DK0948541T3 - Analoge af PTHrP - Google Patents

Analoge af PTHrP

Info

Publication number
DK0948541T3
DK0948541T3 DK97951595T DK97951595T DK0948541T3 DK 0948541 T3 DK0948541 T3 DK 0948541T3 DK 97951595 T DK97951595 T DK 97951595T DK 97951595 T DK97951595 T DK 97951595T DK 0948541 T3 DK0948541 T3 DK 0948541T3
Authority
DK
Denmark
Prior art keywords
pthrp
analogs
parathyroid hormone
pth
acc
Prior art date
Application number
DK97951595T
Other languages
Danish (da)
English (en)
Inventor
Zheng Xin Dong
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/779,768 external-priority patent/US5969095A/en
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Application granted granted Critical
Publication of DK0948541T3 publication Critical patent/DK0948541T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK97951595T 1997-01-07 1997-12-08 Analoge af PTHrP DK0948541T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/779,768 US5969095A (en) 1995-07-13 1997-01-07 Analogs of parathyroid hormone
US08/813,534 US5955574A (en) 1995-07-13 1997-03-07 Analogs of parathyroid hormone

Publications (1)

Publication Number Publication Date
DK0948541T3 true DK0948541T3 (da) 2006-07-17

Family

ID=27119618

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05026436.5T DK1645566T3 (da) 1997-01-07 1997-12-08 Parathyroidhormonanaloger
DK97951595T DK0948541T3 (da) 1997-01-07 1997-12-08 Analoge af PTHrP

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05026436.5T DK1645566T3 (da) 1997-01-07 1997-12-08 Parathyroidhormonanaloger

Country Status (24)

Country Link
US (1) US5955574A (ko)
EP (3) EP2206725A1 (ko)
JP (1) JP3963482B2 (ko)
KR (2) KR100497709B1 (ko)
CN (1) CN1137898C (ko)
AR (3) AR011517A1 (ko)
AT (2) ATE321784T1 (ko)
AU (1) AU741584B2 (ko)
BR (1) BR9714200A (ko)
CA (1) CA2276614C (ko)
CZ (2) CZ301497B6 (ko)
DE (2) DE69739912D1 (ko)
DK (2) DK1645566T3 (ko)
ES (2) ES2258286T3 (ko)
HK (1) HK1026215A1 (ko)
HU (1) HUP9904596A3 (ko)
IL (1) IL130794A0 (ko)
NO (1) NO993341L (ko)
NZ (1) NZ336610A (ko)
PL (1) PL191898B1 (ko)
PT (2) PT1645566E (ko)
RU (1) RU2198182C2 (ko)
SI (2) SI1645566T1 (ko)
WO (1) WO1998030590A2 (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410948B2 (en) * 1995-07-13 2008-08-12 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Analogs of parathyroid hormone
US6544949B1 (en) 1995-07-13 2003-04-08 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Analogs of parathyroid hormone
EP1005359B1 (en) 1997-09-09 2005-06-15 F. Hoffmann-La Roche Ag FRACTURE HEALING USING PTHrP ANALOGS
CA2327509A1 (en) * 1998-05-05 1999-11-11 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Pth2 receptor selective compounds
AU3826899A (en) * 1998-07-20 2000-02-14 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Peptide analogues of pacap
US6660843B1 (en) † 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
WO2001060862A1 (en) * 2000-02-18 2001-08-23 Dabur Research Foundation Vasoactive intestinal peptide analogs
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
DE60218842T2 (de) * 2001-06-01 2007-12-20 Novartis Ag Orale verabreichung von parathyroidhormon und calcitonin
WO2003009804A2 (en) * 2001-07-23 2003-02-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (pth) analogs
JP2007501241A (ja) * 2003-08-06 2007-01-25 ローディア インコーポレイティド 骨成長を促進する方法
AU2006315132A1 (en) 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
US7803770B2 (en) 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
BRPI0719821B8 (pt) * 2006-10-03 2021-05-25 Ipsen Pharma Sas composição estável na armazenagem apropriada para administração a pacientes
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
US7820179B2 (en) * 2006-10-13 2010-10-26 Eli Lilly And Company Pegylated PTH as PTH receptor modulators and uses thereof
BRPI0814962B8 (pt) 2007-08-01 2021-05-25 Chugai Pharmaceutical Co Ltd métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica
CN102448482A (zh) 2009-03-27 2012-05-09 范安德尔研究所 甲状旁腺素肽和甲状旁腺素相关蛋白肽及使用方法
EP2509996A1 (en) 2009-12-07 2012-10-17 Michigan Technological University Black bear parathyroid hormone and methods of using black bear parathyroid hormone
EP3106159A1 (en) 2010-05-12 2016-12-21 Radius Health, Inc. Therapeutic regimens
RU2604809C2 (ru) 2010-05-13 2016-12-10 Дзе Дженерал Хоспитал Корпорейшн Аналоги паратиреоидного гормона и их применение
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
MX2017013802A (es) 2015-04-29 2018-08-15 Radius Pharmaceuticals Inc Métodos para tratar el cáncer.
CN108025042A (zh) * 2015-07-06 2018-05-11 董正欣 PTHrP类似物的新型制剂
RU2022108295A (ru) 2016-06-22 2022-04-06 Эллипсес Фарма Лтд Способы лечения ar+ рака молочной железы
KR102557321B1 (ko) 2017-01-05 2023-07-18 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP3817821A1 (en) 2018-07-04 2021-05-12 Radius Pharmaceuticals, Inc. Polymorphic forms of rad 1901-2hcl

