DK1076704T3 - IL-2-selektive agonister og antagonister - Google Patents

IL-2-selektive agonister og antagonister

Info

Publication number
DK1076704T3
DK1076704T3 DK99924232T DK99924232T DK1076704T3 DK 1076704 T3 DK1076704 T3 DK 1076704T3 DK 99924232 T DK99924232 T DK 99924232T DK 99924232 T DK99924232 T DK 99924232T DK 1076704 T3 DK1076704 T3 DK 1076704T3
Authority
DK
Denmark
Prior art keywords
antagonists
selective agonists
agonists
selective
Prior art date
Application number
DK99924232T
Other languages
Danish (da)
English (en)
Inventor
Armen B Shanafelt
Jeffrey M Greve
Kenneth J Lembach
Gary Jesmok
Gayle D Wetzel
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Application granted granted Critical
Publication of DK1076704T3 publication Critical patent/DK1076704T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
DK99924232T 1998-05-15 1999-05-13 IL-2-selektive agonister og antagonister DK1076704T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8008098A 1998-05-15 1998-05-15
PCT/US1999/010643 WO1999060128A1 (fr) 1998-05-15 1999-05-13 Agonistes et antagonistes selectifs de l'il-2

Publications (1)

Publication Number Publication Date
DK1076704T3 true DK1076704T3 (da) 2007-03-12

Family

ID=22155135

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99924232T DK1076704T3 (da) 1998-05-15 1999-05-13 IL-2-selektive agonister og antagonister

Country Status (39)

