DK0954608T3 - Methyleringsspecifik påvisning - Google Patents

Methyleringsspecifik påvisning

Info

Publication number
DK0954608T3
DK0954608T3 DK97927933T DK97927933T DK0954608T3 DK 0954608 T3 DK0954608 T3 DK 0954608T3 DK 97927933 T DK97927933 T DK 97927933T DK 97927933 T DK97927933 T DK 97927933T DK 0954608 T3 DK0954608 T3 DK 0954608T3
Authority
DK
Denmark
Prior art keywords
methylation
pcr
specific detection
msp
dna
Prior art date
Application number
DK97927933T
Other languages
Danish (da)
English (en)
Inventor
James G Herman
Stephen B Baylin
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/656,716 external-priority patent/US5786146A/en
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of DK0954608T3 publication Critical patent/DK0954608T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
DK97927933T 1996-06-03 1997-06-03 Methyleringsspecifik påvisning DK0954608T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/656,716 US5786146A (en) 1996-06-03 1996-06-03 Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US08/835,728 US6017704A (en) 1996-06-03 1997-04-11 Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids

Publications (1)

Publication Number Publication Date
DK0954608T3 true DK0954608T3 (da) 2006-08-21

Family

ID=27097252

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97927933T DK0954608T3 (da) 1996-06-03 1997-06-03 Methyleringsspecifik påvisning

Country Status (11)

Country Link
US (2) US6017704A (enExample)
EP (2) EP1690948A3 (enExample)
JP (2) JP3612080B2 (enExample)
AT (1) ATE326549T1 (enExample)
CA (1) CA2257104C (enExample)
DE (1) DE69735894T2 (enExample)
DK (1) DK0954608T3 (enExample)
ES (1) ES2264165T3 (enExample)
IL (1) IL127342A (enExample)
PT (1) PT954608E (enExample)
WO (1) WO1997046705A1 (enExample)