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
EP0293158A3 (en) * 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroid hormone antagonists
US5457047A (en) * 1989-02-23 1995-10-10 Gesellschaft Fur Biotechnologische Forschung Mbh (Gbf) DNA Sequences coding for PTH variants, PTH variants, expression vector, bacterial host, use and therapeutic composition
CA2040264A1 (en) * 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
JPH0532696A (ja) * 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
WO1993006846A1 (en) * 1991-10-10 1993-04-15 Pang Peter K T Parathyroid hormone analogues and use in osteoporosis treatment
US5434246A (en) * 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
CA2098639A1 (en) * 1992-06-19 1993-12-20 K. Anne Kronis Bone stimulating, non-vasoactive parathyroid hormone variants
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5821225A (en) * 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
SK74495A3 (en) 1993-01-06 1997-01-08 Kinerton Ltd Ionic molecular conjugates of biodegradable polyesters with bioactive polypeptides and a method of preparation thereof
CN1070500C (zh) * 1993-07-13 2001-09-05 森德克斯(美国)股份有限公司 甲状旁腺激素类似物和甲状旁腺激素相关肽：合成和治疗骨质疏松症的用途
JPH10511095A (ja) * 1994-12-19 1998-10-27 ベス イスラエル ディーコネス メディカル センター インコーポレイテッド 副甲状腺ホルモン又はその作動薬の低用量継続投与
CA2178894A1 (en) * 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone

Also Published As

Publication number Publication date
CZ301497B6 (cs) 2010-03-24
KR20060030006A (ko) 2006-04-07
NO993341D0 (no) 1999-07-06
PL191898B1 (pl) 2006-07-31
AR038552A2 (es) 2005-01-19
CN1137898C (zh) 2004-02-11
HUP9904596A3 (en) 2000-07-28
KR20000069952A (ko) 2000-11-25
PT1645566E (pt) 2010-08-31
ES2258286T3 (es) 2006-08-16
CZ239899A3 (cs) 2000-01-12
PT948541E (pt) 2006-07-31
EP0948541A2 (en) 1999-10-13
WO1998030590A3 (en) 1998-12-10
KR100699422B1 (ko) 2007-03-28
EP0948541B1 (en) 2006-03-29
CA2276614C (en) 2002-06-11
CN1254347A (zh) 2000-05-24
EP1645566A2 (en) 2006-04-12
IL130794A0 (en) 2001-01-28
BR9714200A (pt) 2000-03-28
DE69735603T2 (de) 2006-11-30
AU741584B2 (en) 2001-12-06
AR051906A2 (es) 2007-02-14
AR011517A1 (es) 2000-08-30
NZ336610A (en) 2001-07-27
EP1645566A3 (en) 2006-10-11
CZ298937B6 (cs) 2008-03-19
EP1645566B1 (en) 2010-06-16
CA2276614A1 (en) 1998-07-16
PL334438A1 (en) 2000-02-28
NO993341L (no) 1999-09-06
JP2001508439A (ja) 2001-06-26
ES2347154T3 (es) 2010-10-26
DE69735603D1 (de) 2006-05-18
ATE321784T1 (de) 2006-04-15
DE69739912D1 (de) 2010-07-29
RU2198182C2 (ru) 2003-02-10
EP2206725A1 (en) 2010-07-14
US5955574A (en) 1999-09-21
DK1645566T3 (da) 2010-09-27
HK1026215A1 (en) 2000-12-08
SI0948541T1 (sl) 2006-06-30
JP3963482B2 (ja) 2007-08-22
HUP9904596A1 (hu) 2000-06-28
WO1998030590A2 (en) 1998-07-16
WO1998030590A9 (en) 1999-08-19
SI1645566T1 (sl) 2010-11-30
KR100497709B1 (ko) 2005-06-23
ATE471342T1 (de) 2010-07-15
AU5519998A (en) 1998-08-03

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