DK0513387T3 - Thiazolderivater som inhibitorer af aktivt oxygen - Google Patents
Thiazolderivater som inhibitorer af aktivt oxygenInfo
- Publication number
- DK0513387T3 DK0513387T3 DK91920815T DK91920815T DK0513387T3 DK 0513387 T3 DK0513387 T3 DK 0513387T3 DK 91920815 T DK91920815 T DK 91920815T DK 91920815 T DK91920815 T DK 91920815T DK 0513387 T3 DK0513387 T3 DK 0513387T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- active oxygen
- thiazole derivatives
- thiazole
- derivatives
- Prior art date
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 title 1
- 239000001301 oxygen Substances 0.000 title 1
- 150000007979 thiazole derivatives Chemical class 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33772790 | 1990-11-30 | ||
PCT/JP1991/001659 WO1992009586A1 (en) | 1990-11-30 | 1991-11-29 | Active oxygen inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0513387T3 true DK0513387T3 (da) | 2000-06-05 |
Family
ID=18311399
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK91920815T DK0513387T3 (da) | 1990-11-30 | 1991-11-29 | Thiazolderivater som inhibitorer af aktivt oxygen |
DK01112988T DK1130017T3 (da) | 1990-11-30 | 1991-11-29 | Azolderivater og deres anvendelse som superoxidradikalinhibitorer |
DK99107493T DK0934937T3 (da) | 1990-11-30 | 1991-11-29 | Azolderivater som superoxidradikalinhibitor |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK01112988T DK1130017T3 (da) | 1990-11-30 | 1991-11-29 | Azolderivater og deres anvendelse som superoxidradikalinhibitorer |
DK99107493T DK0934937T3 (da) | 1990-11-30 | 1991-11-29 | Azolderivater som superoxidradikalinhibitor |
Country Status (11)
Country | Link |
---|---|
US (4) | US5643932A (de) |
EP (3) | EP1130017B1 (de) |
JP (2) | JP2829451B2 (de) |
KR (2) | KR100195433B1 (de) |
CA (3) | CA2396738C (de) |
DE (3) | DE69133471T2 (de) |
DK (3) | DK0513387T3 (de) |
ES (3) | ES2144403T3 (de) |
HK (1) | HK1003938A1 (de) |
TW (1) | TW311136B (de) |
WO (1) | WO1992009586A1 (de) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5639770A (en) * | 1992-05-29 | 1997-06-17 | Otsuka Pharmaceutical Co., Ltd. | Thiazole derivatives |
EP0600092A4 (en) * | 1992-05-29 | 1994-09-21 | Otsuka Pharma Co Ltd | Thiazole derivative. |
NZ255580A (en) * | 1992-09-14 | 1997-08-22 | Yamanouchi Pharma Co Ltd | 2-(imidazolyl)alkylene-condensed thiazole derivatives and pharmaceutical compositions |
EP0637588A4 (de) * | 1993-01-19 | 1995-12-13 | Shiseido Co Ltd | Inhibitor von aktiven sauerstoff. |
EP0749966A4 (de) * | 1994-03-11 | 1997-07-02 | Yamanouchi Pharma Co Ltd | 5-ht 3-rezeptor agonisten, neue thiazol-derivate und zwischenprodukte |
EP0772606A1 (de) * | 1994-07-27 | 1997-05-14 | G.D. SEARLE & CO. | Substituierte thiazole zur behandlung von entzündungen |
US5693647A (en) | 1994-12-22 | 1997-12-02 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
US6696459B1 (en) | 1994-12-22 | 2004-02-24 | Ligand Pharmaceuticals Inc. | Steroid receptor modulator compounds and methods |
ATE269336T1 (de) * | 1994-12-22 | 2004-07-15 | Ligand Pharm Inc | Steroidrezeptor-modulator verbindungen und methoden |
