DE843818T1 - Kultivierung von lawsonia intracellularis, impfstoffe gegen lawsonia intracellularis und diagnostische agenzien - Google Patents
Kultivierung von lawsonia intracellularis, impfstoffe gegen lawsonia intracellularis und diagnostische agenzienInfo
- Publication number
- DE843818T1 DE843818T1 DE0843818T DE96921391T DE843818T1 DE 843818 T1 DE843818 T1 DE 843818T1 DE 0843818 T DE0843818 T DE 0843818T DE 96921391 T DE96921391 T DE 96921391T DE 843818 T1 DE843818 T1 DE 843818T1
- Authority
- DE
- Germany
- Prior art keywords
- bacteria
- intracellularis
- cells
- infected
- animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001148567 Lawsonia intracellularis Species 0.000 title claims abstract 25
- 229960005486 vaccine Drugs 0.000 title claims abstract 8
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 241000894006 Bacteria Species 0.000 claims abstract 26
- 238000000034 method Methods 0.000 claims abstract 18
- 230000002238 attenuated effect Effects 0.000 claims abstract 13
- 241001465754 Metazoa Species 0.000 claims abstract 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 9
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 9
- 239000001301 oxygen Substances 0.000 claims abstract 9
- 239000000725 suspension Substances 0.000 claims abstract 8
- 230000028993 immune response Effects 0.000 claims abstract 7
- 230000001939 inductive effect Effects 0.000 claims abstract 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 239000002054 inoculum Substances 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims 20
- 239000012472 biological sample Substances 0.000 claims 4
- 238000003306 harvesting Methods 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
- C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56922—Campylobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/825—Bacterial vaccine for porcine species, e.g. swine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/465,337 US5714375A (en) | 1995-06-05 | 1995-06-05 | Ileal symbiont intracellularis propagation in suspended host cells |
| US08/658,194 US5885823A (en) | 1995-06-05 | 1996-06-04 | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| PCT/US1996/009576 WO1996039629A1 (en) | 1995-06-05 | 1996-06-05 | Lawsonia intracellularis cultivation, anti-lawsonia intracellularis vaccines and diagnostic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE843818T1 true DE843818T1 (de) | 2002-11-28 |
Family
ID=27041284
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0843818T Pending DE843818T1 (de) | 1995-06-05 | 1996-06-05 | Kultivierung von lawsonia intracellularis, impfstoffe gegen lawsonia intracellularis und diagnostische agenzien |
| DE69638016T Expired - Lifetime DE69638016D1 (de) | 1995-06-05 | 1996-06-05 | Lawsonia intracellularis Kultivierung, anti-Lawsonia intracellularis Impfstoffe und diagnostische Mittel |
| DE69637251.7T Expired - Lifetime DE69637251T3 (de) | 1995-06-05 | 1996-06-05 | Kultivierung von Lawsonia intracellularis, Impfstoffe gegen Lawsonia intracellularis und diagnostische Mittel |
| DE122007000102C Pending DE122007000102I1 (de) | 1995-06-05 | 1996-06-05 | Kultivierung von Lawsonia intracellularis, Impfstoffe gegen Lawsonia intracellularis und diagnostische Mittel |
| DE69634334T Expired - Lifetime DE69634334T2 (de) | 1995-06-05 | 1996-06-05 | Kultivierung von lawsonia intracellularis, impfstoffe gegen lawsonia intracellularis und diagnostische agenzien |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69638016T Expired - Lifetime DE69638016D1 (de) | 1995-06-05 | 1996-06-05 | Lawsonia intracellularis Kultivierung, anti-Lawsonia intracellularis Impfstoffe und diagnostische Mittel |
