DK0599376T4 - Fremgangsmåde til fremstilling af finasterid - Google Patents

Fremgangsmåde til fremstilling af finasterid

Info

Publication number
DK0599376T4
DK0599376T4 DK93203163T DK93203163T DK0599376T4 DK 0599376 T4 DK0599376 T4 DK 0599376T4 DK 93203163 T DK93203163 T DK 93203163T DK 93203163 T DK93203163 T DK 93203163T DK 0599376 T4 DK0599376 T4 DK 0599376T4
Authority
DK
Denmark
Prior art keywords
finasteride
magnesium halide
disclosed
preparation
androst
Prior art date
Application number
DK93203163T
Other languages
Danish (da)
English (en)
Inventor
Ulf H Dolling
James A Mccauley
Richard J Varsolona
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26681536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0599376(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0599376T4 publication Critical patent/DK0599376T4/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/003—Compounds containing elements of Groups 2 or 12 of the Periodic Table without C-Metal linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N5/00—Details of television systems
    • H04N5/74—Projection arrangements for image reproduction, e.g. using eidophor
    • H04N5/7416—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal
    • H04N5/7458—Projection arrangements for image reproduction, e.g. using eidophor involving the use of a spatial light modulator, e.g. a light valve, controlled by a video signal the modulator being an array of deformable mirrors, e.g. digital micromirror device [DMD]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Multimedia (AREA)
  • Signal Processing (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
  • Dental Preparations (AREA)
  • Seasonings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK93203163T 1992-11-19 1993-11-12 Fremgangsmåde til fremstilling af finasterid DK0599376T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97853592A 1992-11-19 1992-11-19
US08/010,734 US5468860A (en) 1992-11-19 1993-01-29 New finasteride processes

Publications (1)

Publication Number Publication Date
DK0599376T4 true DK0599376T4 (da) 2008-07-28

Family

ID=26681536

Family Applications (2)

Application Number Title Priority Date Filing Date
DK95200270T DK0655458T3 (da) 1992-11-19 1993-11-12 Ny fremgangsmåde til fremstilling af finasterid
DK93203163T DK0599376T4 (da) 1992-11-19 1993-11-12 Fremgangsmåde til fremstilling af finasterid

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK95200270T DK0655458T3 (da) 1992-11-19 1993-11-12 Ny fremgangsmåde til fremstilling af finasterid

Country Status (33)

