 |
| JP4440471B2 (ja) | 2010-03-24 |
| CA2339034C (fr) | 2010-10-12 |
| SI1105466T1 (sl) | 2006-08-31 |
| EP1105466B1 (fr) | 2006-04-26 |
| HRP20010113A2 (en) | 2002-02-28 |
| IL141130A0 (en) | 2002-02-10 |
| HUP0103091A3 (en) | 2002-03-28 |
| CZ2001570A3 (cs) | 2001-09-12 |
| ES2262333T3 (es) | 2006-11-16 |
| EP1105466A4 (fr) | 2002-05-15 |
| PT1105466E (pt) | 2006-07-31 |
| EP1105466A1 (fr) | 2001-06-13 |
| EA200100236A1 (ru) | 2001-08-27 |
| AU5469899A (en) | 2000-03-06 |
| DE69931053T2 (de) | 2006-11-23 |
| PL347472A1 (en) | 2002-04-08 |
| BR9913026A (pt) | 2001-09-25 |
| ATE324436T1 (de) | 2006-05-15 |
| NZ509610A (en) | 2002-10-25 |
| DE69931053D1 (de) | 2006-06-01 |
| KR20010072470A (ko) | 2001-07-31 |
| DK1105466T3 (da) | 2006-08-14 |
| CN1354787A (zh) | 2002-06-19 |
| JP2003520188A (ja) | 2003-07-02 |
| CA2339034A1 (fr) | 2000-02-24 |
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