Families Citing this family (313)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871917A (en) 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US6617434B1 (en) 1996-05-31 2003-09-09 North Shore Long Island Jewish Research Institute Identificiaton of differentially methylated and mutated nucleic acids
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
AUPP312998A0 (en) 1998-04-23 1998-05-14 Commonwealth Scientific And Industrial Research Organisation Diagnostic assay
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6994991B1 (en) 1998-11-18 2006-02-07 North Shore - Long Island Jewish Research Institute Identification of differentially methylated multiple drug resistance loci
DE19853398C1 (de) * 1998-11-19 2000-03-16 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischer DNA
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
AUPP844899A0 (en) * 1999-02-01 1999-02-25 University Of Western Australia, The A method for detecting methylated nucleic acids
US7655443B1 (en) * 1999-05-07 2010-02-02 Siemens Healthcare Diagnostics, Inc. Nucleic acid sequencing with simultaneous quantitation
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US20030190644A1 (en) * 1999-10-13 2003-10-09 Andreas Braun Methods for generating databases and databases for identifying polymorphic genetic markers
WO2001026536A2 (en) * 1999-10-13 2001-04-19 The Johns Hopkins University School Of Medicine Methods of diagnosing and treating hepatic cell proliferative disorders
US6709818B1 (en) * 1999-10-13 2004-03-23 The Johns Hopkins University School Of Medicine Methods of diagnosing and treating hepatic cell proliferative disorders
US20030207297A1 (en) * 1999-10-13 2003-11-06 Hubert Koster Methods for generating databases and databases for identifying polymorphic genetic markers
WO2001036669A2 (de) * 1999-11-12 2001-05-25 Epigenomics Ag Verfahren zur kontrollierbaren durchführung komplexer pcr-amplifikationen
DE19957827C2 (de) 1999-11-25 2003-06-12 Epigenomics Ag Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche
US20030170649A1 (en) * 1999-12-03 2003-09-11 Haas Oskar A. Method for detecting and evaluating a potentially aberrantly methylated dna region on the x chromosome, or the clonality
DE19959691A1 (de) * 1999-12-06 2001-08-16 Epigenomics Ag Verfahren zur parallelen Detektions des Methylierungszustandes von genomischer DNA
GB9929720D0 (en) * 1999-12-17 2000-02-09 Zeneca Ltd Diagnostic method
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
DE10010282B4 (de) 2000-02-25 2006-11-16 Epigenomics Ag Verfahren zur Detektion von Cytosin-Methylierung in DNA Proben
DE10013847A1 (de) * 2000-03-15 2001-09-27 Epigenomics Ag Oligonukleotide oder PNA-Oligomere und Verfahren zur parallelen Detektion des Methylierungszustandes genomischer DNA
US20040076956A1 (en) * 2000-04-06 2004-04-22 Alexander Olek Diagnosis of diseases associated with dna repair
US20040006036A1 (en) * 2000-04-12 2004-01-08 Gmr, A Delaware Corporation Silencing transcription by methylation
DE10029915B4 (de) * 2000-06-19 2005-06-16 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen
WO2002000926A2 (en) * 2000-06-30 2002-01-03 Epigenomics Ag Diagnosis of diseases associated with signal transduction
CA2312051A1 (en) * 2000-07-13 2002-01-13 Quebepharma Inc. Methylated nucleotide regulation of gene expression
DE10038733A1 (de) * 2000-08-02 2002-02-21 Epigenomics Ag Verfahren zur Altersbestimmung von Individuen
AU2001286514A1 (en) * 2000-08-15 2002-02-25 National Cancer Center Research Institute Diagnosis and treatment of tumor-suppressor associated disorders
CA2421102A1 (en) * 2000-08-25 2002-03-07 Lovelace Respiratory Research Institute Nested methylation-specific polymerase chain reaction cancer detection method
WO2002061410A1 (en) * 2000-09-01 2002-08-08 Spectrumedix Corporation System and method for temperature gradient capillary electrophoresis
JP2004509643A (ja) * 2000-09-29 2004-04-02 ザ　ジョンズ　ホプキンス　ユニバーシティー　スクール　オブ　メディシン アルキル化剤を用いた化学療法による治療に対する臨床反応を予測する方法
DE10050942B4 (de) * 2000-10-10 2005-11-17 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen
WO2002031199A1 (en) * 2000-10-11 2002-04-18 Spectrumedix Corporation System and method for determining the presence of methylated cytosines in polynucleotides
GB0025913D0 (en) 2000-10-23 2000-12-06 Guldberg Per Materials and methods relating to nucleic acid amplification and profiling
JP2004512050A (ja) * 2000-10-23 2004-04-22 キャンサー・リサーチ・テクノロジー・リミテッド 核酸の増幅およびプロファイリングに関連する物質および方法
JP2004535757A (ja) * 2000-11-08 2004-12-02 ユニバーシティ・オブ・サザン・カリフォルニア ヘミメチル化の検出及び定量のための新規アッセイ法
DE10056802B4 (de) * 2000-11-14 2005-06-16 Epigenomics Ag Verfahren zur Detektion von Methylierungszuständen zur toxikologischen Diagnostik
US6756200B2 (en) * 2001-01-26 2004-06-29 The Johns Hopkins University School Of Medicine Aberrantly methylated genes as markers of breast malignancy
US6893820B1 (en) * 2001-01-31 2005-05-17 The Ohio State University Research Foundation Detection of methylated CpG rich sequences diagnostic for malignant cells
JP2004536596A (ja) * 2001-06-08 2004-12-09 ユー．エス． ジェノミクス， インコーポレイテッド メチル化状態に基づいて核酸を分析するための方法および生成物
DE10128509A1 (de) * 2001-06-14 2003-01-02 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata- und Nierenkarzinomen
DE10128508A1 (de) * 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
US8207142B2 (en) * 2001-07-31 2012-06-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Inhibitor of DNA methylation
DE10139283A1 (de) * 2001-08-09 2003-03-13 Epigenomics Ag Verfahren und Nukleinsäuren zur Analyse von Colon-Krebs
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
DE10151055B4 (de) 2001-10-05 2005-05-25 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierung in CpG Inseln
WO2003031932A2 (en) * 2001-10-05 2003-04-17 Case Western Reserve University Methods and compositions for detecting colon cancers
EP1451372A1 (en) * 2001-10-18 2004-09-01 Spectrumedix Corporation System and method for temperature gradient capillary electrophoresis