JP3896552B2 (ja) * | 1996-03-25 | 2007-03-22 | 大塚製薬株式会社 | チアゾール誘導体−金属錯体 |
WO1998008841A1 (de) * | 1996-08-26 | 1998-03-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue thiazol-derivate mit phosphodiesterase inhibierender wirkung |
WO1998008844A1 (de) * | 1996-08-26 | 1998-03-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thiazol-derivate als selektive inhibitoren der pde-iv |
JP4300373B2 (ja) * | 1996-09-30 | 2009-07-22 | 大塚製薬株式会社 | サイトカイン産生抑制剤及び接着抑制剤 |
JP4305662B2 (ja) * | 1996-09-30 | 2009-07-29 | 大塚製薬株式会社 | サイトカイン産生抑制剤及び接着抑制剤 |
JP4305668B2 (ja) * | 1996-09-30 | 2009-07-29 | 大塚製薬株式会社 | サイトカイン異常産生又は接着作用の亢進に伴う疾患を予防又は治療するための薬剤 |
MY128323A (en) | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
AU5652698A (en) * | 1996-11-12 | 1998-06-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors |
JP2001506271A (ja) * | 1996-12-23 | 2001-05-15 | デュポン ファーマシューティカルズ カンパニー | Xa因子阻害剤としての酸素またはイオウを含む複素環式芳香族化合物 |
US6187797B1 (en) | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
HUP0003906A2 (hu) * | 1997-06-19 | 2001-05-28 | Du Pont Pharmaceuticals Co. | Xa faktort gátló hatású heterociklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények |
US5998424A (en) * | 1997-06-19 | 1999-12-07 | Dupont Pharmaceuticals Company | Inhibitors of factor Xa with a neutral P1 specificity group |
ZA985251B (en) | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Inhibitors of factor Xa with a neutral P1 specificity group. |
US6339099B1 (en) | 1997-06-20 | 2002-01-15 | Dupont Pharmaceuticals Company | Guanidine mimics as factor Xa inhibitors |
US5886191A (en) * | 1997-08-18 | 1999-03-23 | Dupont Pharmaceuticals Company | Amidinoindoles, amidinoazoles, and analogs thereof |
JPH11193281A (ja) * | 1997-10-27 | 1999-07-21 | Takeda Chem Ind Ltd | アデノシンa3受容体拮抗剤およびチアゾール化合物 |
WO1999038829A1 (fr) | 1998-01-28 | 1999-08-05 | Shionogi & Co., Ltd. | Nouveau compose tricyclique |
DE19816880A1 (de) * | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
US6322449B1 (en) | 1998-02-04 | 2001-11-27 | Klitsner Industrial Design, Llc | Mechanical interface device |
EP1092711A4 (de) | 1998-07-01 | 2002-07-31 | Takeda Chemical Industries Ltd | Retinoidassoziierte regulatoren von rezeptoren |
US6083966A (en) | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
EP1143951A3 (de) * | 1998-09-21 | 2002-02-06 | University Of Florida Research Foundation, Inc. | Mittel gegen malaria |
JP4336913B2 (ja) * | 1999-02-12 | 2009-09-30 | 大塚製薬株式会社 | アミド誘導体の製造方法 |
JP2000281664A (ja) * | 1999-03-30 | 2000-10-10 | Otsuka Pharmaceut Co Ltd | チアゾール誘導体 |
ES2197092T3 (es) | 1999-04-02 | 2004-01-01 | Bristol-Myers Squibb Pharma Company | Sulfonil arilos como inhibidores del factor xa. |
ATE312820T1 (de) * | 1999-10-28 | 2005-12-15 | Trine Pharmaceuticals Inc | Pumpeninhibitoren zur freisetzung von medikamenten |
JP2001131151A (ja) * | 1999-11-02 | 2001-05-15 | Shionogi & Co Ltd | オレフィン誘導体の新規用途 |
JP2004510764A (ja) * | 2000-10-02 | 2004-04-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 代謝共役型グルタミン酸受容体拮抗剤 |
