DK0520406T3 - Diastereomert salt af optisk aktiv quinolinmevalonsyre - Google Patents
Diastereomert salt af optisk aktiv quinolinmevalonsyreInfo
- Publication number
- DK0520406T3 DK0520406T3 DK92110636T DK92110636T DK0520406T3 DK 0520406 T3 DK0520406 T3 DK 0520406T3 DK 92110636 T DK92110636 T DK 92110636T DK 92110636 T DK92110636 T DK 92110636T DK 0520406 T3 DK0520406 T3 DK 0520406T3
- Authority
- DK
- Denmark
- Prior art keywords
- optically active
- diastereomeric salt
- mevalonic acid
- active quinoline
- quinoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15181091 | 1991-06-24 | ||
| JP12727792A JP3528186B2 (ja) | 1991-06-24 | 1992-05-20 | 光学活性キノリンメバロン酸のジアステレオマー塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0520406T3 true DK0520406T3 (da) | 1998-12-14 |
Family
ID=26463266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92110636T DK0520406T3 (da) | 1991-06-24 | 1992-06-24 | Diastereomert salt af optisk aktiv quinolinmevalonsyre |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5284953A (fr) |
| EP (2) | EP0742209A3 (fr) |
| JP (1) | JP3528186B2 (fr) |
| KR (1) | KR100208867B1 (fr) |
| AT (1) | ATE170513T1 (fr) |
| CA (1) | CA2072162C (fr) |
| DE (1) | DE69226822T2 (fr) |
| DK (1) | DK0520406T3 (fr) |
| ES (1) | ES2120973T3 (fr) |
| TW (1) | TW293007B (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3776452B2 (ja) * | 1994-02-25 | 2006-05-17 | ダイセル化学工業株式会社 | 光学活性なメバロノラクトン系化合物の製造方法 |
| IL128862A (en) | 1995-07-17 | 2007-12-03 | Warner Lambert Co | [R - (R * R *)] - 2 - (4 - fluorophenyl) - ß, d - dihydroxy - 5 - (1 - methyl - ethyl) 3 - phenyl - 4 - [(phenamino) carbonyl)] - 1H - Pyrol - 1 - Patenoic acid Hydrogen salt Hydrogen crystalline (Atorostatin) Crystalline hydrate |
| DE69625046T2 (de) * | 1995-12-22 | 2003-04-10 | Kowa Co., Ltd. | Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium |
| GB9614804D0 (en) * | 1996-07-15 | 1996-09-04 | Chiroscience Ltd | Resolution process |
| NZ504346A (en) * | 1997-12-19 | 2001-11-30 | Warner Lambert Exp Ltd | Process for the synthesis of 1,3-diols characterised by either reconcentration step with either trialkylborane or dialkylalkoxyborane or a mixture of both trialkylborane and dialkylalkoxyborane |
| RU2214402C2 (ru) | 1998-07-23 | 2003-10-20 | Ниссан Кемикал Индастриз, Лтд. | Способ получения 3-((2-циклопропил-4-(4-фторфенил)-3-хинолил)проп-2-еналя и промежуточное соединение |
| KR100311645B1 (ko) * | 1999-12-24 | 2001-10-12 | 이홍천 | 간판 |
| GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| KR100838135B1 (ko) * | 2001-04-05 | 2008-06-13 | 닛산 가가쿠 고교 가부시키 가이샤 | 7-퀴놀리닐-3,5-디히드록시헵트-6-엔산에스테르의 제조법 |
| JP4783998B2 (ja) * | 2001-05-15 | 2011-09-28 | 宇部興産株式会社 | （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法 |