WO2003064682A1 (en) * 2001-10-18 2003-08-07 Lovelace Respiratory Research Institute Cancer monitoring by aberrant promotor methylation of the transcription factor genes pax5 alpha pax5 beta, novel loop helix loop protein, novel gene 2, and beta3 genes
WO2003035860A1 (en) * 2001-10-24 2003-05-01 The Trustees Of Columbia University In The City Of New York A method for gene identification based on differential dna methylation
DE10154317B4 (de) 2001-10-26 2005-06-09 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen in immobilisierten DNA Proben
AU2002352745A1 (en) * 2001-11-16 2003-06-10 The Johns Hopkins University School Of Medicine Method of detection of prostate cancer
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
AU2002353043B2 (en) 2001-11-30 2008-07-03 The Johns Hopkins University Methods for analyzing methylated CpG islands and GC rich regions
DE10201138B4 (de) * 2002-01-08 2005-03-10 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern durch exponentielle Ligation hybridisierter Sondenoligonukleotide (MLA)
WO2003064700A2 (en) * 2002-01-30 2003-08-07 Epigenomics Ag Identification of cell differentiation states based on methylation patterns
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
KR100470221B1 (ko) * 2002-02-20 2005-02-05 굿젠 주식회사 유전자 프로모터 ＣｐＧ 아일랜드의 메틸화 여부를분석하는 염기서열분석형 올리고뉴클레오타이드칩, 이의제조방법 및 이를 이용한 암 검색방법
EP1340818A1 (en) * 2002-02-27 2003-09-03 Epigenomics AG Method and nucleic acids for the analysis of a colon cell proliferative disorder
DK1342794T3 (da) * 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
US20040038254A1 (en) * 2002-03-08 2004-02-26 Risa Peoples Compositions and methods for detecting nucleic acid methylation
WO2003083107A1 (en) * 2002-03-25 2003-10-09 The Board Of Trustees Of The University Of Arkansas Cpg retrieval of dna from formalin-fixed pathology specimen for promoter methylation analysis
US6872530B2 (en) * 2002-04-24 2005-03-29 Spectrumedix, Llc Method for determining the presence of DNA variants using peptide nucleic acid probes
AU2003228809A1 (en) * 2002-05-03 2003-11-17 Sequenom, Inc. Kinase anchor protein muteins, peptides thereof, and related methods
AU2003251483A1 (en) * 2002-06-05 2003-12-22 Case Western Reserve University Methods and compositions for detecting cancers
WO2004001307A1 (ja) * 2002-06-21 2003-12-31 Hinode Co,. Ltd. 傘のしずく取り装置及びこの装置の設置促進システム
EP2339025B1 (en) * 2002-06-26 2013-10-09 Cold Spring Harbor Laboratory Methods for determining the methylation profiles
US20040178070A1 (en) * 2002-07-16 2004-09-16 Zhaowei Liu Method and system for comparative genomics for organisms using temperature gradient electrophoresis
DE60328618D1 (de) 2002-10-01 2009-09-10 Epigenomics Ag Verfahren für die behandlung von proliferativen erkrankungen von brustzellen
AU2003279101A1 (en) * 2002-10-02 2004-04-23 Northwestern University Methylation profile of cancer
CA2442438C (en) 2002-10-04 2012-06-19 Nisshinbo Industries, Inc. Oligonucleotide-immobilized substrate for detecting methylation
AU2003298733B2 (en) 2002-11-27 2009-06-18 Agena Bioscience, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
DE60331852D1 (de) * 2002-12-02 2010-05-06 Illumina Cambridge Ltd Bestimmung der methylierung von nukleinsäuresequenzen
AU2003900368A0 (en) * 2003-01-24 2003-02-13 Human Genetic Signatures Pty Ltd Assay for nucleic acid molecules
US20040146868A1 (en) * 2003-01-24 2004-07-29 Epigenomics Ag Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the development of peripheral zone prostate cancer
DE10304219B3 (de) * 2003-01-30 2004-08-19 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
US20070141570A1 (en) * 2003-03-07 2007-06-21 Sequenom, Inc. Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
AU2004221394A1 (en) * 2003-03-17 2004-09-30 The Johns Hopkins University Aberrantly methylated genes in pancreatic cancer
WO2004087957A2 (en) * 2003-04-03 2004-10-14 Oncomethylome Sciences S.A. Hypermethylated genes and cervical cancer
US20040203004A1 (en) * 2003-04-10 2004-10-14 Bernard Hans Ulrich Diagnostic apparatus and method
EP1618216A2 (en) * 2003-04-25 2006-01-25 Sequenom, Inc. Fragmentation-based methods and systems for de novo sequencing
US7288373B2 (en) * 2003-05-02 2007-10-30 Human Genetic Signatures Pty Ltd. Treatment of methylated nucleic acid
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
US20050026183A1 (en) * 2003-05-15 2005-02-03 Jian-Bing Fan Methods and compositions for diagnosing conditions associated with specific DNA methylation patterns
US8150626B2 (en) * 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
US8150627B2 (en) 2003-05-15 2012-04-03 Illumina, Inc. Methods and compositions for diagnosing lung cancer with specific DNA methylation patterns
ATE476523T1 (de) * 2003-06-17 2010-08-15 Human Genetic Signatures Pty Verfahren zur genomamplifikation
EP1636381B1 (en) 2003-06-23 2011-01-05 Epigenomics AG Methods and nucleic acids for the analysis of colon cell proliferative disorders
EP2354248B1 (en) 2003-06-23 2018-01-03 Epigenomics AG Methods for analyses of colorectal cell proliferative disorders
US20040265833A1 (en) * 2003-06-23 2004-12-30 Cathy Lofton-Day Methods and nucleic acids for the analysis of colorectal cell proliferative disorders
AU2004252554B2 (en) 2003-06-23 2012-01-19 Epigenomics Ag Methods and nucleic acids for analyses of colorectal cell proliferative disorders
EP1649050A2 (en) * 2003-06-24 2006-04-26 Epigenomics AG Improved heavymethyl assay for the methylation analysis of the gstpi gene
US7303879B2 (en) * 2003-07-31 2007-12-04 Applera Corporation Determination of SNP allelic frequencies using temperature gradient electrophoresis
EP1651778A1 (en) * 2003-08-01 2006-05-03 U.S. Genomics, Inc. Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions
US20060183128A1 (en) * 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
US8415100B2 (en) 2003-08-14 2013-04-09 Case Western Reserve University Methods and compositions for detecting gastrointestinal and other cancers
WO2005017207A2 (en) * 2003-08-14 2005-02-24 Case Western Reserve University Methods and compositions for detecting colon cancers
