DK0726894T3 - Kortvarigt virkende dihydropyridiner - Google Patents
Kortvarigt virkende dihydropyridinerInfo
- Publication number
- DK0726894T3 DK0726894T3 DK95900347T DK95900347T DK0726894T3 DK 0726894 T3 DK0726894 T3 DK 0726894T3 DK 95900347 T DK95900347 T DK 95900347T DK 95900347 T DK95900347 T DK 95900347T DK 0726894 T3 DK0726894 T3 DK 0726894T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- pct
- chloro
- methyl
- nitro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9303657A SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Short-acting dihydropyridines |
| PCT/SE1994/001031 WO1995012578A1 (en) | 1993-11-05 | 1994-11-03 | Short-acting dihydropyridines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0726894T3 true DK0726894T3 (da) | 2000-10-23 |
Family
ID=20391655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95900347T DK0726894T3 (da) | 1993-11-05 | 1994-11-03 | Kortvarigt virkende dihydropyridiner |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US5856346A (ru) |
| EP (1) | EP0726894B1 (ru) |
| JP (1) | JP3712209B2 (ru) |
| KR (1) | KR100331663B1 (ru) |
| CN (1) | CN1049428C (ru) |
| AT (1) | ATE194330T1 (ru) |
| AU (1) | AU685532B2 (ru) |
| BR (1) | BR9407946A (ru) |
| CA (1) | CA2174969C (ru) |
| CZ (1) | CZ285691B6 (ru) |
| DE (1) | DE69425152T2 (ru) |
| DK (1) | DK0726894T3 (ru) |
| EE (1) | EE03230B1 (ru) |
| EG (1) | EG20539A (ru) |
| ES (1) | ES2150544T3 (ru) |
| FI (1) | FI110429B (ru) |
| FR (1) | FR12C0053I2 (ru) |
| GR (1) | GR3034469T3 (ru) |
| HK (1) | HK1013292A1 (ru) |
| HU (1) | HU215591B (ru) |
| IL (1) | IL111127A (ru) |
| IS (1) | IS1674B (ru) |
| LU (1) | LU92209I2 (ru) |
| MY (1) | MY111770A (ru) |
| NO (1) | NO305656B1 (ru) |
| NZ (1) | NZ275915A (ru) |
| PL (1) | PL185099B1 (ru) |
| PT (1) | PT726894E (ru) |
| RU (1) | RU2139278C1 (ru) |
| SA (1) | SA94150250B1 (ru) |
| SE (1) | SE9303657D0 (ru) |
| SK (1) | SK281467B6 (ru) |
| TW (1) | TW279859B (ru) |
| UA (1) | UA45959C2 (ru) |
| WO (1) | WO1995012578A1 (ru) |
| ZA (1) | ZA947570B (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9804002D0 (sv) * | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
| WO2003059193A2 (en) * | 2001-12-21 | 2003-07-24 | Alcon, Inc. | Use of nanoparticles as carriers for biocides in ophthalmic compositions |
| FR2922439B1 (fr) * | 2007-10-18 | 2010-12-10 | Hill Rom Ind Sa | Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre |
| BRPI0916936B8 (pt) | 2008-08-01 | 2021-05-25 | Chiesi Farm Spa | composições farmacêuticas, uso de clevidipina e método de reduzir impurezas. |
| ES2543470T3 (es) * | 2009-09-30 | 2015-08-19 | Microdose Therapeutx, Inc. | Métodos y composiciones para el tratamiento del fenómeno de Raynaud |
| CN101780036B (zh) * | 2010-03-30 | 2011-11-16 | 武汉武药科技有限公司 | 丁酸氯维地平脂微球注射液及其制备方法 |
| CA2701087A1 (en) * | 2010-04-12 | 2011-10-12 | Alphora Research Inc. | Preparation of clevidipine butyrate ring the same |
| US8455655B2 (en) | 2010-05-07 | 2013-06-04 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
| EP2386544B1 (en) | 2010-05-07 | 2016-02-10 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
| US8658676B2 (en) | 2010-10-12 | 2014-02-25 | The Medicines Company | Clevidipine emulsion formulations containing antimicrobial agents |
| MX2013004151A (es) | 2010-10-12 | 2013-05-20 | Medicines Co | Formulaciones de emulsion de clevidipina que contienen agentes antimicrobianos. |
| JP2014509654A (ja) * | 2011-04-01 | 2014-04-21 | ザ メディシンズ カンパニー | 脳卒中損傷の低減に使用するための短時間作用型ジヒドロピリジン（クレビジピン） |
| CN103906508A (zh) | 2011-08-26 | 2014-07-02 | 沃克哈特有限公司 | 治疗心血管疾病的方法 |
| CN103420899B (zh) * | 2012-05-25 | 2016-01-27 | 四川科伦药物研究有限公司 | 一种丁酸氯维地平的纯化方法 |
| CN110840890A (zh) | 2012-10-26 | 2020-02-28 | 凯西制药公司 | 用于在心力衰竭中控制血压和减轻呼吸困难的方法 |
| CN103073485B (zh) * | 2013-01-17 | 2015-09-02 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平的制备方法 |