| WO2003027073A1 (fr) * | 2001-09-19 | 2003-04-03 | Ube Industries, Ltd. | Procede de production d'ester optiquement actif d'acide 7-{2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl}-3,5-dihydroxyhept-6-enoique |
| US6835838B2 (en) * | 2002-01-28 | 2004-12-28 | Novartis Ag | Process for the manufacture of organic compounds |
| JP4524111B2 (ja) | 2002-01-31 | 2010-08-11 | ノバルティス アーゲー | ＨＭＧ−ＣｏＡ還元酵素阻害剤の製造法 |
| KR101067314B1 (ko) | 2002-09-20 | 2011-09-23 | 닛산 가가쿠 고교 가부시키 가이샤 | 3,5-디하이드록시-6-헵테노에이트 제조 방법 |
| WO2004072040A1 (fr) * | 2003-02-12 | 2004-08-26 | Ciba Specialty Chemicals Holding Inc. | Formes cristallines de calcium de pitavastatine |
| EP1614429A4 (fr) * | 2003-04-17 | 2007-05-02 | Kowa Co | Promoteur de l'expression du gene lklf/klf2 |
| WO2005053683A1 (fr) * | 2003-11-26 | 2005-06-16 | Duke University | Technique de prevention ou de traitement du glaucome |
| TWI328006B (en) * | 2003-12-26 | 2010-08-01 | Nissan Chemical Ind Ltd | Crystal form of quinoline compound and process for its production |
| EP1709008A1 (fr) * | 2004-01-19 | 2006-10-11 | Ranbaxy Laboratories Limited | Sels des inhibiteurs de hmg-coa reductase et leur utilisation |
| CN101220021B (zh) * | 2007-01-12 | 2010-12-08 | 上海医药工业研究院 | 4-取代苯氧基喹啉类化合物及其中间体、制备方法和应用 |
| WO2008111055A1 (fr) * | 2007-03-12 | 2008-09-18 | In-Dot Ltd. | Détection de couleur pour un dispositif de lecture et similaire |
| WO2010027060A1 (fr) * | 2008-09-05 | 2010-03-11 | 日産化学工業株式会社 | Procédé pour la fabrication de sel d'amine d'acide 3,5-dihydroxy-6-hepténoïque |
| WO2011089623A2 (fr) | 2010-01-20 | 2011-07-28 | Cadila Healthcare Limited | Procédé pour la préparation de pitavastatine et de sels pharmaceutiquement acceptables de celle-ci |
| WO2012025939A1 (fr) | 2010-08-25 | 2012-03-01 | Cadila Healthcare Limited | Calcium de pitavastatine et son procédé de préparation |
| EP3178812A1 (fr) * | 2010-11-12 | 2017-06-14 | Hetero Research Foundation | Nouveaux polymorphes de calcium de pitavastatine |
| KR101270586B1 (ko) * | 2010-11-26 | 2013-06-03 | 주식회사 아미노로직스 | 광학적으로 순수한 2,2'-디히드록시-1,1'-바이나프틸-3-카르복실산의 제조방법 |
| WO2012140490A2 (fr) | 2011-04-11 | 2012-10-18 | Aurobindo Pharma Limited | Procédé de préparation de dérivé de quinoléine |
| JP2011173912A (ja) * | 2011-04-28 | 2011-09-08 | Ube Industries Ltd | （３ｒ，５ｓ）−７−置換−３，５−ジヒドロキシヘプト−６−エン酸の製法 |
| EP2751081B1 (fr) | 2011-09-12 | 2017-01-04 | Farma GRS, d.o.o. | Forme polymorphe de calcium de pitavastatine |
| JP2013103884A (ja) * | 2011-11-10 | 2013-05-30 | Daito Kk | ピタバスタチンカルシウム塩の工業的製造方法 |
| CN102653523A (zh) * | 2011-12-17 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙重结晶制取方法 |
| WO2013098773A1 (fr) * | 2011-12-28 | 2013-07-04 | Dr. Reddy's Laboratories Limited | Formes cristallines de pitavastatine calcique |
| CN102653524A (zh) * | 2012-01-12 | 2012-09-05 | 东莞达信生物技术有限公司 | 一种匹伐他汀钙中间体的制备方法 |