DE10338308B4 (de) 2003-08-15 2006-10-19 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen in DNA
CN1845991A (zh) * 2003-08-29 2006-10-11 田中纪章 核酸扩增用引物以及利用该引物检查结肠癌的检查方法
US7198900B2 (en) 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
CN1863927B (zh) * 2003-09-04 2010-08-11 人类遗传标记控股有限公司 核酸检测分析
US9394565B2 (en) * 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
DE10348407A1 (de) * 2003-10-17 2005-05-19 Widschwendter, Martin, Prof. Prognostische und diagnostische Marker für Zell-proliferative Erkrankungen von Brustgeweben
WO2005042704A2 (en) 2003-10-21 2005-05-12 Orion Genomics Llc Differential enzymatic fragmentation
JP4824575B2 (ja) 2003-12-01 2011-11-30 エピゲノミクス アクチェンゲゼルシャフト 前立腺細胞増殖性疾患の発症に関連する遺伝子発現の分析のための方法および核酸
DE602004031405D1 (de) 2003-12-11 2011-03-31 Epigenomics Ag Marker zur Prognose der Reaktion auf Therapie bzw. der Überlebensrate von Brustkrebspatienten
DE102004002257B4 (de) * 2004-01-09 2006-11-09 Epigenomics Ag Verfahren zur Untersuchung von Cytosin-Methylierungen in DNA mit Hilfe von DNA-Reparaturenzymen
US7358048B2 (en) * 2004-02-10 2008-04-15 Cornell Research Foundation, Inc. Method for detection of promoter methylation status
WO2005085477A1 (en) * 2004-03-02 2005-09-15 Orion Genomics Llc Differential enzymatic fragmentation by whole genome amplification
US7608394B2 (en) 2004-03-26 2009-10-27 Sequenom, Inc. Methods and compositions for phenotype identification based on nucleic acid methylation
AU2005230936B2 (en) * 2004-03-26 2010-08-05 Agena Bioscience, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US8168777B2 (en) 2004-04-29 2012-05-01 Human Genetic Signatures Pty. Ltd. Bisulphite reagent treatment of nucleic acid
WO2005111244A2 (en) * 2004-05-10 2005-11-24 Exact Sciences Corporation Methods for detecting a mutant nucleic acid
WO2005118872A2 (en) * 2004-06-01 2005-12-15 The Regents Of The University Of Michigan Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
EP1778865A1 (en) * 2004-06-23 2007-05-02 Epigenomics AG Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
EP2281902A1 (en) 2004-07-18 2011-02-09 Epigenomics AG Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
US7981607B2 (en) * 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
WO2006031745A2 (en) * 2004-09-10 2006-03-23 Sequenom, Inc. Methods for long-range sequence analysis of nucleic acids
DE602005022740D1 (de) * 2004-09-10 2010-09-16 Human Genetic Signatures Pty Amplifikationsblocker umfassend interkalierende nukleinsäuren (ina) enthaltend interkalierende pseudonukleotide (ipn)
KR100617649B1 (ko) 2004-09-24 2006-09-04 (주)지노믹트리 대장암 특이적 발현감소 유전자의 메틸화된 프로모터를 함유하는 암 진단용 조성물 및 그 용도
WO2006034879A2 (en) * 2004-09-30 2006-04-06 Epigenomics Ag Epigenetic methods and nucleic acids for the detection of lung cell proliferative disorders
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
JP2008519584A (ja) * 2004-11-09 2008-06-12 シェーリング コーポレイション 患者のｍｇｍｔレベルに基づいて癌を処置するための、テモゾロミドの改良された投薬養生法
CA2589484A1 (en) * 2004-12-02 2006-06-08 Schering Corporation Methods of using temozolomide formulation intrathecally in the treatment of cancers
JP5745202B2 (ja) * 2004-12-02 2015-07-08 エピゲノミックス アクチェンゲゼルシャフト 前立腺細胞増殖障害の予後に関連する遺伝子発現分析のための方法および核酸
ES2399054T3 (es) * 2004-12-03 2013-03-25 Human Genetic Signatures Pty Ltd Métodos para simplificar ácidos nucleicos microbianos mediante modificación química de citosinas
CA2592993C (en) * 2004-12-13 2013-06-18 National University Corporation Okayama University Method for detecting methylation in genes and method for examining neoplasm through detecting methylation in genes
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
CN101142323A (zh) * 2004-12-23 2008-03-12 人类遗传标记控股有限公司 人类乳头瘤病毒的检测
EP2272984B1 (en) 2005-02-01 2012-06-20 John Wayne Cancer Institute Use of ID4 for diagnosis and treatment of cancer
EP1853727A4 (en) 2005-02-14 2010-01-06 Univ Johns Hopkins NEOPLASIE SCREENING COMPOSITIONS AND USE METHOD
WO2006094149A2 (en) * 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
KR100735045B1 (ko) 2005-04-07 2007-07-03 (주) 차바이오텍 마우스의 ｂ1 서열을 이용한 ｄｎａ 메틸화를 측정하는방법 및 이를 이용한 항암제의 항암활성 측정법
KR20080011287A (ko) 2005-04-15 2008-02-01 에피제노믹스 아게 세포 증식 질환을 분석하기 위한 방법 및 핵산
WO2007044071A2 (en) * 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
ES2446250T3 (es) 2005-05-02 2014-03-06 University Of Southern California Marcadores de metilación del ADN asociados con el fenotipo metilador de islas CpG (CIMP) en el cáncer colorrectal humano
AU2006251866B2 (en) * 2005-05-26 2007-11-29 Human Genetic Signatures Pty Ltd Isothermal strand displacement amplification using primers containing a non-regular base
US7439024B2 (en) * 2005-06-01 2008-10-21 The United States Of America As Represented By The Department Of Veterans Affairs Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
US20070037184A1 (en) * 2005-06-16 2007-02-15 Applera Corporation Methods and kits for evaluating dna methylation
US20060286577A1 (en) * 2005-06-17 2006-12-21 Xiyu Jia Methods for detection of methylated DNA
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US20090270479A1 (en) * 2005-07-12 2009-10-29 Antonio Giordano Genetic and Epigenetic Alterations In the Diagnosis and Treatment of Cancer
EP1904649A2 (en) * 2005-07-18 2008-04-02 Epigenomics AG Compositions and methods for cancer diagnostics comprising pan-cancer markers
ATE531820T1 (de) * 2005-09-14 2011-11-15 Human Genetic Signatures Pty Gesundheitszustandstest
US20070059753A1 (en) * 2005-09-15 2007-03-15 Tatiana Vener Detecting gene methylation
WO2007039128A1 (en) * 2005-09-21 2007-04-12 Epigenomics Ag Markers for the prediction of outcome of anthracycline treatment
EP1934369A2 (en) 2005-09-29 2008-06-25 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with tissue classification
WO2007039290A2 (en) * 2005-10-03 2007-04-12 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the prognosis of cell proliferative disorders
US20090042195A1 (en) * 2005-10-07 2009-02-12 Bradford Coffee Methods and systems for screening for and diagnosing dna methylation associated abnormalities and sex chromosome aneuploidies