| CN103086956B (zh) * | 2013-01-17 | 2015-11-04 | 北京嘉林药业股份有限公司 | 一种丁酸氯维地平中间体的纯化方法 |
| CN106456617A (zh) | 2014-05-19 | 2017-02-22 | 医药公司 | 氯维地平纳米颗粒及其药物组合物 |
| CN105367487A (zh) * | 2014-08-23 | 2016-03-02 | 南京海纳医药科技有限公司 | 一种丁酸氯维地平重要中间体新的合成方法 |
| CN104370802A (zh) * | 2014-09-24 | 2015-02-25 | 北京蓝丹医药科技有限公司 | 氯维地平衍生物及其制备方法 |
| JP7045191B2 (ja) | 2015-05-20 | 2022-03-31 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性デプシペプチド化合物 |
| JP6943859B2 (ja) | 2015-12-28 | 2021-10-06 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性デプシペプチド化合物 |
| JP2020504710A (ja) | 2016-11-16 | 2020-02-13 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 駆虫性デプシペプチド化合物 |
| RU2755349C1 (ru) * | 2021-02-16 | 2021-09-15 | Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") | Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117571C3 (de) * | 1971-04-10 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| US4154839A (en) * | 1975-11-05 | 1979-05-15 | Bayer Aktiengesellschaft | 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| KR940003492B1 (ko) * | 1988-10-27 | 1994-04-23 | 주식회사 유한양행 | 1,4-디하이드로피리딘유도체 및 그의 제조방법 |
| US5134139A (en) * | 1989-08-31 | 1992-07-28 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and preparation thereof |
| JPH0641075A (ja) * | 1990-09-01 | 1994-02-15 | Kazuo Achinami | 新規な１，４−ジヒドロピリジン化合物及びその製造方法 |
-
1993
- 1993-11-05 SE SE9303657A patent/SE9303657D0/xx unknown
-
1994
- 1994-09-28 ZA ZA947570A patent/ZA947570B/xx unknown
- 1994-09-29 TW TW083108995A patent/TW279859B/zh not_active IP Right Cessation
- 1994-09-30 IS IS4218A patent/IS1674B/is unknown
- 1994-10-03 IL IL11112794A patent/IL111127A/xx not_active IP Right Cessation
- 1994-10-19 SA SA94150250A patent/SA94150250B1/ar unknown
- 1994-11-02 EG EG68994A patent/EG20539A/xx active
- 1994-11-03 CZ CZ961273A patent/CZ285691B6/cs not_active IP Right Cessation
- 1994-11-03 UA UA96041753A patent/UA45959C2/uk unknown
- 1994-11-03 US US08/356,224 patent/US5856346A/en not_active Expired - Lifetime
- 1994-11-03 EP EP95900347A patent/EP0726894B1/en not_active Expired - Lifetime
- 1994-11-03 CN CN94194500A patent/CN1049428C/zh not_active Expired - Lifetime
- 1994-11-03 SK SK559-96A patent/SK281467B6/sk not_active IP Right Cessation
- 1994-11-03 EE EE9600051A patent/EE03230B1/xx unknown
- 1994-11-03 NZ NZ275915A patent/NZ275915A/en not_active IP Right Cessation
- 1994-11-03 HU HU9601187A patent/HU215591B/hu unknown
- 1994-11-03 CA CA002174969A patent/CA2174969C/en not_active Expired - Lifetime
- 1994-11-03 AU AU81196/94A patent/AU685532B2/en not_active Expired
- 1994-11-03 DE DE69425152T patent/DE69425152T2/de not_active Expired - Lifetime
- 1994-11-03 PL PL94314128A patent/PL185099B1/pl unknown
- 1994-11-03 WO PCT/SE1994/001031 patent/WO1995012578A1/en active IP Right Grant
- 1994-11-03 AT AT95900347T patent/ATE194330T1/de active
- 1994-11-03 DK DK95900347T patent/DK0726894T3/da active
- 1994-11-03 ES ES95900347T patent/ES2150544T3/es not_active Expired - Lifetime
- 1994-11-03 BR BR9407946A patent/BR9407946A/pt not_active Application Discontinuation
- 1994-11-03 KR KR1019960702346A patent/KR100331663B1/ko not_active IP Right Cessation
- 1994-11-03 PT PT95900347T patent/PT726894E/pt unknown
- 1994-11-03 JP JP51317095A patent/JP3712209B2/ja not_active Expired - Lifetime
- 1994-11-03 RU RU96112152A patent/RU2139278C1/ru active
- 1994-11-04 MY MYPI94002934A patent/MY111770A/en unknown
-
1996
- 1996-05-02 NO NO961776A patent/NO305656B1/no not_active IP Right Cessation
- 1996-05-06 FI FI961914A patent/FI110429B/fi not_active IP Right Cessation
-
1998
- 1998-12-22 HK HK98114638A patent/HK1013292A1/xx unknown
-
2000
- 2000-09-21 GR GR20000402158T patent/GR3034469T3/el unknown
-
2012
- 2012-09-18 FR FR12C0053C patent/FR12C0053I2/fr active Active
-
2013
- 2013-06-10 LU LU92209C patent/LU92209I2/fr unknown
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