DK0690864T3 - Krystallinsk ceftiofur på fri syreform - Google Patents
Krystallinsk ceftiofur på fri syreformInfo
- Publication number
- DK0690864T3 DK0690864T3 DK94910721T DK94910721T DK0690864T3 DK 0690864 T3 DK0690864 T3 DK 0690864T3 DK 94910721 T DK94910721 T DK 94910721T DK 94910721 T DK94910721 T DK 94910721T DK 0690864 T3 DK0690864 T3 DK 0690864T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- free acid
- acid form
- crystalline ceftiofur
- date sep
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- ZBHXIWJRIFEVQY-IHMPYVIRSA-N ceftiofur Chemical compound S([C@@H]1[C@@H](C(N1C=1C(O)=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1CSC(=O)C1=CC=CO1 ZBHXIWJRIFEVQY-IHMPYVIRSA-N 0.000 title abstract 2
- 229960005229 ceftiofur Drugs 0.000 title abstract 2
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3329193A | 1993-03-12 | 1993-03-12 | |
| PCT/US1994/001862 WO1994020505A1 (en) | 1993-03-12 | 1994-03-07 | Crystalline ceftiofur free acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0690864T3 true DK0690864T3 (da) | 2001-09-17 |
Family
ID=21869579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94910721T DK0690864T3 (da) | 1993-03-12 | 1994-03-07 | Krystallinsk ceftiofur på fri syreform |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5721359A (en:Method) |
| EP (1) | EP0690864B1 (en:Method) |
| JP (1) | JP3852946B2 (en:Method) |
| KR (1) | KR100296810B1 (en:Method) |
| CN (1) | CN1055090C (en:Method) |
| AT (1) | ATE202109T1 (en:Method) |
| AU (1) | AU694419B2 (en:Method) |
| BR (1) | BR1101034A (en:Method) |
| CA (1) | CA2155322C (en:Method) |
| CZ (1) | CZ289332B6 (en:Method) |
| DE (2) | DE122005000055I2 (en:Method) |
| DK (1) | DK0690864T3 (en:Method) |
| ES (1) | ES2157254T3 (en:Method) |
| FI (1) | FI120307B (en:Method) |
| FR (1) | FR05C0045I2 (en:Method) |
| GR (1) | GR3036514T3 (en:Method) |
| HU (1) | HU222244B1 (en:Method) |
| IL (1) | IL108910A (en:Method) |
| LU (1) | LU91206I2 (en:Method) |
| LV (1) | LV12889B (en:Method) |
| NL (1) | NL300208I2 (en:Method) |
| NO (2) | NO313199B1 (en:Method) |
| NZ (1) | NZ263002A (en:Method) |
| PL (1) | PL184611B1 (en:Method) |
| PT (1) | PT690864E (en:Method) |
| RU (1) | RU2136685C1 (en:Method) |
| SI (1) | SI0690864T1 (en:Method) |
| SK (1) | SK283674B6 (en:Method) |
| TW (1) | TW267170B (en:Method) |
| WO (1) | WO1994020505A1 (en:Method) |
| ZA (1) | ZA941586B (en:Method) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5736151A (en) * | 1996-12-09 | 1998-04-07 | Pharmacia & Upjohn Company | Antibiotic oil suspensions |
| US6074657A (en) * | 1997-03-20 | 2000-06-13 | Pharmacia & Upjohn Company | Administration of an injectable antibiotic in the ear of an animal |
| EP1317256B1 (en) * | 2000-09-12 | 2008-10-29 | Pharmacia & Upjohn Company LLC | Pharmaceutical composition having modified carrier |
| US7829100B2 (en) * | 2000-09-12 | 2010-11-09 | Teagarden Dirk L | Pharmaceutical composition having modified carrier |
| KR100423895B1 (ko) * | 2001-02-19 | 2004-03-24 | 주식회사 엘지생명과학 | 셉티오퍼 하이드로클로라이드의 현탁제 조성물 |
| CA2453182A1 (en) * | 2001-07-10 | 2003-01-23 | Meredith L. Greene | Crystalline thiazine oxazolidinones |
| EP1419151B1 (en) * | 2001-08-15 | 2014-02-26 | Pharmacia & Upjohn Company LLC | Chrystals including a malic acid salt of n-[2-(diethylamino)ethyl] -5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indole-3-ylidene)methyl] -2,4-dimethyl-1h-pyrrole-3-carboxamide, processes for its preparation and compositions thereof |