US7770717B2 (en) * 2005-10-12 2010-08-10 Scanvaegt International A/S Device for transfer of items
US20070087358A1 (en) * 2005-10-19 2007-04-19 Melanie Ehrlich Methods for diagnosing cancer based on DNA methylation status in NBL2
EP2186912A3 (en) 2005-11-08 2011-01-19 Euclid Diagnostics LLC Materials and methods for assaying for methylation of CpG islands associated with genes in the evaluation of cancer
WO2007057231A1 (en) * 2005-11-17 2007-05-24 Epigenomics Ag Method for the determination of the dna methylation level of a cpg position in identical cells within a tissue sample
EP1973569B1 (en) 2006-01-18 2013-05-22 Merck Patent GmbH Specific therapy using integrin ligands for treating cancer
US7820385B2 (en) * 2006-03-22 2010-10-26 The United States Of America As Represented By The Department Of Health And Human Services, Centers For Disease Control And Prevention Method for retaining methylation pattern in globally amplified DNA
CA2648160A1 (en) * 2006-03-29 2007-11-01 John Wayne Cancer Institute Methylation of estrogen receptor alpha and uses thereof
EP1840224A1 (en) 2006-03-29 2007-10-03 Pangaea Biotech, S.A. Method of predicting survival of a non-small-cell lung cancer patient to a chemotherapeutic treatment
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
AU2007237444B2 (en) 2006-04-17 2013-05-23 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US20090317810A1 (en) * 2006-04-17 2009-12-24 Epigenomics Ag Methods and nucleic acids for the detection of colorectal cell proliferative disorders
US20070264672A1 (en) * 2006-05-09 2007-11-15 Bimalendu Dasmahapatra Development of a novel assay for mgmt (methyl guanine methyl transferase)
US20080003609A1 (en) * 2006-05-10 2008-01-03 The Cleveland Clinic Foundation Method of detecting bladder urothelial carcinoma
US20080081333A1 (en) * 2006-05-26 2008-04-03 University Of Maryland, Baltimore Methylated promoters as biomarkers of colon cancer
KR100761031B1 (ko) 2006-05-27 2007-10-04 김연수 디엔에이 메틸화 현상을 이용한 암 진단용 키트
US20080050738A1 (en) * 2006-05-31 2008-02-28 Human Genetic Signatures Pty Ltd. Detection of target nucleic acid
US20080085867A1 (en) * 2006-07-14 2008-04-10 The Johns Hopkins University Early detection and prognosis of colon cancers
WO2008011620A2 (en) 2006-07-21 2008-01-24 Epigenomics Ag Methods and nucleic acids for analyses of cellular proliferative disorders
CA2670082A1 (en) 2006-11-20 2008-05-29 The Johns Hopkins University Dna methylation markers and methods of use
EP3184649A1 (en) 2006-11-24 2017-06-28 Epigenomics AG Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
JP2010516645A (ja) 2007-01-18 2010-05-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌を治療するためのインテグリンリガンドを用いる特異的療法および薬剤
DK2258871T3 (da) 2007-01-19 2014-08-11 Epigenomics Ag Fremgangsmåder og nukleinsyrer til analyse af celleproliferative lidelser
US20090203011A1 (en) * 2007-01-19 2009-08-13 Epigenomics Ag Methods and nucleic acids for analyses of cell proliferative disorders
WO2008096146A1 (en) * 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
JP2010521142A (ja) * 2007-03-16 2010-06-24 ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド 遺伝子発現アッセイ
US9290803B2 (en) 2007-04-12 2016-03-22 University Of Southern California DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight
EP2339022A3 (en) * 2007-04-25 2011-10-26 John Wayne Cancer Institute Use of methylated or unmethylated line-1 DNA as a cancer marker
EP2409700A1 (en) 2007-05-08 2012-01-25 Schering Corporation Methods of treatment using intravenous formulations comprising temozolomide
BRPI0811271A2 (pt) * 2007-05-31 2015-01-20 Monsanto Technology Llc Polimorfismos da soja e processos de genotipagem
WO2008149855A1 (ja) * 2007-06-08 2008-12-11 Bio-Dixam, Llc. メチル化核酸又は非メチル化核酸を増幅する方法
EP2198042B1 (en) 2007-09-17 2016-11-02 MDxHealth SA Novel markers for bladder cancer detection
RU2492243C2 (ru) 2007-09-17 2013-09-10 Конинклейке Филипс Электроникс Н.В. Способ анализа онкологических заболеваний молочной железы
CN101802226A (zh) * 2007-09-17 2010-08-11 皇家飞利浦电子股份有限公司 分析卵巢癌病症的方法
AU2008329549B2 (en) * 2007-11-27 2013-08-22 Human Genetic Signatures Pty Ltd Enzymes for amplification and copying bisulphite modified nucleic acids
AU2008334901A1 (en) 2007-12-11 2009-06-18 Epigenomics Ag Methods and nucleic acids for analyses of lung carcinoma
CA2709632A1 (en) * 2007-12-20 2009-07-02 Human Genetic Signatures Pty Ltd Elimination of contaminants associated with nucleic acid amplification
WO2009089598A2 (en) * 2008-01-18 2009-07-23 Katholieke Universiteit Leuven Msmb-gene methylation based diagnosis, staging and prognosis of prostate cancer
US20110117551A1 (en) 2008-02-19 2011-05-19 Oncomethylome Sciences Sa Detection and prognosis of lung cancer
CA2718092C (en) 2008-03-21 2019-03-19 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
US8372587B2 (en) 2008-04-14 2013-02-12 Nihon University Proliferative disease detection method
BRPI0913578A2 (pt) 2008-05-14 2017-06-06 Dermtech Int diagnose de melanoma e lentigo solar por análise de ácido nucléico
EP2304057B1 (en) 2008-06-17 2014-09-17 Signature Diagnostics AG Method for the detection of ovarian cancer
US8541207B2 (en) 2008-10-22 2013-09-24 Illumina, Inc. Preservation of information related to genomic DNA methylation
WO2010070572A1 (en) 2008-12-18 2010-06-24 Koninklijke Philips Electronics N. V. Method for the detection of dna methylation patterns
ES2368862T3 (es) 2009-01-22 2011-11-23 Heinrich-Heine-Universität Düsseldorf Determinación del grado de metilación de adn.
DK2394170T3 (en) 2009-02-03 2015-07-13 Mdxhealth Sa Methods for detecting colorectal cancer
WO2010102823A1 (en) 2009-03-13 2010-09-16 Oncomethylome Sciences Sa Novel markers for bladder cancer detection
CA2755734A1 (en) 2009-03-17 2010-09-23 Gaetan Otto Improved detection of gene expression
WO2010123354A2 (en) 2009-04-20 2010-10-28 Erasmus University Medical Center Rotterdam Method of diagnosing bladder cancer
US20120130146A1 (en) 2009-05-25 2012-05-24 Merck Patent Gmbh Continuous administration of cilengitide in cancer treatments