JP4160295B2 (ja) * | 2000-12-08 | 2008-10-01 | 武田薬品工業株式会社 | 3−ピリジル基を有する置換チアゾール誘導体、その製造法および用途 |
DE10102084B4 (de) | 2001-01-18 | 2006-06-29 | Wella Ag | 1,4-Diamino-2-(thiazol-2-yl)-benzol-Derivate enthaltende Haarfärbemittel |
US7056917B2 (en) * | 2001-04-26 | 2006-06-06 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
CA2445697A1 (en) * | 2001-04-26 | 2002-11-07 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
ATE305299T1 (de) | 2001-07-24 | 2005-10-15 | Otsuka Pharma Co Ltd | Verwendung von thiazolderivaten zur herstellung eines medikaments zur behandlung von chronischen obstruktiven atemwegserkrankungen |
US8124625B2 (en) | 2001-09-14 | 2012-02-28 | Shionogi & Co., Ltd. | Method of enhancing the expression of apolipoprotein AI using olefin derivatives |
WO2003048140A1 (fr) * | 2001-12-03 | 2003-06-12 | Japan Tobacco Inc. | Compose azole et utilisation medicinale de celui-ci |
FR2835254B1 (fr) * | 2002-01-25 | 2006-04-07 | Sod Conseils Rech Applic | Derives de thiazoles dans le traitement de maladies neurologiques |
US6822097B1 (en) * | 2002-02-07 | 2004-11-23 | Amgen, Inc. | Compounds and methods of uses |
TWI314928B (en) | 2002-02-28 | 2009-09-21 | Novartis A | 5-phenylthiazole derivatives and use as pi3 kinase inhibitors |
US7348348B2 (en) * | 2002-04-30 | 2008-03-25 | Merck & Co. Inc. | Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers |
JP2005530800A (ja) * | 2002-05-15 | 2005-10-13 | スミスクライン・ビーチャム・コーポレイション | ベンゾオキサジンおよびベンゾオキサジノン置換トリアゾール |
US20040132789A1 (en) * | 2002-08-22 | 2004-07-08 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
US20040044220A1 (en) * | 2002-08-22 | 2004-03-04 | University Of Florida | Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin |
DE20301728U1 (de) | 2002-10-11 | 2004-03-11 | Ligand Pharmaceuticals, Inc., San Diego | 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen |
US20040147561A1 (en) * | 2002-12-27 | 2004-07-29 | Wenge Zhong | Pyrid-2-one derivatives and methods of use |
MXPA05010945A (es) * | 2003-04-09 | 2005-11-25 | Japan Tobacco Inc | Compuesto pentaciclico heteroaromatico y uso medicinal del mismo. |
TW200503700A (en) * | 2003-07-17 | 2005-02-01 | Otsuka Pharma Co Ltd | Enema preparation |
AU2003270473A1 (en) * | 2003-09-09 | 2005-04-27 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
WO2005103022A1 (en) * | 2004-04-20 | 2005-11-03 | Transtech Pharma, Inc. | Substituted thiazole and pyrimidine derivatives as melanocortin receptor modulators |
US7655680B2 (en) * | 2004-05-17 | 2010-02-02 | Otsuka Pharmaceutical Co., Ltd. | Thiazole compound and use thereof |
EP3190106B1 (de) | 2005-04-04 | 2019-05-08 | University of Florida Research Foundation, Inc. | Desferrithiocinpolyether-analoga |
WO2007043400A1 (ja) * | 2005-10-07 | 2007-04-19 | Kissei Pharmaceutical Co., Ltd. | 含窒素芳香族複素環化合物およびそれを含有する医薬組成物 |
AR056893A1 (es) * | 2005-12-28 | 2007-10-31 | Takeda Pharmaceutical | Compuestos heterociclicos fusionados y no fusionados, antagonistas de receptores mineralocorticoides |