| CN105189458A (zh) * | 2013-03-29 | 2015-12-23 | 中化帝斯曼制药有限公司荷兰公司 | 匹伐他汀和罗素伐他汀的胺盐 |
| MX2015013696A (es) * | 2013-03-29 | 2016-02-26 | Dsm Sinochem Pharm Nl Bv | Sales de amina de pitavastatina y rosuvastatina. |
| CN103508949B (zh) * | 2013-10-22 | 2015-12-09 | 黄河三角洲京博化工研究院有限公司 | 一种（e）-3-[2-环丙基-4-（4-氟-苯基）-3-喹啉基]丙烯醛的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH576447A5 (fr) * | 1972-03-10 | 1976-06-15 | Ciba Geigy Ag | |
| US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| CA1336714C (fr) * | 1987-08-20 | 1995-08-15 | Yoshihiro Fujikawa | Mevalonolactone de type quinoleine utilisee comme inhibiteurs de la biosynthese du cholesterol |
| DE3905908A1 (de) * | 1989-02-25 | 1990-09-06 | Bayer Ag | Substituierte chinoline, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| DE3925636A1 (de) * | 1989-08-03 | 1991-02-07 | Bayer Ag | Imino-substituierte pyridine |
| EP0430129A3 (en) * | 1989-11-30 | 1992-02-26 | Tanabe Seiyaku Co., Ltd. | Novel phenylethylene derivatives, processes for preparing the same and intermediates therefor |
| JPH054943A (ja) * | 1990-08-30 | 1993-01-14 | Sagami Chem Res Center | 光学活性β，δ−ジケト酸エステル及びその還元体 |
-
1992
- 1992-05-20 JP JP12727792A patent/JP3528186B2/ja not_active Expired - Lifetime
- 1992-06-12 TW TW081104622A patent/TW293007B/zh active
- 1992-06-23 US US07/902,863 patent/US5284953A/en not_active Expired - Lifetime
- 1992-06-23 CA CA002072162A patent/CA2072162C/fr not_active Expired - Lifetime
- 1992-06-24 EP EP96107815A patent/EP0742209A3/fr not_active Withdrawn
- 1992-06-24 KR KR1019920011018A patent/KR100208867B1/ko not_active IP Right Cessation
- 1992-06-24 AT AT92110636T patent/ATE170513T1/de active
- 1992-06-24 ES ES92110636T patent/ES2120973T3/es not_active Expired - Lifetime
- 1992-06-24 DK DK92110636T patent/DK0520406T3/da active
- 1992-06-24 EP EP92110636A patent/EP0520406B1/fr not_active Expired - Lifetime
- 1992-06-24 DE DE69226822T patent/DE69226822T2/de not_active Expired - Lifetime
-
1993
- 1993-09-20 US US08/123,117 patent/US5473075A/en not_active Expired - Lifetime
-
1995
- 1995-05-25 US US08/450,383 patent/US5514804A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0742209A2 (fr) | 1996-11-13 |
| KR930000486A (ko) | 1993-01-15 |
| US5284953A (en) | 1994-02-08 |
| ES2120973T3 (es) | 1998-11-16 |
| EP0520406B1 (fr) | 1998-09-02 |
| KR100208867B1 (ko) | 1999-07-15 |
| DE69226822D1 (de) | 1998-10-08 |
| CA2072162A1 (fr) | 1992-12-25 |
| ATE170513T1 (de) | 1998-09-15 |
| EP0520406A1 (fr) | 1992-12-30 |
| JP3528186B2 (ja) | 2004-05-17 |
| DE69226822T2 (de) | 1999-02-11 |
| CA2072162C (fr) | 2002-11-19 |
| EP0742209A3 (fr) | 1997-05-14 |
| US5514804A (en) | 1996-05-07 |
| JPH05148237A (ja) | 1993-06-15 |
| US5473075A (en) | 1995-12-05 |
| TW293007B (fr) | 1996-12-11 |
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