US20120184447A1 (en) 2009-06-26 2012-07-19 Reinhold Wasserkort Methods and Nucleic Acids for Analysis of Bladder Cell Proliferative Disorders
EP2309005B1 (en) 2009-08-03 2015-03-04 Epigenomics AG Methods for preservation of genomic DNA sequence complexity
US8642271B2 (en) * 2009-08-27 2014-02-04 Case Western Reserve University Aberrant methylation of C6Orf150 DNA sequences in human colorectal cancer
WO2011036173A1 (en) 2009-09-24 2011-03-31 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
US8399138B2 (en) * 2009-10-14 2013-03-19 GM Global Technology Operations LLC Liquid rechargeable lithium ion battery
WO2011051414A1 (en) 2009-10-28 2011-05-05 Signature Diagnostics Ag Method for the prognosis of ovarian carcinoma
US20110104695A1 (en) 2009-11-05 2011-05-05 Epigenomics Ag Methods of predicting therapeutic efficacy of cancer therapy
JP2013511991A (ja) * 2009-11-25 2013-04-11 クアンタライフ， インコーポレイテッド 遺伝子材料を検出する方法および組成物
WO2011112845A2 (en) * 2010-03-11 2011-09-15 Board Of Regents, The University Of Texas System Methods and compositions related to a multi-methylation assay to predict patient outcome
WO2011135058A2 (en) 2010-04-30 2011-11-03 Mdxhealth Sa Methods for detecting epigenetic modifications
PH12012502017A1 (en) 2010-04-30 2013-01-21 Novartis Ag Predictive markers useful in the treatment of fragile x syndrome (fxs)
DK2576832T3 (en) 2010-05-25 2016-06-20 Univ Johns Hopkins CONFIGURATIONS AND METHODS FOR DETECTION OF neoplasia
MX2013000521A (es) 2010-07-16 2013-03-05 Merck Patent Gmbh Partido para usarse en tratamiento de cancer de mama y/o metastasis osea.
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
ES2686309T3 (es) 2011-02-02 2018-10-17 Exact Sciences Development Company, Llc Análisis digital de secuencia de la metilación de ADN
CN103562407A (zh) 2011-02-09 2014-02-05 伯乐生命医学产品有限公司 核酸的分析
WO2012162139A1 (en) 2011-05-20 2012-11-29 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
CA2840149C (en) 2011-07-08 2021-10-26 Epigenomics Ag Methods and nucleic acids for determining the prognosis of a cancer subject
DK2753710T3 (en) 2011-09-07 2017-02-06 Human Genetic Signatures Pty Ltd MOLECULAR DETECTION ASSAY
US9605312B2 (en) 2011-12-06 2017-03-28 Mdxhealth, Sa Methods of detecting mutations in BRAF and epigenetic changes
WO2013096661A1 (en) 2011-12-22 2013-06-27 Illumina, Inc. Methylation biomarkers for ovarian cancer
WO2013131981A1 (en) 2012-03-08 2013-09-12 Novartis Ag Predictive markers useful in the diagnosis and treatment of fragile x syndrome (fxs)
US9428813B2 (en) 2012-03-26 2016-08-30 The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services DNA methylation analysis for the diagnosis, prognosis and treatment of adrenal neoplasms
EP2644705A1 (en) 2012-03-30 2013-10-02 RWTH Aachen Biomarker for bladder cancer
WO2013165748A1 (en) 2012-04-30 2013-11-07 Raindance Technologies, Inc Digital analyte analysis
WO2013174432A1 (en) 2012-05-24 2013-11-28 Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) Method for the identification of the origin of a cancer of unknown primary origin by methylation analysis
EP2859353B1 (en) 2012-06-11 2018-09-12 Medizinische Hochschule Hannover Susceptibility to and stratification for monoaminergic antidepressants
CN105378108A (zh) 2013-03-13 2016-03-02 雅培分子公司 用于分离核酸的系统和方法
ES2947873T3 (es) 2013-03-14 2023-08-23 Mayo Found Medical Education & Res Detección de neoplasias
EP2971171A4 (en) 2013-03-14 2016-11-02 Abbott Molecular Inc SYSTEMS AND METHODS FOR MULTIPLEX AMPLIFICATION SPECIFIC TO METHYLATION
EP2986762B1 (en) 2013-04-19 2019-11-06 Bio-Rad Laboratories, Inc. Digital analyte analysis
CN104250663B (zh) * 2013-06-27 2017-09-15 北京大学 甲基化CpG岛的高通量测序检测方法
GB201322034D0 (en) 2013-12-12 2014-01-29 Almac Diagnostics Ltd Prostate cancer classification
US11578373B2 (en) 2019-03-26 2023-02-14 Dermtech, Inc. Gene classifiers and uses thereof in skin cancers
WO2015124921A1 (en) 2014-02-19 2015-08-27 The University Court Of The University Of Edinburgh Methods and uses for determining the presence of inflammatory bowel disease
US11078539B2 (en) 2014-03-31 2021-08-03 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
WO2015169857A1 (en) 2014-05-07 2015-11-12 Université Libre de Bruxelles Breast cancer epigenetic markers useful in anthracycline treatment prognosis
US10801067B2 (en) 2014-05-09 2020-10-13 Eurofins Lifecodexx Gmbh Detection of DNA that originates from a specific cell-type and related methods
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
EP2942401A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Detection of DNA that originates from a specific cell-type
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
EP3230744B1 (en) 2014-12-12 2021-05-12 Exact Sciences Development Company, LLC Compositions and methods for performing methylation detection assays
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
EP3274440B1 (en) 2015-03-27 2026-03-04 Exact Sciences Corporation Detecting esophageal disorders
WO2016193151A1 (en) 2015-05-29 2016-12-08 Vito Nv Epigenetic markers for respiratory allergy
GB201510684D0 (en) 2015-06-17 2015-08-05 Almac Diagnostics Ltd Gene signatures predictive of metastatic disease
JP6871926B2 (ja) 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ 胃の新生物を検出すること
EP3162899A1 (en) 2015-10-29 2017-05-03 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Biomarker for breast cancer
KR102811214B1 (ko) 2015-10-30 2025-05-27 이그잭트 사이언시즈 코포레이션 복합 증폭 검출 분석 및 혈장으로부터 dna의 분리 및 검출 방법
EP3168309B8 (en) 2015-11-10 2020-06-03 Eurofins LifeCodexx GmbH Detection of foetal chromosomal aneuploidies using dna regions that are differentially methylated between the foetus and the pregnant female
EP3798321B1 (en) 2015-12-17 2025-08-27 Illumina, Inc. Distinguishing methylation levels in complex biological samples
US10913986B2 (en) 2016-02-01 2021-02-09 The Board Of Regents Of The University Of Nebraska Method of identifying important methylome features and use thereof
CA3022911A1 (en) 2016-05-05 2017-11-09 Exact Sciences Development Company, Llc Detection of lung neoplasia by analysis of methylated dna