TWI394753B (zh) * | 2006-03-17 | 2013-05-01 | Otsuka Pharma Co Ltd | 新穎替妥牟拉(tetomilast)晶體 |
TW200815054A (en) | 2006-06-19 | 2008-04-01 | Otsuka Pharma Co Ltd | Methods of using a thiazole derivative |
CN102772411A (zh) | 2006-07-05 | 2012-11-14 | 奈科明有限责任公司 | 用于治疗炎症性肺部疾病的HMG-CoA还原酶抑制剂与磷酸二酯酶4抑制剂的组合 |
TW200815428A (en) | 2006-08-15 | 2008-04-01 | Wyeth Corp | Oxazolidone derivatives as PR modulators |
US7538107B2 (en) | 2006-08-15 | 2009-05-26 | Wyeth | Oxazinan-2-one derivatives useful as PR modulators |
US7649007B2 (en) | 2006-08-15 | 2010-01-19 | Wyeth Llc | Oxazolidine derivatives as PR modulators |
WO2008021309A1 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Imidazolidin-2-one derivatives useful as pr modulators |
WO2008021338A2 (en) | 2006-08-15 | 2008-02-21 | Wyeth | Tricyclic oxazolidone derivatives useful as pr modulators |
CN101674730B (zh) * | 2007-02-02 | 2014-09-10 | 贝勒医学院 | 用于治疗代谢疾病的组合物和方法 |
US9212179B2 (en) | 2007-02-02 | 2015-12-15 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic disorders |
US9233941B2 (en) | 2007-02-02 | 2016-01-12 | Baylor College Of Medicine | Methods and compositions for the treatment of body weight related disorders |
US9187485B2 (en) | 2007-02-02 | 2015-11-17 | Baylor College Of Medicine | Methods and compositions for the treatment of cancer and related hyperproliferative disorders |
US9085566B2 (en) | 2007-02-02 | 2015-07-21 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and related disorders |
CA2680592C (en) * | 2007-03-15 | 2016-07-05 | University Of Florida Research Foundation, Inc. | Desferrithiocin polyether analogues and uses thereof in treating pathological conditions |
BR122018001851B1 (pt) | 2007-08-13 | 2019-08-20 | Monsanto Technology Llc | Método de controle de nematódeos parasitas de plantas |
US8299106B2 (en) * | 2007-09-06 | 2012-10-30 | Boston Biomedical, Inc. | Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases |
US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
ES2927660T3 (es) * | 2008-06-16 | 2022-11-10 | Univ Tennessee Res Found | Compuestos para el tratamiento del cáncer |
US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
CA2731442A1 (en) * | 2008-08-29 | 2010-03-04 | Transtech Pharma, Inc. | Substituted aminothiazole derivatives, pharmaceutical compositions, and methods of use |
WO2010042998A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1p receptors modulators |
CA2740484C (en) * | 2008-10-17 | 2021-09-21 | Akaal Pharma Pty Ltd | S1p receptors modulators and their use thereof |
CN102883607B (zh) | 2010-03-01 | 2015-07-22 | Gtx公司 | 用于治疗癌的化合物 |
CA2837268C (en) * | 2011-06-07 | 2020-05-12 | Oren M. Becker | Compositions and methods for modulating a kinase |
US20140094465A1 (en) * | 2011-06-10 | 2014-04-03 | N30 Pharmaceuticals, Inc. | Compounds as S-Nitrosoglutathione Reductase Inhibitors |
AU2012352025B2 (en) | 2011-12-16 | 2018-01-18 | University Of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