| DE69637251.7T Expired - Lifetime DE69637251T3 (de) | 1995-06-05 | 1996-06-05 | Kultivierung von Lawsonia intracellularis, Impfstoffe gegen Lawsonia intracellularis und diagnostische Mittel |
| DE122007000102C Pending DE122007000102I1 (de) | 1995-06-05 | 1996-06-05 | Kultivierung von Lawsonia intracellularis, Impfstoffe gegen Lawsonia intracellularis und diagnostische Mittel |
| DE69634334T Expired - Lifetime DE69634334T2 (de) | 1995-06-05 | 1996-06-05 | Kultivierung von lawsonia intracellularis, impfstoffe gegen lawsonia intracellularis und diagnostische agenzien |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5885823A (enExample) |
| EP (5) | EP2199795B1 (enExample) |
| JP (4) | JP3765834B2 (enExample) |
| KR (4) | KR100758614B1 (enExample) |
| AT (3) | ATE441863T1 (enExample) |
| AU (1) | AU717045B2 (enExample) |
| BG (1) | BG64292B1 (enExample) |
| BR (2) | BRPI9612938B8 (enExample) |
| CA (1) | CA2222643C (enExample) |
| CZ (1) | CZ295933B6 (enExample) |
| DE (5) | DE843818T1 (enExample) |
| DK (3) | DK0843818T3 (enExample) |
| ES (3) | ES2332587T3 (enExample) |
| FR (1) | FR07C0071I2 (enExample) |
| HU (1) | HU230199B1 (enExample) |
| LU (1) | LU91405I2 (enExample) |
| NL (1) | NL300331I2 (enExample) |
| NZ (1) | NZ319994A (enExample) |
| PL (6) | PL189287B1 (enExample) |
| PT (3) | PT1645567E (enExample) |
| RO (1) | RO118885B1 (enExample) |
| RU (2) | RU2265849C2 (enExample) |
| WO (1) | WO1996039629A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9611623A (pt) * | 1995-11-30 | 1999-12-28 | Daratech Pty Ltd | Composição de vacina e processo para a profilaxia ou tratamento de infecção em um animal ou pássaro por lawsonia intracelularis ou microorganismo relacionado, molécula de ácido nucleico isolada, e, vacina genética. |
| FR2772047B1 (fr) | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
| NZ515331A (en) * | 1999-05-13 | 2003-07-25 | Pfizer Prod Inc | Lawsonia derived gene and related FlgE polypeptides, peptides and proteins and their uses |
| US7052697B1 (en) * | 1999-05-13 | 2006-05-30 | Agriculture Victoria Services Pty Ltd | Lawsonia derived gene and related OmpH polypeptides, peptides and proteins and their uses |
| BR0011290A (pt) * | 1999-05-13 | 2002-05-21 | Agriculture Victoria Serv Pty | Gene derivado de lawsonia e polipeptìdeos, peptìdeos e proteìnas de omph relacionados e seus usos |
| NZ515363A (en) * | 1999-05-13 | 2003-07-25 | Pfizer Prod Inc | Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses |
| EP1177212A4 (en) * | 1999-05-13 | 2002-08-28 | Pfizer Prod Inc | LAWSONIA DERIVATIVE GENE AND RELATED POLYPEPTIDES, PEPTIDES AND SODC PROTEINS, AND USES THEREOF |
| US7029683B1 (en) | 1999-05-13 | 2006-04-18 | Pfizer Products, Inc. | Lawsonia derived gene and related hemolysin polypeptides, peptides and proteins and their uses |
| US6605696B1 (en) * | 1999-10-22 | 2003-08-12 | Pfizer, Inc. | Lawsonia intracellularis proteins, and related methods and materials |
| AU9315101A (en) * | 2000-09-29 | 2002-04-08 | Univ Arizona | Improved vaccines for proliferative ileitis and methods of making and using the same |
| EP1332154A4 (en) * | 2000-11-10 | 2005-05-11 | Agriculture Victoria Serv Pty | NEW THERAPEUTIC COMPOSITIONS FOR TREATING LAWSONIA SPP INFECTION |
| AUPR138100A0 (en) | 2000-11-10 | 2000-12-07 | Agriculture Victoria Services Pty Ltd | Novel therapeutic compositions for treating infection by lawsonia spp |
| EP1219711B1 (en) * | 2000-12-20 | 2006-06-14 | Intervet International BV | Lawsonia intracellularis vaccine |
| US20030087421A1 (en) * | 2001-07-11 | 2003-05-08 | Gebhart Connie J | Lawsonia intracellularis |
| EP1570045A4 (en) * | 2002-10-04 | 2007-09-05 | Univ Minnesota | NUCLEIC ACID AND POLYPEPTIDE SEQUENCES FROM LAWSONIA INTRACELLULARIS AND METHOD OF USE |
