US5245047A
(en)
*
|
1988-02-22 |
1993-09-14 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
JP3171931B2
(ja)
*
|
1992-06-02 |
2001-06-04 |
高砂香料工業株式会社 |
(R)−(−)−4−シアノ−3−ヒドロキシ酪酸t−ブチルエステル及びその製造方法
|
US5298627A
(en)
*
|
1993-03-03 |
1994-03-29 |
Warner-Lambert Company |
Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
|
GB9512837D0
(en)
*
|
1995-06-23 |
1995-08-23 |
Zeneca Ltd |
reduction of ketone groups
|
HRP960312B1
(en)
|
1995-07-17 |
2001-10-31 |
Warner Lambert Co |
NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
|
US6087511A
(en)
*
|
1996-07-16 |
2000-07-11 |
Warner-Lambert Company |
Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
|
US5908953A
(en)
*
|
1996-12-18 |
1999-06-01 |
Mitsubishi Chemical Corporation |
Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
|
JPH11171850A
(ja)
*
|
1997-12-12 |
1999-06-29 |
Kanegafuchi Chem Ind Co Ltd |
酪酸エステル誘導体の製造方法
|
WO1999032434A1
(en)
*
|
1997-12-19 |
1999-07-01 |
Warner-Lambert Export Limited |
Process for the synthesis of 1,3-diols
|
CA2329893A1
(en)
*
|
1998-04-30 |
1999-11-11 |
Kaneka Corporation |
Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
|
ES2294236T3
(es)
|
1998-08-05 |
2008-04-01 |
Kaneka Corporation |
Procedimiento para la preparacion de esteres sustituidos con 3,5-dihidroxi como intermedios para producir derivados de acido 2-(6-hiximetil)-1,3-dioxan-4-il) acetico opticamente activos.
|
KR100313668B1
(ko)
*
|
1999-02-03 |
2001-11-26 |
박영구 |
(r)-4-시아노-3-히드록시부티르산 에스테르의 제조방법
|
HU227840B1
(en)
*
|
1999-05-06 |
2012-05-02 |
Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag |
Intermediates of atorvastatin synthesis and process for producing them
|
CA2339357A1
(en)
*
|
1999-06-04 |
2000-12-14 |
Kenji Inoue |
Processes for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives
|
US20040063969A1
(en)
*
|
1999-10-18 |
2004-04-01 |
Egis Gyogyszergyar Rt. |
Process for the preparation of amorphous atorvastatin calcium
|
MXPA02004078A
(es)
|
1999-12-17 |
2002-10-11 |
Warner Lambert Res & Dev |
Un proceso a escala industrial para producir sal de hemi calcio de trihidrato de atorvastatin cristalino.
|
CA2391357C
(en)
*
|
1999-12-17 |
2009-01-06 |
Warner Lambert Research And Development Ireland Limited |
A process for producing crystalline atorvastatin calcium
|
CN100368386C
(zh)
*
|
2000-05-31 |
2008-02-13 |
中国医学科学院药物研究所 |
(±)对氟-2-(2-甲基-丙酰基)-4-氧-n,3-二苯基-苯丁酰胺的合成方法以及其中的中间体
|
CN101250133B
(zh)
*
|
2000-05-31 |
2010-06-09 |
中国医学科学院药物研究所 |
(±)对氟-2-(2-甲基-丙酰基)-4-氧-n,3-二苯基-苯丁酰胺的合成方法以及其中的中间体
|
US6476235B2
(en)
|
2001-01-09 |
2002-11-05 |
Warner-Lambert Company |
Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
|
EP1724256A3
(en)
|
2001-01-09 |
2007-03-21 |
Warner-Lambert Company LLC |
Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
|
WO2002057229A1
(en)
*
|
2001-01-19 |
2002-07-25 |
Biocon India Limited |
FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
|
SI20814A
(sl)
*
|
2001-01-23 |
2002-08-31 |
LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. |
Priprava amorfnega atorvastatina
|
SI20848A
(sl)
|
2001-03-14 |
2002-10-31 |
Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. |
Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
|
PL367943A1
(en)
|
2001-06-29 |
2005-03-07 |
Warner-Lambert Company Llc |
Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
|
DK1404642T3
(da)
|
2001-07-06 |
2010-05-17 |
Basf Se |
Fremgangsmåde til fremstillimg af 7-amino-syn-3,5-dihydroxyheptansyrederivater, mellemprodukter derfor og fremgangsmåder til deres fremstilling
|
HUP0401014A2
(hu)
|
2001-07-06 |
2004-08-30 |
Teva Pharmaceutical Industries Ltd. |
Eljárás 7-amino-szin-3,5-dihidroxi-heptánsavszármazékok előállítására, 6-ciano-szin-3,5-dihidroxi-hexánsav származékokon keresztül