WO2014030001A1 (en) * | 2012-08-23 | 2014-02-27 | The Institute Of Cancer Research: Royal Cancer Hospital | Fused heterocyclic compounds and their use |
WO2014074926A1 (en) * | 2012-11-09 | 2014-05-15 | Rutgers, The State University Of New Jersey | Therapeutic hydroxyquinolones |
JP6835472B2 (ja) | 2013-03-05 | 2021-02-24 | ユニバーシティ オブ テネシー リサーチ ファウンデーション | 癌の処置のための組成物 |
US9408796B2 (en) | 2013-03-13 | 2016-08-09 | Avon Products, Inc | Cosmetic compositions for improving the appearance of skin |
CA2922703A1 (en) * | 2013-08-29 | 2015-03-05 | Baylor College Of Medicine | Compositions and methods for the treatment of metabolic and body weight related disorders |
EP3071201A4 (de) | 2013-11-22 | 2017-04-26 | University of Florida Research Foundation, Inc. | Desferrithiocin-analoga und verwendungen davon |
US10647688B2 (en) * | 2014-12-19 | 2020-05-12 | Galderma Research & Development | Compounds, synthesis method thereof and use of same in medicine and in cosmetics |
CN107708693A (zh) | 2015-04-27 | 2018-02-16 | 佛罗里达大学研究基金会 | 代谢程序化的金属螯合剂及其用途 |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1970656A (en) * | 1931-11-04 | 1934-08-21 | Winthrop Chem Co Inc | Thiazole compound and process of producing the same |
NL284415A (de) * | 1961-10-19 | |||
JPS3910130B1 (de) * | 1962-05-10 | 1964-06-10 | ||
US3320270A (en) * | 1963-10-08 | 1967-05-16 | Tri Kem Corp | Certain 2-acylimidothiazole compounds |
US3401120A (en) * | 1965-10-23 | 1968-09-10 | Gaf Corp | Corrosion inhibitors |
GB1139940A (en) * | 1966-09-30 | 1969-01-15 | Ici Ltd | Oxazole derivatives |
DE1670383A1 (de) * | 1966-09-14 | 1970-10-29 | Ciba Geigy | Neue Tetrahydroimidazole und Verfahren zu ihrer Herstellung |
US3462448A (en) * | 1966-10-27 | 1969-08-19 | Dow Chemical Co | Substituted phenyl thiazole compounds |
IL28803A (en) * | 1966-11-18 | 1974-05-16 | Wyeth John & Brother Ltd | Oxazole and thiazole compounds,their preparation and pharmaceutical compositions containing them |
GB1226548A (de) * | 1967-06-14 | 1971-03-31 | Wyeth John & Brother Ltd | |
GB1245087A (en) * | 1967-10-26 | 1971-09-02 | Wyeth John & Brother Ltd | Heterocyclic compounds |
US3625999A (en) * | 1968-02-19 | 1971-12-07 | Lever Brothers Ltd | Process for the preparation of phosphonium sulfonate salts |
FR96117E (fr) * | 1968-03-28 | 1972-05-19 | Aquitaine Petrole | Synthese d'oxazoles. |
CY800A (en) * | 1968-04-09 | 1976-12-01 | Wyeth John & Brother Ltd | Novel thiazoline derivatives, the preparation thereof and compositions containing the same |
GB1248070A (en) * | 1968-12-16 | 1971-09-29 | Science Union & Cie | Thiazolyl-benzoic acid derivatives and process for preparing them |
US4001420A (en) * | 1968-12-12 | 1977-01-04 | Science Union Et Cie, Societe Francaise De Recherche Medical | Thiazolyl benzoic acid compounds |
US3635999A (en) | 1969-03-25 | 1972-01-18 | Aquitaine Petrole | Synthesis of oxazoles |
JPS4637822B1 (de) * | 1969-05-31 | 1971-11-08 | ||
US3705153A (en) * | 1969-05-14 | 1972-12-05 | Sumitomo Chemical Co | Novel thiazolyacetic acids and salts thereof |
JPS4624696B1 (de) * | 1969-06-30 | 1971-07-15 | ||