Country Link
EP (1) EP1076704B1 (fr)
JP (1) JP4276783B2 (fr)
KR (1) KR100607609B1 (fr)
CN (2) CN101319247B (fr)
AR (1) AR020322A1 (fr)
AT (1) ATE351907T1 (fr)
AU (1) AU759697B2 (fr)
BG (1) BG65139B1 (fr)
BR (1) BRPI9910504B1 (fr)
CA (1) CA2327349C (fr)
CO (1) CO5070701A1 (fr)
CU (2) CU23273B7 (fr)
CY (1) CY1107533T1 (fr)
CZ (1) CZ302071B6 (fr)
DE (1) DE69934881T2 (fr)
DK (1) DK1076704T3 (fr)
DZ (1) DZ2788A1 (fr)
ES (1) ES2281175T3 (fr)
HK (1) HK1039963B (fr)
HN (1) HN1999000075A (fr)
HU (1) HU226142B1 (fr)
IL (2) IL139136A0 (fr)
MY (1) MY130274A (fr)
NO (1) NO329235B1 (fr)
NZ (1) NZ508098A (fr)
PA (1) PA8472601A1 (fr)
PE (1) PE20000475A1 (fr)
PL (1) PL201675B1 (fr)
PT (1) PT1076704E (fr)
RO (1) RO122150B1 (fr)
RU (1) RU2235729C2 (fr)
SI (1) SI20643B (fr)
SK (1) SK288100B6 (fr)
SV (1) SV1999000061A (fr)
TN (1) TNSN99090A1 (fr)
TR (1) TR200003354T2 (fr)
TW (1) TWI223663B (fr)
UA (1) UA73719C2 (fr)
WO (1) WO1999060128A1 (fr)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566500B1 (en) 1999-03-30 2003-05-20 Board Of Regents, The University Of Texas System Compositions and methods for modifying toxic effects of proteinaceous compounds
EP1935431A3 (fr) 2000-05-15 2008-08-13 Health Research, Inc. Traitements anti-cancéreux utilisant une combinaison d'anticorps contre le HER2 et l'interleukine-2
US6689353B1 (en) * 2000-06-28 2004-02-10 Bayer Pharmaceuticals Corporation Stabilized interleukin 2
US7723102B2 (en) * 2000-09-28 2010-05-25 Bayer Corporation Enhanced transfection system
MY139948A (en) * 2000-09-28 2009-11-30 Bayer Corp Enhanced transfection system
US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
PT1454138E (pt) * 2001-12-04 2012-03-28 Merck Patent Gmbh Imunocitoquinas com seletividade modulada
WO2005007121A2 (fr) 2003-07-18 2005-01-27 Massachusetts Institute Of Technology Polypeptides de l'interleukine-2(il-2) mutante
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
ES2359473T3 (es) * 2003-07-21 2011-05-23 Transgene S.A. Citoquinas multifuncionales.
EP1694360B1 (fr) 2003-11-04 2010-08-04 Novartis Vaccines and Diagnostics, Inc. Utilisation d'anticorps antagonistes anti-cd40 pour le traitement de maladies autoimmunes et inflammatoires et le rejet d'organes transplantes
JP5744369B2 (ja) * 2004-02-27 2015-07-08 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル IL15−Rα用IL−15結合部位およびアゴニスト/アンタゴニスト活性を有する特異的IL−15突然変異体
RU2006135112A (ru) * 2004-03-05 2008-04-10 Чирон Корпорейшн (Us) Тест-система in vitro для прогнозирования устойчивости пациента к терапевтическим средствам
WO2009061853A2 (fr) * 2007-11-05 2009-05-14 Massachusetts Institute Of Technology Polypeptides d'interleukine-2 (il-2) mutants
CN101244261B (zh) * 2008-03-10 2010-09-15 山东大学 一种含未复性重组蛋白的生物制剂及其制备方法与应用
DE102008023820A1 (de) * 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
CA2749539C (fr) 2009-01-21 2022-07-19 Amgen Inc. Compositions et methodes comprenant des mutants d'interleukine-2 destinees au traitement de maladies inflammatoires et auto-immunes
CN102101885B (zh) * 2010-09-01 2013-06-05 南京发士达生物科技有限公司 低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途
PT2637694T (pt) 2010-11-12 2021-05-05 Nektar Therapeutics Conjugados de uma fração de il-2 e um polímero
CU23923B1 (es) * 2010-11-12 2013-07-31 Ct De Inmunología Molecular Polipéptidos derivados de la il-2 con actividad agonista
US9428567B2 (en) 2010-12-22 2016-08-30 The Board Of Trustees Of The Leland Stanford Junior University Antagonists of interleukin-2 receptor
DK3489255T3 (da) 2011-02-10 2021-08-23 Roche Glycart Ag Muterede interleukin-2-polypeptider
WO2012119093A1 (fr) * 2011-03-03 2012-09-07 Board Of Trustees Of The Leland Stanford Junior University Superagonistes et antagonistes de l'interleukine-2
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
US20140044675A1 (en) 2012-08-10 2014-02-13 Roche Glycart Ag Interleukin-2 fusion proteins and uses thereof
EP3049445A4 (fr) 2013-09-24 2017-10-25 Medicenna Therapeutics, Inc. Protéines hybrides de l'interleukine-2 et leurs utilisations
MA39250B1 (fr) 2014-02-06 2018-09-28 Hoffmann La Roche Protéines hybrides de l'interleukine-2 et leurs utilisations
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
CA2946398A1 (fr) 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonistes, agonistes et antagonistes partiels de l'interleukine-2
SG11201700629TA (en) * 2014-08-11 2017-02-27 Delinia Inc Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
WO2017201432A2 (fr) * 2016-05-19 2017-11-23 Jounaidi Youssef Interleukine-2 liée à son récepteur il-2rbêta, plate-forme pour améliorer l'activité des cellules tueuses naturelles et des lymphocytes t régulateurs