| BR0308523A (pt) † | 2002-03-21 | 2005-02-01 | Upjohn Co | Método de administração de um antibiótico injetável à orelha de um animal |
| US20040022815A1 (en) * | 2002-08-05 | 2004-02-05 | Orchid Health Care | Novel pharmaceutical composition of ceftiofur |
| KR20040015622A (ko) * | 2002-08-13 | 2004-02-19 | 대한뉴팜(주) | 세프티오푸르나트륨을 활성성분으로 함유하는 현탁주사액조성물 |
| US20040115822A1 (en) * | 2002-09-12 | 2004-06-17 | Schapaugh Randal Lee | Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition |
| US7659061B2 (en) * | 2002-11-19 | 2010-02-09 | Pharmacia & Upjohn Company | Pharmaceutical compositions having a modified vehicle |
| US20040115837A1 (en) * | 2002-11-27 | 2004-06-17 | Schapaugh Randal Lee | Methods of measuring the dissolution rate of an analyte in a non-aqueous liquid composition |
| US7842791B2 (en) * | 2002-12-19 | 2010-11-30 | Nancy Jean Britten | Dispersible pharmaceutical compositions |
| PT1606293E (pt) * | 2003-03-27 | 2009-10-14 | Basilea Pharmaceutica Ag | Cefalosporina sob forma cristalina |
| US8039482B2 (en) * | 2004-03-25 | 2011-10-18 | Astellas Pharma Inc. | Composition of solifenacin or salt thereof for use in solid formulation |
| US7815939B2 (en) | 2005-07-20 | 2010-10-19 | Astellas Pharma Inc. | Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms |
| US8212024B2 (en) * | 2005-10-12 | 2012-07-03 | Orchid Chemicals & Pharmaceuticals Ltd. | Crystalline sodium salt of cephalosporin antibiotic |
| US8470809B2 (en) * | 2005-10-12 | 2013-06-25 | Orchid Chemicals & Pharmaceuticals Limited | Crystalline sodium salt of cephalosporin antibiotic |
| WO2009024823A2 (en) | 2007-08-22 | 2009-02-26 | Astrazeneca Ab | Oxadiazole derivatives as dgat inhibitors |
| EP2303026B1 (en) | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| US8431562B2 (en) * | 2008-08-22 | 2013-04-30 | Orchid Chemicals & Pharmaceuticals Limited | Crystalline sodium salt of cephalosporin antibiotic |
| AU2009316708B2 (en) * | 2008-11-19 | 2014-07-17 | Boehringer Ingelheim Animal Health USA Inc. | Formulations comprising ceftiofur and ketoprofen or ceftiofur and benzyl alcohol |
| US20110288142A1 (en) * | 2009-01-30 | 2011-11-24 | Chen Pingyun Y | CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
| TW201039825A (en) | 2009-02-20 | 2010-11-16 | Astrazeneca Ab | Cyclopropyl amide derivatives 983 |
| KR20130034009A (ko) * | 2010-02-18 | 2013-04-04 | 아스트라제네카 아베 | 시클로프로필 아미드 유도체를 포함하는 고체 형태 |
| US20110201623A1 (en) * | 2010-02-18 | 2011-08-18 | Uczynski Michael A | Crystalline Form Of A Cyclopropyl Benzamide Derivative |
| AU2012251438A1 (en) * | 2011-05-02 | 2013-11-14 | Pfizer Inc. | Novel cephalosporins useful as antibacterial agents |
| AU2012285816B2 (en) | 2011-07-20 | 2015-07-23 | Brigham Young University | Hydrophobic ceragenin compounds and devices incorporating same |
| RU2652308C2 (ru) | 2011-09-13 | 2018-04-25 | Брайем Янг Юниверсити | Способы и продукты для заживления ран тканей |
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| CN102584855B (zh) * | 2012-02-16 | 2014-06-25 | 青岛科技大学 | 一种改进的头孢噻呋的制备方法 |
| US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
| WO2013165574A2 (en) | 2012-05-02 | 2013-11-07 | Brigham Young University | Ceragenin particulate materials and methods for making same |
| EP2908826A1 (en) | 2012-10-17 | 2015-08-26 | Brigham Young University | Treatment and prevention of mastitis |