FR2082164A5 (en) * | 1970-03-05 | 1971-12-10 | Aries Robert | Phenylalkyl esters of oxazolyl and thiazolyl carboxylic - acids - analgesics, antiinflammatories, tranquilisers |
GB1308028A (en) * | 1970-06-12 | 1973-02-21 | Science Union & Cie | Thiazolylbenzoic acid derivatives and a process for their manufactur |
DE2048272C3 (de) * | 1970-10-01 | 1974-10-17 | Dynamit Nobel Ag, 5210 Troisdorf | Verfahren zur Herstellung von 1,1,2-Trimethoxyäthanund o-Essigsäuremethylester |
CA962269A (en) | 1971-05-05 | 1975-02-04 | Robert E. Grahame (Jr.) | Thiazoles, and their use as insecticides |
GB1381860A (en) * | 1971-06-03 | 1975-01-29 | Wyeth John & Brother Ltd | Tetrazole derivatives |
JPS471469A (de) * | 1971-06-22 | 1972-01-25 | ||
DE2152367C2 (de) * | 1971-10-21 | 1985-01-03 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von 4- Methyl-oxazolen |
BE791087A (fr) * | 1971-11-15 | 1973-03-01 | Lepetit Spa | Oxazoles 2,4,5-trisubstitues et leur preparation |
BE794096A (fr) * | 1972-08-07 | 1973-05-16 | Lepetit Spa | Oxazoles 2,4,5-trisubstitues et leur preparation |
JPS4938268A (de) * | 1972-08-16 | 1974-04-09 | ||
JPS4938267A (de) * | 1972-08-18 | 1974-04-09 | ||
JPS5327586B2 (de) * | 1972-08-23 | 1978-08-09 | ||
JPS503315A (de) * | 1973-05-10 | 1975-01-14 | ||
US4072689A (en) * | 1973-02-22 | 1978-02-07 | Gruppo Lepetit S.P.A. | Monoamino 2,4,5-trisubstituted oxazoles |
JPS5030619A (de) * | 1973-07-23 | 1975-03-26 | ||
HU168036B (de) * | 1973-11-09 | 1976-02-28 | ||
DE2711655A1 (de) * | 1977-03-17 | 1978-09-21 | Basf Ag | Pyridinyl-aminoalkylaether |
US4259341A (en) * | 1977-06-01 | 1981-03-31 | Merck & Co., Inc. | Di- and tri-substituted thiazoles |
US4153703A (en) * | 1977-06-30 | 1979-05-08 | Uniroyal, Inc. | Method of controlling insects and acarids with certain aryl-substituted thiazoles |
JPS5461936A (en) * | 1977-10-26 | 1979-05-18 | Ricoh Co Ltd | Photoreceptor for electrophotography |
JPS6051475B2 (ja) * | 1977-11-08 | 1985-11-14 | 久光製薬株式会社 | 新規なフエニル酢酸誘導体 |
GB1574583A (en) * | 1978-02-09 | 1980-09-10 | Wyeth John & Brother Ltd | Process for preparing thiazoles |
US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
US4221584A (en) * | 1979-02-09 | 1980-09-09 | Chevron Research Company | Herbicidal and plant-growth-regulating N-(heterocyclyl)-methylacetanilides |
JPS55111418A (en) * | 1979-02-21 | 1980-08-28 | Santen Pharmaceut Co Ltd | Remedy for eye disease and its preparation |
AU534093B2 (en) * | 1979-03-19 | 1984-01-05 | Ici Australia Limited | Thiazoles,benzthiazoles, benzoxazoles and benzimidazoles |
NZ193011A (en) * | 1979-03-19 | 1983-03-15 | Ici Australia Ltd | Diarylamine derivatives intermediates herbicidal compositions |
JPS55133366A (en) * | 1979-04-05 | 1980-10-17 | Otsuka Pharmaceut Factory Inc | Thiazole derivative |
US4298743A (en) * | 1979-09-11 | 1981-11-03 | Merck & Co., Inc. | 4-(Substituted phenyl thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones |
JPS56123544A (en) * | 1980-03-03 | 1981-09-28 | Hitachi Ltd | Composite type electrophotographic plate and electrophotographic method using it |