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
JP7461741B2 (ja) 2016-06-20 2024-04-04 カイマブ・リミテッド 抗pd-l1およびil-2サイトカイン
EP3475413B1 (fr) 2016-06-22 2024-02-14 David Klatzmann Lymphocytes t génétiquement modifiés
WO2018083248A1 (fr) 2016-11-03 2018-05-11 Kymab Limited Anticorps, combinaisons comprenant des anticorps, biomarqueurs, utilisations et procédés
US11077172B2 (en) 2016-11-08 2021-08-03 Delinia, Inc. IL-2 variants for the treatment of psoriasis
BR112019011799B1 (pt) * 2016-12-13 2021-12-21 Delinia, Inc Proteína de fusão, proteína dimérica e composição farmacêutica
CA3056630A1 (fr) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Immunotolerance ciblee
CA3064435A1 (fr) 2017-05-24 2018-11-29 Pandion Therapeutics, Inc. Immunotolerance ciblee
EP3630162A1 (fr) * 2017-05-24 2020-04-08 Novartis AG Protéines greffées anticorps-cytokine et méthodes d'utilisation
JOP20190271A1 (ar) * 2017-05-24 2019-11-21 Novartis Ag بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة
US11542312B2 (en) 2017-06-19 2023-01-03 Medicenna Therapeutics, Inc. IL-2 superagonists in combination with anti-PD-1 antibodies
US20200181220A1 (en) * 2017-08-03 2020-06-11 Synthorx, Inc. Cytokine conjugates for the treatment of proliferative and infectious diseases
US20200299349A1 (en) * 2017-11-21 2020-09-24 The Board Of Trustees Of The Leland Stanford Junior University Partial agonists of interleukin-2
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
JP2021506291A (ja) 2017-12-19 2021-02-22 ゼンコア インコーポレイテッド 改変されたil−2 fc融合タンパク質
EP3752178A1 (fr) 2018-02-16 2020-12-23 Iltoo Pharma Utilisation de l'interleukine 2 pour traiter le syndrome de sjögren
MX2020009975A (es) 2018-03-28 2020-10-12 Bristol Myers Squibb Co Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso.
AU2019246389A1 (en) 2018-03-28 2020-08-27 Ascendis Pharma Oncology Division A/S IL-2 conjugates
WO2020007937A1 (fr) 2018-07-03 2020-01-09 Iltoo Pharma Utilisation de l'interleukine-2 pour le traitement de la sclérose systémique
CA3106858A1 (fr) * 2018-07-24 2020-01-30 Biontech Rna Pharmaceuticals Gmbh Agonistes d'il2
WO2020035482A1 (fr) 2018-08-13 2020-02-20 Iltoo Pharma Combinaison d'interleukine 2 et d'un inhibiteur de l'interleukine 1, conjugués et utilisations thérapeutiques de celle-ci
MX2020007072A (es) * 2018-09-17 2020-11-11 Gi Innovation Inc Proteina de fusion que comprende proteina il-2 y proteina cd80 y uso de la misma.
TW202034945A (zh) 2018-12-21 2020-10-01 大陸商江蘇恆瑞醫藥股份有限公司 一種人白細胞介素2變體或其衍生物
BR112021023345A2 (pt) 2019-05-20 2022-02-01 Pandion Operations Inc Imunotolerância com alvo em madcam
TW202115105A (zh) * 2019-06-24 2021-04-16 德商拜恩迪克Rna製藥有限公司 Il2激動劑
MX2022001866A (es) * 2019-08-13 2022-03-11 Amgen Inc Muteinas de interleucina-2 para la expansion de celulas t reguladoras.
JP2023505590A (ja) 2019-12-12 2023-02-09 イルトゥー・ファルマ インターロイキン2キメラ構築物
CA3162705A1 (fr) 2019-12-17 2021-06-24 Amgen Inc. Double agoniste de l'interleukine-2/ recepteur du tnf destine a etre utilise en therapie
US11633488B2 (en) 2020-01-10 2023-04-25 Bright Peak Therapeutics Ag Modified IL-2 polypeptides and uses thereof
KR102653906B1 (ko) 2020-01-14 2024-04-03 신테카인, 인크. 편향된 il2 뮤테인 방법 및 조성물
KR20220155316A (ko) 2020-03-19 2022-11-22 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 인터루킨-2 돌연변이 및 이의 용도
AR121713A1 (es) 2020-03-31 2022-06-29 Hanmi Pharm Ind Co Ltd Nuevos análogos de il-2 inmunoestimulantes
EP4161956A1 (fr) 2020-06-03 2023-04-12 Ascendis Pharma Oncology Division A/S Séquences d'il-2 et leurs utilisations
CN114507643A (zh) * 2020-10-29 2022-05-17 未来智人再生医学研究院(广州)有限公司 一种表达il-2的多能干细胞衍生物及应用
KR20230097094A (ko) 2020-10-29 2023-06-30 브리스톨-마이어스 스큅 컴퍼니 질환의 치료를 위한 융합 단백질
CN113308477A (zh) * 2021-04-08 2021-08-27 华南农业大学 一种鸭il-2基因真核表达重组质粒及其制备方法
TW202320862A (zh) 2021-09-22 2023-06-01 大陸商信達生物製藥(蘇州)有限公司 介白素2突變體以及其融合蛋白
WO2023057588A1 (fr) 2021-10-06 2023-04-13 Iltoo Pharma Constructions chimériques d'interleukine 2 ont une spécificité de ciblage vis-à-vis des tissus enflammés
CN114875069B (zh) * 2022-04-22 2023-09-15 四川大学 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途
WO2023245097A2 (fr) * 2022-06-16 2023-12-21 Cephalon Llc Immunoconjugués anticorps anti-pd1-il2 atténuée et leurs utilisations
WO2024056154A1 (fr) 2022-09-12 2024-03-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Interleukine-2 pour le traitement des troubles du spectre autistique
FR3140287A1 (fr) 2022-10-03 2024-04-05 Arkema France Procede de granulation de composes azoiques et granules obtenus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696234A (en) * 1994-08-01 1997-12-09 Schering Corporation Muteins of mammalian cytokine interleukin-13