|
PT1404642E
(pt)
|
2001-07-06 |
2010-03-29 |
Basf Se |
Processo para a preparação de derivados do ácido 7-amino sin 3,5-dihidroxi heptanoico, intermediários respectivos e métodos para a sua preparação
|
JP4765217B2
(ja)
*
|
2001-07-30 |
2011-09-07 |
住友化学株式会社 |
(r)−4−シアノ−3−ヒドロキシブタン酸エステルの製造法
|
EP2292600A1
(en)
|
2001-07-30 |
2011-03-09 |
Dr. Reddy's Laboratories Ltd. |
Crystaline forms VI and VII of atorvastatin calcium
|
PE20030324A1
(es)
*
|
2001-07-31 |
2003-04-03 |
Warner Lambert Co |
Composiciones farmaceuticas de amlodipina y atorvastatina
|
US7563911B2
(en)
*
|
2001-08-31 |
2009-07-21 |
Morepen Laboratories Ltd. |
Process for the preparation of amorphous atorvastin calcium salt (2:1)
|
UA77990C2
(en)
*
|
2001-12-12 |
2007-02-15 |
|
Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
|
KR100849880B1
(ko)
*
|
2001-12-20 |
2008-08-01 |
주식회사 중외제약 |
광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
|
CZ296967B6
(cs)
|
2002-02-01 |
2006-08-16 |
Zentiva, A.S. |
Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
|
DE10212492B4
(de)
*
|
2002-03-21 |
2012-02-02 |
Daimler Ag |
Kolbenpumpe
|
CA2494269A1
(en)
*
|
2002-08-06 |
2004-02-19 |
Warner-Lambert Company Llc |
Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
|
AU2003258187A1
(en)
*
|
2002-08-09 |
2004-02-25 |
Codexis, Inc. |
Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
|
US20060122403A1
(en)
*
|
2002-09-03 |
2006-06-08 |
Sanjay Suri |
Atorvastatin calcium form vi or hydrates thereof
|
HRP20020885B1
(en)
*
|
2002-11-11 |
2007-05-31 |
GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. |
SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
|
WO2004089894A1
(en)
*
|
2003-04-14 |
2004-10-21 |
Warner-Lambert Company Llc |
Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
|
US20040248972A1
(en)
*
|
2003-05-16 |
2004-12-09 |
Ambit Biosciences Corporation |
Compounds and uses thereof
|
US20050182125A1
(en)
*
|
2003-05-16 |
2005-08-18 |
Ambit Biosciences Corporation |
Pyrrole compounds and uses thereof
|
JP2007500219A
(ja)
*
|
2003-05-16 |
2007-01-11 |
アンビット バイオサイエンシス コーポレーション |
複素環化合物およびその使用法
|
US7790197B2
(en)
*
|
2003-06-09 |
2010-09-07 |
Warner-Lambert Company Llc |
Pharmaceutical compositions of atorvastatin
|
US20040253305A1
(en)
*
|
2003-06-12 |
2004-12-16 |
Luner Paul E. |
Pharmaceutical compositions of atorvastatin
|
US7655692B2
(en)
*
|
2003-06-12 |
2010-02-02 |
Pfizer Inc. |
Process for forming amorphous atorvastatin
|
US20050271717A1
(en)
*
|
2003-06-12 |
2005-12-08 |
Alfred Berchielli |
Pharmaceutical compositions of atorvastatin
|
CN101318923A
(zh)
*
|
2003-09-17 |
2008-12-10 |
沃尼尔·朗伯有限责任公司 |
[R-(R*,R*)]-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-[(苯基氨基)羰基]-1H-吡咯-1-庚酸的结晶形式
|
US7557238B2
(en)
*
|
2003-09-18 |
2009-07-07 |
Biocon Limited |
Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
|
AU2004309313A1
(en)
*
|
2003-12-29 |
2005-07-14 |
Lek Pharmaceuticals D.D. |
Process for preparing amorphous (4R-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid
|
CA2456430A1
(en)
*
|
2004-01-28 |
2005-07-28 |
Brantford Chemicals Inc. |
Improved process for the preparation of amorphous atorvastatin calcium
|
EP1577297A1
(en)
|
2004-03-17 |
2005-09-21 |
Ranbaxy Laboratories, Ltd. |
Process for the production of atorvastatin calcium in amorphous form
|
JP2007532622A
(ja)
*
|
2004-04-16 |
2007-11-15 |
ファイザー・プロダクツ・インク |
非晶質アトルバスタチン・カルシウムの形成方法
|
US7875731B2
(en)
|
2004-05-05 |
2011-01-25 |
Pfizer Inc. |
Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid
|
CA2573969C
(en)
*
|
2004-07-16 |
2014-02-04 |
Lek Pharmaceuticals D.D. |
Oxidative degradation products of atorvastatin calcium