US4322428A (en) * | 1980-04-02 | 1982-03-30 | Eli Lilly And Company | 2(4-Fluorophenyl)-4,5,-bis(4-methoxyphenyl)thiazole and method of use |
ZA811691B (en) * | 1980-04-03 | 1982-10-27 | Wyeth John & Brother Ltd | Thiazoles |
US4329459A (en) * | 1980-05-05 | 1982-05-11 | The Upjohn Company | Tetrahydrobenzopyran derivatives |
US4282364A (en) * | 1980-05-22 | 1981-08-04 | Merck & Co., Inc. | Process for the preparation of thiazoles |
JPS58120257A (ja) * | 1982-01-12 | 1983-07-18 | Hitachi Chem Co Ltd | 電子写真感光体 |
DD204094A1 (de) * | 1982-02-11 | 1983-11-16 | Horst Hartmann | Verfahren zur herstellung von 2-aryl-4-cumaryl-(3')- bzw. 2,4-bis-cumaryl-(3')-thiazolen |
JPS58201771A (ja) * | 1982-05-19 | 1983-11-24 | Tanabe Seiyaku Co Ltd | アルキルオキサゾリル酢酸誘導体 |
JPS58219169A (ja) * | 1982-06-15 | 1983-12-20 | Takeda Chem Ind Ltd | オキサゾ−ル酢酸誘導体 |
JPS5925381A (ja) * | 1982-06-30 | 1984-02-09 | Hisamitsu Pharmaceut Co Inc | 新規なフエニル酢酸誘導体 |
JPS5925380A (ja) * | 1982-06-30 | 1984-02-09 | Hisamitsu Pharmaceut Co Inc | 新規なフエニル酢酸誘導体 |
US4659657A (en) * | 1982-12-24 | 1987-04-21 | Bayer Aktiengesellschaft | Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases |
JPS6058981A (ja) * | 1983-09-09 | 1985-04-05 | Takeda Chem Ind Ltd | 5−ピリジル−1,3−チアゾ−ル誘導体,その製造法およびそれを含んでなる医薬組成物 |
JPS6051111A (ja) * | 1983-08-30 | 1985-03-22 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
JPS60151045A (ja) * | 1984-01-19 | 1985-08-08 | 富士写真フイルム株式会社 | 感光材料用包装材料 |
DE3406329A1 (de) * | 1984-02-22 | 1985-08-22 | Merck Patent Gmbh, 6100 Darmstadt | Pyridone |
JPS6133186A (ja) * | 1984-07-25 | 1986-02-17 | Kanebo Ltd | 新規なジフエニルピロリルチアゾ−ル誘導体、その製造法およびそれを有効成分とする医薬組成物 |
JPS60222481A (ja) * | 1984-04-19 | 1985-11-07 | Kanebo Ltd | 新規なジフエニルピロリルチアゾ−ル誘導体、その製造法およびそれを有効成分とする医薬組成物 |
JPS61200985A (ja) * | 1985-02-28 | 1986-09-05 | Kanebo Ltd | 新規なジフエニルピロリルチアゾ−ル誘導体、その製造法およびそれを有効成分とする医薬組成物 |
US4659726A (en) * | 1984-04-19 | 1987-04-21 | Kanebo, Ltd. | Novel 4,5-Bis (4-methoxyphenyl)-2-(pyrrol-2-yl) thiazoles and pharmaceutical composition containing the same |
JPS60230147A (ja) * | 1984-04-27 | 1985-11-15 | Ricoh Co Ltd | 電子写真製版用印刷原版 |
DE3425118A1 (de) * | 1984-07-07 | 1986-01-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue redox-indikatoren |
JPS6123790A (ja) * | 1984-07-12 | 1986-02-01 | Hitachi Cable Ltd | NiまたはNi合金表面へのメツキ方法 |
DE3501696A1 (de) * | 1985-01-19 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Pyridopyrimidine, mehrere verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE3525689C1 (de) * | 1985-07-18 | 1986-10-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren und Einrichtung zum Betrieb eines mit einer Protonenuebertragungsreaktion arbeitenden Farbstoff-Lasers |
CA1292226C (en) * | 1986-01-16 | 1991-11-19 | Terumi Hachiya | Indenothiazole derivative and process for preparing the same |
DE3601411A1 (de) * | 1986-01-20 | 1987-07-23 | Nattermann A & Cie | 3-amino-1-(2-thiazolyl)-2-pyrazoline, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