US11685955B2 (en) 2016-05-16 2023-06-27 Dimo Dietrich Method for predicting response of patients with malignant diseases to immunotherapy
DE102016005947B3 (de) 2016-05-16 2017-06-08 Dimo Dietrich Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen
EP3464642A4 (en) 2016-05-31 2020-02-19 The Regents of the University of California METHOD FOR EVALUATING, MONITORING AND MODULATING THE AGING PROCESS
WO2018009707A1 (en) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Solid tumor methylation markers and uses thereof
WO2018009703A1 (en) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Breast and ovarian cancer methylation markers and uses thereof
US12359257B2 (en) 2016-07-06 2025-07-15 Helio Health Inc. Liver cancer methylation markers and uses thereof
US12351876B2 (en) 2016-07-06 2025-07-08 Helio Health, Inc. Colon cancer methylation markers and uses thereof
US10093986B2 (en) 2016-07-06 2018-10-09 Youhealth Biotech, Limited Leukemia methylation markers and uses thereof
CN106011278B (zh) * 2016-07-18 2020-01-21 宁波大学医学院附属医院 人胃肠肿瘤中piezo2基因的检测试剂
EP3978624B1 (en) 2016-07-19 2025-03-26 Exact Sciences Corporation Methylated control dna
AU2017318700B2 (en) 2016-09-02 2022-09-22 Exact Sciences Corporation Detecting hepatocellular carcinoma
HUE059194T2 (hu) 2016-12-16 2022-10-28 Eurofins Genomics Europe Sequencing GmbH Epigenetikai markerek és a kapcsolódó eljárások, valamint eszközök a petefészekrák kimutatására és kezelésére
JP7289264B2 (ja) 2017-01-27 2023-06-09 エグザクト サイエンシーズ コーポレーション メチル化ｄｎａの分析による結腸腫瘍の検出
CN118147307A (zh) 2017-02-28 2024-06-07 梅约医学教育与研究基金会 用于表征来自人患者的样品的方法
US10513739B2 (en) 2017-03-02 2019-12-24 Youhealth Oncotech, Limited Methylation markers for diagnosing hepatocellular carcinoma and lung cancer
US11433074B2 (en) 2017-06-22 2022-09-06 Triact Therapeutics, Inc. Methods of treating glioblastoma
EP3652338A1 (en) 2017-07-14 2020-05-20 Universite Libre De Bruxelles Method for predicting responsiveness to immunotherapy
EP3687501A4 (en) 2017-09-29 2021-06-23 Triact Therapeutics, Inc. INIPARIB FORMULATIONS AND THEIR USES
CN111742062B (zh) 2017-10-06 2023-11-17 优美佳肿瘤技术有限公司 用于诊断癌症的甲基化标志物
DE102017125780B3 (de) 2017-11-05 2018-12-13 Dimo Dietrich Verfahren zur Bestimmung des Ansprechens einer malignen Erkrankung auf eine Immuntherapie
KR20250117473A (ko) 2017-11-30 2025-08-04 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 유방암 검출방법
US11648551B2 (en) 2017-12-12 2023-05-16 Essenlix Corporation Sample manipulation and assay with rapid temperature change
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
US20200347461A1 (en) 2018-01-17 2020-11-05 The Regents Of The University Of California Phenotypic age and dna methylation based biomarkers for life expectancy and morbidity
US11976332B2 (en) 2018-02-14 2024-05-07 Dermtech, Inc. Gene classifiers and uses thereof in non-melanoma skin cancers
WO2020076983A1 (en) 2018-10-10 2020-04-16 The Regents Of The University Of California Dna methylation based biomarkers for life expectancy and morbidity
US12404540B2 (en) 2018-10-17 2025-09-02 The University Of Queensland Epigenetic biomarker and uses therefor
EP3880847B1 (en) 2018-11-16 2025-09-03 Oslo Universitetssykehus HF Methods and compositions for characterizing bladder cancer
US20220090200A1 (en) 2019-01-18 2022-03-24 The Regents Of The University Of California Dna methylation measurement for mammals based on conserved loci
EP3962920A4 (en) * 2019-04-22 2023-06-07 Behavioral Diagnostics, LLC COMPOSITIONS AND METHODS FOR CORRECTING CELL MIXTURE IN EPIGENETIC ANALYZES
EP3976816A4 (en) 2019-05-28 2023-10-25 Case Western Reserve University COMPOSITIONS AND METHODS FOR PRESERVING DNA METHYLATION
US11396679B2 (en) 2019-05-31 2022-07-26 Universal Diagnostics, S.L. Detection of colorectal cancer
US11001898B2 (en) 2019-05-31 2021-05-11 Universal Diagnostics, S.L. Detection of colorectal cancer
WO2021050962A1 (en) 2019-09-11 2021-03-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cancer detection and classification
WO2021087275A1 (en) 2019-10-31 2021-05-06 Mayo Foundation For Medical Education And Research Detecting ovarian cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN115398548A (zh) * 2020-02-06 2022-11-25 昂科霍斯特公司 疗法响应的机器学习预测
CN119685477A (zh) 2020-03-20 2025-03-25 上海鹍远健康科技有限公司 筛查结直肠瘤的方法和试剂盒
WO2021228418A1 (en) 2020-05-15 2021-11-18 Universal Diagnostics, S.L. Methods and systems for identifying methylation biomarkers
AU2021281223A1 (en) 2020-05-27 2023-01-05 Case Western Reserve University Compositions and methods for preserving DNA methylation
JP2023540161A (ja) * 2020-06-29 2023-09-22 ペンタベース エーピーエス メチル化状態の検出
US11530453B2 (en) 2020-06-30 2022-12-20 Universal Diagnostics, S.L. Systems and methods for detection of multiple cancer types
CA3188230A1 (en) 2020-08-19 2022-02-24 John B. Kisiel Detecting non-hodgkin lymphoma
WO2022165247A1 (en) 2021-01-29 2022-08-04 Mayo Foundation For Medical Education And Research Detecting the presence or absence of multiple types of cancer
US20240410004A1 (en) 2021-09-30 2024-12-12 Tivenix Sa A method for diagnosing and predicting progression of neurodegenerative diseases or disorders
EP4419717B1 (en) 2021-10-19 2025-12-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Dna methylation signature for diagnosing hepatocellular carcinoma
EP4170661A1 (en) 2021-10-19 2023-04-26 Institut National de la Santé et de la Recherche Médicale (INSERM) Methylation profile analysis using smoothing method
US20250210133A1 (en) 2022-03-15 2025-06-26 Genknowme S.A. Method Determining the Difference Between the Biological Age and the Chronological Age of a Subject
EP4299764A1 (en) 2022-06-28 2024-01-03 Universal Diagnostics, S.A. Methods for detecting pancreatic cancer using dna methylation markers
WO2024105132A1 (en) 2022-11-16 2024-05-23 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using dna methylation markers
WO2024256726A1 (en) 2023-06-15 2024-12-19 Genknowme S.A. Computer implemented method determining a value of allostatic load of a human being