| JP6310396B2 (ja) * | 2012-12-03 | 2018-04-11 | 株式会社カネカ | 還元型補酵素ｑ１０誘導体およびその製造方法 |
| JP6294352B2 (ja) | 2013-01-07 | 2018-03-14 | ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ | 細胞増殖を減少させ、ある特定の疾患を治療する方法 |
| US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
| KR102282183B1 (ko) | 2013-03-15 | 2021-07-26 | 브라이엄 영 유니버시티 | 염증, 자가면역 장애 및 통증의 치료 방법 |
| RU2546675C2 (ru) * | 2013-04-11 | 2015-04-10 | Федеральное казённое предприятие "Государственный научно-исследовательский институт химических продуктов" (ФКП "ГосНИИХП") | Способ определения степени кристалличности составов на основе дифениламина |
| US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
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| US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
| US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
| CA2844321C (en) | 2014-02-27 | 2021-03-16 | Brigham Young University | Cationic steroidal antimicrobial compounds |
| US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
| US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
| US9931350B2 (en) | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
| US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
| US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
| US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
| US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
| US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
| CN111888368B (zh) | 2014-10-21 | 2024-02-02 | 武田药品工业株式会社 | 5-氯-n4-[2-(二甲基磷酰基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺的晶形 |
| WO2016172543A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| WO2016172553A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
| KR101753842B1 (ko) * | 2015-05-12 | 2017-07-04 | 한국화학연구원 | 불화퀴놀론계 항생제를 담지한 서방형 제제 및 이의 제조방법 |
| US9434759B1 (en) | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
| CN106543203B (zh) * | 2015-09-18 | 2019-07-02 | 瑞普（天津）生物药业有限公司 | 一种长效头孢噻呋自由酸晶体的制备方法 |
| JP7046815B2 (ja) * | 2016-01-22 | 2022-04-04 | サンド・アクチエンゲゼルシヤフト | 結晶質エラバサイクリンビス塩酸塩 |
| US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
| KR101898282B1 (ko) * | 2016-05-24 | 2018-09-13 | 주식회사 고려비엔피 | 항생제의 서방형 수의학적 조성물 및 이의 제조방법 |
| MX389964B (es) * | 2016-07-07 | 2025-03-19 | Cyclerion Therapeutics Inc | Formas sólidas de un estimulador de guanilato ciclasa soluble (sgc). |
| US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
| US11186556B1 (en) * | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
| UA119735C2 (uk) | 2018-12-20 | 2019-07-25 | Анатолій Семенович Редер | Фармацевтична сполука, спосіб її отримання та застосування як лікарського засобу |
| US12186328B2 (en) | 2019-05-23 | 2025-01-07 | Brigham Young University | Use of CSA compounds to stimulate stem cells and hair growth |
| TW202233625A (zh) * | 2020-11-18 | 2022-09-01 | 美商傳達治療有限公司 | Ｆｇｆｒ抑制劑及其製造及使用方法 |
| CN117229296A (zh) * | 2023-09-14 | 2023-12-15 | 广东温氏大华农生物科技有限公司 | 一种头孢噻呋酸晶体及其制备方法与应用 |
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| DE1207933B (de) * | 1962-12-26 | 1965-12-30 | American Home Prod | Verfahren zur Herstellung von kristallwasser-freiem D-alpha-Aminobenzylpenicillin |
| US3489750A (en) * | 1967-09-05 | 1970-01-13 | Bristol Myers Co | 7-amino-cephalosporanic and decephalosporanic acid derivatives |
| DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