|
CA2672554C
(en)
|
2004-07-20 |
2012-01-03 |
Warner-Lambert Company Llc |
Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1)
|
US7645888B2
(en)
*
|
2004-08-27 |
2010-01-12 |
Biocon Limited |
Process for the production of amorphous atorvastatin calcium
|
BRPI0519996A2
(pt)
|
2004-10-28 |
2009-04-07 |
Warner Lambert Co |
processo para formar atorvastatina amorfa
|
US20090208539A1
(en)
*
|
2004-11-22 |
2009-08-20 |
Adel Penhasi |
Stable atorvastatin formulations
|
US20090088465A1
(en)
*
|
2004-12-02 |
2009-04-02 |
Stephen Craig Dyar |
Pharmaceutical Compositions of Amorphous Atorvastatin and Process for Preparing Same
|
EP1922301A1
(en)
*
|
2005-09-09 |
2008-05-21 |
Pfizer Science and Technology Ireland Limited |
Preparation of an atorvastatin intermediate
|
DE602005014686D1
(de)
*
|
2005-09-09 |
2009-07-09 |
Pfizer Science & Tech Ltd |
Herstellung eines atorvastatin-zwischenprodukts
|
US20090216029A1
(en)
*
|
2005-09-16 |
2009-08-27 |
Yatendra Kumar |
Process for the production of atorvastatin calcium in amorphous form
|
CA2547216A1
(en)
|
2005-09-21 |
2007-03-21 |
Renuka D. Reddy |
Process for annealing amorphous atorvastatin
|
ES2304335T3
(es)
|
2005-11-21 |
2010-05-19 |
Warner-Lambert Company Llc |
Formas nuevas del acido (r-(r*,r*))-2-(4-fluorofenil)-b,b-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)1h-pirrol-1-heptanoico, de magnesio.
|
EP1810667A1
(en)
|
2006-01-20 |
2007-07-25 |
KRKA, tovarna zdravil, d.d., Novo mesto |
Pharmaceutical composition comprising amorphous atorvastatin
|
EP2066788B1
(en)
|
2006-10-02 |
2014-07-23 |
Codexis, Inc. |
Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
|
WO2008053312A2
(en)
*
|
2006-11-02 |
2008-05-08 |
Cadila Pharmaceuticals Limited |
Process for preparing amorphous atorvastatin hemi calcium salt and its intermediate
|
WO2008059366A2
(en)
*
|
2006-11-17 |
2008-05-22 |
Pfizer Products Inc. |
Process for the preparation of cis-1, 3-diols from the corresponding beta-hydroxy ketones employing microbial ketone reductases
|
US7834195B2
(en)
*
|
2007-01-24 |
2010-11-16 |
Apotex Pharmachem Inc. |
Atorvastatin calcium propylene glycol solvates
|
US20110142883A1
(en)
*
|
2007-07-20 |
2011-06-16 |
Actavis Group Ptc Ehf |
Amorphous Coprecipitates of Atorvastatin Pharmaceutically Acceptable Salts
|
WO2009019561A2
(en)
*
|
2007-08-03 |
2009-02-12 |
Pfizer Products Inc. |
Process for preparing chiral compounds
|
EP2075246A1
(en)
|
2007-12-27 |
2009-07-01 |
M. J. Institute of Research |
A process for preparation of amorphous form of atorvastatin hemi-calcium salt
|
US8115015B2
(en)
*
|
2009-01-26 |
2012-02-14 |
Cadila Healthcare Limited |
Process for the preparation of amorphous atorvastatin calcium
|
GB2474687A
(en)
|
2009-10-23 |
2011-04-27 |
Phoenix Chemicals Ltd |
A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
|
KR20120011249A
(ko)
|
2010-07-28 |
2012-02-07 |
주식회사 경보제약 |
아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
|
EP2614057B1
(en)
*
|
2010-09-09 |
2015-10-21 |
DSM Sinochem Pharmaceuticals Netherlands B.V. |
Salts of 7-amino-3,5-dihydroxyheptanoic acid esters
|
WO2013004591A1
(en)
|
2011-07-01 |
2013-01-10 |
Dsm Sinochem Pharmaceuticals Netherlands B.V. |
Micronized crystals of atorvastatin hemicalcium
|
CN102766072B
(zh)
*
|
2012-08-07 |
2013-12-25 |
浙江宏元药业有限公司 |
一种制备阿托伐他汀钙手性侧链的方法
|
CN103145584B
(zh)
*
|
2013-03-05 |
2015-08-26 |
复旦大学 |
一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
|
CN106397241A
(zh)
*
|
2016-08-23 |
2017-02-15 |
杨锋 |
一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
|
CN108033899B
(zh)
*
|
2017-12-06 |
2020-04-10 |
浙江科技学院 |
一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法
|