Country Link
US (3) US5468860A (bg)
EP (3) EP0655458B1 (bg)
JP (2) JPH07110875B2 (bg)
CN (1) CN1058018C (bg)
AT (2) ATE164850T1 (bg)
AU (1) AU658774B2 (bg)
BG (2) BG62362B1 (bg)
CA (1) CA2103107C (bg)
CY (1) CY2135B1 (bg)
CZ (3) CZ301191B6 (bg)
DE (4) DE69323754T2 (bg)
DK (2) DK0655458T3 (bg)
DZ (1) DZ1733A1 (bg)
ES (2) ES2052476T5 (bg)
FI (4) FI107450B (bg)
GR (4) GR940300045T1 (bg)
HK (1) HK1008338A1 (bg)
HR (2) HRP931410B1 (bg)
HU (2) HU216195B (bg)
IL (1) IL107574A (bg)
IS (2) IS1692B (bg)
LV (2) LV12212B (bg)
MX (1) MX9307222A (bg)
MY (2) MY110410A (bg)
NO (3) NO305912B1 (bg)
PH (1) PH31120A (bg)
RO (2) RO115164B1 (bg)
RU (1) RU2120445C1 (bg)
SI (1) SI9300603B (bg)
SK (2) SK286488B6 (bg)
TW (1) TW257766B (bg)
UA (1) UA41341C2 (bg)
WO (1) WO1994011387A2 (bg)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
IT1270660B (it) * 1994-10-13 1997-05-07 Poli Ind Chimica Spa Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
US5670643A (en) * 1995-03-16 1997-09-23 Glaxo Wellcome Inc. Method for preparing finasteride
US5585383A (en) * 1995-05-03 1996-12-17 Merck & Co., Inc. Process for crystallizing a 4-azasteroid 5alpha-reductase inhibitor
JPH11512434A (ja) * 1995-09-15 1999-10-26 メルク エンド カンパニー インコーポレーテッド アンドロゲン過剰状態治療用の４−アザステロイド
GB2338234B (en) * 1998-06-10 2000-05-03 Torcan Chemical Ltd Preparation of finasteride
ES2153789B1 (es) * 1999-07-05 2001-10-16 Raga Consultores S L Procedimiento para la obtencion de 178-(n-terc-butlcarbamoil)-3-ona-4-aza-esteroides
EA200200524A1 (ru) * 1999-11-01 2002-10-31 Торкан Кемикал Лтд. Получение полиморфных форм i и ii финастерида путем образования комплексов с солями металлов группы i или ii
CN1468254A (zh) * 2000-09-07 2004-01-14 雷迪实验室有限公司 17-β-(N-叔丁基氨基甲酰基)-4-氮杂-5-α-雄甾-1-烯-3-酮的新颖多晶型物及其制备方法
CZ2003679A3 (cs) * 2000-09-07 2004-02-18 Dr. Reddy´S Laboratories Ltd. Nová polymorfní forma 17beta-(N-terc-butylkarbamoyl)-4-aza-5alfa-androst-1-en-3-on a způsob její přípravy
EP1322663A1 (en) * 2000-09-07 2003-07-02 Dr. Reddy's Laboratories Ltd. Novel polymorphic form of 17-beta-(n-ter.butyl carbamoyl)-4-aza-5- g(a)-androst-1-en-3-one and a process for preparing it
KR100415858B1 (ko) * 2001-09-22 2004-01-24 한미약품 주식회사 17베타-(엔-3차-부틸카바모일)-3-온 스테로이드 화합물의제조방법
CN100428897C (zh) * 2002-08-16 2008-10-29 浙江寿峰堂生物工程有限公司 抗疲劳改善亚健康的保健食品及其制备方法
ES2206065B1 (es) * 2002-10-31 2005-08-16 Ragactives, S.L. Procedimiento para la obtencion de la forma polimorfica i de finasterida.
WO2004083230A1 (en) * 2003-03-19 2004-09-30 Hetero Drugs Limited Novel crystalline forms of finasteride
EP1651661B1 (en) * 2003-07-03 2008-08-27 Cipla Ltd. Process for the preparation of finasteride form i
US20050136015A1 (en) * 2003-12-17 2005-06-23 McKie Derrick B. Topical use of halosalicylic acid derivatives
US20070167477A1 (en) * 2006-01-13 2007-07-19 Mandava Venkata Naga Brahmeswa Processes to prepare finasteride polymorphs
US7531658B2 (en) * 2006-01-20 2009-05-12 Apotex Pharmachem Inc. Process for the preparation of 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones
EP1993569B1 (en) 2006-02-03 2014-07-23 OMP, Inc. Anti-aging treatment using copper and zinc compositions
US7897800B2 (en) 2006-02-03 2011-03-01 Jr Chem, Llc Chemical compositions and methods of making them
US7687650B2 (en) 2006-02-03 2010-03-30 Jr Chem, Llc Chemical compositions and methods of making them
US7867522B2 (en) 2006-09-28 2011-01-11 Jr Chem, Llc Method of wound/burn healing using copper-zinc compositions
US20090076058A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched finasteride
US8273791B2 (en) 2008-01-04 2012-09-25 Jr Chem, Llc Compositions, kits and regimens for the treatment of skin, especially décolletage
WO2009135799A2 (en) * 2008-05-05 2009-11-12 Abbott Gmbh & Co. Kg Method for evaluating the solubility of a crystalline substance in a polymer
US20160184354A1 (en) 2009-01-23 2016-06-30 Jr Chem, Llc Rosacea treatments and kits for performing them
US8952057B2 (en) 2011-01-11 2015-02-10 Jr Chem, Llc Compositions for anorectal use and methods for treating anorectal disorders

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
NZ211145A (en) 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
DE3888378T2 (de) * 1987-04-03 1994-09-29 Merck & Co Inc Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
JP3282731B2 (ja) * 1990-06-15 2002-05-20 メルク エンド カムパニー インコーポレーテッド 結晶の構造および大きさを改良する結晶化方法
EP0462662A3 (en) * 1990-06-20 1992-08-19 Merck & Co. Inc. 17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
US5091534A (en) 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5120847A (en) † 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
US5061801A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
CA2050824A1 (en) * 1990-09-24 1992-03-25 John M. Williams Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes

Also Published As

Publication number Publication date
EP0655458A2 (en) 1995-05-31
CY2135B1 (en) 2002-05-21
CZ301160B6 (cs) 2009-11-18
HU216195B (hu) 1999-05-28
EP0823436A2 (en) 1998-02-11
ES2072848T3 (es) 1999-05-01
AU658774B2 (en) 1995-04-27
IL107574A (en) 2000-07-16
RU95112521A (ru) 1997-02-10
JP2742409B2 (ja) 1998-04-22
NO992580D0 (no) 1999-05-28
DZ1733A1 (fr) 2002-02-17
IS1671B (is) 1997-12-19
FI952422A0 (fi) 1995-05-18
JPH09235294A (ja) 1997-09-09
EP0599376A3 (en) 1994-09-28
ATE164850T1 (de) 1998-04-15
NO307888B3 (no) 2000-06-13
DE69323754T2 (de) 1999-10-07
EP0599376B1 (en) 1998-04-08
DE599376T1 (de) 1994-12-08
MY110411A (en) 1998-05-30
CZ301191B6 (cs) 2009-12-02
LV12460B (en) 2000-09-20
SK286488B6 (sk) 2008-11-06
GR940300045T1 (en) 1994-07-29
SK65995A3 (en) 1995-10-11
HU9303275D0 (en) 1994-03-28
US5886184A (en) 1999-03-23
JPH06199889A (ja) 1994-07-19
DE655458T1 (de) 1995-11-30
NO951986D0 (no) 1995-05-19
ES2052476T3 (es) 1998-06-16
HK1008338A1 (en) 1999-05-07
DE69323754D1 (de) 1999-04-08
LV12212A (lv) 1999-01-20
CN1058018C (zh) 2000-11-01
SI9300603A (en) 1994-06-30
EP0599376B2 (en) 2008-04-16
FI114800B (fi) 2004-12-31
FI116941B (fi) 2006-04-13
FI20010289A (fi) 2001-02-15
AU5078793A (en) 1994-06-16
SI9300603B (sl) 2004-06-30
MX9307222A (es) 1994-07-29
TW257766B (bg) 1995-09-21
NO951986L (no) 1995-05-19
CA2103107A1 (en) 1994-05-20
GR3026577T3 (en) 1998-07-31
LV12212B (en) 1999-03-20
DE69317856D1 (de) 1998-05-14
BG62362B1 (bg) 1999-09-30
IS4094A (is) 1994-05-20
ATE177112T1 (de) 1999-03-15
FI107450B (fi) 2001-08-15
GR3029554T3 (en) 1999-06-30
ES2052476T1 (es) 1994-07-16
EP0823436A3 (en) 1998-11-25
UA41341C2 (uk) 2001-09-17
IL107574A0 (en) 1994-02-27
PH31120A (en) 1998-02-23
FI20010290A (fi) 2001-02-15
CZ287842B6 (en) 2001-02-14
NO990468L (no) 1995-05-19
US5652365A (en) 1997-07-29
HU210535A9 (en) 1995-04-28
BG103170A (bg) 1999-09-30
NO307609B1 (no) 2000-05-02
NO305912B1 (no) 1999-08-16
FI20040559A (fi) 2004-04-21
CA2103107C (en) 2010-09-28
CZ126895A3 (en) 1995-12-13
RU2120445C1 (ru) 1998-10-20
DK0655458T3 (da) 1999-09-27
US5468860A (en) 1995-11-21
CN1090583A (zh) 1994-08-10
MY110410A (en) 1998-05-30
EP0599376A2 (en) 1994-06-01
HRP931410B1 (en) 2000-06-30
SK281765B6 (sk) 2001-07-10
ES2072848T1 (es) 1995-08-01
WO1994011387A2 (en) 1994-05-26
BG99637A (bg) 1996-04-30
HRP20000295B1 (en) 2002-08-31
NO307888B1 (no) 2000-06-13
FI952422A (fi) 1995-05-18
GR950300043T1 (en) 1995-07-31
HRP20000295A2 (en) 2000-08-31
EP0655458B1 (en) 1999-03-03
RO115164B1 (ro) 1999-11-30
JPH07110875B2 (ja) 1995-11-29
ES2052476T5 (es) 2008-11-01
FI114215B (fi) 2004-09-15
LV12460A (lv) 2000-04-20
NO990468D0 (no) 1999-02-01
DE69317856T2 (de) 1998-11-05
HUT66973A (en) 1995-01-30
IS1692B (is) 1998-04-20
EP0655458A3 (en) 1996-07-10
WO1994011387A3 (en) 1994-09-29
HRP931410A2 (en) 1996-06-30
IS4286A (is) 1994-05-20
BG64464B1 (bg) 2005-03-31
RO115165B1 (ro) 1999-11-30
NO992580L (no) 1995-05-19

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DK0599376T4 (da) Fremgangsmåde til fremstilling af finasterid