| DE2760123C2 (de) * | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| GB1532682A (en) * | 1976-04-27 | 1978-11-22 | Bristol Myers Co | Process for the preparation of cephadroxil |
| FR2479229B1 (fr) * | 1980-03-26 | 1986-01-17 | Clin Midy | Nouveaux derives des cephalosporines, leur procede de preparation et les medicaments utilisables comme antibiotiques qui contiennent lesdits derives |
| IL63968A (en) * | 1980-10-01 | 1985-10-31 | Glaxo Group Ltd | Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it |
| US4400503A (en) * | 1981-10-30 | 1983-08-23 | Eli Lilly And Company | Purification of syn-7-[[(2-amino-4-thiazolyl)(methoxyimino) acetyl]amino]-3-methyl-3-cephem-4-carboxylic acid |
| DE3313818A1 (de) * | 1983-04-16 | 1984-10-18 | Hoechst Ag, 6230 Frankfurt | Neue kristallmodifikation von ceftazidim |
| HU196714B (en) * | 1984-10-04 | 1989-01-30 | Monsanto Co | Process for producing non-aqueous composition comprising somatotropin |
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-
1994
- 1994-03-07 JP JP52002594A patent/JP3852946B2/ja not_active Expired - Lifetime
- 1994-03-07 CA CA002155322A patent/CA2155322C/en not_active Expired - Lifetime
- 1994-03-07 ES ES94910721T patent/ES2157254T3/es not_active Expired - Lifetime
- 1994-03-07 WO PCT/US1994/001862 patent/WO1994020505A1/en active IP Right Grant
- 1994-03-07 AU AU63510/94A patent/AU694419B2/en not_active Expired
- 1994-03-07 ZA ZA941586A patent/ZA941586B/xx unknown
- 1994-03-07 HU HU9501960A patent/HU222244B1/hu active Protection Beyond IP Right Term
- 1994-03-07 NZ NZ263002A patent/NZ263002A/en not_active IP Right Cessation
- 1994-03-07 DE DE122005000055C patent/DE122005000055I2/de active Active
- 1994-03-07 RU RU95121942A patent/RU2136685C1/ru active
- 1994-03-07 US US08/549,821 patent/US5721359A/en not_active Expired - Lifetime
- 1994-03-07 CN CN94191448A patent/CN1055090C/zh not_active Expired - Lifetime
- 1994-03-07 EP EP94910721A patent/EP0690864B1/en not_active Expired - Lifetime
- 1994-03-07 PL PL94310556A patent/PL184611B1/pl unknown
- 1994-03-07 SK SK1114-95A patent/SK283674B6/sk not_active IP Right Cessation
- 1994-03-07 SI SI9430374T patent/SI0690864T1/xx unknown
- 1994-03-07 PT PT94910721T patent/PT690864E/pt unknown
- 1994-03-07 DK DK94910721T patent/DK0690864T3/da active
- 1994-03-07 CZ CZ19952290A patent/CZ289332B6/cs unknown
- 1994-03-07 DE DE69427469T patent/DE69427469T2/de not_active Expired - Lifetime
- 1994-03-07 KR KR1019950703858A patent/KR100296810B1/ko not_active Expired - Lifetime
- 1994-03-07 AT AT94910721T patent/ATE202109T1/de active
- 1994-03-09 IL IL10891094A patent/IL108910A/en not_active IP Right Cessation
- 1994-03-12 TW TW083102155A patent/TW267170B/zh not_active IP Right Cessation
-
1995
- 1995-09-11 NO NO19953564A patent/NO313199B1/no not_active IP Right Cessation
- 1995-09-11 FI FI954250A patent/FI120307B/fi not_active IP Right Cessation
-
1997
- 1997-05-14 BR BR1101034-7A patent/BR1101034A/pt active IP Right Grant
-
2001
- 2001-09-04 GR GR20010401374T patent/GR3036514T3/el unknown
-
2002
- 2002-06-13 LV LVP-02-107A patent/LV12889B/lv unknown
-
2005
- 2005-11-16 LU LU91206C patent/LU91206I2/fr unknown
- 2005-11-17 FR FR05C0045C patent/FR05C0045I2/fr active Active
- 2005-11-18 NO NO2005025C patent/NO2005025I2/no unknown
- 2005-11-21 NL NL300208C patent/NL300208I2/nl unknown
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