Also Published As

Publication number Publication date
RU2235729C2 (ru) 2004-09-10
DZ2788A1 (fr) 2003-12-01
BRPI9910504B1 (pt) 2016-08-09
KR100607609B1 (ko) 2006-08-02
BG104929A (en) 2001-09-28
PE20000475A1 (es) 2000-07-07
CO5070701A1 (es) 2001-08-28
NO20005762L (no) 2001-01-11
TR200003354T2 (tr) 2001-03-21
CA2327349A1 (fr) 1999-11-25
WO1999060128A1 (fr) 1999-11-25
EP1076704A1 (fr) 2001-02-21
PT1076704E (pt) 2007-02-28
RO122150B1 (ro) 2009-01-30
CN101319247B (zh) 2012-12-12
UA73719C2 (en) 2005-09-15
SK17242000A3 (sk) 2001-07-10
CA2327349C (fr) 2010-10-26
SV1999000061A (es) 2000-03-14
HU226142B1 (en) 2008-05-28
TWI223663B (en) 2004-11-11
SI20643B (sl) 2008-02-29
KR20010043602A (ko) 2001-05-25
CZ20004213A3 (en) 2001-05-16
MY130274A (en) 2007-06-29
HUP0101948A2 (hu) 2001-09-28
TNSN99090A1 (fr) 2005-11-10
PA8472601A1 (es) 2000-09-29
ES2281175T3 (es) 2007-09-16
PL201675B1 (pl) 2009-04-30
IL139136A0 (en) 2001-11-25
DE69934881D1 (de) 2007-03-08
CN100366742C (zh) 2008-02-06
CN1309705A (zh) 2001-08-22
HN1999000075A (es) 1999-09-29
CY1107533T1 (el) 2013-03-13
AU759697B2 (en) 2003-04-17
PL344407A1 (en) 2001-11-05
EP1076704B1 (fr) 2007-01-17
CZ302071B6 (cs) 2010-09-29
JP4276783B2 (ja) 2009-06-10
BR9910504A (pt) 2001-01-09
CN101319247A (zh) 2008-12-10
SI20643A (sl) 2002-02-28
CU23273B7 (es) 2008-04-09
AR020322A1 (es) 2002-05-08
NO20005762D0 (no) 2000-11-14
CU23272A1 (es) 2008-04-09
ATE351907T1 (de) 2007-02-15
HUP0101948A3 (en) 2003-08-28
IL139136A (en) 2009-05-04
NO329235B1 (no) 2010-09-20
DE69934881T2 (de) 2007-11-08
HK1039963A1 (en) 2002-05-17
HK1039963B (zh) 2008-09-05
AU4078499A (en) 1999-12-06
JP2002515247A (ja) 2002-05-28
NZ508098A (en) 2003-09-26
SK288100B6 (sk) 2013-07-02
BG65139B1 (bg) 2007-03-30

Similar Documents

Publication Publication Date Title
DK1076704T3 (da) IL-2-selektive agonister og antagonister
NO20004778D0 (no) Amidderivater og nociceptin antagonister
NO20032753L (no) Forbindelse og anvendelse derav
NO20011775L (no) Borefluidadditiver og fremgangsmåter derav
DK1454907T3 (da) Quninazolin og pyridopyrmidin-derivativer
DE60031119D1 (de) Richtbohrvorrichtung und -verfahren
NO20021449D0 (no) Substituerte 2-tio-3,5-dicyano-4-aryl-6-aminopyridiner og anvendelse derav
IS5667A (is) 4-bensýlpíperidínalkýlsúlfoxíð-heteróhringir og not þeirra sem undirtegunda-valbundin nmda-þega-mótlyf
NO20006488D0 (no) Sammensetning og anvendelse
NO20010804L (no) Muskariniske agonister og antagonister
DE59608834D1 (de) Bohr- und Meisselgerät
DK1112003T3 (da) Ny sammensætning og anvendelse
NO20004274D0 (no) Proteaseaktivert reseptor 4 og anvendelse derav
DE69921110D1 (de) Bohrflüssigkeiten und zusatzstoffen
NO20013237D0 (no) 3,3-biarylpiperidin og 2,2-biarylmorfolinderivater
NO963331D0 (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
DE69805154T2 (de) Programmierbares Gerät
DK1140952T3 (da) Phosphororganiske forbindelser og anvendelse heraf
ATE272118T1 (de) T-zell selektive interleukin-4 agoniste
NO20003268D0 (no) Hyperhydrert kitikolin, fremgangsmÕte og anvendelse
DE29810384U1 (de) Programmierbares Gerät
DK1115389T3 (da) Fructosamin-oxidase: antagonister og inhibitorer
DK1127052T3 (da) Substituerede 2-phenylbenzimidazoler, fremstilling og anvendelse heraf
DK1133300T3 (da) Desmethylolanzapinsammensætninger og fremgangsmåder
DK1049777T3 (da) ACPL-DNA og -polypeptider