KR900000566B1 (ko) * | 1986-04-30 | 1990-01-31 | 에프 엠 씨 코포레이션 | 광활성 아졸 살충제 |
JPH075579B2 (ja) * | 1986-09-01 | 1995-01-25 | 吉富製薬株式会社 | アミノチアゾ−ル化合物 |
JPS63192755A (ja) * | 1987-02-06 | 1988-08-10 | Fujisawa Pharmaceut Co Ltd | 2−フエニルアゾ−ル誘導体およびその塩 |
US4791200A (en) * | 1987-06-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2-substituted-4-aryl-substituted thiazoles |
JPS6422861A (en) * | 1987-07-18 | 1989-01-25 | Kirin Brewery | New substance ag55-2 |
MY104933A (en) * | 1987-09-30 | 1994-07-30 | Pfizer Ltd | Platelet activating factor antagonists |
JPH02171280A (ja) * | 1988-12-26 | 1990-07-02 | Agency Of Ind Science & Technol | インクジェット用蛍光性インク組成物 |
DE3929233A1 (de) | 1989-09-02 | 1991-03-07 | Bayer Ag | 5-heterocyclyl-pyridin-3-carbon-benzylamide und -anilide |
AU621245B2 (en) * | 1989-10-17 | 1992-03-05 | Boehringer Mannheim Gmbh | Hydrolase substrates, a process for the preparation thereof and agents containing them |
-
1991
- 1991-11-29 CA CA002396738A patent/CA2396738C/en not_active Expired - Lifetime
- 1991-11-29 WO PCT/JP1991/001659 patent/WO1992009586A1/ja active IP Right Grant
- 1991-11-29 KR KR1019920701815A patent/KR100195433B1/ko not_active IP Right Cessation
- 1991-11-29 DK DK91920815T patent/DK0513387T3/da active
- 1991-11-29 ES ES91920815T patent/ES2144403T3/es not_active Expired - Lifetime
- 1991-11-29 TW TW080109410A patent/TW311136B/zh not_active IP Right Cessation
- 1991-11-29 DE DE69133471T patent/DE69133471T2/de not_active Expired - Lifetime
- 1991-11-29 DE DE69132006T patent/DE69132006T2/de not_active Expired - Lifetime
- 1991-11-29 EP EP01112988A patent/EP1130017B1/de not_active Expired - Lifetime
- 1991-11-29 DE DE69132944T patent/DE69132944T2/de not_active Expired - Lifetime
- 1991-11-29 EP EP99107493A patent/EP0934937B1/de not_active Expired - Lifetime
- 1991-11-29 EP EP91920815A patent/EP0513387B1/de not_active Expired - Lifetime
- 1991-11-29 CA CA002074933A patent/CA2074933C/en not_active Expired - Lifetime
- 1991-11-29 ES ES99107493T patent/ES2173683T3/es not_active Expired - Lifetime
- 1991-11-29 CA CA002547947A patent/CA2547947C/en not_active Expired - Lifetime
- 1991-11-29 ES ES01112988T patent/ES2245660T3/es not_active Expired - Lifetime
- 1991-11-29 DK DK01112988T patent/DK1130017T3/da active
- 1991-11-29 DK DK99107493T patent/DK0934937T3/da active
- 1991-11-29 JP JP3342495A patent/JP2829451B2/ja not_active Expired - Lifetime
-
1995
- 1995-05-19 US US08/444,728 patent/US5643932A/en not_active Ceased
- 1995-06-07 US US08/482,657 patent/US5677319A/en not_active Expired - Lifetime
-
1997
- 1997-03-25 US US08/826,343 patent/US6080764A/en not_active Expired - Fee Related
- 1997-08-13 JP JP23337097A patent/JP3182556B2/ja not_active Expired - Lifetime
-
1998
- 1998-04-16 HK HK98103139A patent/HK1003938A1/xx not_active IP Right Cessation
- 1998-11-18 KR KR1019980709313A patent/KR100249545B1/ko not_active IP Right Cessation
-
1999
- 1999-02-08 US US09/245,914 patent/USRE37556E1/en not_active Expired - Lifetime
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