| SI1651260T2 (sl) * | 2003-07-25 | 2018-09-28 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia intracellularis evropskega izvora in vakcine, diagnostična sredstva in postopki za njihovo uporabo |
| DE602004024423D1 (de) | 2003-09-12 | 2010-01-14 | Intervet Int Bv | Impfstoff mit lawsonia intracellularis-untereinheit |
| BRPI0417440A (pt) * | 2003-12-09 | 2007-03-06 | Intervet Int Bv | ácido nucleico, fragmento e molécula de dna, veìculo recombinante vivo, célula hospedeira, proteìna de lawsonia intracellularis, vacina para combater as infecções com lawsonia intracelularis, método para a preparação de uma vacina, e, testes de diagnóstico para aldetecção de anticorpos contra lawsonia intracellularis e material antigênico de lawsonia intracellularis |
| EP1709067B1 (en) * | 2004-01-22 | 2010-06-09 | Intervet International BV | Lawsonia intracellularis subunit vaccines |
| EP1609870A1 (en) * | 2004-06-24 | 2005-12-28 | Boehringer Ingelheim Vetmedica Gmbh | Method of diagnosing lawsonia intracellularis |
| MY146476A (en) | 2004-06-24 | 2012-08-15 | Boehringer Ingelheim Vetmed | Method of diagnosing lawsonia intracellularis |
| US20060021536A1 (en) * | 2004-07-30 | 2006-02-02 | Limin Song | Method for creating an absorbent article exhibiting a harmonic color scheme |
| KR100621882B1 (ko) * | 2004-09-30 | 2006-09-19 | 건국대학교 산학협력단 | 돼지 증식성 회장염 감염돈에서 로소니아인트라셀룰라리스 균을 분리하는 방법 |
| EP1817409A1 (en) * | 2004-11-24 | 2007-08-15 | Pharmacia & Upjohn Company LLC | Methods for cultivating lawsonia intracellularis |
| US20070212373A1 (en) * | 2004-12-08 | 2007-09-13 | Akzo Nobel N.V. | Lawsonia Intracellularis 26 Kd Subunit Vaccine |
| UA95602C2 (ru) | 2004-12-30 | 2011-08-25 | Берингер Ингельхейм Ветмедика, Инк. | Иммуногенная композиция цвс2 и способы приготовления такой композиции |
| US7700285B1 (en) | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
| US7833707B2 (en) * | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
| US8834891B2 (en) | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| US8398994B2 (en) * | 2005-07-15 | 2013-03-19 | Boehringer Ingelheim Vetmedica, Inc. | Lawsonia vaccine and methods of use thereof |
| US20080181910A1 (en) | 2005-12-29 | 2008-07-31 | Boehringer Ingelheim Vetmedica, Inc. | Use of a pcv2 immunogenic composition for lessening clinical symptoms in pigs |
| EP3868400A1 (en) | 2005-12-29 | 2021-08-25 | Boehringer Ingelheim Animal Health USA Inc. | Multivalent pcv2 immunogenic compositions and methods of producing such compositions |
| US8470336B2 (en) * | 2006-05-25 | 2013-06-25 | Boehringer Ingelheim Vetmedica, Inc. | Vaccination of young animals against Lawsonia intracellularis infections |
| US20080241190A1 (en) * | 2006-11-13 | 2008-10-02 | Boehringer Ingelheim Vetmedica, Inc. | Vaccination of horses against lawsonia intracellularis |
| EP2859900A1 (en) | 2006-12-11 | 2015-04-15 | Boehringer Ingelheim Vetmedica, Inc. | Effective method of treatment of porcine circovirus and lawsonia intracellularis infections |
| ES2726777T3 (es) | 2006-12-15 | 2019-10-09 | Boehringer Ingelheim Animal Health Usa Inc | Vacuna porcina anti-PCV2 en dosis única |
| EP1941903A1 (en) | 2007-01-03 | 2008-07-09 | Boehringer Ingelheim Vetmedica Gmbh | Prophylaxis and treatment of PRDC |
| EP1958644A1 (en) | 2007-02-13 | 2008-08-20 | Boehringer Ingelheim Vetmedica Gmbh | Prevention and treatment of sub-clinical pcvd |
| US7829274B2 (en) * | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
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| CN111757752B (zh) * | 2018-02-28 | 2024-08-09 | 勃林格殷格翰动物保健有限公司 | 用于减少动物中的粪臭素和/或吲哚的方法 |
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