DK0652868T3 - Hæmmere af c-AMP-phosphodiesterase - Google Patents
Hæmmere af c-AMP-phosphodiesteraseInfo
- Publication number
- DK0652868T3 DK0652868T3 DK93917937T DK93917937T DK0652868T3 DK 0652868 T3 DK0652868 T3 DK 0652868T3 DK 93917937 T DK93917937 T DK 93917937T DK 93917937 T DK93917937 T DK 93917937T DK 0652868 T3 DK0652868 T3 DK 0652868T3
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- directed
- amp phosphodiesterase
- inhibitors
- pharmaceutical use
- Prior art date
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
- C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
- C07C217/88—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
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- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
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- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
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Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929216006A GB9216006D0 (en) | 1992-07-28 | 1992-07-28 | New use |
GB929216008A GB9216008D0 (en) | 1992-07-28 | 1992-07-28 | Novel compositions of matter |
GB929216005A GB9216005D0 (en) | 1992-07-28 | 1992-07-28 | New compounds |
GB929215989A GB9215989D0 (en) | 1992-07-28 | 1992-07-28 | Novel compounds |
GB929216764A GB9216764D0 (en) | 1992-08-07 | 1992-08-07 | Novel compounds |
GB939310633A GB9310633D0 (en) | 1993-05-21 | 1993-05-21 | New compositions of matter |
GB939310938A GB9310938D0 (en) | 1993-05-27 | 1993-05-27 | New compositions of matter |
GB939311281A GB9311281D0 (en) | 1993-06-01 | 1993-06-01 | Novel composition of matter |
GB939314847A GB9314847D0 (en) | 1993-07-16 | 1993-07-16 | New use |
PCT/GB1993/001597 WO1994002465A1 (en) | 1992-07-28 | 1993-07-28 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF |
Publications (1)
Publication Number | Publication Date |
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DK0652868T3 true DK0652868T3 (da) | 2005-02-14 |
Family
ID=27576348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93917937T DK0652868T3 (da) | 1992-07-28 | 1993-07-28 | Hæmmere af c-AMP-phosphodiesterase |
Country Status (18)
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EP (1) | EP0652868B1 (de) |
JP (1) | JP3775684B2 (de) |
AT (1) | ATE282025T1 (de) |
AU (1) | AU4717693A (de) |
CA (1) | CA2140441C (de) |
CZ (1) | CZ14795A3 (de) |
DE (1) | DE69333688T2 (de) |
DK (1) | DK0652868T3 (de) |
ES (1) | ES2227519T3 (de) |
FI (1) | FI950375A (de) |
HU (1) | HUT72656A (de) |
IL (1) | IL106517A0 (de) |
MX (1) | MX9304571A (de) |
NO (1) | NO950319L (de) |
NZ (1) | NZ254881A (de) |
PL (1) | PL307265A1 (de) |
PT (1) | PT652868E (de) |
WO (1) | WO1994002465A1 (de) |
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KR102192739B1 (ko) | 2012-12-05 | 2020-12-18 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 |
AU2014218599C1 (en) | 2013-02-25 | 2018-09-06 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists for use in colonic cleansing |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス,インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
JP2017222576A (ja) * | 2014-10-31 | 2017-12-21 | 石原産業株式会社 | 有害生物防除剤 |
CN109134358B (zh) * | 2018-09-20 | 2020-08-04 | 浙江理工大学 | 一种3,5-二溴-4-氨基吡啶的合成方法 |
JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス, インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
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GB9007762D0 (en) * | 1990-04-05 | 1990-06-06 | Beecham Group Plc | Novel compounds |
US5393788A (en) * | 1990-07-10 | 1995-02-28 | Smithkline Beecham Corporation | Phenylalkyl oxamides |
US5124455A (en) * | 1990-08-08 | 1992-06-23 | American Home Products Corporation | Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents |
CA2095429A1 (en) * | 1990-11-06 | 1992-05-07 | Paul E. Bender | Imidazolidinone compounds |
IE71647B1 (en) * | 1991-01-28 | 1997-02-26 | Rhone Poulenc Rorer Ltd | Benzamide derivatives |
-
1993
- 1993-07-28 PL PL93307265A patent/PL307265A1/xx unknown
- 1993-07-28 PT PT93917937T patent/PT652868E/pt unknown
- 1993-07-28 NZ NZ254881A patent/NZ254881A/en unknown
- 1993-07-28 EP EP93917937A patent/EP0652868B1/de not_active Expired - Lifetime
- 1993-07-28 CZ CZ95147A patent/CZ14795A3/cs unknown
- 1993-07-28 DK DK93917937T patent/DK0652868T3/da active
- 1993-07-28 WO PCT/GB1993/001597 patent/WO1994002465A1/en active IP Right Grant
- 1993-07-28 AU AU47176/93A patent/AU4717693A/en not_active Abandoned
- 1993-07-28 MX MX9304571A patent/MX9304571A/es unknown
- 1993-07-28 AT AT93917937T patent/ATE282025T1/de active
- 1993-07-28 DE DE69333688T patent/DE69333688T2/de not_active Expired - Lifetime
- 1993-07-28 IL IL10651793A patent/IL106517A0/xx unknown
- 1993-07-28 HU HU9500265A patent/HUT72656A/hu unknown
- 1993-07-28 ES ES93917937T patent/ES2227519T3/es not_active Expired - Lifetime
- 1993-07-28 JP JP50433094A patent/JP3775684B2/ja not_active Expired - Lifetime
- 1993-07-28 CA CA002140441A patent/CA2140441C/en not_active Expired - Lifetime
-
1995
- 1995-01-27 FI FI950375A patent/FI950375A/fi unknown
- 1995-01-27 NO NO950319A patent/NO950319L/no unknown
Also Published As
Publication number | Publication date |
---|---|
HU9500265D0 (en) | 1995-03-28 |
NZ254881A (en) | 1996-09-25 |
NO950319D0 (no) | 1995-01-27 |
JPH08503925A (ja) | 1996-04-30 |
IL106517A0 (en) | 1994-08-26 |
EP0652868A1 (de) | 1995-05-17 |
HUT72656A (en) | 1996-05-28 |
PL307265A1 (en) | 1995-05-15 |
CZ14795A3 (en) | 1996-07-17 |
WO1994002465A1 (en) | 1994-02-03 |
PT652868E (pt) | 2005-01-31 |
NO950319L (no) | 1995-03-27 |
FI950375A0 (fi) | 1995-01-27 |
ATE282025T1 (de) | 2004-11-15 |
CA2140441C (en) | 2006-11-21 |
FI950375A (fi) | 1995-01-27 |
EP0652868B1 (de) | 2004-11-10 |
CA2140441A1 (en) | 1994-02-03 |
JP3775684B2 (ja) | 2006-05-17 |
DE69333688D1 (de) | 2004-12-16 |
DE69333688T2 (de) | 2005-11-03 |
AU4717693A (en) | 1994-02-14 |
ES2227519T3 (es) | 2005-04-01 |
MX9304571A (es) | 1994-05-31 |
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