DK0547165T3 - Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc - Google Patents

Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc

Info

Publication number
DK0547165T3
DK0547165T3 DK91918278T DK91918278T DK0547165T3 DK 0547165 T3 DK0547165 T3 DK 0547165T3 DK 91918278 T DK91918278 T DK 91918278T DK 91918278 T DK91918278 T DK 91918278T DK 0547165 T3 DK0547165 T3 DK 0547165T3
Authority
DK
Denmark
Prior art keywords
preparation
compounds
alkoxyc
hydroxy
water
Prior art date
Application number
DK91918278T
Other languages
Danish (da)
English (en)
Inventor
Joseph Marian Fortunak
Jeffery Lee Wood
Antonietta Rose Mastrocola
Mark Mellinger
Patrick Lee Burk
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of DK0547165T3 publication Critical patent/DK0547165T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK91918278T 1990-09-28 1991-09-23 Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc DK0547165T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28
PCT/US1991/006888 WO1992005785A1 (fr) 1990-09-28 1991-09-23 Analogues de camptothecine solubles dans l'eau, procedes et methodes

Publications (1)

Publication Number Publication Date
DK0547165T3 true DK0547165T3 (da) 2000-03-27

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91918278T DK0547165T3 (da) 1990-09-28 1991-09-23 Fremgangsmåde til fremstilling af vandopløselige camptothecinanaloger såvel som forbindelserne 10-hydroxy-11-C(1-6)-alkoxyc

Country Status (25)

Country Link
US (1) US5734056A (fr)
EP (1) EP0547165B1 (fr)
JP (1) JP2848958B2 (fr)
CN (1) CN1033509C (fr)
AT (1) ATE186461T1 (fr)
AU (1) AU664830B2 (fr)
CA (1) CA2090967C (fr)
CZ (1) CZ51593A3 (fr)
DE (1) DE69131775T2 (fr)
DK (1) DK0547165T3 (fr)
ES (1) ES2137932T3 (fr)
FI (1) FI931384A (fr)
GR (1) GR3031823T3 (fr)
HK (1) HK1012283A1 (fr)
HU (1) HUT70024A (fr)
IE (1) IE913402A1 (fr)
IL (1) IL99571A (fr)
NO (1) NO931153L (fr)
NZ (1) NZ239947A (fr)
PT (1) PT99109B (fr)
SI (1) SI9111599A (fr)
SK (1) SK283693B6 (fr)
WO (1) WO1992005785A1 (fr)
YU (1) YU159991A (fr)
ZA (1) ZA917748B (fr)

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US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
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US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
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US8349863B2 (en) * 2005-10-10 2013-01-08 Cipla Limited Crystalline polymorphic form of a camptothecin analogue
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EP2038654A4 (fr) * 2006-06-12 2010-08-11 Bipar Sciences Inc Procédé permettant de traiter des maladies avec des inhibiteurs de parp
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
WO2008030891A2 (fr) * 2006-09-05 2008-03-13 Bipar Sciences, Inc. Inhibition de la synthèse d'acides gras au moyen d'inhibiteurs parp et méthodes de traitement associées
CN101522609A (zh) * 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en) 2007-04-11 2011-07-12 Scinopharm Taiwan, Ltd. Process for making topotecan
JP2011500684A (ja) * 2007-10-19 2011-01-06 バイパー サイエンシズ，インコーポレイティド ベンゾピロン系ｐａｒｐ阻害剤を用いる癌の処置方法および組成物
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CN101918003A (zh) * 2007-11-12 2010-12-15 彼帕科学公司 单独使用parp抑制剂或与抗肿瘤剂组合治疗子宫癌和卵巢癌
CN101917982B (zh) * 2007-11-12 2013-03-20 彼帕科学公司 使用4-碘-3-硝基苯甲酰胺与抗肿瘤剂组合治疗乳腺癌
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CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
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JP2012518598A (ja) 2009-02-25 2012-08-16 Ｍｓｄ株式会社 ピリミドピリミドインダゾール誘導体
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JP2014504638A (ja) 2011-02-01 2014-02-24 グラクソスミスクライン インテレクチュアル プロパティ リミテッド 組合せ
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (fr) * 2013-12-03 2015-06-10 Synbias Pharma AG Procédé pour la synthèse de l'irinotécan
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US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
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Also Published As

Publication number Publication date
US5734056A (en) 1998-03-31
ZA917748B (en) 1992-09-30
SK283693B6 (sk) 2003-12-02
HUT70024A (en) 1995-09-28
CN1033509C (zh) 1996-12-11
EP0547165B1 (fr) 1999-11-10
ES2137932T3 (es) 2000-01-01
CA2090967C (fr) 2007-02-06
DE69131775T2 (de) 2000-04-20
FI931384A0 (fi) 1993-03-26
FI931384A (fi) 1993-03-26
CN1062731A (zh) 1992-07-15
JP2848958B2 (ja) 1999-01-20
HK1012283A1 (en) 1999-07-30
SI9111599A (sl) 1998-02-28
NO931153D0 (no) 1993-03-26
EP0547165A4 (fr) 1994-03-30
PT99109A (pt) 1992-08-31
DE69131775D1 (de) 1999-12-16
CA2090967A1 (fr) 1992-03-29
IE913402A1 (en) 1992-04-08
WO1992005785A1 (fr) 1992-04-16
GR3031823T3 (en) 2000-02-29
HU9300878D0 (en) 1993-06-28
PT99109B (pt) 1999-02-26
NO931153L (no) 1993-03-26
IL99571A0 (en) 1992-08-18
NZ239947A (en) 1994-07-26
AU8739991A (en) 1992-04-28
EP0547165A1 (fr) 1993-06-23
CZ51593A3 (en) 1994-01-19
JPH06501476A (ja) 1994-02-17
IL99571A (en) 2000-08-31
SK25993A3 (en) 1993-07-07
YU159991A (sh) 1994-06-10
ATE186461T1 (de) 1999-11-15
AU664830B2 (en) 1995-12-07

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