ATE324436T1 - Verfahren zur reinigung von menschlichen, dem papillomavirus ähnlichen partikeln. - Google Patents

Verfahren zur reinigung von menschlichen, dem papillomavirus ähnlichen partikeln.

Info

Publication number
ATE324436T1
ATE324436T1 AT99940950T AT99940950T ATE324436T1 AT E324436 T1 ATE324436 T1 AT E324436T1 AT 99940950 T AT99940950 T AT 99940950T AT 99940950 T AT99940950 T AT 99940950T AT E324436 T1 ATE324436 T1 AT E324436T1
Authority
AT
Austria
Prior art keywords
papilloma virus
particles similar
vlps
cleaning human
human particles
Prior art date
Application number
AT99940950T
Other languages
English (en)
Inventor
James C Cook Iii
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE324436T1 publication Critical patent/ATE324436T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20051—Methods of production or purification of viral material
AT99940950T 1998-08-14 1999-08-10 Verfahren zur reinigung von menschlichen, dem papillomavirus ähnlichen partikeln. ATE324436T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9656898P 1998-08-14 1998-08-14

Publications (1)

Publication Number Publication Date
ATE324436T1 true ATE324436T1 (de) 2006-05-15

Family

ID=22257989

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99940950T ATE324436T1 (de) 1998-08-14 1999-08-10 Verfahren zur reinigung von menschlichen, dem papillomavirus ähnlichen partikeln.

Country Status (24)

Country Link
US (1) US6602697B1 (de)
EP (1) EP1105466B1 (de)
JP (1) JP4440471B2 (de)
KR (1) KR20010072470A (de)
CN (1) CN1354787A (de)
AT (1) ATE324436T1 (de)
AU (1) AU760633B2 (de)
BR (1) BR9913026A (de)
CA (1) CA2339034C (de)
CY (1) CY1105084T1 (de)
CZ (1) CZ2001570A3 (de)
DE (1) DE69931053T2 (de)
DK (1) DK1105466T3 (de)
EA (1) EA200100236A1 (de)
ES (1) ES2262333T3 (de)
HR (1) HRP20010113A2 (de)
HU (1) HUP0103091A3 (de)
IL (1) IL141130A0 (de)
NZ (1) NZ509610A (de)
PL (1) PL347472A1 (de)
PT (1) PT1105466E (de)
SI (1) SI1105466T1 (de)
SK (1) SK2232001A3 (de)
WO (1) WO2000009671A1 (de)