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
EP0464147B1 (en) * 1989-03-21 2002-06-26 THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE Matrix metalloproteinase inhibitor peptides
US5324634A (en) * 1992-03-31 1994-06-28 The Research Foundation Of State University Of New York Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer
IL108978A (en) * 1994-03-15 1998-02-22 Yissum Res Dev Co Assay for monitoring the progress of cml
US5856094A (en) * 1995-05-12 1999-01-05 The Johns Hopkins University School Of Medicine Method of detection of neoplastic cells
US5871917A (en) * 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids

Also Published As

Publication number Publication date
EP0954608B1 (en) 2006-05-17
JP2000511776A (ja) 2000-09-12
US6265171B1 (en) 2001-07-24
US6017704A (en) 2000-01-25
CA2257104C (en) 2008-01-29
PT954608E (pt) 2006-08-31
EP0954608A1 (en) 1999-11-10
CA2257104A1 (en) 1997-12-11
JP2004290200A (ja) 2004-10-21
JP3725535B2 (ja) 2005-12-14
ATE326549T1 (de) 2006-06-15
IL127342A (en) 2002-07-25
WO1997046705A1 (en) 1997-12-11
ES2264165T3 (es) 2006-12-16
DE69735894D1 (de) 2006-06-22
EP1690948A3 (en) 2006-11-22
EP0954608A4 (en) 2003-09-10
IL127342A0 (en) 1999-10-28
DE69735894T2 (de) 2007-04-19
JP3612080B2 (ja) 2005-01-19
EP1690948A2 (en) 2006-08-16

Similar Documents

Publication Publication Date Title
DK0954608T3 (da) Methyleringsspecifik påvisning
DE69816286D1 (de) Verfahren zur Erkennung von Nukleinsäuremethylierungen durch AFLP
IL130477A0 (en) Processes for amplifying nucleic acid
EP2287308A3 (en) Materials and methods for identifying and analyzing intermediate tandem repeat DNA markers
AU4700699A (en) Nucleotide detection method
AU3027699A (en) Nucleic acid analysis method
EP1961826A3 (en) A method for direct nucleic acid sequencing
AU2003220291A8 (en) Discovery and diagnostic methods using 5-methylcytosine dna glycosylase
IL144374A0 (en) Method of identifying cytosine methylation patterns in genomic dna samples
DE10083729D2 (de) Verfahren zur parallelen Detektion des Methylierungszustandes von genomischer DNA
ATE473296T1 (de) Verfahren zum nachweis abnormal methylierter nukleinsäure in heterogenen biologischen proben
WO2001077383A3 (en) Nucleic acid detection medium
AU5062500A (en) Primers for identifying typing or classifying nucleic acids
IL142323A0 (en) A method for analyzing polynucleotides
IL143176A (en) Method for identifying cytosine methylation patterns in genomic dna
AU2001242277A1 (en) Method for detecting cytosine methylation in DNA samples
DE602004004988D1 (de) Methylierungsstatus-Detektionsassays mittels methylierungsspezifischer Primerextension (MSPE)
WO2002046454A3 (de) Diagnose von mit angiogenese assoziierten krankheiten durch bestimmung der methylierung von mit angiogenese assoziierten genen
WO2001009384A3 (en) Serial analysis of genetic alterations
WO2001066797A3 (en) Multiplex hybridization system for identification of pathogenic mycobacterium and method of use
WO2001029262A3 (en) Genotyping reagents, kits and methods of use thereof
WO2001027317A3 (de) Verfahren zur unterscheidung von 5-position methylierungsänderungen
WO2002012554A3 (de) Diagnose von mit cd24 assoziierten krankheiten
WO1999066077A3 (en) Methods for the detection of nucleic acids
WO2002103041A3 (en) Method and nucleic acids for the differentiation of prostate and renal carcinomas