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TR200101055T2 (tr) * 1998-10-16 2001-09-21 Smithkline Beecham Biologicals S.A. Adjuvan sistemler ve aşılar
JP2000262280A (ja) * 1999-03-18 2000-09-26 Asahi Optical Co Ltd ウィルスまたはウィルス性抗原の精製方法およびワクチンの製造方法
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
GB0206360D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
MY139500A (en) * 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
SG150501A1 (en) * 2004-02-05 2009-03-30 Millipore Corp Porous adsorptive or chromatographic media
EP1730175B1 (de) * 2004-03-24 2010-04-28 Merck Sharp & Dohme Corp. Optimierte expression von hpv-52-l1 in hefe
WO2006028214A1 (ja) 2004-09-10 2006-03-16 Asahi Glass Company, Limited 経口投与ワクチン
EP1736538A1 (de) * 2005-06-21 2006-12-27 Cytos Biotechnology AG Prozess für die preparative Reinigung von Virus-ähnlichen Partikeln (VLPs)
WO2008027861A1 (en) * 2006-08-30 2008-03-06 Ge Healthcare Bio-Sciences Corp. System and method for characterizing membranes and membrane filtration devices
LT2601970T (lt) * 2006-09-29 2017-04-25 Takeda Vaccines, Inc. Vakcinos prieš noro virusą kompozicijos
AU2008217189B2 (en) * 2007-02-22 2013-06-13 Baxalta GmbH Method of purification of hydrophobic proteins
CA2683977C (en) * 2007-03-14 2017-04-25 Ligocyte Pharmaceuticals, Inc. A method of norovirus virus-like particle purification comprising ion exchange chromatography
US9428555B2 (en) 2007-04-29 2016-08-30 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of Human Papillomavirus type 16
US9364529B2 (en) 2007-04-29 2016-06-14 Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Truncated L1 protein of human papillomavirus type 18
DK2154149T3 (da) * 2007-05-29 2019-10-14 Univ Xiamen En trunkeret l1-protein af human papillomavirus 6
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
US20100266636A1 (en) * 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
KR20100083150A (ko) * 2007-09-18 2010-07-21 리고사이트 파머슈티컬즈 인코퍼레이티드 노로바이러스에 대한 보호면역반응을 제공하는 방법
EP2011573B1 (de) * 2007-11-05 2010-07-21 Agilent Technologies, Inc. Einfrierung eines mikrofluidischen Chips
US20090130738A1 (en) * 2007-11-19 2009-05-21 Mikhail Kozlov Media for membrane ion exchange chromatography
CN102177233B (zh) * 2008-08-08 2015-04-15 莱戈赛特医药股份有限公司 用于增强交叉反应性的包含复合衣壳氨基酸序列的病毒样颗粒
WO2011088225A1 (en) * 2010-01-15 2011-07-21 Bio-Rad Laboratories, Inc. Surface neutralization of apatite
SG184833A1 (en) 2010-04-14 2012-11-29 Emd Millipore Corp Methods of producing high titer, high purity virus stocks and methods of use thereof
US8895707B2 (en) 2010-08-18 2014-11-25 Bio-Rad Laboratories, Inc. Elution of proteins from hydroxyapatite resins without resin deterioration
EP2670704B1 (de) 2011-02-02 2018-12-12 Bio-Rad Laboratories, Inc. Apatitoberflächenneutralisierung mit alkalischen lösungen
CR20190540A (es) 2011-07-11 2022-04-04 Takeda Vaccines Inc FORMULACIONES PARENTERALES DE VACUNAS CONTRA LOS NOVOVIRUS (Divisional 2014-0069)
RU2642287C2 (ru) * 2011-12-01 2018-01-24 Юниверсити Оф Кейп Таун Химерная частица hpv
US9815695B2 (en) 2012-05-30 2017-11-14 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
JOP20130186B1 (ar) 2012-06-22 2021-08-17 Takeda Vaccines Montana Inc تنقية الجزيئات الشبيهة بالفيروسات
KR101559622B1 (ko) * 2012-07-30 2015-10-13 중앙대학교 산학협력단 인유두종바이러스 바이러스 유사입자의 고효율 정제방법
JP6479305B2 (ja) * 2013-07-12 2019-03-06 株式会社Ｕｍｎファーマ ウイルス様粒子の精製方法
WO2015200299A2 (en) 2014-06-23 2015-12-30 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
CN105392569B (zh) 2014-06-23 2019-08-20 生物辐射实验室股份有限公司 磷灰石预处理
CN105907729B (zh) * 2015-05-05 2019-08-16 广东东阳光药业有限公司 一种制备人乳头瘤病毒l1蛋白类病毒样颗粒的方法
CN108524929B (zh) * 2017-03-06 2019-05-07 广州瑞贝斯药业有限公司 一种狂犬病疫苗的生产方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6078999A (ja) * 1983-10-05 1985-05-04 Chemo Sero Therapeut Res Inst ＨＢｓ抗原の精製方法
SE9000650L (sv) 1989-02-28 1990-08-29 Asahi Optical Co Ltd Separation av celler eller virus
CA2189882C (en) 1994-05-16 2005-09-20 Kathrin U. Jansen Papillomavirus vaccines
JPH10506014A (ja) * 1994-09-22 1998-06-16 メルク エンド カンパニー インコーポレーテッド ヒトパピローマウイルス６ａ型をコードするＤＮＡ
AR004464A1 (es) * 1994-11-14 1998-12-16 Merck Sharp & Dohme Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) * 1995-03-22 2005-11-20 Merck & Co Inc Dna encoding human papillomavirus type 18
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
WO1997008298A1 (en) * 1995-08-30 1997-03-06 Genzyme Corporation Chromatographic purification of adenovirus and aav

Also Published As

Publication number Publication date
AU5469899A (en) 2000-03-06
CZ2001570A3 (cs) 2001-09-12
DK1105466T3 (da) 2006-08-14
AU760633B2 (en) 2003-05-22
SK2232001A3 (en) 2001-08-06
CA2339034C (en) 2010-10-12
DE69931053D1 (de) 2006-06-01
JP2003520188A (ja) 2003-07-02
PT1105466E (pt) 2006-07-31
IL141130A0 (en) 2002-02-10
CN1354787A (zh) 2002-06-19
JP4440471B2 (ja) 2010-03-24
ES2262333T3 (es) 2006-11-16
EP1105466B1 (de) 2006-04-26
HUP0103091A3 (en) 2002-03-28
KR20010072470A (ko) 2001-07-31
BR9913026A (pt) 2001-09-25
CA2339034A1 (en) 2000-02-24
NZ509610A (en) 2002-10-25
HRP20010113A2 (en) 2002-02-28
DE69931053T2 (de) 2006-11-23
SI1105466T1 (sl) 2006-08-31
PL347472A1 (en) 2002-04-08
CY1105084T1 (el) 2009-11-04
EP1105466A4 (de) 2002-05-15
WO2000009671A1 (en) 2000-02-24
HUP0103091A2 (hu) 2001-12-28
US6602697B1 (en) 2003-08-05
EA200100236A1 (ru) 2001-08-27
EP1105466A1 (de) 2001-06-13

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